Download or read book Angiogenesis and Direct Myocardial Revascularization written by Roger J. Laham and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.

Download or read book Direct Myocardial Revascularization History Methodology Technology written by Peter Whittaker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last five years have witnessed an increasing interest in the subject of transmyocardial laser revascularization (TMR) as illustrated by the number of abstracts presented at the meetings of the American Heart Association and the American College of Cardiology (Figure). The ideas and concepts associated with this particular method of myocardial revascularization have changed dramatically over even this short period of time. The original premise of "de-evolving" mammalian hearts to recreate a reptilian-like myocardial circulation by making multiple channels through the myocardium has been almost (but perhaps not quite) completely dismissed. Now, the most popular notion is that there is an angiogenic response to myocardial channel making. It is this development of new blood vessels that is thought to be responsible for the apparent improvements in symptoms and blood flow. Along the way, the idea that a channel could stay open and allow blood to flow directly from the ventricular chamber has found little support. Rather than directly explore all of these issues and merely duplicate previously published articles, our aim was to take a novel approach: that is, to step back from these arguments and provide perspective from the vantage point of distance. In the case of trans myocardial revascularization, distance comes both in terms of history and in terms of methodology and knowledge from other fields of research. Historically, innovative methods of myocardial revascularization are by no means uncommon. The first two chapters deal with this historical' perspective.

Download or read book Angiogenesis and Direct Myocardial Revascularization 2005 written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Myocardial Revascularization and Angiogenesis written by Stephen E Epstein and published by CRC Press. This book was released on 1999-09-23 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid development of myocardial revascularization from angioplasty to stents, and now to new laser technology has meant that there is an abundance of information available which has not been distilled into a user-friendly format. Confusion exists as to where we are with angiogenesis: what can it do? how do we do it? what is acceptable as a satisfactory result? Drs Kornowski, Epstein and Leon answer the need for a concise reference on the subject. They have assembled a team of internationally-recognised experts who are at the forefront of research and clinical application on myocardial revascularization and angiogenesis. They examine direct, transmyocardial and percutaneous approaches to revascularization. In the latter part of the Handbook, there is discussion about growth factors protein and gene therapy which should serve as a guide and provide background facts so as to ensure greater informational access to the interventional cardiologist.

Download or read book Angiogenesis and Cardiovascular Disease written by J. Anthony Ware and published by . This book was released on 1999 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis and Cardiovascular Disease provides a comprehensive review of the basic scientific and clinical advances in the field of angiogenesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a singlesource. Topics addressed focus first on aspects of development and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic cardiovascular disease. Vascular development, endothelial cell biology, the vascular matrix, and growthfactors are discussed. Up to date information on current clinical trials, and practical advice concerning application to cardiovascular therapeutic options, are also stressed.

Download or read book Bone Marrow Cell Transplantation for Therapeutic Angiogenesis in Ischemic Myocardium written by Hung-Fat Tse and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Bone Marrow Cell Transplantation for Therapeutic Angiogenesis in Ischemic Myocardium: From Bench to Bedside" by Hung-fat, Tse, 謝鴻發, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract Abstract of thesis entitled Bone Marrow Cell Transplantation for Therapeutic Angiogenesis in Ischemic Myocardium- From Bench to Bedside Submitted by Hung-Fat TSE for the Degree of Doctor of Philosophy (Ph.D.) at The University of Hong Kong in May 2007 Abstract Coronary artery disease (CAD) remains the leading cause of morbidity and mortality in the Western world and in Asia, including Hong Kong and China. Despite the advances in medical and surgical therapies, up to 20%-37% of patients with severely CAD are either unsuitable or can only receive incomplete revascularization with conventional revascularization procedures. Recent experimental studies showed that bone marrow (BM) cells can be used to regenerate cardiomyocytes and to induce neovascularization in injured myocardium after myocardial infarction. Nevertheless, several major issues concerning autologous BM cell therapy remained to be addressed. This thesis comprises both experimental and clinical studies on the use of BM cells for therapeutic angiogenesis in chronic ischemic left ventricular (LV) myocardium. In a swine model, I demonstrated the acute safety and feasibility of catheter-based direct endomyocardial injection for delivering BM cells into the targeted sites within the LV. Furthermore, the functional role of BM mononuclear cells (MNC) versus BM endothelial progenitor cells (EPC) in enhancing therapeutic angiogenesis was studied in a porcine chronic ischemic myocardium model. It was found that catheter-based direct endomyocardial injection of BM-MNC was more effective than BM-EPC or saline in enhancing neovascularization and improving LV function in chronic ischemic myocardium. I performed the world's first human study on percutaneous direct endomyocardial injection of autologous BM-MNC in patients with "end-stage" CAD. The initial clinical results suggested that autologous transplantation of BM-MNCs enhanced myocardial perfusion and improved symptoms in these patients. Mid-term of follow-up of patients in this pilot study suggested that direct endomyocardial injection Abstract of autologous BM cells was not associated with any major adverse effects. Furthermore, the beneficial effect of direct endomyocardial injection was over and beyond those noted in those treated with percutaneous laser myocardial revascularization, suggesting a potential direct therapeutic effect of BM cells, rather than the effects resulting from myocardial channeling alone. Nevertheless, the possible potent placebo effect on symptoms observed in these pilot studies highlights the need for a randomized, placebo-controlled group to prove the clinical efficacy of cell based angiogenic therapy for treatment of severe CAD. In the first human randomized controlled study (PROTECT-CAD) including 28 patients enrolled from 2 centers, I studied the safety and clinical efficacy of electromechanical guided catheter-based direct endomyocardial delivery of BM cells into targeted ischemic myocardium. This randomized, placebo controlled trial showed beneficial effects of BM cell therapy over saline injection on symptoms and functional capacity in patients with chronic myocardial ischemia who failed conventional medical and revascularization procedures. In conclusion, the findings of this thesis provide important information

Download or read book Angiogenesis and Growth Factor Expression in a Model of Transmyocardial Revascularization written by Marc P. Pelletier and published by . This book was released on 2000 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Results. Mortality was similar in both groups (5/25 vs. 8/28, p = NS). Group II had significantly greater vascular density than Group I (5.65 vs. 4.06 vessels/HPF, p

Download or read book The AHA Clinical Cardiac Consult written by J. V. Nixon and published by Lippincott Williams & Wilkins. This book was released on 2010-10-18 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ideal source of fast, reliable guidance on diagnosis and management of both common and rare cardiovascular problems, this handbook covers more than 170 problems, diseases, syndromes, and chief complaints in the popular, easy-to-read, two-page 5-Minute Consult format.

Download or read book The Collateral Circulation of the Heart written by Wolfgang Schaper and published by . This book was released on 1971 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Coronary Artery Disease written by Gregory W. Barsness and published by Springer Science & Business Media. This book was released on 2011-12-07 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: A book directed towards individuals with an interest in the clinical treatment of patients with unrevascularizable angina. It explores the treatment options in the setting of a sound scientific background and provides guidance and predictions for future directions in this rapidly developing field. It is the only textbook of its kind and fulfils an unmet need for practicing internal medicine, family practice and cardiovascular clinicians. It also provides a reliable reference for clinical and basic researchers interested in this topic.

Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Download or read book Advanced Therapy in Cardiac Surgery written by Kenneth L. Franco and published by PMPH-USA. This book was released on 2003 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Therapy in Cardiac Surgery - Second Edition This second edition of Advanced Therapy in Cardiac Surgery presents state-of-the-art techniques and an in-depth review of cardiac surgery from the leading authorities. Each of the 62 succinct chapters represents the personal treatment protocols of the experts. The Advanced ......

Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.

Download or read book Vascularization for Tissue Engineering and Regenerative Medicine written by Wolfgang Holnthoner and published by Springer. This book was released on 2021-06-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.

Download or read book Stem Cell and Regenerative Medicine written by Herman S. Cheung and published by Bentham Science Publishers. This book was released on 2010-12-10 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The potential use of stem cells in transplantation for the purpose of tissue regeneration is an exciting area of research currently undergoing rapid development. Implantation of human embryonic or autologous, ex vivo-expanded adult stem cells, particularl"

Download or read book Controversies in Cardiology written by John A. Ambrose and published by Springer. This book was released on 2015-09-10 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will consider several clinical and interventional topics for which there is uncertainty, continued debate and/or no consensus based on current guidelines. While there are numerous guidelines in cardiology, new and on-going trials that address new drugs treatments and procedures raise many unanswered questions. Furthermore, most practicing cardiologist taking care of the patients are likely unable to digest all of these studies or guidelines and necessarily correctly apply them to their patients. If one considers in the guidelines the frequent use of Level C (consensus), there are many areas or situations where no trial exists. Also, when applying the results of a trial to an individual patient, there can be uncertainty of how this patient should be managed based on the present body of evidence.

Download or read book Shockwave Medicine written by C.-J. Wang and published by Karger Medical and Scientific Publishers. This book was released on 2018-04-05 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference work provides a detailed overview of shockwave therapy, a relatively new clinical specialty in modern medicine. It follows the evolution of Extracorporeal Shockwave Therapy (ESWT) from its initial stage as the gold standard for the disintegration of kidney stones to its regenerative effects in biological tissues. Starting with the basic principles of shockwave treatment, the book goes on to review its application in musculoskeletal disorders, including osteonecrosis of the hip, tendinopathy, fracture treatment, and treatment of sports related injuries. The application of ESWT in cardiovascular diseases is discussed. This includes preclinical and clinical applications for ischemic cardiovascular disease and effects on angiogenesis and anti-inflammation-molecular-cellular signaling pathways. The treatment of urinary diseases and erectile dysfunction by ESWT is elaborated. The book concludes with a discussion of future prospects of the shockwave therapy. Scholars and research fellows interested in shockwave medicine will benefit greatly from this work. It is also a useful clinical resource for nephrologists, urologists, cardiologists, and orthopedists.