Download or read book Alcohol and Aldehyde Metabolizing Systems IV written by Ronald Thurman and published by Springer. This book was released on 2013-04-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by Ronald G. Thurman and published by Elsevier. This book was released on 2014-05-10 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Aldehyde Metabolizing Systems, Volume III: Intermediary Metabolism and Neurochemistry contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues such as the effects of alcohol and aldehydes on intermediary metabolism. Comprised of 64 chapters, this volume begins with an analysis of the non-equilibrium behavior of biochemical systems, followed by a discussion on the configurational specificity of glycolytic enzymes. The reader is methodically introduced to redox compartmentation and the measurement of intracellular compartmentation of metabolites in rat liver; effect of chronic alcohol and oxygen tension on the development of hepatic necrosis in rats; and actions of ethanol metabolism on fatty acid synthesis in the liver. Subsequent chapters focus on regional metabolic rate in the central nervous system as related to function; effects of tetrahydroisoquinoline derivatives of catecholamines and aldehydes on tyrosine hydroxylase; and lowering of blood acetaldehyde levels as a therapeutic approach to alcoholism. This book will be of value to practitioners and researchers from a variety of disciplines, including neurochemistry, biochemistry, physiology, cell biology, and pharmacology.
Download or read book Alcohol and Aldehyde Metabolizing Systems IV written by Ont.) International Symposium on Alcohol and Aldehyde Metabolizing Systems (3d : 1979 : Toronto and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and aldehyde metabolizing systems written by and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by Ronald G. Thurman and published by Academic Press. This book was released on 2014-05-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Aldehyde Metabolizing Systems, Volume II: Enzymology and Subcellular Organelles contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues ranging from the molecular structure of enzymes to the clinical actions of alcohol in humans. Comprised of 43 chapters, this volume begins by comparing the enzymatically catalyzed oxidation of glyceraldehyde-3-phosphate and lactate, followed by an analysis of liver alcohol dehydrogenase and its mechanism of action. The reader is methodically introduced to the kinetics and mechanism of activated liver alcohol dehydrogenase; structural and functional changes in different alcohol dehydrogenases during evolution; and localization and properties of aldehyde reductase. Subsequent chapters deal with the correlation between the activity of acetaldehyde dehydrogenase and the structure of mitochondria; the distribution of subcellular organelles; and peroxisomes and microsomes. This book will be of value to practitioners and researchers from a variety of disciplines, including biochemistry, physiology, cell biology, and pharmacology.
Download or read book Alcohol and Aldehyde Metabolizing Systems written by International Symposium on Alcohol and Aldehyde Metabolizing Systems$ (1er : 1973 : Stockholm) and published by . This book was released on 1974 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by Ronald G. Thurman and published by . This book was released on 1977 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by Ronald G. Thurman and published by . This book was released on 1974 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by International Symposium on Alcohol and Aldehyde Metabolizing Systems, 1st, Stockholm, 1973 and published by . This book was released on 1974 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by International Symposium on Alcohol and Aldehyde Metabolizing Systems (3, 1979, Toronto) and published by . This book was released on 1980 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems IV written by Ronald Thurman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this book represent the proceedings of the Third International Symposium, which was held at the Addiction Research Foundation in Toronto in July, 1979. The purpose of this meeting was to bring together experts in the field from a wide variety of backgrounds in an attempt to gain some clarity and insight into the problems of alcohol and aldehyde metabolism. One might ask, "Why have such a meeting and a collection of research papers?" The answer is clear. The societal problem of alcoholism is, unlike many other health problems, growing instead of abating. Treatment efforts are largely ineffective (e.g., Griffith Edwards' classic work)', and fundamental research has yet to identify rational therapy based on sound mechanisms for this disease which effects 5% of the population severely and a much greater percentage to a lesser degree or indirectly. I have become impressed with the possibility that this lack of progress may be-in large part-due to a fundamental oversight on the part of investigators in the field of alcohol research. Simply, this possible problem could be stated as follows: an alcoholic is defined the same way as all other alcoholics. Attempts to identify possible subpopulations of alcoholics with defined and treatable diseases have been minimal. One could argue, however, that little evidence, with the exception of the gross psychiatric definitions (e.g., Jellinek) exists that there are different types of alcoholics. This argument is countered, first, by the dismal lack of progress made in this field by classifying an alcoholic equal to other alcoholics, and second, by analogy with cancer research. Now we know that "cancer" is only a generic term which defines a broad group of diseases, some caused by specific environmental chemicals, others by viruses, etc. Progress was only possible after suitable animal models were developed. More importantly, however, is the fact that once specific forms of the disease (i.e., once the diseases themselves were separated from the generic term) were identified, it was a relatively easy task to develop tests for early identification of some forms of the disease (e.g., the pap smear, etc.). This analogy can be extended to alcoholism's. First, let us assume that we have failed to develop tests for early identification of alcoholisms because the population is not carefully defined into subgroups. If we assume that subpopulations of alcoholics exist, we can again turn to the cancer literature for examples of how to proceed. Much progress in this field rests. On the careful development of strains of animals which differ in their susceptibility to certain carcinogens. By analogy, distinct forms of alcoholisms could be identified by the use of genetics (e.g., Goodwin). First, distinct phenotypes need to be developed for certain characteristics suspected to be important in alcoholism. Second, a test specific for early identification of this specific phenotype can then be developed. Third, longitudinal studies must be performed in humans to see if the animal work can be applied to man. Implicit in this rationale is the thought that progress is not possible by studying alcoholics 20 years after primary changes had occurred, nor even by studying pre-alcoholics until specific sub forms of the disease are identified. Thus, the need for fundamental research into the mechanisms responsible for alcoholism is required. Unfortunately, alcohol research appears to suffer some of the stigma of the alcoholic
Download or read book Alcohol and Aldehyde Metabolizing Systems written by and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by and published by . This book was released on 1974 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems IV written by Ronald Thurman and published by Springer. This book was released on 1980-09-01 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol Research Health written by and published by . This book was released on 2002 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alcohol and Aldehyde Metabolizing Systems written by and published by . This book was released on 1974 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
