EBookClubs

Read Books & Download eBooks Full Online

EBookClubs

Read Books & Download eBooks Full Online

Book Advanced Diffusion Encoding Methods in MRI

Download or read book Advanced Diffusion Encoding Methods in MRI written by Daniel Topgaard and published by Royal Society of Chemistry. This book was released on 2020-08-17 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medical MRI community is by far the largest user of diffusion NMR techniques and this book captures the current surge of methods and provides a primary source to aid adoption in this field. There is a trend to adapting the more advanced diffusion encoding sequences developed by NMR researchers within the fields of porous media, chemical engineering, and colloid science to medical research. Recently published papers indicate great potential for improved diagnosis of the numerous pathological conditions associated with changes of tissue microstructure that are invisible to conventional diffusion MRI. This book disseminates these recent developments to the wider community of MRI researchers and clinicians. The chapters cover the theoretical basis, hardware and pulse sequences, data analysis and validation, and recent applications aimed at promoting further growth in the field. This is a fast moving field and chapters are written by key MRI scientists that have contributed to the successful translation of the advanced diffusion NMR methods to the context of medical MRI, from global locations.

Book Advanced analysis of diffusion MRI data

Download or read book Advanced analysis of diffusion MRI data written by Xuan Gu and published by Linköping University Electronic Press. This book was released on 2019-11-19 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion magnetic resonance imaging (diffusion MRI) is a non-invasive imaging modality which can measure diffusion of water molecules, by making the MRI acquisition sensitive to diffusion. Diffusion MRI provides unique possibilities to study structural connectivity of the human brain, e.g. how the white matter connects different parts of the brain. Diffusion MRI enables a range of tools that permit qualitative and quantitative assessments of many neurological disorders, such as stroke and Parkinson. This thesis introduces novel methods for diffusion MRI data analysis. Prior to estimating a diffusion model in each location (voxel) of the brain, the diffusion data needs to be preprocessed to correct for geometric distortions and head motion. A deep learning approach to synthesize diffusion scalar maps from a T1-weighted MR image is proposed, and it is shown that the distortion-free synthesized images can be used for distortion correction. An evaluation, involving both simulated data and real data, of six methods for susceptibility distortion correction is also presented in this thesis. A common problem in diffusion MRI is to estimate the uncertainty of a diffusion model. An empirical evaluation of tractography, a technique that permits reconstruction of white matter pathways in the human brain, is presented in this thesis. The evaluation is based on analyzing 32 diffusion datasets from a single healthy subject, to study how reliable tractography is. In most cases only a single dataset is available for each subject. This thesis presents methods based on frequentistic (bootstrap) as well as Bayesian inference, which can provide uncertainty estimates when only a single dataset is available. These uncertainty measures can then, for example, be used in a group analysis to downweight subjects with a higher uncertainty.

Book Diffusion MRI

    Book Details:
  • Author : Derek K Jones
  • Publisher : Oxford University Press
  • Release : 2010-11-11
  • ISBN : 0199708703
  • Pages : 784 pages

Download or read book Diffusion MRI written by Derek K Jones and published by Oxford University Press. This book was released on 2010-11-11 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professor Derek Jones, a world authority on diffusion MRI, has assembled most of the world's leading scientists and clinicians developing and applying diffusion MRI to produce an authorship list that reads like a "Who's Who" of the field and an essential resource for those working with diffusion MRI. Destined to be a modern classic, this definitive and richly illustrated work covers all aspects of diffusion MRI from basic theory to clinical application. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.

Book Accelerating Data Acquisition for Advanced Diffusion MRI Models

Download or read book Accelerating Data Acquisition for Advanced Diffusion MRI Models written by Daniel Vincent Olson and published by . This book was released on 2018 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Advanced Image Processing in Magnetic Resonance Imaging

Download or read book Advanced Image Processing in Magnetic Resonance Imaging written by Luigi Landini and published by CRC Press. This book was released on 2018-10-03 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The popularity of magnetic resonance (MR) imaging in medicine is no mystery: it is non-invasive, it produces high quality structural and functional image data, and it is very versatile and flexible. Research into MR technology is advancing at a blistering pace, and modern engineers must keep up with the latest developments. This is only possible with a firm grounding in the basic principles of MR, and Advanced Image Processing in Magnetic Resonance Imaging solidly integrates this foundational knowledge with the latest advances in the field. Beginning with the basics of signal and image generation and reconstruction, the book covers in detail the signal processing techniques and algorithms, filtering techniques for MR images, quantitative analysis including image registration and integration of EEG and MEG techniques with MR, and MR spectroscopy techniques. The final section of the book explores functional MRI (fMRI) in detail, discussing fundamentals and advanced exploratory data analysis, Bayesian inference, and nonlinear analysis. Many of the results presented in the book are derived from the contributors' own work, imparting highly practical experience through experimental and numerical methods. Contributed by international experts at the forefront of the field, Advanced Image Processing in Magnetic Resonance Imaging is an indispensable guide for anyone interested in further advancing the technology and capabilities of MR imaging.

Book Preclinical MRI of the Kidney

    Book Details:
  • Author : Andreas Pohlmann
  • Publisher : Humana
  • Release : 2022-02-19
  • ISBN : 9781071609804
  • Pages : 0 pages

Download or read book Preclinical MRI of the Kidney written by Andreas Pohlmann and published by Humana. This book was released on 2022-02-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preface... Table of Contents... Contributing Authors... Part I Introduction 1. Recommendations for Preclinical Renal MRI: A Comprehensive Open-Access Protocol Collection to Improve Training, Reproducibility, and Comparability of Studies Andreas Pohlmann, Susan J. Back, Andrea Fekete, Iris Friedli, Stefanie Hectors, Neil Peter Jerome, Min-Chi Ku, Dario Livio Longo, Martin Meier, Jason M. Millward, João S. Periquito, Erdmann Seeliger, Suraj D. Serai, Sonia Waiczies, Steven Sourbron, Christoffer Laustsen, and Thoralf Niendorf Part II Animal Models, Preparation, Monitoring, and Physiological Interventions 2. Animal Models of Renal Pathophysiology and Disease Adam Hosszu, Tamas Kaucsar, Erdmann Seeliger, and Andrea Fekete 3. Preparation and Monitoring of Small Animals in Renal MRI Tamas Kaucsar, Adam Hosszu, Erdmann Seeliger, Henning M. Reimann, and Andrea Fekete 4. Reversible (Patho-)Physiologically Relevant Test Interventions: Rationale and Examples Kathleen Cantow, Mechthild Ladwig-Wiegard, Bert Flemming, Andrea Fekete, Adam Hosszu, Erdmann Seeliger 5. Preparation of Ex Vivo Rodent Phantoms for Developing, Testing, and Training MR Imaging of the Kidney and Other Organs Jason M. Millward, João S. Periquito, Paula Ramos Delgado, Christian Prinz, Thoralf Niendorf, and Sonia Waiczies Part III Basic Concepts of Measurement Techniques 6. Quantitative Assessment of Renal Perfusion and Oxygenation by Invasive Probes: Basic Concepts Kathleen Cantow, Roger G. Evans, Dirk Grosenick, Thomas Gladytz, Thoralf Niendorf, Bert Flemming, and Erdmann Seeliger 7. Ultrasound and Photoacoustic Imaging of the Kidney: Basic Concepts and Protocols Sandra Meyer, Dieter Fuchs, and Martin Meier 8. Hardware Considerations for Preclinical Magnetic Resonance of the Kidney Paula Ramos Delgado, Ekkehard Küstermann, André Kühne, Jason M. Millward, Thoralf Niendorf, Andreas Pohlmann, and Martin Meier 9. MRI Mapping of Renal T1: Basic Concept Stefanie Hectors, Sabrina Doblas, Philippe Garteiser, Gwenaël Pagé, Bernard E. Van Beers, John C. Waterton, and Octavia Bane 10. MRI Mapping of the Blood Oxygenation Sensitive Parameter T2* in the Kidney: Basic Concept Lu-Ping Li, Bradley Hack, Erdmann Seeliger, and Pottumarthi V. Prasad 11. Renal Diffusion Weighted Imaging (DWI) for Apparent Diffusion Coefficient (ADC), Intra Voxel Incoherent Motion (IVIM), and Diffusion Tensor Imaging (DTI): Basic Concept Neil Peter Jerome, Anna Caroli, and Alexandra Ljimani 12. Dynamic Contrast Enhancement (DCE)-MRI Derived Renal Perfusion and Filtration: Basic Concepts Michael Pedersen, Pietro Irrera, Walter Dastrù, Frank G. Zöllner, Kevin M. Bennett, Scott C. Beeman, G. Larry Bretthorst, Joel R. Garbow, and Dario Livio Longo 13. Non-Invasive Renal Perfusion Measurement Using Arterial Spin Labelling (ASL) MRI: Basic Concept Min-Chi Ku, María A. Fernández-Seara, Frank Kober, and Thoralf Niendorf 14. Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST)-MRI: Basic Concepts Dario Livio Longo, Pietro Irrera, Lorena Consolino, Phillip Zhe Sun, and Michael T. McMahon 15. Sodium (23Na) MRI of the Kidney: Basic Concept James T. Grist, Esben Søvsø Hansen, Frank G. Zöllner, and Christoffer Laustsen 16. Hyperpolarized Carbon (13C) MRI of the Kidneys: Basic Concepts Cornelius von Morze, Galen D. Reed, Zhen J. Wang, Michael A. Ohliger, and Christoffer Laustsen 17. Functional Imaging Using Fluorine (19F) MR Methods: Basic Concepts Sonia Waiczies, Christian Prinz, Ludger Starke, Jason M. Millward, Paula Ramos Delgado, Jens Rosenberg, Marc Nazaré, Helmar Waiczies, Andreas Pohlmann, and Thoralf Niendorf 18. MR Elastography of the Abdomen: Basic Concepts Suraj D. Serai and Meng Yin Part IV Experimental Protocols 19. Monitoring Renal H

Book DIFFUSION MRI OF THE BREAST  E Book

Download or read book DIFFUSION MRI OF THE BREAST E Book written by Mami Iima and published by Elsevier Health Sciences. This book was released on 2022-06-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion weighted imaging (DWI) is a key emerging imaging modality for the management of patients with possible breast lesions, and Diffusion MRI of the Breast is the first book to focus on all aspects of DWI in today’s practice. It covers the knowledge necessary to undertake clinical breast DWI, with a thorough review of how DWI is currently used as a breast imaging modality and how breast lesions appear on DWI. Expert clinicians and physicists from around the world share their knowledge and expertise on everything from technical requirements and image analysis to clinical applications of DWI (diagnosis, prognosis, treatment monitoring) with case examples, and upcoming developments in the field (radiomics, AI). Offers an in-depth discussion of DWI’s clinical applications in breast imaging, including the position of DWI with respect to other modalities, the use of DWI in the diagnosis of suspicious lesions with a multiparametric protocol, the use of DWI as an imaging biomarker of prognosis and response prediction, the potential role of DWI for unenhanced breast MR screening, and more. Provides a basic introduction to DWI before discussing a practical approach to clinical interpretation and quality assurance issues. Covers specific challenges and advanced techniques (IVIM, non-Gaussian diffusion, DTI, and other novel techniques), radiomics and artificial intelligence, and different vendor approaches in breast DWI packages. Features more than 500 high-quality images throughout. Explains how DWI could be specifically used to provide information on prognosis and prediction factors. Evaluates the current status of DWI, its potential for the management of breast cancer patients, and possible future developments in the field.

Book Annual Reports on NMR Spectroscopy

Download or read book Annual Reports on NMR Spectroscopy written by and published by Academic Press. This book was released on 2022-08-31 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports on NMR Spectroscopy, Volume 107, the latest release in a series that has established itself as a premier resource for both specialists and non-specialists interested in new techniques and applications pertaining to NMR spectroscopy, includes a variety of updated chapters covering NMR Diffusion Studies, Recent Advances in Understanding of Nucleus Contributions to NMR Nuclear Shieldings, and more. Serves as the premier resource for learning new techniques and applications in NMR spectroscopy Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules Covers all aspects of molecular science, including MRI (Magnetic Resonance Imaging)

Book Diffusive Spreading in Nature  Technology and Society

Download or read book Diffusive Spreading in Nature Technology and Society written by Armin Bunde and published by Springer Nature. This book was released on 2023-05-08 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: What do the movements of molecules and the migration of humans have in common? How does the functionality of our brain tissue resemble the flow of traffic in New York City? How can understanding the spread of ideas, rumors, and languages help us tackle the spread a pandemic? This book provides an illuminating look into these seemingly disparate topics by exploring and expertly communicating the fundamental laws that govern the spreading and diffusion of objects. A collection of leading scientists in disciplines as diverse as epidemiology, linguistics, mathematics, and physics discuss various spreading phenomena relevant to their own fields, revealing astonishing similarities and correlations between the objects of study—be they people, particles, or pandemics. This updated and expanded second edition of an award-winning book introduces timely coverage of a subject with the greatest societal impact in recent memory—the global fight against COVID-19. Winner of the 2019 Literature Prize of the German Chemical Industry Fund and brainchild of the international and long-running Diffusion Fundamentals conference series, this book targets an interdisciplinary readership, featuring an introductory chapter that sets the stage for the topics discussed throughout. Each chapter provides ample opportunity to whet the appetite of those readers seeking a more in-depth treatment, making the book also useful as supplementary reading in appropriate courses dealing with complex systems, mass transfer, and network theory.

Book Intravoxel Incoherent Motion  IVIM  MRI

Download or read book Intravoxel Incoherent Motion IVIM MRI written by Denis Le Bihan and published by CRC Press. This book was released on 2018-11-05 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: First book ever on the topic Discusses current concepts and methodological issues for the successful implementation of IVIM MRI to investigate tissue perfusion non-invasively Covers a wide range of clinical applications Contributions by leading experts in the field from USA, Europe, and Asia and written with a good balance of methodological and clinical chapters Includes an extensive bibliography for further reading

Book Fast 2D Solution state NMR

    Book Details:
  • Author : Jean-Nicolas Dumez
  • Publisher : Royal Society of Chemistry
  • Release : 2023-05-17
  • ISBN : 1839168072
  • Pages : 560 pages

Download or read book Fast 2D Solution state NMR written by Jean-Nicolas Dumez and published by Royal Society of Chemistry. This book was released on 2023-05-17 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by active investigators in the field, this book describes state-of-the-art methods that can accelerate the acquisition of 2D NMR spectra in solution-state NMR. The acquisition of fast multi-dimensional NMR data has motivated numerous ground-breaking developments in NMR pulse sequences and associated data processing methods. These in turn have revolutionized the way 2D NMR acquisitions are performed, at the same time broadening the scope of applications of 2D NMR. The first part of the book provides an in-depth description of the concepts and implementation of major fast 2D NMR methods. The second part follows with illustrations of how such methods can be used in applications that require the acquisition of fast 2D NMR spectra, from reaction monitoring to hyperpolarization, including applications to a broad variety of samples and experimental conditions. Appealing to readers from both the methodology and applications communities, this title will fill a gap in the market for a book focused on small molecule NMR, and researchers from both academia and industry will find a rich plethora of knowledge.

Book Quantitative Magnetic Resonance Imaging

Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Book Development and Assessment of Advanced Quantitative Body Diffusion Weighted MRI

Download or read book Development and Assessment of Advanced Quantitative Body Diffusion Weighted MRI written by Yuxin Zhang and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion-Weighted MRI (DW-MRI) has a unique ability to non-invasively probe tissue microstructure without the need for ionizing radiation or contrast agent administration. This ability makes DW-MRI a powerful tool for the detection, staging, and treatment monitoring of cancer. However, DWI remains limited by multiple imaging challenges, especially in extracranial organs such as liver and prostate. The major challenges include: 1) relatively long acquisition time in multi-parametric mapping, 2), T2-shinethrough effect 3) artifacts caused by tissue motion and 4) image distortions arising from local magnetic field heterogeneities. In this thesis, technical developments are introduced to address these challenges in prostate and liver DWI. A STimulated-Echo based mapping (STEM) approach is developed and optimized to achieve simultaneous T1, T2 and ADC mapping within five minutes. The STE-DWI sequence is also evaluated in patients with prostate cancer, in order to achieve high contrast-to-noise ratio (CNR) with moderate b-values. To address the motion artifacts in liver DWI caused by cardiac motion, a M1-Optimized Diffusion Imaging (MODI) method is proposed to compensate the motion sensitivity while maintaining the blood-suppression effect using optimized diffusion encoding gradient waveforms. Additionally, reduced Field-of-View and multi-shot EPI acquisitions are assessed in prostate DWI to reduce the geometric distortion artifacts. Finally, a synergistic combination of MODI and multi-shot EPI acquisitions are proposed for motion-robust, reduced-distortion liver DWI. In this work, the feasibility, quantitative accuracy and reproducibility of the proposed techniques are evaluated in simulations, quantitative diffusion phantoms, healthy volunteers and a small number of patients with known or suspected cancer.

Book Diffusion MRI

    Book Details:
  • Author : Heidi Johansen-Berg
  • Publisher : Academic Press
  • Release : 2013-11-04
  • ISBN : 0124055095
  • Pages : 627 pages

Download or read book Diffusion MRI written by Heidi Johansen-Berg and published by Academic Press. This book was released on 2013-11-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie. Fully revised and updated edition of the first comprehensive reference on a powerful technique in brain imaging Covers all aspects of a diffusion MRI study from acquisition through analysis to interpretation, and from fundamental theory to cutting-edge developments New chapters covering connectomics, advanced diffusion acquisition, artifact removal, and applications to the neonatal brain Provides practical advice on running an experiment Includes discussion of applications in psychiatry, neurology, neurosurgery, and basic neuroscience Full color throughout

Book Medical Imaging Systems

Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.

Book MRI from Picture to Proton

    Book Details:
  • Author : Donald W. McRobbie
  • Publisher : Cambridge University Press
  • Release : 2017-04-13
  • ISBN : 1316688259
  • Pages : 405 pages

Download or read book MRI from Picture to Proton written by Donald W. McRobbie and published by Cambridge University Press. This book was released on 2017-04-13 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: MR is a powerful modality. At its most advanced, it can be used not just to image anatomy and pathology, but to investigate organ function, to probe in vivo chemistry, and even to visualise the brain thinking. However, clinicians, technologists and scientists struggle with the study of the subject. The result is sometimes an obscurity of understanding, or a dilution of scientific truth, resulting in misconceptions. This is why MRI from Picture to Proton has achieved its reputation for practical clarity. MR is introduced as a tool, with coverage starting from the images, equipment and scanning protocols and traced back towards the underlying physics theory. With new content on quantitative MRI, MR safety, multi-band excitation, Dixon imaging, MR elastography and advanced pulse sequences, and with additional supportive materials available on the book's website, this new edition is completely revised and updated to reflect the best use of modern MR technology.

Book Spatiotemporal Encoding Methods for Brain Magnetic Resonance Imaging

Download or read book Spatiotemporal Encoding Methods for Brain Magnetic Resonance Imaging written by Fuyixue Wang and published by . This book was released on 2021 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is a widely used non-invasive imaging technology for both clinical diagnosis and neuroscientific research. However, the imaging sensitivity and specificity of brain MRI are limited by the well-known technical challenge of MRI acquisition-low image encoding efficiency, leading to limited acquisition speed, spatial resolution and signal-to-noise ratio especially for in-vivo imaging. In order to address these challenges, this thesis presents newly developed spatiotemporal encoding methods, which are used to improve the sensitivity and specificity as well as provide time and cost savings for different MRI applications, including diffusion, quantitative relaxometry and functional imaging. The novel encoding strategies in high-dimensional space together with efficient data sampling schemes allow better use of radio-frequency pulse, modern receiver coil arrays and shared data correlation. The high imaging efficiency provided by these spatiotemporal acquisition methods was demonstrated to help overcome several long-standing challenges in brain MRI, which should help increase its diagnosis power and gain further understanding of the structural and functional organization of the human brain.