Download or read book Advances in Invasive and non Invasive Brain Stimulation in Parkinson s Disease From Basic Science to New Technologies written by Maria Sheila Guimarães Rocha and published by Frontiers Media SA. This book was released on 2022-07-14 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Innovative Technologies and Clinical Applications for Invasive and Non Invasive Neuromodulation From the Workbench to the Bedside written by Matteo Bologna and published by Frontiers Media SA. This book was released on 2020-02-13 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The possibility of harvesting the power of electric and magnetic impulses in the human body, commonly referred to as “neuromodulation,” is one of the most recent and promising developments of the modern science. Since the late ´60s, multiple invasive and non-invasive technologies have been developed and tested in experimental and clinical settings with the final aim of modulating the function of the central and peripheral nervous system. Clinical applications include, but are not limited to, common neurological disorders such as Parkinson’s disease and other movement disorders. The bulk of evidence supporting the clinical efficacy of various invasive and non-invasive approaches for neuromodulation has progressively led scientific societies, patients’ associations, and regulatory entities to acknowledge the critical role played by neuromodulation in the therapeutic algorithms of a wide range of neurological disorders. As a result, new technologies have been recently introduced into the market or are currently under validation. Their potential implementation into innovative protocols for neuromodulation demands a critical revision of what are the unmet needs for neuromodulation in movement disorders.

Download or read book Surgery for Parkinson s Disease written by Robert R. Goodman and published by Springer. This book was released on 2018-12-28 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deep brain stimulation for the treatment of patients with Parkinson’s disease was introduced in the 1990s. Initially performed only at academic centers, over the past decade it has become a widespread surgical procedure. A variety of surgical techniques are employed and innovations are introduced frequently. This book is an ideal source of information for the many practicing neurosurgeons who did not learn this surgery during their training but would now like to add it to their practice, as well as an excellent update on exciting new developments in surgery for Parkinson’s disease. This book is designed to provide practicing neurosurgeons with current knowledge on the practical aspects of surgical treatment of patients with Parkinson’s disease. It explains how to identify surgical candidates and determine the optimal surgery, describes the various surgical techniques that are currently employed, and offers insights into how to optimize deep brain stimulation therapy after implantation. The keys to avoidance of surgical complications are carefully elucidated. In addition, an overview is provided of potential advances on the near-term horizon, including closed-loop deep brain stimulation, gene therapy, and optogenetics. All topics are covered by experienced Parkinson’s disease surgeons, in a concise and digestable format. The book will be an ideal source of information for the many practicing neurosurgeons who would like to add deep brain stimulation to their practice, as well as an excellent update on new developments in surgery for Parkinson’s disease.

Download or read book Towards the Next Generation of Deep Brain Stimulation Therapies Technological Advancements Computational Methods and New Targets written by George C. McConnell and published by Frontiers Media SA. This book was released on 2021-10-04 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Non Invasive Brain Stimulation New Prospects in Cognitive Neurorehabilitation written by Carlo Professor Miniussi and published by Psychology Press. This book was released on 2012-12-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognitive deficits are a common consequence of neurological disease, and there is evidence that specific cognitive training may be effective in rehabilitation. Behavioural dysfunction following neurological disease constitutes one of the major causes of disability worldwide, exerts a major impact on the daily life of affected individuals, and their families, also with a financial burden both for patients, and the society in general. Therefore, the adequate treatment of cognitive dysfunction is a much relevant issue, with social and economical implications, over and above the neuropsychological problem per se. Several investigations emphasise the fact that interacting with neural activity, by means of cortical stimulation, can affect cognitive performance. A number of studies have reported enhanced performance in specific cognitive tasks in patients with several types of neurological disease, after receiving Non Invasive Brain Stimulation (NIBS) to specific cortical areas, namely: Transcranial Magnetic Stimulation, and transcranial Electrical Stimulation. In general, the evidence highlights the possibility of inducing changes in cortical excitability, which, in turn, may lead to a plastic reorganization of dysfunctional networks, responsible for the impaired cognitive functions. Despite these advances, a number of important questions remain open, regarding the use of stimulation techniques in cognitive rehabilitation. This special issue puts together international leading experts in the field, to review and discuss recent advances as to whether NIBS techniques alone, or combined with behavioural cognitive rehabilitation, can lead to performance enhancements, and why. The issue is timely and promises to have a huge impact across many domains of clinical and basic neuroscience.

Download or read book Brain Stimulation written by David H. Benninger and published by Elsevier Inc. Chapters. This book was released on 2013-11-11 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: In advanced Parkinson’s disease (PD), the emergence of symptoms refractory to conventional therapy poses therapeutic challenges. The success of deep brain stimulation (DBS) and advances in the understanding of the pathophysiology of PD have raised interest in noninvasive brain stimulation as an alternative therapeutic tool. The rationale for its use draws from the concept that reversing abnormalities in brain activity and physiology thought to cause the clinical deficits may restore normal functioning. Currently the best evidence in support of this concept comes from DBS, which improves motor deficits, and modulates brain activity and motor cortex physiology, although whether a causal interaction exists remains largely undetermined. Most trials of noninvasive brain stimulation in PD have applied repetitive transcranial magnetic stimulation (rTMS), targeting the motor cortex. Current studies suggest a possible therapeutic potential for rTMS and transcranial direct current stimulation (tDCS), but clinical effects so far have been small and negligible with regard to functional independence and quality of life. Approaches to potentiate the efficacy of rTMS include increasing stimulation intensity and novel stimulation parameters that derive their rationale from studies on brain physiology. These novel parameters are intended to simulate normal firing patterns or to act on the hypothesized role of oscillatory activity in the motor cortex and basal ganglia with regard to motor control and its contribution to the pathogenesis of motor disorders. Noninvasive brain stimulation studies will enhance our understanding of PD pathophysiology and might provide further evidence for potential therapeutic applications.

Download or read book Non invasive Brain Stimulation NIBS in Neurodevelopmental Disorders written by and published by Elsevier. This book was released on 2021-07-09 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Volume 264 presents the latest updates on recent techniques used to examine the potential treatment of psychiatric and neurological disorders in adults. In this special issue, the book's authors and contributors provide a unique focus on the potential effects of non-invasive brain stimulation. Topics cover a range of reviews, opinions, methodologies, original research articles, and suggestions on how to better translate scientific knowledge into practice. This new release will help guide basic research and the development of therapeutic interventions for children and adolescents who suffer from neurodevelopmental disorders. Covers the effects of brain stimulation on different neurodevelopmental disorders Includes experimental studies in humans, animals and associated theoretical reviews Provides the most accurate and up-to-date coverage from selected international experts

Download or read book Non invasive Brain Stimulation in Neurology and Psychiatry written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (TDCS), modify brain function through interaction with multiple neurotransmitters and networks. The implementation of these non-invasive stimulation techniques in physiology, behavioral studies, with modelling or functional imaging has provided an outstanding causal link between brain structure and function and helped identify neural networks mediating cognitive or motor function. The potential efficacy of non-invasive brain stimulation procedures for the management of specific symptoms in diverse neurological and psychiatric conditions has been tested in the past decade or so. For example, repetitive TMS over prefrontal areas has been extensively investigated as a treatment for patients with medication-resistant depression and has been shown to be associated with improvement of mood. Similarly, non-invasive stimulation techniques have been applied to various symptoms of Parkinson's disease such as bradykinesia and dyskinesias, with variables degrees of success reported. However, attempts to expand previously observed clinical improvements to other neurological disorders (e.g. Tourette's syndrome, autism, epilepsy) has been controversial. In trying to bypass potential confounding elements, researchers aim to target neural populations altered in disease to either increase or decrease their corrupted baseline activity. In addition, a complementary approach is to extend stimulation protocols that results enhanced behavior in healthy participants. One of the potential limitation of this latter strategy has been that most of the protocols evaluated in healthy participants have been tested in populations that are not comparable to the patient populations. This Frontiers Research Topic on non-invasive brain stimulation and enhancement of function seeks to combine contributions from researchers who found non-invasive brain stimulation induced improvement of either a motoric, cognitive or behavioral nature investigated behaviorally, physiologically or using brain imaging techniques in clinical populations. Investigation of the relation between enhancement of function in healthy populations and improvement of symptoms in patients with neurological or psychiatric disorders needs further consideration. Critically, the topic will be centered on the following topics to expand current knowledge: • selection of adequate stimulation protocols, including simple questions such as whether TMS or TDCS is more efficacious for inducing enhancement of function in brain disease; • methodological issues such as optimizing cortical targets and the use of good control groups; • which symptoms to tackle in different brain disorders. For example, is it possible to de-activate hyperactive cortical regions present in Parkinson disease to induce clinical amelioration? Do protocols used in healthy populations produce similar predictable effects in parkinsonian persons?; • potential of using stimulation protocols in combination with pharmacological or cognitive therapy; • the use of appropriate clinical, behavioral, physiological and imaging tools to measure brain plastic changes. Consideration about possible multi-centre clinical trials: feasibility, problems and authorization pathways. Studies or reviews on cost-effectiveness. The aim of this topic is to determine which disease signs are treatable with non-invasive brain stimulation and available protocols to interfere with altered brain systems and produce enhanced motor and behavior outcomes. This Frontiers Research Topic will be important in identifying new avenues of clinical research for rapid advances in the field.

Download or read book Brain Stimulation written by John C. Rothwell and published by Elsevier Inc. Chapters. This book was released on 2013-11-11 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been a large number of basic research studies of noninvasive brain stimulation in Parkinson’s disease. Initial work focused on measuring: (1) the excitability of corticospinal output with threshold and input–output measures, and (2) the effectiveness of intracortical γ-aminobutyric acid (GABA)ergic inhibitory systems using short-interval intracortical inhibition (SICI), long-interval intracortical inhibition (LICI), and silent period measures. Early suggestions of increased excitability and reduced inhibition have been progressively modified. There are conflicting reports on changes in excitability, silent period, and LICI, and the more consistent reduction in SICI is now viewed as a superimposed excitation rather than a primary deficit in a GABAergic mechanism. A small number of studies have suggested that premovement increases in corticospinal excitability may be prolonged in Parkinson’s disease, consistent with the suggestion of slower buildup of the motor command to move; there are also modifications of interhemispheric connections in patients with mirror movements. Transcranial magnetic stimulation (TMS) has also been used to explore the involvement of motor cortex and cerebellum in resting and postural tremors by examining how readily they can be reset by single TMS pulses over each area. It can also probe the effects of deep brain stimulation of motor cortex excitability. Finally, new TMS techniques that examine synaptic plasticity in motor cortex have shown reduced excitability in patients off therapy which is restored when on therapy. Data are also emerging about the possible role of cortical plasticity in compensating for gradual loss of dopaminergic function prior to onset of clinical symptoms.

Download or read book Non invasive Brain Stimulation in Neurology and Psychiatry written by Ignacio Obeso and published by Frontiers Media SA. This book was released on 2017-04-11 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential efficacy of non-invasive brain stimulation procedures for the management of specific symptoms in diverse neurological and psychiatric conditions has been tested in the past decade or so. For example, repetitive transcranial magnetic stimulation (rTMS) over prefrontal areas has been extensively investigated as a treatment for patients with medication-resistant depression and has been shown to be associated with improvement of mood. Similarly, non-invasive stimulation techniques have been applied to various symptoms of Parkinson's disease such as bradykinesia and dyskinesias, with variables degrees of success reported. However, attempts to expand previously observed clinical improvements to other neurological disorders (e.g. Tourette's syndrome, autism, epilepsy) has been controversial. In trying to bypass potential confounding elements, researchers aim to target neural populations altered in disease to either increase or decrease their corrupted baseline activity. In addition, a complementary approach is to extend stimulation protocols that results enhanced behavior in healthy participants. This Frontiers Research Topic on non-invasive brain stimulation and enhancement of function tries to combine a series of articles from researchers who used non-invasive brain stimulation to aim improvement of either a motoric, cognitive or behavioral nature investigated behaviorally, physiologically or using brain imaging techniques in clinical populations. Investigation of the relation between enhancement of function in healthy populations and clinical improvement in patients with neurological or psychiatric disorders needs further consideration.

Download or read book Computational Neurostimulation written by and published by Elsevier. This book was released on 2015-11-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Neurostimulation, the latest volume in the Progress in Brain Research series provides an introduction to a nascent field with contributions from leading researchers. In addition, it addresses a very timely and relevant issue which has long been known to require more treatment. - Part of a well-established international series that examines major areas of basic and clinical research within neuroscience, as well as emerging subfields - Provides an introduction to a nascent field with contributions from leading researchers

Download or read book Intelligent Technologies and Parkinson s Disease Prediction and Diagnosis written by Kumar, Abhishek and published by IGI Global. This book was released on 2024-02-08 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: When it comes to Parkinson's disease, one of the most important issues revolves around early detection and accurate diagnosis. The intricacies of this neurodegenerative disorder often elude timely identification, leaving patients and healthcare providers grappling with its progressive symptoms. Ethical concerns surrounding the use of machine learning to aid in diagnosis further complicate this challenge. This issue is particularly significant for research scholars, PhD fellows, post-doc fellows, and medical and biomedical scholars seeking to unravel the mysteries of Parkinson's disease and develop more effective treatments. Intelligent Technologies and Parkinson’s Disease: Prediction and Diagnosis serves as a beacon of hope in the quest to revolutionize Parkinson's disease diagnosis and treatment. It unveils the remarkable potential of artificial intelligence (AI) and machine learning (ML) in remodeling the way we approach this debilitating condition. With a comprehensive exploration of AI's capacity to analyze speech patterns, brain imaging data, and gait patterns, this book offers a powerful solution to the challenges of early detection and accurate diagnosis.

Download or read book Non Invasive Neuromodulation Therapies for Parkinson s Disease written by Milton C. Biagioni and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Noninvasive brain stimulation (NIBS) technologies have been applied to study brain physiology and, more recently, have been recognized for their therapeutic potential as an adjunctive treatment for various neurologic and psychiatric disorders. Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) are two of the most studied NIBS modalities in Parkinson's disease. They are non-systemic and relatively safe. Most therapeutic trials have been conducted to ameliorate motor symptoms of Parkinson's disease (PD) with overall positive results using various stimulation modalities and methods. Notwithstanding significant results, evidence has not yet been compelling mainly due to small-size studies, lack of standardization of methodologies and other study design limitations. NIBS hold promise for treatment of PD symptoms and PD related complications. Large, well designed clinical trials are needed to corroborate these positive findings and inform its durability and the overall clinical relevance for the treatment of PD.

Download or read book Emerging Horizons in Neuromodulation New Frontiers in Brain and Spine Stimulation written by and published by Academic Press. This book was released on 2021-08-24 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series

Download or read book Surgical Treatment of Parkinson s Disease and Other Movement Disorders written by Daniel Tarsy and published by Springer Science & Business Media. This book was released on 2002-10-14 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Surgical Treatment of Parkinson's Disease and Other Movement Disorders, a panel of highly experienced neurosurgeons, neurophysiologists, neuropsychologists, and neuroanatomists join forces to create an integrated, cutting-edge survey all of the methodologies necessary for successful surgical treatment.

Download or read book Deep Brain Stimulation written by William S. Anderson and published by Thieme. This book was released on 2019-05-10 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: The one-stop resource on deep brain stimulation for functional neurosurgeons! Deep brain stimulation (DBS) is used to modulate dysfunctional circuits in the brain with stimulation pulses applied to specific target areas of the brain. Globally, DBS procedures have been most commonly performed for Parkinson's disease and essential tremor, but there are now new and growing research efforts studying DBS for psychiatric disorders and epilepsy. Deep Brain Stimulation: Techniques and Practices written by the Society for Innovative Neuroscience in Neurosurgery along with Dr. William S. Anderson and distinguished experts presents the latest DBS approaches. The book begins with a history of DBS, general frame-based techniques, patient selection primarily for movement disorders, multidisciplinary collaboration, and ethical considerations. Subsequent chapters detail diverse technologies and disease-specific treatment for Parkinson's disease, essential tremor, dystonia, OCD, epilepsy, major depression, Tourette syndrome, emerging psychiatric indications, and pediatric applications. Key highlights Lead placement techniques utilizing currently available customized platforms and robotics Microelectrode recording and image-based direct targeting with MRI and CT to enhance lead placement Lesioning methods including radiofrequency, and MR-guided focused ultrasound Discussion of recent innovations in tractography to delineate white matter tracts in the brain and closed loop stimulation DBS has helped thousands of patients with intractable conditions, allowing for a programmable therapy with durable treatment effect. This remarkable guide provides the essentials for functional neurosurgeons to pursue intraoperative research opportunities in this growing subspecialty and incorporate DBS into clinical practice.

Download or read book Challenging the Functional Connectivity Disruption in Neurodegenerative Diseases New Therapeutic Perspectives through Non Invasive Neuromodulation and Cutting Edge Technologies written by Giancarlo Zito and published by Frontiers Media SA. This book was released on 2018-10-05 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neurorehabilitation field is increasingly focused on understanding how to efficiently revert the effects that acute (i.e., stroke or traumatic brain injury) or chronic (i.e., neurodegenerative diseases) insults play either on small or large-scale networks, encompassing motor, sensory and cognitive domains. The link between the disrupted neuronal pulse generators and their effectors is being re-shaped through a wide scenario that embraces biorobotics, robot-aided rehabilitation, non-invasive neurostimulation, nanoprosthetics and neuroengineering. For the past decade and at an amazing speed, large investments and efforts allowed enthusiastic and only apparently heterogeneous researchers to borrow theories from neurophysiology, pharmacology, physics and quantum mechanics in order to generate together highly sophisticated tools that restore, resemble or even substitute the basic biological architecture. The idea of actually reverting weakened functions and/or replacing the faulty parts either of the human body or the central and peripheral nervous system is becoming a new reality, opening a fascinating era in this field. In this Research Topic, several researchers showed how the above principles became reality, from theory to the bedside of patients, providing full explanations of the whole mechanistic processes and how they were implemented, up to the final stage.