Download or read book Asymmetric Synthesis in Organophosphorus Chemistry written by Oleg I. Kolodiazhnyi and published by John Wiley & Sons. This book was released on 2016-12-19 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by one of the leading experts in the field, this is the only comprehensive overview of chiral organophosphorus compounds, from asymmetric synthesis to catalysis and pharmacological applications. As such, this unique reference covers the chemical background as well as spectroscopical analysis of phosphorus compounds, and thoroughly describes all the various synthetic strategies for these substances. Metal-, organo- and biocatalyzed reactions for the introduction of phosphorus are explained as are asymmetric oxidation and reduction methods for the preparation of all possible oxidation states of phosphorus. The text also includes industrial applications for these compounds. Of particular interest to chemists working in the field of asymmetric synthesis, as well as to the pharmaceutical industry due to the increasing number of phosphorous-containing drugs.
Download or read book Amino Acid written by Toshiki Asao and published by BoD – Books on Demand. This book was released on 2017-06-28 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amino Acid - New Insights and Roles in Plant and Animal provides useful information on new aspects of amino acid structure, synthesis reactions, dietary application in animals, and metabolism in plants. Section 1 includes chapters that describe the therapeutic uses, antiallergic effects, new aspects in the D-amino acid structure, historical background of desmosines, and stereoselective synthesis of ?-aminophosphonic acids. Section 2 presents the role of amino acids in plants, which includes new insights and aspects of D-amino acids, metabolism and transport in soybean, changes during energy storage compound accumulation of microalgae, and determination of amino acids from natural compounds. Section 3 describes the chapters on methodologies and requirement of dietary amino acids for Japanese quails, laying hens, and finishing pigs. The final chapter identifies potential importance of glutathione S-transferase activity for generating resistance to triclabendazole in Fasciola hepatica.
Download or read book Strategic Applications of Named Reactions in Organic Synthesis written by Laszlo Kurti and published by Elsevier. This book was released on 2005-04-29 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. - The first reference work on named reactions to present colored schemes for easier understanding - 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples - An opening list of abbreviations includes both structures and chemical names - Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works - Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools - Extensive index quickly locates information using words found in text and drawings
Download or read book Green Organic Reactions written by Gopinathan Anilkumar and published by Springer Nature. This book was released on 2021-03-27 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents important developments and applications of green chemistry, especially in the field of organic chemistry. The chapters give a brief account of green organic reactions in water, green organic reactions using microwave and in solvent-free conditions. In depth discussions on the green aspects of ionic liquids, flow reactions, and recoverable catalysts are provided in this book. An exclusive chapter devoted to green Lewis acid is also included. The potential of supercritical fluids as green solvents in various areas of organic reactions is explained as well. This book will be a valuable reference for beginners as well as advanced researchers interested in green organic chemistry.
Download or read book The Art of Process Chemistry written by Nobuyoshi Yasuda and published by John Wiley & Sons. This book was released on 2010-12-01 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating optimized methods for optimal products.
Download or read book Enantioselective Synthesis of Beta Amino Acids written by Eusebio Juaristi and published by John Wiley & Sons. This book was released on 2005-05-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase in the literature published on the subject, interest in ß-amino acids has grown over the past several years. With major pharmaceutical applications, these amino acids are now studied across multiple lines of research, including combinatorial chemistry, medicinal chemistry, molecular design, proteomics, and others. This Second Edition of Enantioselective Synthesis of ß-Amino Acids updates reviews included in the First Edition while also covering new developments since its publication. The book presents detailed discussions of the most important methods for the synthesis of ß-amino acids. In most cases, the lead chemist who originally developed a method provides an authoritative description of it. In addition, Enantioselective Synthesis of ß-Amino Acids, Second Edition: * Features introductory overviews on the structural types of relevant ß-amino acid targets and salient ß-amino acids present in natural products * Dedicates several chapters to advances in the synthesis of oligomers from ß-amino acids * Includes general and practical procedures for the preparation of ß-amino acids in each chapter * Discusses the most important methods that have been recently developed for the asymmetric synthesis of cyclic and open-chain ß-amino acids * Includes a report on the preparation of libraries of enantiopure ß-amino acids using combinatorial approaches The only book of its kind available today, Enantioselective Synthesis of ß-Amino Acids, Second Edition offers upper-level students and professionals an essential resource for pharmaceutical development, medicinal chemistry, and biochemistry.
Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Download or read book Synthesis of Aziridines and Oxaziridines from Imines written by Navjeet Kaur and published by Elsevier. This book was released on 2024-01-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures. The synthetic community is captivated with prospects of selective synthesis and conversions of aziridines. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine. Synthesis of Aziridines and Oxaziridines from Imines describes the new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. - Focuses on the biological importance of different heterocycles - Describes traditional and innovative methods for the synthesis of aziridines from imines - Includes comparison amongst different methods, reagents, reaction conditions in tabulated forms, advantages, disadvantages, and critical analysis of different methodologies with respect to their comparison with green technique
Download or read book Organosulfur Chemistry in Asymmetric Synthesis written by Takeshi Toru and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this first book to gather the information on this hot topic otherwise widely spread throughout the literature, experienced editors and top international authors cover everything the reader needs -- from the synthesis of chiral organosulfur compounds to applications and catalysis: * Asymmetric synthesis of chiral sulfinates and sulfoxides * Synthesis and use of chiral dithioacetal derivatives, ylids, chiral sulfoximines and sulfinamides * Use of chiral sulfoxides as ligands in catalysis * Asymmetric reactions of alpha-sulfenyl, alpha-sulfinyl and alpha-sulfonyl carbanions. As a result, readers will be able to improve their own performance in asymmetric synthesis.
Download or read book Comprehensive Organic Functional Group Transformations II written by and published by Elsevier. This book was released on 2004-12-16 with total page 9196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Organic Functional Group Transformations II (COFGT-II) will provide the first point of entry to the literature for all scientists interested in chemical transformations. Presenting the vast subject of organic synthesis in terms of the introduction and interconversion of all known functional groups, COFGT-II provides a unique information source documenting all methods of efficiently performing a particular transformation. Organised by the functional group formed, COFGT-II consists of 144 specialist reviews, written by leading scientists who evaluate and summarise the methods available for each functional group transformation. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. By systematically treating each functional group in turn the work also identifies what is not known, thus pointing the way to new research areas Follows the systematic layout of the successful 1995 COFGT reference work, based on the arrangement and bonding of hetero-atoms around a central carbon atom The work will save researchers valuable time in their research as each chapter is written by experts who have critically read and reviewed the literature and presented the best methods of forming every known functional group
Download or read book Comprehensive Medicinal Chemistry II written by David J Triggle and published by Elsevier. This book was released on 2006-12-29 with total page 9367 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well. Also available online via ScienceDirect (2006) - featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. Comprehensively reviews - the strategies, technologies, principles and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Download or read book Amino Acids Peptides and Proteins written by J S Davies and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an ever-increasing domain of activity Amino Acids Peptides and Proteins provides an annual compilation of the world's research effort into this important area of biological chemistry. Volume 31 provides a review of literature published during 1998. Comprising a comprehensive review of significant developments at this biology/chemistry interface each volume opens with an overview of amino acids and their applications. Work on peptides is reviewed over several chapters ranging from current trends in their synthesis and conformational and structural analysis to peptidomimetics and the discovery of peptide-related molecules in nature. The application of advanced techniques in structural elucidation is incorporated into all chapters whilst periodic chapters on metal complexes of amino acids, peptides and beta-lactams extend the scope of coverage. Efficient searching of specialist topics is facilitated by the sub-division of chapters into discrete subject areas allowing annual trends to be monitored. All researchers in the pharmaceutical and allied industries and at the biology/chemistry interface in academia will find this an indispensable reference source.
Download or read book Chiral Sulfur Reagents written by Marian Mikolajczyk and published by CRC Press. This book was released on 1997-06-09 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last three decades, more than 40 different classes of chiral (mirror-image) sulfur compounds have been described, and a number of useful procedures and applications have been developed for their use. Emphasizing modern methodologies, Chiral Sulfur Reagents demonstrates the great potential of enantionmerically pure sulfur reagents in transmitting chirality to other centers. Each chapter highlights the synthesis and synthetic uses of a particular class of chiral sulfur reagent, followed by examples of the most important experimental procedures.
Download or read book Principles of Asymmetric Synthesis written by Robert E. Gawley and published by Elsevier. This book was released on 2012-05-29 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions. After an explanation of the basic physical-organic principles governing stereoselective reactions, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Practical Aspects of Asymmetric Synthesis" provides a critical overview of the most common methods for the preparation of enantiomerically pure compounds, techniques for analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods. The authors then present an overview of the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context. A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis that has been accomplished using a given reaction as a key step. - Authoritative glossary to aid understanding of stereochemical terminology - Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type - A handy reference guide to the literature of asymmetric synthesis for practitioners in the field
Download or read book Development of Methodologies for Asymmetric Synthesis and Drug Discovery written by Guangcheng Liu and published by . This book was released on 1998 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alkaloid Synthesis written by Hans-Joachim Knoelker and published by Springer Science & Business Media. This book was released on 2012-01-13 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Download or read book Taxol written by Matthew Suffness and published by CRC Press. This book was released on 2021-12-17 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.
