Download or read book Obtaining Discovery Abroad written by and published by American Bar Association. This book was released on 2005 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newly-revised and expanded edition of Obtaining Discovery Abroad assists those involved in U.S. litigation in understanding the legal and practical steps for bringing evidence from a foreign jurisdiction back to the United States.
Download or read book Textbook of Drug Design and Discovery Third Edition written by Tommy Liljefors and published by CRC Press. This book was released on 2002-07-25 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.
Download or read book Structure Discovery in Natural Language written by Chris Biemann and published by Springer Science & Business Media. This book was released on 2011-12-08 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current language technology is dominated by approaches that either enumerate a large set of rules, or are focused on a large amount of manually labelled data. The creation of both is time-consuming and expensive, which is commonly thought to be the reason why automated natural language understanding has still not made its way into “real-life” applications yet. This book sets an ambitious goal: to shift the development of language processing systems to a much more automated setting than previous works. A new approach is defined: what if computers analysed large samples of language data on their own, identifying structural regularities that perform the necessary abstractions and generalisations in order to better understand language in the process? After defining the framework of Structure Discovery and shedding light on the nature and the graphic structure of natural language data, several procedures are described that do exactly this: let the computer discover structures without supervision in order to boost the performance of language technology applications. Here, multilingual documents are sorted by language, word classes are identified, and semantic ambiguities are discovered and resolved without using a dictionary or other explicit human input. The book concludes with an outlook on the possibilities implied by this paradigm and sets the methods in perspective to human computer interaction. The target audience are academics on all levels (undergraduate and graduate students, lecturers and professors) working in the fields of natural language processing and computational linguistics, as well as natural language engineers who are seeking to improve their systems.
Download or read book Drugs written by Rick Ng and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs." —Doody's Reviews, May 2009 "The second edition of a book that offers a user-friendly step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of preclinical trials." —Chemistry World, February 2009 The new edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs. This second edition features many key enhancements, including Key Points, Chapter Summary, and Review Questions in each chapter, Answers to Review Questions provided in a book-end appendix, and one or two carefully selected "mini" case studies in each chapter. Richly illustrated throughout with over ninety figures and tables, this important book also includes helpful listings of current FDA and European guidelines and a special section on regulatory authority and processes in China. It is an indispensable resource for pharmaceutical industry and academic researchers, pharmaceutical managers and executives, healthcare clinicians, policymakers, regulators, and lobbyists with an interest in drug development. It is also an excellent textbook for students in pharmacy, science, and medicine courses.
Download or read book Drug Discovery and Development Third Edition written by James J. O'Donnell and published by CRC Press. This book was released on 2019-12-13 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business
Download or read book Privacy Aware Knowledge Discovery written by Francesco Bonchi and published by CRC Press. This book was released on 2010-12-02 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering research at the frontier of this field, Privacy-Aware Knowledge Discovery: Novel Applications and New Techniques presents state-of-the-art privacy-preserving data mining techniques for application domains, such as medicine and social networks, that face the increasing heterogeneity and complexity of new forms of data. Renowned authorities
Download or read book The Sedona Principles written by Jonathan M. Redgrave and published by Pike & Fischer - A BNA Company. This book was released on 2007 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Industrial Applications of Machine Learning written by Pedro Larrañaga and published by CRC Press. This book was released on 2018-12-12 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Industrial Applications of Machine Learning shows how machine learning can be applied to address real-world problems in the fourth industrial revolution, and provides the required knowledge and tools to empower readers to build their own solutions based on theory and practice. The book introduces the fourth industrial revolution and its current impact on organizations and society. It explores machine learning fundamentals, and includes four case studies that address a real-world problem in the manufacturing or logistics domains, and approaches machine learning solutions from an application-oriented point of view. The book should be of special interest to researchers interested in real-world industrial problems. Features Describes the opportunities, challenges, issues, and trends offered by the fourth industrial revolution Provides a user-friendly introduction to machine learning with examples of cutting-edge applications in different industrial sectors Includes four case studies addressing real-world industrial problems solved with machine learning techniques A dedicated website for the book contains the datasets of the case studies for the reader's reproduction, enabling the groundwork for future problem-solving Uses of three of the most widespread software and programming languages within the engineering and data science communities, namely R, Python, and Weka
Download or read book Joint Ventures written by and published by American Bar Association. This book was released on 2006 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Joint Ventures: Antitrust Analysis of Collaborations Among Competitors is the first book to provide a comprehensive analysis of antitrust joint venture law in the immediate aftermath of the Supreme Court's landmark Dagher decision. It reviews antitrust principles applicable to joint ventures and other competitor collaborations, taking into account relevant statutory and case law as well as government guidelines and enforcement practices.
Download or read book Drug Discovery and Development E Book written by Raymond G Hill and published by Elsevier Health Sciences. This book was released on 2012-07-20 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. - The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: - Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. - New topic - DMPK Optimization Strategy in drug discovery. - New chapter on Scaffolds: Small globular proteins as antibody substitutes. - Totally updated chapters on Intellectual Property and Marketing - 50 new illustrations in full colour Features - Accessible, general guide to pharmaceutical research and development. - Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. - Written by a strong team of scientists with long experience in the pharmaceutical industry. - Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: '... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. - Highly Commended in the medicine category of the BMA 2006 medical book competition - Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year
Download or read book Knowledge Discovery from Data Streams written by Joao Gama and published by CRC Press. This book was released on 2010-05-25 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the Internet age and the increased use of ubiquitous computing devices, the large volume and continuous flow of distributed data have imposed new constraints on the design of learning algorithms. Exploring how to extract knowledge structures from evolving and time-changing data, Knowledge Discovery from Data Streams presents
Download or read book Mining Software Specifications written by David Lo and published by CRC Press. This book was released on 2011-05-24 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: An emerging topic in software engineering and data mining, specification mining tackles software maintenance and reliability issues that cost economies billions of dollars each year. The first unified reference on the subject, Mining Software Specifications: Methodologies and Applications describes recent approaches for mining specifications of sof
Download or read book Nmap Network Exploration and Security Auditing Cookbook written by Paulino Calderon and published by Packt Publishing Ltd. This book was released on 2021-09-13 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete reference guide to mastering Nmap and its scripting engine, covering practical tasks for IT personnel, security engineers, system administrators, and application security enthusiasts Key FeaturesLearn how to use Nmap and other tools from the Nmap family with the help of practical recipesDiscover the latest and most powerful features of Nmap and the Nmap Scripting EngineExplore common security checks for applications, Microsoft Windows environments, SCADA, and mainframesBook Description Nmap is one of the most powerful tools for network discovery and security auditing used by millions of IT professionals, from system administrators to cybersecurity specialists. This third edition of the Nmap: Network Exploration and Security Auditing Cookbook introduces Nmap and its family - Ncat, Ncrack, Ndiff, Zenmap, and the Nmap Scripting Engine (NSE) - and guides you through numerous tasks that are relevant to security engineers in today's technology ecosystems. The book discusses some of the most common and useful tasks for scanning hosts, networks, applications, mainframes, Unix and Windows environments, and ICS/SCADA systems. Advanced Nmap users can benefit from this book by exploring the hidden functionalities within Nmap and its scripts as well as advanced workflows and configurations to fine-tune their scans. Seasoned users will find new applications and third-party tools that can help them manage scans and even start developing their own NSE scripts. Practical examples featured in a cookbook format make this book perfect for quickly remembering Nmap options, scripts and arguments, and more. By the end of this Nmap book, you will be able to successfully scan numerous hosts, exploit vulnerable areas, and gather valuable information. What you will learnScan systems and check for the most common vulnerabilitiesExplore the most popular network protocolsExtend existing scripts and write your own scripts and librariesIdentify and scan critical ICS/SCADA systemsDetect misconfigurations in web servers, databases, and mail serversUnderstand how to identify common weaknesses in Windows environmentsOptimize the performance and improve results of scansWho this book is for This Nmap cookbook is for IT personnel, security engineers, system administrators, application security enthusiasts, or anyone who wants to master Nmap and its scripting engine. This book is also recommended for anyone looking to learn about network security auditing, especially if they're interested in understanding common protocols and applications in modern systems. Advanced and seasoned Nmap users will also benefit by learning about new features, workflows, and tools. Basic knowledge of networking, Linux, and security concepts is required before taking up this book.
Download or read book Bioinformatics and Drug Discovery written by Richard S. Larson and published by . This book was released on 2012 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.
Download or read book Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition written by Markus Rudin and published by World Scientific. This book was released on 2020-04-04 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.
Download or read book Model Jury Instructions in Criminal Antitrust Cases written by and published by American Bar Association. This book was released on 2009 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, the profile of criminal antitrust matters has changed dramatically. In many ways, this area of antitrust practice has changed more than any other. This book presents a complete treatment of model jury instructions in the complex area of criminal antitrust law. The level of detail found in this book will allow antitrust practitioners and courts across the country to rely on this handbook, and be well instructed of the intricacies of this important area.
Download or read book World Religions written by Jeffrey Brodd and published by Saint Mary's Press. This book was released on 2003 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major religions of the world are a mystery to many high school teens. Now you can help them unlock the doors of these traditions with our new text, World Religions: A Voyage of Discovery. The book is an introductory survey that helps eleventh and twelfth graders understand the people, dimensions, and religious principles of the world's major religions. The textbook includes a chapter on each of eleven major world religions, including Christianity, Islam, Hinduism, Buddhism, Judaism, and others. The text offers the Catholic perspective on interreligious dialogue, an overview of basic questions that religions address, and Ninian Smart's seven dimensions of religion. A glossary and word pronunciations in each chapter help students learn unfamiliar terms. In addition, the second edition of this text incorporates the following new features: a new chapter on modern trends in religion; new, more detailed maps; a new section on the Aztec religion of Mesoamerica; a sidebar in each chapter offering examples of the seven dimensions of religion; and review questions at the end of each chapter.
