Download or read book Alcohol Metabolism Alcohol Intolerance and Alcoholism written by Dharam P. Agarwal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol abuse, alcohol intolerance, alcohol dependence and other alcohol-related disabilities are some of the most challenging public health problems facing our modern-day society. The purpose of this comprehensive monograph is to review the available knowledge concerning the pharmacogenetic basis of alcohol sensitivity and its physiolgical implications and to synthesize the bulk of existing knowledge regarding metabolic features and biomedical disturbances related to alcoholism. The chapters cover a broad array of disciplines including an overview of historical and epidemiological aspects, biochemistry and molecular genetics of enzymes involved in alcohol metabolism, biochemical and neuropsychopharmacological effects of alcohol. Major emphasis is placed on the role of genetic factors in alcoholism. The experimental details are summarized and a comprehensive bibliography is included.
Download or read book Alcohol in Health and Disease written by Dharam Agarwal and published by CRC Press. This book was released on 2001-06-01 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, based on presentations from the symposium on the health effects of alcohol held in Titisee, Germany, examines the physical and psychological consequences of alcohol use and abuse, and considers environmental and ethnic factors that lead to addiction and dependence. Discusses epidemiological studies that show the influence of light to moderate intake of alcoholic beverages on coronary heart disease. Featuring contributions from nearly 60 internationally recognized and respected authors, and over 2900 references for further investigation of the subject, Alcohol in Health and Disease analyzes biochemical, pharmacogenetic, and pathologic disturbances that follow acute and chronic ingestion of alcohol; describes complications that arise from social, biological, and environmental factors; examines alcohol metabolic genes and their role in alcohol sensitivity, drinking habits, and dependence; spotlights hepatic and nutritional disorders associated with alcoholism; considers the relationship of alcohol to cancer; debates the French paradox and more. Covering a multitude of disciplines, including molecular biochemistry, genetics, epidemiology, pathophysiology, neurobiology, and cardiology, Alcohol in Health and Disease is a critical reference for addiction psychiatrists, neuropsychopharmacologists, psychologists, geneticists, toxicologists, biochemists, environmental and public health scientists, health policy makers, social workers, counselors, and graduate and medical school students in these disciplines.
Download or read book The Genetics of Alcoholism written by Henri Begleiter and published by Alcohol and Alcoholism. This book was released on 1995 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an in-depth look at the genetic influences that contribute to the development of alcoholism. Part I: Epidemiologic Studies contains five chapters that examine the various approaches employed in the study of the genetics of alcoholism. It provides a historical perspectiveand details all the essentials of this subject. Part II: Selective Breeding Studies highlights the results of research involving the selective breeding of rodents. This type of research has produced homogenous strains exhibiting specific behavioral responses considered significant in thedevelopment and maintenance of alcohol dependence. The studies presented in Part III: Phenotypic Studies investigate and analyze phenotypic markers that serve as correlates to the genotypic determinants of alcoholism. Through its broad scope, this volume provides for the first time a panoramic viewof the knowledge available on the hereditary influences of alcoholism.
Download or read book Metabolic Changes Induced by Alcohol written by Gustav A. Martini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: In nearly all parts of the world, the consumption of alcohol is increasing, and the morbidity and mortality of diseases induced by alcohol are rising correspondingly. It has been stated that alcohol is consumed because it pro duces intoxication. This effect is due to its toxicological influence on the central nervous system with the resulting functional disturbances. For many years, the concept that alcoholic liver disease was of nutritional origin and only indirectly related to alcohol consumption and metabolism was accepted. Opinion has changed gradually in recent years and tends now to regard alcohol itself through its combustion, as responsible for many metabolic disorders. Interest in this problem has increased during the past decade, and numerous papers bearing on this subject have appeared. It seems that the oxidation of alcohol in the liver interferes in many ways with the intermediary metabolism of lipids, carbohydrates and proteins, including enzymes and hormones, and exerts damaging influence on the liver, the musculature, the heart, the brain and the kidneys. The "Workshop Symposium" brought together a limited number of the scientists involved in the new development, biochemists, physiologists, pharmacologists, pathologists and clinicians from eight European countries and from the United States and allowed a very lively and informal exchange. The symposium was honored by the presence of Sir Hans Krebs, whose vast experience stimulated the discussion. It is a great pleasure to dedicate this volume to Sir Hans on the occasion of his 70th birthday on August 25th.
Download or read book Alcohol Research Health written by and published by . This book was released on 2002 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Molecular Pathology of Alcoholism written by T. Norman Palmer and published by . This book was released on 1991 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last few years have seen major advances in our understanding of the molecular and genetic events associated with alcohol abuse. The advent of recombinant DNA technology has allowed the structure of the genes and proteins of alcohol metabolism to be identified, and this work has formed the basis for genetic studies of factors that influence drinking behavior and alcoholism. This book provides an introduction for the non-specialist reader to recent developments concerning the molecular pathology of alcohol-related disease. It gives substance to the view that alcoholism is an organic disorder that stems from the specific interaction of alcohol and its metabolites with cellular components. Particular attention is paid to the molecular biology of the enzymes of alcohol metabolism.
Download or read book Edwards Treatment of Drinking Problems written by Keith Humphreys and published by Cambridge University Press. This book was released on 2016-04-28 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state-of-the-art, accessible reviews of the science of alcohol treatment and guidance for the management of clinical situations.
Download or read book Alcohol Nutrition and Health Consequences written by Ronald Ross Watson and published by Springer Science & Business Media. This book was released on 2012-08-24 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic alcohol use is associated with heart, liver, brain, and other organ pathology. Alcohol is a drug of abuse and a caloric food and it causes poor intake and absorption of nutrients, thus playing a major role in many aspects of clinical consequences. Alcohol use lowers consumption of fruit and vegetables, lowers tissue nutrients, and, in some cases, requires nutritional therapy by clinicians. Alcohol, Nutrition, and Health Consequences will help the clinician define the causes and types of nutritional changes due to alcohol use and also explain how nutrition can be used to ameliorate its consequences. Chapters present the application of current nutritional knowledge by physicians and dietitians. Specific areas involving alcohol-related damage due to nutritional changes are reviewed, including heart disease, obesity, digestive tract cancers, lactation, brain function, and liver disease. In addition, alcohol’s effects on absorption of minerals and nutrients, a key role in causing damage are treated. The importance of diet in modifying alcohol and its metabolite damage is also explained. Alcohol, Nutrition, and Health Consequences is essential reading for alcohol therapists and researchers as well as primary care physicians and dietitians and is an easy reference to help the clinician, student, and dietitian comprehend the complex changes caused by direct and indirect effects of ethanol at the cellular level via its nutritional modification.
Download or read book Human Metabolism of Alcohol Volume I written by Kathryn E. Crow and published by CRC Press. This book was released on 1989-04-30 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume text provides a comprehensive review and reference source for those with a teaching, research, or practical involvement in alcohol metabolism in humans. Written by 70 contributing authors from 12 countries, this publication covers a wide range of material, from medicolegal aspects of alcohol metabolism to the structure of enzymes involved in metabolizing alcohol. Although primarily concerned with human alcohol metabolism, information from animal experiments is included where it clarifies results of human studies, or where information for human subjects is not available.
Download or read book Biological Aspects of Alcoholism written by Boris Tabakoff and published by . This book was released on 1995 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therefore this volume is invaluable for a wide range of treatment professionals, health care and law enforcement managers and policy makers, as well as for researchers involved with the biomedical and psychosocial consequences of alcoholism. Medically-oriented lay readers will also find this book to be a refreshingly direct and authoritative review of the field.
Download or read book Alcohol and Public Policy written by National Research Council and published by National Academies Press. This book was released on 1981-02-01 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems IV written by Ronald Thurman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this book represent the proceedings of the Third International Symposium, which was held at the Addiction Research Foundation in Toronto in July, 1979. The purpose of this meeting was to bring together experts in the field from a wide variety of backgrounds in an attempt to gain some clarity and insight into the problems of alcohol and aldehyde metabolism. One might ask, "Why have such a meeting and a collection of research papers?" The answer is clear. The societal problem of alcoholism is, unlike many other health problems, growing instead of abating. Treatment efforts are largely ineffective (e.g., Griffith Edwards' classic work)', and fundamental research has yet to identify rational therapy based on sound mechanisms for this disease which effects 5% of the population severely and a much greater percentage to a lesser degree or indirectly. I have become impressed with the possibility that this lack of progress may be-in large part-due to a fundamental oversight on the part of investigators in the field of alcohol research. Simply, this possible problem could be stated as follows: an alcoholic is defined the same way as all other alcoholics. Attempts to identify possible subpopulations of alcoholics with defined and treatable diseases have been minimal. One could argue, however, that little evidence, with the exception of the gross psychiatric definitions (e.g., Jellinek) exists that there are different types of alcoholics. This argument is countered, first, by the dismal lack of progress made in this field by classifying an alcoholic equal to other alcoholics, and second, by analogy with cancer research. Now we know that "cancer" is only a generic term which defines a broad group of diseases, some caused by specific environmental chemicals, others by viruses, etc. Progress was only possible after suitable animal models were developed. More importantly, however, is the fact that once specific forms of the disease (i.e., once the diseases themselves were separated from the generic term) were identified, it was a relatively easy task to develop tests for early identification of some forms of the disease (e.g., the pap smear, etc.). This analogy can be extended to alcoholism's. First, let us assume that we have failed to develop tests for early identification of alcoholisms because the population is not carefully defined into subgroups. If we assume that subpopulations of alcoholics exist, we can again turn to the cancer literature for examples of how to proceed. Much progress in this field rests. On the careful development of strains of animals which differ in their susceptibility to certain carcinogens. By analogy, distinct forms of alcoholisms could be identified by the use of genetics (e.g., Goodwin). First, distinct phenotypes need to be developed for certain characteristics suspected to be important in alcoholism. Second, a test specific for early identification of this specific phenotype can then be developed. Third, longitudinal studies must be performed in humans to see if the animal work can be applied to man. Implicit in this rationale is the thought that progress is not possible by studying alcoholics 20 years after primary changes had occurred, nor even by studying pre-alcoholics until specific sub forms of the disease are identified. Thus, the need for fundamental research into the mechanisms responsible for alcoholism is required. Unfortunately, alcohol research appears to suffer some of the stigma of the alcoholic
Download or read book Recent Advances in the Biology of Alcoholism written by Charles S. Lieber and published by Psychology Press. This book was released on 1982 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable book, written by eminent researchers, focuses on the exciting developments in the field of alcohol metabolism and alcohol-endocrine interactions. They contribute significantly to our understanding of the metabolism of ethanol and its effects on the body with comprehensive chapters on the heterogeneity of aldehyde dehydrogenase, alcohol-drug interactions, the pathogenesis of alcoholic liver disease, and more.
Download or read book The Pharmacology of Alcohol and Alcohol Dependence written by Henri Begleiter and published by Oxford University Press, USA. This book was released on 1996 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.
Download or read book Medical and Nutritional Complications of Alcoholism written by Charles S. Lieber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the Western world, alcohol is the most abused drug. recognized that a majority of patients with cirrhosis do For all the attention being directed toward heroin, co admit to excessive alcohol consumption. Other tissues caine, and marijuana, the favorite mood-altering drug in can also be severely affected, including brain, gut, the United States, as in almost every human society, is heart, endocrine systems, bone, blood, and muscle. A question often raised is, "In what way does an alcoholic alcohol. In nature, the fermentation of sugars is the differ from a nonalcoholic?" Inquiries have focused on major source of ethanol, but how humans first encoun tered it is unclear. It most likely occurred in either psychological make-up, behavioral differences, and socio fermented fruit juices (wine), fermented grain (beer), or economic factors. More recently, however, physical dif fermented honey (mead). Whether the Paleolithic Stone ferences have been delineated. Prior to the development Age man knew of ethanol is undetermined, but it is of various disease entities, chronic ethanol exposure abundantly clear that his Neolithic descendants were results in profound biochemical and morphological familiar with the product of fermentation. With the changes. Consequently, an alcoholic does not respond exception of the original inhabitants of Tierra del Fuego, normally to alcohol, other drugs, or even other toxic the Australian aborigines, and some polar tribes, all agents.
Download or read book The Biology of Alcoholism written by Benjamin Kissin and published by Springer. This book was released on 1971-06 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers neurophysioligcal and psychological effects of alcohol on man. Includes extensive bibliographies covering the literature from 1920 through 1970.
Download or read book Diagnosis of Alcohol Abuse written by Ronald Ross Watson and published by CRC Press. This book was released on 1989-07-31 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest methods used to diagnose alcoholism are discussed in this timely publication. Old systems are reviewed, and their efficacy in the diagnosis of alcoholism is analyzed. Laboratory methods that could improve the objectivity and accuracy of clinical tests are highlighted. Additionally, physical, psychological, and biochemical tests used to diagnose severe alcoholism are explored.
