Download or read book Aging and Age related Diseases written by Michał Karasek and published by Nova Publishers. This book was released on 2006 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ageing has become a great problem for many countries. Due to world-wide life prolongation the number of people over 6o years old has grown rapidly into a ten percent piece of the world population. The growing age of the world population raises many social, economical, and medical problems. The proportion of people in the economically active age groups to those who are over 65 is constantly decreasing. A major consequence of the increasing numbers of individuals in advanced age groups is increasing numbers of patients suffering from age-related diseases. The aim of this book is to present the basic data on human ageing as well as on age-related diseases.
Download or read book Prevention and Treatment of Age related Diseases written by Suresh I.S. Rattan and published by Springer Science & Business Media. This book was released on 2007-05-09 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a broad-ranging assessment of current efforts of the molecular, cellular, hormonal, nutritional and lifestyle strategies being tested and applied by biogerontologists in the search for effective means of intervention, prevention and treatment of age-related diseases, and for achieving healthy old age. Employing a semi-academic style, the book presents data from experimental systems, while focusing primarily on their applications to humans in the prevention and treatment of age-related impairments.
Download or read book Aging and Age Related Disorders written by Stephen Bondy and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Download or read book Anti aging Drugs written by Alexander M Vaiserman and published by Royal Society of Chemistry. This book was released on 2017-02-01 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.
Download or read book Models Molecules and Mechanisms in Biogerontology written by Pramod C. Rath and published by Springer. This book was released on 2020-06-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.
Download or read book Providing Healthy and Safe Foods As We Age written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-29 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.
Download or read book The Aging Cardiovascular System written by Vladimir Veniaminovich Frolʹkis and published by . This book was released on 1996 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diseases in the Elderly written by Nages Nagaratnam and published by Springer. This book was released on 2016-02-25 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the two important issues relating to disease in elderly: the age-related changes and the pathophysiology of the diseases. The book contains 19 chapters that are arranged by organ system and structured to cover the specific areas for a quick but in-depth understanding of diseases in aging patients. Unlike any other book on the market, this text is concise and yet thorough in approach to the stipulated areas. This book includes multiple-choice questions that reinforce the concepts that are most vital to understanding and treating geriatric patients, making it an outstanding resource on its own or as a companion to larger geriatric texts. Diseases in the Elderly is the ultimate resource for geriatricians, medical students, primary care physicians, hospital doctors, geriatric nurses, and all other medical professionals treating and diagnosing diseases in elderly patients.
Download or read book Human Aging written by Calogero Caruso and published by Academic Press. This book was released on 2021-05-11 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research
Download or read book The Biology of Senescence written by Alex 1920- Comfort and published by Hassell Street Press. This book was released on 2021-09-09 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book Retooling for an Aging America written by Institute of Medicine and published by National Academies Press. This book was released on 2008-09-27 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the first of the nation's 78 million baby boomers begin reaching age 65 in 2011, they will face a health care workforce that is too small and woefully unprepared to meet their specific health needs. Retooling for an Aging America calls for bold initiatives starting immediately to train all health care providers in the basics of geriatric care and to prepare family members and other informal caregivers, who currently receive little or no training in how to tend to their aging loved ones. The book also recommends that Medicare, Medicaid, and other health plans pay higher rates to boost recruitment and retention of geriatric specialists and care aides. Educators and health professional groups can use Retooling for an Aging America to institute or increase formal education and training in geriatrics. Consumer groups can use the book to advocate for improving the care for older adults. Health care professional and occupational groups can use it to improve the quality of health care jobs.
Download or read book Epigenetics of Aging written by Trygve O. Tollefsbol and published by Springer Science & Business Media. This book was released on 2009-11-11 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Download or read book Perioperative Care of the Elderly written by Gabriella Bettelli and published by Cambridge University Press. This book was released on 2017-11-16 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This innovative, comprehensive book covers the key elements of perioperative management of older patients. The book's chapter structure coincides with the clinical path patients tread during their treatment, from preoperative evaluation to post-hospital care. Epidemiological aspects and aging processes are illustrated, providing keys to understanding the quick expansion of geriatric surgery and defining the clinical profile of older surgical patients in a cybernetic perspective. Preoperative evaluation and preparation for surgery, including medication reconciliation and pre-habilitation, are developed in the light of supporting decision-making about surgery in an evidence-based and patient-focused way. Intra- and postoperative management are discussed, aiming to tailor anesthetic, surgical and nursing approaches to specific patients' needs, in order to prevent both general and age-related complications. This volume also addresses issues relevant to geriatric surgery, from different organizational models to clinical risk management and systems engineering applied to hospital organization.
Download or read book Molecular Mechanisms of Skin Aging and Age Related Diseases written by Taihao Quan and published by CRC Press. This book was released on 2016-04-21 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes
Download or read book Ageless written by Andrew Steele and published by Anchor. This book was released on 2021-03-23 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.
Download or read book Inflammation Aging and Cancer written by Mahin Khatami and published by Springer. This book was released on 2018-01-17 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.
