Download or read book Advances in Adrenergic Receptor Biology written by Qin Wang and published by Academic Press. This book was released on 2011-06-27 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on adrenergic receptor biology, beginning with a review of past successes and historical perspectives then further discussing current general trends in adrenic receptor studies in various contexts. This publication also includes discussions of the role and relationship of adrenergic receptors to different systems and diseases, establishing adrenergic receptor biology as a needed, practical reference for researchers.
Download or read book Adrenergic Receptors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenergic Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Adrenergic Receptors in a concise format. The editors have built Adrenergic Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book beta Adrenergic Receptors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: beta Adrenergic Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about beta Adrenergic Receptors in a compact format. The editors have built beta Adrenergic Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about beta Adrenergic Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of beta Adrenergic Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Adrenergic beta Receptors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenergic beta Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Adrenergic beta Receptors in a concise format. The editors have built Adrenergic beta Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic beta Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic beta Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Adrenergic alpha Receptors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adrenergic alpha Receptors in a compact format. The editors have built Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic alpha Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Adrenergic Receptors Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenergic Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adrenergic Receptors in a compact format. The editors have built Adrenergic Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book beta Adrenergic Receptor Kinases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: beta-Adrenergic Receptor Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about beta-Adrenergic Receptor Kinases in a compact format. The editors have built beta-Adrenergic Receptor Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about beta-Adrenergic Receptor Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of beta-Adrenergic Receptor Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Adrenergic Receptors Advances in Research and Application 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenergic Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Adrenergic alpha Receptors in a concise format. The editors have built Adrenergic Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic alpha Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Beta adrenergic Receptor Stability Engineering for the Advancement of GPCR Structural Biology written by Christopher B. Roth and published by . This book was released on 2008 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: G-protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, accounting for >1% of the human genome and are the target of more than 30% of currently marketed pharmaceuticals. Although structural information is vital to the thorough understanding of this important class of receptors, progress has been greatly limited by the instability of these molecules in the detergent solutions used for their extraction, purification, and crystallization. To surmount this obstacle, we developed an engineering strategy where targeted amino acid substitutions were introduced at transmembrane helix (TM) interfaces in order to stabilize the receptor core fold, while at the same time maintaining normal receptor biochemistry. In the first chapter, background information on GPCR phylogeny, structure, and mechanism is reviewed. In the second chapter, the development of technology and methods for characterizing engineered [beta]-adrenergic receptors is described, including a high throughput flow-cytometric determination of receptor expression, and a novel HPLC-based system for rapid screening of receptor aggregation state and thermal stability. In the third chapter, the discovery of a stabilized mutant of the [beta]2-adrenergic receptor ([beta]2AR) is described where mutation of Glu-1223·41 to tryptophan resulted in a dramatic increase in receptor thermal stability while preserving near wild-type biochemistry and may do so by stabilizing the conserved break in TM5 at Pro-2115·50 . In the final chapter, agonist docking studies were performed using the recently published [beta]2AR X-ray crystal structure, which revealed that flexibility in TM5 is critical to the full engagement of key agonist-binding residues in TM3, TM5, TM6 and TM7, and may be an early step in the GPCR activation mechanism.
Download or read book Receptors written by J. Jacob and published by Elsevier. This book was released on 2016-01-26 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology and Therapeutics, Volume l: Receptors contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of receptors, their pharmacology, and their therapeutic applications. Topics covered range from opiate receptors and their endogenous ligands to membrane receptors in eukaryotic cells. Applications of binding to pharmacological research are also discussed. This volume is comprised of 29 chapters and opens with an overview of the chemistry and biochemistry of pituitary endorphins, paying particular attention to the correlation between the analgesic potency, receptor binding properties, preferred solution conformation, and metabolic stability of natural and synthetic opioid peptides. The reader is then introduced to the biosynthesis and release of the enkephalins; opiate receptors and their endogenous ligands; denervation supersensitivity in skeletal muscle; and biochemistry and physiology of dopaminergic and beta-adrenergic receptors in mammalian central nervous system. The following chapters explore the role of guanylnucleotides in the regulation of hormonally stimulated adenylate cyclase; interactions of cholera toxin with cell membranes; problems in studying hormone receptor binding; and the mechanism of action of anti-hormones. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.
Download or read book Adrenergic Receptor Protocols written by Curtis A. Machida and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenergic receptors are important modulators in the sympathetic c- trol of various metabolic processes in the central and peripheral nervous s- tems. These receptors are localized at multiple sites throughout the central nervous system (CNS) and serve as important regulators of CNS-mediated behavior and neural functions, including mood, memory, neuroendocrine c- trol, and stimulation of autonomic function. Adrenergic Receptor Protocols consists of 35 chapters dealing with va- ous aspects of adrenergic receptor analyses, including the use of genetic, RNA, protein expression, transactivator, second messenger, immunocytochemical, electrophysiological, transgenic, and in situ hybridization approaches. This volume details the use of various methods to examine the adrenergic receptor system, using aspects of the genetic flow of information as a guide (DNA? RNA ? transactivator ? protein expression ? second messenger analyses ? cellular analyses ? transgenic whole animal approaches). Adrenergic Receptor Protocols displays step-by-step methods for s- cessful replication of experimental procedures, and would be useful for both experienced investigators and newcomers in the field, including those beg- ning graduate study or undergoing postdoctoral training. The Notes section contained in each chapter provides valuable troubleshooting guides to help develop working protocols for your laboratory. With Adrenergic Receptor Protocols, it has been my intent to develop a comprehensive collection of modern molecular methods for analyzing adrenergic receptors. I would like to thank the many chapter authors for their contributions.
Download or read book Receptor Regulation written by R. J. Lefkowitz and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: ROBERT J. LEFKOWITZ, M. D. Receptor Regulation (Receptors and Recognition, Series B, Volume 13) Edited by R. J. Lefkowitz Published in 1981 by Chapman and Hall, 11 New Fetter Lane, London EC4P 4EE © 1981 Chapman and Hall The study of hormone and drug receptors has become one of the most excit ing and rapidly moving areas of biomedical research. Elucidation of receptor mechanisms and receptor structure has become the common goal of many scientists from diverse backgrounds. The rapid advances achieved have been due, in large part, to the concentrated effort of workers from a variety of disciplines including classical pharmacology, biochemistry, endocrinology, cell biology, genetics' and molecular biology, among others. Hormone and drug receptors appear to be of three major types, which may be classified by their cellular locations. Found in the plasma membranes of cells are the receptors for a wide variety of polypeptide hormones, catecholamines and a variety of neurotransmitters. Included within this group are those receptors coupled to the enzyme adenylate cyclase. The second group of receptors are the soluble cytoplasmic receptors for the steroid hormones. A third type of hormone receptor is the receptor for the thyroid hormones which appears to be confined to the nucleus. Not only may these different types of receptor be distinguished in terms of their cellular locations but also by their mechanisms of action.
Download or read book Catecholamine Receptors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catecholamine Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Catecholamine Receptors. The editors have built Catecholamine Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Catecholamine Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Catecholamine Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book The Adrenergic Receptors written by Dianne M. Perez and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
Download or read book Microcirculation written by Ronald F. Tuma and published by Academic Press. This book was released on 2011-04-28 with total page 999 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.