Download or read book Systems Analysis and Systems Engineering in Environmental Remediation Programs at the Department of Energy Hanford Site written by Committee on Remediation of Buried and Tank Wastes and published by National Academies Press. This book was released on 1998-09-04 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary purpose of systems engineering is to organize information and knowledge to assist those who manage, direct, and control the planning, development, production, and operation of the systems necessary to accomplish a given mission. However, this purpose can be compromised or defeated if information production and organization becomes an end unto itself. Systems engineering was developed to help resolve the engineering problems that are encountered when attempting to develop and implement large and complex engineering projects. It depends upon integrated program planning and development, disciplined and consistent allocation and control of design and development requirements and functions, and systems analysis. The key thesis of this report is that proper application of systems analysis and systems engineering will improve the management of tank wastes at the Hanford Site significantly, thereby leading to reduced life cycle costs for remediation and more effective risk reduction. The committee recognizes that evidence for cost savings from application of systems engineering has not been demonstrated yet.

Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Download or read book Research Priorities for Airborne Particulate Matter written by National Research Council and published by National Academies Press. This book was released on 2001-06-13 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory standards are already on the books at the the U.S. Environmental Protection Agency (EPA) to address health risks posed by inhaling tiny particles from smoke, vehicle exhaust, and other sources. At the same time, Congress and EPA have initiated a multimillion dollar research effort to better understand the sources of these airborne particles, the levels of exposure to people, and the ways that these particles cause damage. To provide independent guidance to the EPA, Congress asked the National Research Council to study the relevant issues. The result is a series of four reports on the particulate-matter research program. The first two books offered a conceptual framework for a national research program, identified the 10 most critical research needs, and described the recommended timing and estimated costs of such research. This, the third volume, begins the task of assessing the progress made in implementing the research program. The National Research Council ultimately concludes that the ongoing program is appropriately addressing many of the key uncertainties. However, it also identifies a number of critical specific subjects that should be given greater attention. Research Priorities for Airborne Particulate Matter focuses on the most current and planned research projects with an eye toward the fourth and final report, which will contain an updated assessment.

Download or read book Real Analysis written by Brian S. Thomson and published by ClassicalRealAnalysis.com. This book was released on 2008 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of a graduate level real analysis textbook formerly published by Prentice Hall (Pearson) in 1997. This edition contains both volumes. Volumes one and two can also be purchased separately in smaller, more convenient sizes.

Download or read book Introduction to Numerical Analysis written by J. Stoer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: On the occasion of this new edition, the text was enlarged by several new sections. Two sections on B-splines and their computation were added to the chapter on spline functions: Due to their special properties, their flexibility, and the availability of well-tested programs for their computation, B-splines play an important role in many applications. Also, the authors followed suggestions by many readers to supplement the chapter on elimination methods with a section dealing with the solution of large sparse systems of linear equations. Even though such systems are usually solved by iterative methods, the realm of elimination methods has been widely extended due to powerful techniques for handling sparse matrices. We will explain some of these techniques in connection with the Cholesky algorithm for solving positive definite linear systems. The chapter on eigenvalue problems was enlarged by a section on the Lanczos algorithm; the sections on the LR and QR algorithm were rewritten and now contain a description of implicit shift techniques. In order to some extent take into account the progress in the area of ordinary differential equations, a new section on implicit differential equa tions and differential-algebraic systems was added, and the section on stiff differential equations was updated by describing further methods to solve such equations.

Download or read book Assessing Prevalence and Trends in Obesity written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-09-30 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity has come to the forefront of the American public health agenda. The increased attention has led to a growing interest in quantifying obesity prevalence and determining how the prevalence has changed over time. Estimates of obesity prevalence and trends are fundamental to understanding and describing the scope of issue. Policy makers, program planners, and other stakeholders at the national, state, and local levels are among those who search for estimates relevant to their population(s) of interest to inform their decision-making. The differences in the collection, analysis, and interpretation of data have given rise to a body of evidence that is inconsistent and has created barriers to interpreting and applying published reports. As such, there is a need to provide guidance to those who seek to better understand and use estimates of obesity prevalence and trends. Assessing Prevalence and Trends in Obesity examines the approaches to data collection, analysis, and interpretation that have been used in recent reports on obesity prevalence and trends at the national, state, and local level, particularly among U.S. children, adolescents, and young adults. This report offers a framework for assessing studies on trends in obesity, principally among children and young adults, for policy making and program planning purposes, and recommends ways decision makers and others can move forward in assessing and interpreting reports on obesity trends.

Download or read book Statistical Models and Analysis in Auditing A Study of Statistical Models and Methods for Analyzing Nonstandard Mixtures of Distributions in Auditing written by Panel on Nonstandard Mixtures of Distributions and published by National Academies Press. This book was released on 1988-01-01 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The National Children s Study Research Plan written by National Research Council and published by National Academies Press. This book was released on 2008-08-16 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Children's Study (NCS) is planned to be the largest long-term study of environmental and genetic effects on children's health ever conducted in the United States. It proposes to examine the effects of environmental influences on the health and development of approximately 100,000 children across the United States, following them from before birth until age 21. By archiving all of the data collected, the NCS is intended to provide a valuable resource for analyses conducted many years into the future. This book evaluates the research plan for the NCS, by assessing the scientific rigor of the study and the extent to which it is being carried out with methods, measures, and collection of data and specimens to maximize the scientific yield of the study. The book concludes that if the NCS is conducted as proposed, the database derived from the study should be valuable for investigating hypotheses described in the research plan as well as additional hypotheses that will evolve. Nevertheless, there are important weaknesses and shortcomings in the research plan that diminish the study's expected value below what it might be.

Download or read book Forensic Analysis written by National Research Council and published by National Academies Press. This book was released on 2004-04-26 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1960s, testimony by representatives of the Federal Bureau of Investigation in thousands of criminal cases has relied on evidence from Compositional Analysis of Bullet Lead (CABL), a forensic technique that compares the elemental composition of bullets found at a crime scene to the elemental composition of bullets found in a suspect's possession. Different from ballistics techniques that compare striations on the barrel of a gun to those on a recovered bullet, CABL is used when no gun is recovered or when bullets are too small or mangled to observe striations. Forensic Analysis: Weighing Bullet Lead Evidence assesses the scientific validity of CABL, finding that the FBI should use a different statistical analysis for the technique and that, given variations in bullet manufacturing processes, expert witnesses should make clear the very limited conclusions that CABL results can support. The report also recommends that the FBI take additional measures to ensure the validity of CABL results, which include improving documentation, publishing details, and improving on training and oversight.

Download or read book Cost Effectiveness in Health and Medicine written by Peter J. Neumann and published by Oxford University Press. This book was released on 2017 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: CEAs (cost-effectiveness analyses) are used by decision makers in the health sector to make enlightened evaluations and this book provides an in depth look at how to evaluate the evaluator. The book is aimed specifically at Public health specialists.

Download or read book Advanced Technology for Human Support in Space written by National Research Council and published by National Academies Press. This book was released on 1997-08-02 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Technology for Human Support in Space was written in response to a request from NASA's Office of Life and Microgravity Sciences and Applications (OLMSA) to evaluate its Advanced Human Support Technology Program. This report reviews the four major areas of the program: advanced life support (ALS), environmental monitoring and control (EMC), extravehicular activities (EVA), and space human factors (SHF). The focus of this program is on long-term technology development applicable to future human long-duration space missions, such as for a hypothetical new mission to the Moon or Mars.

Download or read book Real Analysis written by Jay Cummings and published by . This book was released on 2019-07-15 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is designed for students. Rather than the typical definition-theorem-proof-repeat style, this text includes much more commentary, motivation and explanation. The proofs are not terse, and aim for understanding over economy. Furthermore, dozens of proofs are preceded by "scratch work" or a proof sketch to give students a big-picture view and an explanation of how they would come up with it on their own. Examples often drive the narrative and challenge the intuition of the reader. The text also aims to make the ideas visible, and contains over 200 illustrations. The writing is relaxed and includes interesting historical notes, periodic attempts at humor, and occasional diversions into other interesting areas of mathematics. The text covers the real numbers, cardinality, sequences, series, the topology of the reals, continuity, differentiation, integration, and sequences and series of functions. Each chapter ends with exercises, and nearly all include some open questions. The first appendix contains a construction the reals, and the second is a collection of additional peculiar and pathological examples from analysis. The author believes most textbooks are extremely overpriced and endeavors to help change this.Hints and solutions to select exercises can be found at LongFormMath.com.

Download or read book Finite Element Analysis for Building Assessment written by Paulo B. Lourenço and published by Taylor & Francis. This book was released on 2022-05-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Existing structures represent a heterogeneous category in the global built environment as often characterized by the presence of archaic materials, damage and disconnections, uncommon construction techniques and subsequent interventions throughout the building history. In this scenario, the common linear elastic analysis approach adopted for new buildings is incapable of an accurate estimation of structural capacity, leading to overconservative results, invasive structural strengthening, added intervention costs, excessive interference to building users and possible losses in terms of aesthetics or heritage values. For a rational and sustainable use of the resources, this book deals with advanced numerical simulations, adopting a practical approach to introduce the fundamentals of Finite Element Method, nonlinear solution procedures and constitutive material models. Recommended material properties for masonry, timber, reinforced concrete, iron and steel are discussed according to experimental evidence, building standards and codes of practice. The examples examined throughout the book and in the conclusive chapter support the analyst’s decision-making process toward a safe and efficient use of finite element analysis. Written primarily for practicing engineers, the book is of value to students in engineering and technical architecture with solid knowledge in the field of continuum mechanics and structural design.

Download or read book Intelligence Analysis for Tomorrow written by National Research Council and published by National Academies Press. This book was released on 2011-04-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intelligence community (IC) plays an essential role in the national security of the United States. Decision makers rely on IC analyses and predictions to reduce uncertainty and to provide warnings about everything from international diplomatic relations to overseas conflicts. In today's complex and rapidly changing world, it is more important than ever that analytic products be accurate and timely. Recognizing that need, the IC has been actively seeking ways to improve its performance and expand its capabilities. In 2008, the Office of the Director of National Intelligence (ODNI) asked the National Research Council (NRC) to establish a committee to synthesize and assess evidence from the behavioral and social sciences relevant to analytic methods and their potential application for the U.S. intelligence community. In Intelligence Analysis for Tomorrow: Advances from the Behavioral and Social Sciences, the NRC offers the Director of National Intelligence (DNI) recommendations to address many of the IC's challenges. Intelligence Analysis for Tomorrow asserts that one of the most important things that the IC can learn from the behavioral and social sciences is how to characterize and evaluate its analytic assumptions, methods, technologies, and management practices. Behavioral and social scientific knowledge can help the IC to understand and improve all phases of the analytic cycle: how to recruit, select, train, and motivate analysts; how to master and deploy the most suitable analytic methods; how to organize the day-to-day work of analysts, as individuals and teams; and how to communicate with its customers. The report makes five broad recommendations which offer practical ways to apply the behavioral and social sciences, which will bring the IC substantial immediate and longer-term benefits with modest costs and minimal disruption.

Download or read book Understanding and Evaluating Research written by Sue L. T. McGregor and published by SAGE Publications. This book was released on 2017-10-25 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding and Evaluating Research: A Critical Guide shows students how to be critical consumers of research and to appreciate the power of methodology as it shapes the research question, the use of theory in the study, the methods used, and how the outcomes are reported. The book starts with what it means to be a critical and uncritical reader of research, followed by a detailed chapter on methodology, and then proceeds to a discussion of each component of a research article as it is informed by the methodology. The book encourages readers to select an article from their discipline, learning along the way how to assess each component of the article and come to a judgment of its rigor or quality as a scholarly report.

Download or read book Conducting Biosocial Surveys written by National Research Council and published by National Academies Press. This book was released on 2010-10-02 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen a growing tendency for social scientists to collect biological specimens such as blood, urine, and saliva as part of large-scale household surveys. By combining biological and social data, scientists are opening up new fields of inquiry and are able for the first time to address many new questions and connections. But including biospecimens in social surveys also adds a great deal of complexity and cost to the investigator's task. Along with the usual concerns about informed consent, privacy issues, and the best ways to collect, store, and share data, researchers now face a variety of issues that are much less familiar or that appear in a new light. In particular, collecting and storing human biological materials for use in social science research raises additional legal, ethical, and social issues, as well as practical issues related to the storage, retrieval, and sharing of data. For example, acquiring biological data and linking them to social science databases requires a more complex informed consent process, the development of a biorepository, the establishment of data sharing policies, and the creation of a process for deciding how the data are going to be shared and used for secondary analysis-all of which add cost to a survey and require additional time and attention from the investigators. These issues also are likely to be unfamiliar to social scientists who have not worked with biological specimens in the past. Adding to the attraction of collecting biospecimens but also to the complexity of sharing and protecting the data is the fact that this is an era of incredibly rapid gains in our understanding of complex biological and physiological phenomena. Thus the tradeoffs between the risks and opportunities of expanding access to research data are constantly changing. Conducting Biosocial Surveys offers findings and recommendations concerning the best approaches to the collection, storage, use, and sharing of biospecimens gathered in social science surveys and the digital representations of biological data derived therefrom. It is aimed at researchers interested in carrying out such surveys, their institutions, and their funding agencies.

Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.