Download or read book Aging and Health A Systems Biology Perspective written by A.I. Yashin and published by Karger Medical and Scientific Publishers. This book was released on 2014-10-14 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Download or read book Explaining Health Across the Sciences written by Jonathan Sholl and published by Springer Nature. This book was released on 2020-08-28 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.
Download or read book Health Illness and Optimal Aging written by Carolyn M. Aldwin and published by SAGE. This book was released on 2004 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors undertake the difficult task of assembling an objective and holistic picture of human aging, including the physical aspects of aging, chronic disease and health promotion in the later years, for students and professionals.
Download or read book Biology of Aging written by Robert Arking and published by Oxford University Press. This book was released on 2006-02-02 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert Arking's Biology of Aging is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging.
Download or read book Biochemistry and Cell Biology of Ageing Part II Clinical Science written by J. Robin Harris and published by Springer. This book was released on 2019-03-19 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.
Download or read book Health Illness and Optimal Aging written by Carolyn M. Aldwin and published by SAGE Publications. This book was released on 2003-07-17 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: FROM THE FOREWORD by James Birren: "Gaining understanding of aging is one of the most complex issues facing twenty-first century science. This book addresses the complexity of the factors that interact and influence the course of our longer life expectancy....How we humans grow old is a product of our genetic background as members of a species and our families. But the genome expresses itself in physical and social environments that modulate the appearance of heredity traits. In a sense aging is an ecological problem in which the dynamics are often difficult to explain....This book brings information from the sciences together in a way that is rarely done.....It provides an integration of knowledge about the dynamics of aging and can promote wisdom about how we can modify the life course to our advantage." In Health, Illness, and Optimal Aging: Biological and Psychosocial Perspectives, Carolyn M. Aldwin and Diane F. Gilmer undertake the challenging task of assembling an objective and holistic picture of human aging. The authors provide comprehensive, multidisciplinary coverage of the physical aspects of aging, including age-related changes and disease-related processes, the demography of the aging population, theories of aging, and the promotion of optimal aging. In addition, the book covers the psychosocial aspects of aging, including mental health, stress and coping, spirituality, and care giving in later years. Features of this book: Integrated. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Comprehensive. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Pedagogical. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data.Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Discusses both the biological aspects and psychosocial factors of aging, thus providing integrated coverage of information from the fields of biology, psychology, and the social sciences. Covers every part of the aging process including the physical effect on the different systems of the human body, quality of life, social support, and health promotion programs. Examples in each chapter enhance students′ understanding of real-life situations, and methodological issues help students become more critical consumers of research and data. Health, Illness and Optimal Aging is recommended for researchers seeking an overview of health psychology and aging, as well as undergraduate and graduate students taking classes in the social, behavioral, and health sciences. This text is also valuable for practitioners working with the elderly in fields such as nursing, social work, occupational and physical therapy, day-care and nursing home administration, psychology, and rehabilitation.
Download or read book Computational Systems Biology written by Andres Kriete and published by Elsevier Inc. Chapters. This book was released on 2013-11-26 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: What makes the study of aging particularly challenging is the wide spectrum of phenotypical changes that can be observed during its progression. While initial attention was paid to damage accumulation, dysfunction, and failure, it is now realized that aging, and associated diseases including dementias, are influenced by a multitude of interacting factors. Proximal mechanisms beyond passive accumulation of damage include regulatory mechanisms, stress responses, changes in networks, as well as genetic and stochastic effects. The application of computational systems biology in aging, which is in line with other attempts to overcome the study of isolated or compartmentalized mechanisms, has made initial progress allowing us to simulate partial aspects of the aging dynamics and to make new hypotheses about how these aging mechanism shape disease progression. Here we provide examples for analysis of networks, regulatory mechanisms, and spatiotemporal effects in the study of proximal mechanisms of aging and Parkinson’s Disease. In addition, we introduce complexity theories that may contribute to explain the ultimate causes of aging with an evolutionary view.
Download or read book Human Aging written by Augustine Gaspar DiGiovanna and published by McGraw-Hill Companies. This book was released on 1994 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides comprehensive coverage of biological aspects of human ageing at a level accessible to students with little or no science background. It is aimed at students pursuing a career working with, or for, the elderly. Each system is covered in its own chapter. Individual chapters present the structure and function of each body system, followed by natural age changes, and conclude with abnormal changes or diseased conditions of the elderly. Homeostasis is a unifying theme throughout the text: systems are presented relative to the body's ability to maintain homeostasis and good health is the main theme.
Download or read book Health Illness and Optimal Aging Second Edition written by Carolyn M. Aldwin and published by Springer Publishing Company. This book was released on 2013-01-17 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Print+CourseSmart
Download or read book The Gerontological Imagination written by Kenneth F. Ferraro and published by Oxford University Press. This book was released on 2018 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The power of the gerontological imagination -- Causality -- Life course analysis -- Multifaceted change -- Heterogeneity -- Accumulation process -- Ageism -- The gerontological imagination at work in scientific communities
Download or read book The Aging Immune System and Health written by Valquiria Bueno and published by Frontiers Media SA. This book was released on 2020-01-15 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contribute to the low-grade inflammatory process observed (inflammaging). Aging is a complex and multifactorial process in which functions of the organism are adjusted (remodelled) in order to deal with damaging events during life. One of the most important changes in aging individuals occurs in the immune system (innate and adaptive responses) with consequences such as poor response to new infections and vaccinations; increased susceptibility to cancer development and autoimmune diseases; frailty, and organ dysfunction. In addition, it has been proposed that immunosenescence not only reflects the aging of the organism but also contributes to this process. Bone marrow presents decreased hematopoiesis, the thymus undergoes involution and lymphoid organs (lymph nodes, spleen) also present reduced functionality. Therefore, cells derived, matured, or residing in these tissues decline in number and function. These changes have been identified in experimental models, in vitro conditions, peripheral blood, and biopsies via biomarkers such as cell phenotype, stimulus-induced proliferation, cytokines and antibodies levels. Telomere length and telomerase activity also decline in bone marrow-derived and peripheral blood cells and have been shown to play a role in immunosenescence. More recently, the investigation of short non-coding RNA molecules (microRNAs; miRNAs) pointed to this system as a possible control of aging-related mechanisms. Data obtained on these markers for aging individuals could lead to the generation of a marker panel for pathology prediction, to indicate interventions, and to evaluate the efficacy of interventions. Interventions such as nutrition supplements, exercise, vaccination (different dose, concentration of antigen, adjuvants) have been proposed to circumvent age-related diseases. Considering the heterogeneity in the aging process, further investigation is vital before the indication of interventions for aging individuals. As the extension of life expectancy is a reality, it is a challenge to understand how the aging population copes with the remodelling of the organism and how interventions could provide longevity in good health.
Download or read book Biological Anthropology and Aging written by Douglas E. Crews and published by . This book was released on 1994 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume explores evolutionary, cross-cultural, physiological, environmental, and pathological influences on variation in human biological aging. Chapters by leading experts use models traditionally unique to anthropological research in order to illuminate human biological aging as a heterogeneous and variable process. By explicitly emphasizing evolutionary biology and human variation, the book presents the fascinating perspective of human biological aging as the end result of a set of co-adapted genetic complexes associated with successful growth, development, reproduction, and parenting of offspring. While examining human life span and life-history parameters as population-level phenomena, the book also emphasizes human phenotypic plasticity as key to understanding aging. This broad evolutionary perspective is unique in biological gerontology, a field that is often reductionist in method and theory. The book is sure to appeal to students, teachers, and researchers of geriatrics, gerontology, biology and anthropology of aging, and human population biology.
Download or read book Grand Challenges of Our Aging Society written by National Research Council and published by National Academies Press. This book was released on 2010-03-04 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging populations are generating both challenges and opportunities for societies around the globe. Increases in longevity and improvements in health raise many questions. What steps can be taken to optimize physical and cognitive health and productivity across the life span? How will older people finance their retirement and health care? What will be the macroeconomic implications of an aging population? How will communities be shaped by the shift in age structure? What global interconnections will affect how each society handles the aging of its population? To address these questions, the National Academies organized a symposium, summarized in the present volume, to determine how best to contribute to an evidence-based dialogue on population aging that will shape policies and programs. Presentations in the fields of biology, public health, medicine, informatics, macroeconomics, finance, urban planning, and engineering approached the challenges of aging from many different angles. The presenters reviewed the current state of knowledge in their respective fields, identifying areas of consensus and controversy and delineating the priority questions for further research and policy development.
Download or read book Psychology of Aging written by Brian Yochim, PhD, ABPP and published by Springer Publishing Company. This book was released on 2017-12-28 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The book goes well beyond the information in undergraduate texts and provides stimulating and useful coverage of key topics in biopsychosocial aging. Psychology is not prepared for the future growth of our older adult population, and I suggest Psychology of Aging: A Biopsychosocial Perspective as required reading for students" --William E. Haley, PhD; Professor; School of Aging Studies; College of Behavioral and Community Sciences, Tampa, FL "This book distinguishes itself from previous publications on the topic with a thorough review of the history profession of geropsychology and its timely inclusion of chapters on brain imaging techniques and the aging brain, cultural differences in aging ethnic and sexual minorities, cognitive interventions, and more. This book is a must read for undergraduate and graduate students studying aging, and one I will definitely recommend to students new to the area."--Sherry A. Beaudreau, Ph.D., ABPP, VA Palo Alto Health Care System and Stanford University School of Medicine "Brian Yochim and Erin Woodhead have created an invaluable tool for learning about and teaching geropsychology...This book will serve as a seminal text in training psychologists, social workers, and many other disciplines in the psychology of aging." --Erin E. Emery-Tiburcio, Ph.D., ABPP, Rush University, Chicago, IL The only graduate text to encompass the full range of issues regarding the psychology of aging This is the first graduate-level text that offers a comprehensive, in-depth chronicle of issues surrounding the psychology of aging emphasizing psychology, with a foundation in the biology, and an expansion into the sociological aspects of aging. The text is divided into three sections: biological underpinnings of aging, psychological components of aging, and social aspects of aging. Among the multitude of topics addressed are biological theories of aging, neuroimaging methods in aging research, neuroplasticity, cognitive reserve and cognitive interventions, a detailed overview of neurocognitive disorders in aging such as Alzheimer's disease and Lewy body disease, relationships in aging, work vs. retirement, cultural issues in aging, and aging and the legal system, to name just a few critical topics. With an emphasis on promoting critical thinking, the text is enriched with discussion questions in each chapter along with suggestions for more in-depth readings. In addition it includes chapter PowerPoints and an Instructor’s Manual with sample syllabi for a 10-week course and a 15-week course. Written for graduate students in multiple gerontology-related disciplines, the text is also of value to individuals studying nursing, medicine, social work, biology, and occupational, physical, and speech therapies. Key Features: Addresses the biological underpinnings of aging, psychological components, and social aspects Written by a variety of experts on each area Emphasizes critical thinking throughout the text Presents discussion questions in each chapter Includes PowerPoints and an Instructor’s Manual with sample syllabi Tailored to graduate students from multiple disciplines embarking on clinical or research careers involving older adults.
Download or read book Human Aging written by Calogero Caruso and published by Academic Press. This book was released on 2021-05-11 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research
Download or read book Cellular Ageing and Replicative Senescence written by Suresh I.S. Rattan and published by Springer. This book was released on 2016-05-09 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.
Download or read book Cells and Surveys written by National Research Council and published by National Academies Press. This book was released on 2001-01-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.
