Download or read book Aging dependent Effects of Repetitive Loading Exercise and Antioxidant Supplementation on Oxidative Stress in Skeletal Muscle written by Michael James Ryan and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oxidative Stress Exercise and Aging written by Helaine M. Alessio and published by Imperial College Press. This book was released on 2006 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together some of the leading researchers in the actively investigated field of oxidative stress, an area of study which is of importance to human health and disease. It examines oxidative stress in a variety of models, at rest and after exercise, in young and old. Key concepts of oxidative stress, exercise and aging are presented in clear and easy-to-understand terms. Oxidative stress in different types of exercises OCo isometric, isotonic and sports OCo is explained in detail, with several chapters focusing on acute and chronic adaptations of skeletal muscles following both aerobic and non-aerobic exercises. The book includes current knowledge of the underlying mechanisms influencing health and disease processes associated with oxidative stress. Contents: Chemistry of Reactive Oxygen Species and Antioxidants (D C Close & A E Hagerman); Oxidative Stress in Plants and Animals (D C Close & A E Hagerman); The Exercise Continuum (R L Wiley); Oxidative Stress and Muscle Size, Type, and Action (H M Alessio); Oxidative Stress Across the Exercise Continuum (H M Alessio); Oxidative Stress and Antioxidant Defense: Effects of Aging and Exercise (L L Ji); Muscle, Oxidative Stress and Aging (J S Moylan et al.); Aging, Exercise, Antioxidants, and Cardioprotection (J Quindry & S Powers); Genetic Expressions: Oxidative Stress, Exercise, and Aging (N B Schweitzer & H M Alessio). Readership: Academics, researchers, upper undergraduate and graduate students in biochemistry, biological chemistry, physiology, gerontology, and cell & molecular biology; companies that develop and market products for sports, health, antioxidants and anti-aging interventions."

Download or read book Oxidative Stress in Skeletal Muscle written by Reznick and published by Birkhäuser. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletal muscle consumes significant amounts of oxygen, and its oxygen flux increases significantly under conditions of exercise and muscle contraction. This makes the muscle vulnerable to oxidative stress since concomitantly with the increase of oxygen flow there is an increase of free oxygen radicals which are a byproduct of muscle respiration. A number of studies in the last decade have documented the involvement of free oxygen radicals in exercising muscles. The consequences of muscle oxidative stress have resulted mainly in increased muscle protein oxidation, elevation of lipid peroxidation, and depletion of muscle antioxidants. The mechanisms of this oxidative stress are under extensive investigation in laboratories around the world and are topics of the chapters in this volume. This book is intended for professionals who are interested in muscle function, physiology, pathophysiology and well-being, such as therapists, trainers and medical professionals as well as for researchers in the field of muscle physiology.

Download or read book Redox Regulation in Skeletal Muscle Aging and Exercise written by Brian McDonagh and published by Frontiers Media SA. This book was released on 2017-07-05 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ‘age well’, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life quality for the aging population. One of the most effective interventions to maintain muscle mass and function is through exercise. Skeletal muscle generates reactive oxygen and reactive nitrogen (ROS/RNS) species in response to muscle contractions. The concentration and species of ROS/RNS generated can depend on the age and fitness of the individual, muscle fibre type and the intensity of the muscle contractions. ROS/RNS generate unique signaling cascades that are not only essential in skeletal muscle contraction and adaptation but also play a role in a wide array of cell processes including cell proliferation, protein synthesis/degradation, immune response and antioxidant defense. ROS/RNS generated by contractions are involved in a co-ordinated local response that is tightly controlled at all levels from generation to detoxification. This collection of original articles and reviews highlights investigations that measure different aspects of the redox response of skeletal muscle to aging and exercise.

Download or read book Antioxidants in Sport Nutrition written by Manfred Lamprecht and published by CRC Press. This book was released on 2014-09-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Download or read book Oxidative Stress in Skeletal Muscle written by 3Island Press and published by . This book was released on 1998-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Free Radicals in Exercise and Aging written by Zsolt Radák and published by Human Kinetics. This book was released on 2000 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the emerging field of free radical biology, exercise, and aging with this definitive reference. Free Radicals in Exercise and Agingaddresses the current debate regarding whether free radicals released during exercise accelerate the aging process. It explains how free radicals can serve as important regulators of aerobic processes, and it clarifies the importance of exercise in increasing the efficiency of the antioxidant and oxidative repair systems. Mounting research data indicate that free radicals are involved in a variety of physiological and pathophysiological processes. This book focuses on exercise-induced adaptation. In general, a person's ability to adapt to internal and external changes decreases during the aging process. However, by continually exposing the body to different challenges, regular exercise triggers an adaptation process that keeps the body and mind fit. Free Radicals in Exercise and Agingelucidates the role of free radical species in regulating this process. This text is also one of the first to provide an in-depth review of skeletal muscle oxidative stress and aging. This issue is pivotal because muscle serves such a critical role in mobility and normal life. Free Radicals in Exercise and Aging shares the most current understanding of how reactive oxygen species influence the biology of skeletal muscles. It explores some of the unique characteristics that skeletal muscle displays during aging, both in terms of free radical production and with regard to antioxidant systems. The implications of this research are far-reaching. Mutation of DNA is linked very closely to cancer, and if regular exercise improves the regulation of the antioxidant systems and the oxidative damage repair system, these mechanisms may be a very important tool against this deadly disease. This research-oriented text presents the latest information on the subject. It reviews and critiques current literature and provides critical information for exercise physiologists, sports medicine specialists, sport nutritionists, and gerontologists.

Download or read book Oxidative Eustress in Exercise Physiology written by James N. Cobley and published by CRC Press. This book was released on 2022-06-19 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions. Features Defines essential redox biology reactions and concepts in exercise physiology Assesses key redox parameters in an in vivo human exercise context Identifies the challenges, opportunities and boundaries of current knowledge Includes a critique of the underlying mechanisms Summarises examples of translationally important research relating to disease states Related Titles Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1) Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

Download or read book Antioxidants Exercise and Brain Function written by Akram Sidhu and published by . This book was released on 2016 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is associated with a decline in psychomotor and cognitive function. Interventions such as exercise and antioxidants supplementation when investigated independently have been beneficial counteracting oxidative stress and improving brain function in both human and animals. A large number of health conscious individuals often combine exercise with vitamin supplementation, anticipating a synergistic effect maximizing their performance. While some studies reported additive effects, others have also indicated a potential for an antagonistic action of the antioxidants on the beneficial effects of exercise. To date, it has not been well established what the nature of the interaction between antioxidant supplementation and exercise is in terms of functional outcomes and whether age will influence the outcomes. The purpose of this study was to determine if combination of antioxidant supplementation, and moderate exercise could ameliorate psychomotor and cognitive performance of young and old male mice Using vitamins C and E and a treadmill-based forced exercise in young and old C57BL/6J mice, we explored the nature of that interaction on functional and biochemical outcomes. We examined the mice for spatial learning and memory, working memory and executive function, coordinated running performance, muscular reflexes, spontaneous locomotor activity, anxiety and muscle strength. Our data suggested that the male mice exhibited age-associated declines in psychomotor and cognitive performance. Antioxidants supplementation worsened the cognitive flexibility of old mice but improved the depression-like symptoms in young mice. Overall, exercise training reversed the age-related declines in reflexes and balance of old mice, and improved strength and associative learning of young mice only. Furthermore, combination of exercise and antioxidant improved reflexes, motor and cognitive performance, but additive or antagonistic effects of antioxidants on the beneficial effects of exercise were not observed. Hence we can conclude that, combining antioxidants and exercise may not be provide any additional benefit in reversing age-related functional impairments.

Download or read book Effects of Antioxidant Supplementation on Muscle Damage and Oxidative Stress in Rats After Downhill Exercise written by Tongjian You and published by . This book was released on 2002 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Localization and Quantitation of Oxidative Damage in Skeletal Muscle from Aging Rhesus Monkeys written by Theodor Abidin Zainal and published by . This book was released on 1999 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oxidative Damage in Heart Brain and Skeletal Muscle in the Context of Aging Sex and Inherited Exercise Capacity written by Rita Musleh and published by . This book was released on 2021* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: As life expectancy rises, the number of patients with age-related conditions grows. One of the most accepted theories to explain the mechanism of aging is the accumulation of oxidative damage over time. Oxidative stress, defined as the imbalance between reactive oxygen species production and the antioxidant defenses, can result in macromolecular damage of lipids, proteins, and DNA. Over time, this eventually leads to progressive loss of tissue and organ function, a main feature of aging. However, the factors affecting this complex process are still poorly understood. It has been suggested that sex and inherited exercise capacity are two defining factors in the body's response to aging and its corresponding pathologies. Women live longer and develop many diseases with a 10-year delay compared to men. Similarly, high inherited exercise capacity has been associated with a higher life expectancy. Since the influence of the intrinsic (inherited) exercise capacity is hard to investigate in humans separately from the extrinsic form, a specifically bred rat model for high (HCR) and low (LCR) intrinsic aerobic running capacity was developed. In fact, HCRs showed to live almost one third longer than LCRs. We aimed to investigate the antioxidant defense system and oxidative damage markers in the context of aging, sex, low and high inherited exercise capacity. Heart, brain, and gastrocnemius muscle tissues of each female and male rats were tested in 4 different groups: young (4 months old), old (24 months old), HCRs & LCRs. Antioxidant capacity was evaluated through photometric measurements of the 3 most important antioxidant enzyme activities: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). On the other hand, oxidative damage markers related to lipid peroxidation (4-hydroxynonenal: 4-HNE) and protein carbonylation (PCO) were quantified by western blots and spectrophotometric measurements, respectively.

Download or read book Oxidants and Antioxidants written by Lester Packer and published by Gulf Professional Publishing. This book was released on 1999 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Total Antioxidant Activity * Vitamin C * Polyphenols and Flavanoids * Thiols * Vitamin E and Coenzyme Q10 * Carotenoids and Retinoids.

Download or read book Skeletal Muscle Oxidative Stress and Dietary Antioxidants written by Geny and published by Academic Press. This book was released on 2019-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effects of Antioxidant Supplementation on Exercise induced Oxidative Stress in Cyclists written by Matthew Soden and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Age on Iron Accumulation and Oxidative Stress in Skeletal Muscle of Rats written by Seung Ho Jung and published by . This book was released on 2007 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book An Investigation of the Effects of Regular Exercise in Older Males on Oxidative Stress Skeletal Muscle Apoptosis and Atrophy related Gene Expression in Response to Muscle Insult written by Thomas Wayne Buford and published by . This book was released on 2009 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purposes of the present study were to examine the role of physical activity in males between 55-75 years of age on skeletal muscle strength and biochemical pathways indicative of muscle atrophy before and after eccentric treadmill exercise. Twenty-seven apparently-healthy, non-smoking men (62.22±6.16 yr, 175.26±5.31 cm, 88.74±12.53 kg) participated in the study and were grouped at either physically-active (N=14, at least 15 hours of exercise per month) or sedentary (N=13, no regular exercise). Following a familiarization session, participants completed skeletal muscle performance testing as well as an eccentric treadmill protocol ( -17.5% grade) consisting of three 15 minute sets at 75% of VO2max. Participants donated venous blood prior to, immediately following, and 24h following exercise and a muscle biopsy sample prior to, 3h following, and 24h following exercise. Muscle performance was determined using a Biodex Isokinetic Dynamometer. Venous blood was analyzed for CK, LDH, cortisol, TNF[alpha], IL1[beta], protein carbonyls, 8-isoprostane, and total antioxidant activity. Skeletal muscle tissue samples were analyzed for mRNA expression of atrophy-related genes (Atrogin1, MURF1, FOXO1, FOXO3, IKKB, Ubiquitin, Ubiqutin E2, HSP27, HSP72, Id1, Id2, Id3, Myostatin, 20S C2, 20S C3, Calpain1, and Calpain2), protein content of pIKB[alpha], Caspase3, Bax, and Bcl2, and DNA binding activity of p53, NFkB p50, NFkB p65, and GC receptor. At baseline, significant differences existed between groups for body weight (p=0.047), VO2max (p