Download or read book Angelica s Discoveries written by Otilia Greco and published by iUniverse. This book was released on 2012-02-06 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: High in the Swiss Alps in a quaint village far away from the chaos and destruction of World War II, Angelica leads an idyllic childhood haunted by only one thingher fear of water. But as Angelica develops into a strong, independent woman, her desire to travel becomes overpowering, and she vows to overcome her paralyzing fear one day. Now her chance has come. Even as Angelicas father attempts to squelch her insatiable desire to explore Greece and eventually meet her Uncle Victor in the New World, Angelica secures a job as a travel guide and bravely books her first passage on a voyage captained by an old Greek. As Captain Angelis adds wisdom and comfort to Angelicas first voyage, he has no idea that an unexpected adventure awaits them in the unpredictable Mediterranean Sea. Strengthened by her traumatic experience, Angelica safely arrives in Greece where she quickly proves herself in her new job. But when she is pursued by a handsome Greek, she soon realizes that her heart lies with someone else. As Angelicas heart leads her in a new direction, she must bravely face her fear once again as she embarks on a challenging adventure to the New World where her true destiny awaits.
Download or read book Angelica s Discoveries written by Otilia Greco and published by . This book was released on 2021-12-03 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: High in the Swiss Alps in a quaint village far away from the chaos and destruction of World War II, Angelica leads an idyllic childhood haunted by only one thing--her fear of water. But as Angelica develops into a strong, independent woman, her desire to travel becomes overpowering, and she vows to overcome her paralyzing fear one day. Now her chance has come. Even as Angelica's father attempts to squelch her insatiable desire to explore Greece and eventually meet her Uncle Victor in the New World, Angelica secures a job as a travel guide and bravely books her first passage on a voyage captained by an old Greek. As Captain Angelis adds wisdom and comfort to Angelica's first voyage, he has no idea that an unexpected adventure awaits them in the unpredictable Mediterranean Sea. Strengthened by her traumatic experience, Angelica safely arrives in Greece where she quickly proves herself in her new job. But when she is pursued by a handsome Greek, she soon realizes that her heart lies with someone else. As Angelica's heart leads her in a new direction, she must bravely face her fear once again as she embarks on a challenging adventure to the New World where her true destiny awaits.
Download or read book The Lady with the Purple Hat written by Otilia Greco and published by iUniverse. This book was released on 2017-03-29 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ten years ago, Daisy left her husband, Bernard, to create a new life for herself. But now as their divorce proceedings continue to drag on and Bernard battles terminal cancer, Daisy determines she would rather be his widow than his ex-wife and decides to play with fate. After she dons an outlandish large purple hat to disguise her face, Daisy glides through the hospital corridors, hell-bent on poisoning her husband to accelerate his death. When she finally arrives at his door and opens it, she is shocked to see a woman sitting by his bedside. With her plan foiled, Daisy rushes out of the room as she transforms from the hunter into the hunted. Still obsessed with ending Bernards life, Daisy retreats into her memories, unaware that a surprise is waiting in the shadows. Now only time will tell if fate will intervene to save Daisy or if she will lose her soul to the dark side, where it can never be retrieved. In this contemporary thriller, a woman intent on ending her husbands life is propelled on a journey through her memories that leads her to an unexpected truth.
Download or read book From Islands to Portraits written by Sergio Perosa and published by IOS Press. This book was released on 2000 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the long course of literature, islands have accumulated uncanny connotations of death, together with peculiarities of linguistic definition and expression. Since the age of discovery, after the Caribbean Islands, America itself, and later the archipelagos and atolls in the Pacific became known to travellers and conquistadores, islands have been sought, searched, explored and physically possessed as women; cultural recognition takes the form of sexual and physical possession (Venus was born from the sea, and is identified with an island). These are the themes of the first two variations discussed in this book.
Download or read book The Discovery of California written by Otto Von Sadovszky and published by James Currey. This book was released on 1996 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Discovery and Development written by Vishwanath Gaitonde and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.
Download or read book The Discovery of Witchcraft written by Reginald Scot and published by DigiCat. This book was released on 2023-11-23 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Discovery of Witchcraft is an exposé of the early modern witchcraft. Originally published in 1584, the book was written against the belief in witches, to show that witchcraft did not exist. Part of its content exposed how feats of magic were done, and the book is often deemed the first textbook on conjuring. Moreover, the book contains a small section which describes how the charlatans were able to fool the public and why the prosecutions of the accused were unwarranted for and un-Christian. The author also provocatively held the Roman church responsible to the prosecutions. The book became highly popular as an exhaustive encyclopaedia of contemporary beliefs about witchcraft, spirits, alchemy, magic, and legerdemain. William Shakespeare also drew from his study of Scot's book hints for his picture of the witches in Macbeth, and Thomas Middleton in his play of The Witch likewise was indebted to this source.
Download or read book Discovery and Development of Neuroprotective Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2017-05-18 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer's disease, Parkinson's disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. - Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases - Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab
Download or read book New Avenues in Drug Discovery and Bioactive Natural Products written by Raja Chakraborty and published by Bentham Science Publishers. This book was released on 2023-08-01 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Avenues in Drug Discovery and Bioactive Natural Products is the second volume of the Natural Medicine book series. It is devoted to current research in drug discovery from natural sources. The volume features 13 chapters that cover modern analytical and scientific approaches. The book starts with chapters on advanced analytical and research techniques, such as genomic mining, quality control of herbal drugs, DNA fingerprinting, high-throughput screening, molecular docking and extraction techniques. The contributors provide a summary of challenges for researchers and commercial applications where possible. The book also features chapters dedicated to specific medicinal agents that target a disease (glycosides, SARS-CoV2 spike protein inhibitors, and andrographolides. The collection of important research topics in natural product chemistry aims to help the scholars and researchers in the scientific community that are involved in the extraction and development of new medicines.
Download or read book Handbook of Research on Advanced Phytochemicals and Plant Based Drug Discovery written by Singh, Ajeet and published by IGI Global. This book was released on 2022-06-24 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great deal of interest has been generated recently in the isolation, characterization, and biological activity of phytochemicals. Phytochemicals have the potential to enhance pharmaceuticals and drug discovery. As such, there is an urgent need for current research in the global scope of phytochemicals including the chemical and physical characteristics, analytical procedures, biological activity, safety, and industrial applications. The Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery examines the applications of bioactive molecules from a health perspective, examining the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany and medicinal properties. Moreover, it presents a novel dietary approach for human disease management. Covering topics such as computer-aided drug design, government regulation, and medicinal plant taxonomy, this major reference work is beneficial to pharmacists, medical practitioners, phytologists, hospital administrators, government officials, faculty and students of higher education, librarians, researchers, and academicians.
Download or read book Phytochemical Drug Discovery for Central Nervous System Disorders written by Chukwuebuka Egbuna and published by John Wiley & Sons. This book was released on 2023-08-29 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: PHYTOCHEMICAL DRUG DISCOVERY FOR CENTRAL NERVOUS SYSTEM DISORDERS Understand herbal and plant-based treatments for chronic disorders with this groundbreaking work Due in part to the aging of the global population, disorders of the central nervous system have become an increasingly grave public health concern in recent years. Demand for pharmaceutical treatments has been correspondingly high, but there are many barriers to the successful development of effective synthetic drugs. Phytomedicines, or plant-based and herbal medicines, have proven to be an effective alternative, boasting lower toxicity and cost and higher efficacy, and one that demands greater research and broader-based practitioner knowledge. Phytochemical Drug Discovery for Central Nervous System Disorders meets this demand with a timely, clearly-structured guide. It thorough coverage presents a wide range of phytochemicals with potential as candidates for drug discovery, describing their sources, properties, and therapeutic efficacy. The result is a vital contribution to the ongoing fight against central nervous system (CNS) disorders. Phytochemical Drug Discovery for Central Nervous System Disorders readers will also find: Detailed treatment of CNS-active plant products, neuroprotective chemicals, plant-based nutraceutical products, and more Up-to-date information on FDA-approved drugs and existing plant-based products used to treat CNS disorders An authorial team featuring experts from across the globe Phytochemical Drug Discovery for Central Nervous System Disorders is essential for drug discovery scientists, drug developers, medicinal chemists, biochemists, and any researchers and professionals in the health care or pharmaceutical industries.
Download or read book Plant Bioactives and Drug Discovery written by Valdir Cechinel-Filho and published by John Wiley & Sons. This book was released on 2012-05-22 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.
Download or read book The Heavenly Twins written by Sarah Grand and published by University of Michigan Press. This book was released on 1992 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating exploration of gender issues and feminist agendas of the New Woman movement of the late 1800s
Download or read book Medicinal Plants Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID 19 written by Mithun Rudrapal and published by Bentham Science Publishers. This book was released on 2023-11-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference explores medicinal plants, phytomedicines, and traditional herbal remedies as potential sources for the prevention and treatment of COVID-19. It features 9 chapters authored and edited by renowned experts. The book specifically highlights the promising drug discovery opportunities grounded in bioactive compounds from medicinal plants and herbal medicines, offering insights into combatting SARS-CoV-2 infections and respiratory complications. Key Highlights: Drug Discovery Potential: Explores the vast potential of medicinal plants, phytomedicine, and traditional remedies against COVID-19, shedding light on groundbreaking drug discovery avenues. Cutting-Edge Insights: Provides up-to-date insights into the use of medicinal plants, herbal drugs, and traditional medicines in the fight against COVID-19. Natural Immune Boosters: Details the use of indigenous herbs, spices, functional foods, and herbal drugs for boosting immunity and preventing SARS-CoV-2 infections. Drug Repurposing: Highlights innovative drug repurposing strategies using phytomedicine-derived bioactive compounds and phytochemical databases for COVID-19 drug development. Additional features of the book include a reader-friendly introduction to each topic and a list of references for advanced readers. This timely reference is an informative resource for a broad range of readers interested in strategies to control COVID-19, including postgraduate researchers, and pharmaceutical R&D experts. It also serves as a handbook for professionals in clinical and herbal medicine.
Download or read book Integrative Multi Omics for Diagnosis Treatments and Drug Discovery of Aging Related Neuronal Diseases written by Min Tang and published by Frontiers Media SA. This book was released on 2022-11-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
Download or read book RNA Seq in Drug Discovery and Development written by Feng Cheng and published by CRC Press. This book was released on 2023-08-17 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research and development process in modern drug discovery and development is a complex and challenging task. Using traditional biological test methods such as PCR to measure the expression levels or function of these genes is costly and time-consuming. RNA-seq can measure the expression patterns of thousands of genes simultaneously and provide insights into functional pathways or regulations in biological processes, which has revolutionized the way biological scientists examine gene functions. This book addresses the various aspects of the RNA-seq technique, especially its application in drug discovery and development. Features • One of the few books that focuses on the applications of the RNA-seq technique in drug discovery and development. • Comprehensive and timely publication which relates RNA sequencing to drug targets, mechanisms of action, and resistance. • The editor has extensive experience in the field of computational medicinal chemistry, computational biophysics, and bioinformatics. • Chapter authors are at the frontline of the academic and industrial science in this particular area of RNA sequencing.
Download or read book Machine Learning and Principles and Practice of Knowledge Discovery in Databases written by Irena Koprinska and published by Springer Nature. This book was released on 2023-01-30 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume constitutes the papers of several workshops which were held in conjunction with the International Workshops of ECML PKDD 2022 on Machine Learning and Principles and Practice of Knowledge Discovery in Databases, ECML PKDD 2022, held in Grenoble, France, during September 19–23, 2022. The 73 revised full papers and 6 short papers presented in this book were carefully reviewed and selected from 143 submissions. ECML PKDD 2022 presents the following workshops: Workshop on Data Science for Social Good (SoGood 2022) Workshop on New Frontiers in Mining Complex Patterns (NFMCP 2022) Workshop on Explainable Knowledge Discovery in Data Mining (XKDD 2022) Workshop on Uplift Modeling (UMOD 2022) Workshop on IoT, Edge and Mobile for Embedded Machine Learning (ITEM 2022) Workshop on Mining Data for Financial Application (MIDAS 2022) Workshop on Machine Learning for Cybersecurity (MLCS 2022) Workshop on Machine Learning for Buildings Energy Management (MLBEM 2022) Workshop on Machine Learning for Pharma and Healthcare Applications (PharML 2022) Workshop on Data Analysis in Life Science (DALS 2022) Workshop on IoT Streams for Predictive Maintenance (IoT-PdM 2022)
