Download or read book Antimicrobial peptides and their druggability bio safety stability and resistance written by Jianhua Wang and published by Frontiers Media SA. This book was released on 2024-05-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibiotics written by Claudio O. Gualerzi and published by John Wiley & Sons. This book was released on 2013-09-05 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Download or read book Clinical Microbiology Procedures Handbook written by and published by John Wiley & Sons. This book was released on 2020-08-06 with total page 2954 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the ever-changing needs and responsibilities of the clinical microbiology field, Clinical Microbiology Procedures Handbook, Fourth Edition has been extensively reviewed and updated to present the most prominent procedures in use today. The Clinical Microbiology Procedures Handbook provides step-by-step protocols and descriptions that allow clinical microbiologists and laboratory staff personnel to confidently and accurately perform all analyses, including appropriate quality control recommendations, from the receipt of the specimen through processing, testing, interpretation, presentation of the final report, and subsequent consultation.
Download or read book Insect Immunity written by Dan Hultmark and published by . This book was released on 1982 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Amphipathic Helix written by Richard M. Epand and published by CRC Press. This book was released on 1993-07-09 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysics, and pharmacology.
Download or read book Bacterial Resistance to Antibiotics written by Boyan B. Bonev and published by John Wiley & Sons. This book was released on 2019-03-14 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Download or read book Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design written by Sanjeev Kumar Singh and published by Springer Nature. This book was released on 2021-02-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.
Download or read book Antimicrobial Peptides and Human Disease written by William Shafer and published by Springer Science & Business Media. This book was released on 2006-10-05 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.
Download or read book Specificity of Proteolysis written by Borivoj Keil and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specificity of Proteolysis presents a survey and conclusions on the action or proteinases - enzymes which are cleaving proteins or peptides. The specificity of proteinases which is determined as the sequence of amino acids at the cleavage site of a substrate, is an important criteria to choose an enzyme as tool in protein research. Whenever one is looking for an enzyme to act at a defined site or to give defined cleavage products one will find comprehensive information in this work. Comprehensive information about more than 280 endopeptidases which are based on the database LYSIS including a calculation program to determine cleavage sites, is given in the book.
Download or read book Inhibitors of Protein Protein Interactions written by Ali Tavassoli and published by Royal Society of Chemistry. This book was released on 2020-12-07 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.
Download or read book Human Amniotic Membrane Basic Science And Clinical Application written by Abdul Aziz Nather and published by World Scientific. This book was released on 2017-08-23 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide for all tissue bank operators to screen, procure and process amniotic membrane for clinical application.The amnion comes close to being the ideal biological membrane or dressing — readily available, inexpensive to procure and process. Its basic science is discussed in detail — anatomy, biological and biomechanical properties.It can be procured from the placenta in normal vaginal deliveries and from Caesarean Sections. Processing is by freeze-drying or by air-drying process with sterilisation using gamma irradiation.The product has low antigenicity, has anti-microbial properties with ability to enhance epithelisation with marked relief of pain. It is useful as a dressing for wounds — flap wounds, burn wounds, injury wounds, diabetic ulcers, leprous ulcers and post-surgery wounds and post-radiation wounds. It is also used as a biological scaffold for cells in tissue engineering. Its ophthalmic applications include treatment of corneal ulcers and conjunctival tumours. Oral uses include gingiva depigmentation and periodontal regeneration.
Download or read book Bacterial Cell Wall Structure and Dynamics written by Tobias Dörr and published by Frontiers Media SA. This book was released on 2019-12-27 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial cells are encased in a cell wall, which is required to maintain cell shape and to confer physical strength to the cell. The cell wall allows bacteria to cope with osmotic and environmental challenges and to secure cell integrity during all stages of bacterial growth and propagation, and thus has to be sufficiently rigid. Moreover, to accommodate growth processes, the cell wall at the same time has to be a highly dynamic structure: During cell enlargement, division, and differentiation, bacteria continuously remodel, degrade, and resynthesize their cell wall, but pivotally need to assure cell integrity during these processes. Finally, the cell wall is also adjusted according to both environmental constraints and metabolic requirements. However, how exactly this is achieved is not fully understood. The major structural component of the bacterial cell wall is peptidoglycan (PG), a mesh-like polymer of glycan chains interlinked by short-chain peptides, constituting a net-like macromolecular structure that has historically also termed murein or murein sacculus. Although the basic structure of PG is conserved among bacteria, considerable variations occur regarding cross-bridging, modifications, and attachments. Moreover, different structural arrangements of the cell envelope exist within bacteria: a thin PG layer sandwiched between an inner and outer membrane is present in Gram-negative bacteria, and a thick PG layer decorated with secondary glycopolymers including teichoic acids, is present in Gram-positive bacteria. Furthermore, even more complex envelope structures exist, such as those found in mycobacteria. Crucially, all bacteria possess a multitude of often redundant lytic enzymes, termed “autolysins”, and other cell wall modifying and synthesizing enzymes, allowing to degrade and rebuild the various structures covering the cells. However, how cell wall turnover and cell wall biosynthesis are coordinated during different stages of bacterial growth is currently unclear. The mechanisms that prevent cell lysis during these processes are also unclear. This Research Topic focuses on the dynamics of the bacterial cell wall, its modifications, and structural rearrangements during cell growth and differentiation. It pays particular attention to the turnover of PG, its breakdown and recycling, as well as the regulation of these processes. Other structures, for example, secondary polymers such as teichoic acids, which are dynamically changed during bacterial growth and differentiation, are also covered. In recent years, our view on the bacterial cell envelope has undergone a dramatic change that challenged old models of cell wall structure, biosynthesis, and turnover. This collection of articles aims to contribute to new understandings of bacterial cell wall structure and dynamics.
Download or read book Peptide based Drug Discovery written by Ved Srivastava and published by Royal Society of Chemistry. This book was released on 2017-06-26 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.
Download or read book The Business of Healthcare Innovation written by Lawton R. Burns and published by Cambridge University Press. This book was released on 2005-08-25 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first wide-ranging analysis of business trends in the manufacturing segment of the health care industry.
Download or read book Peptide Drug Discovery and Development written by Miguel Castanho and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.
Download or read book Normal Mode Analysis written by Qiang Cui and published by CRC Press. This book was released on 2005-12-12 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid developments in experimental techniques continue to push back the limits in the resolution, size, and complexity of the chemical and biological systems that can be investigated. This challenges the theoretical community to develop innovative methods for better interpreting experimental results. Normal Mode Analysis (NMA) is one such technique