Download or read book Adherence to Antipsychotics in Schizophrenia written by Emilio Sacchetti and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poor adherence to therapy is one of the main obstacles to treatment effectiveness in schizophrenia. It is the main determinant of relapse, hospitalization, symptom persistence, and poor psychosocial functioning and outcome. Adherence to treatment is affected by various factors related to the disease characteristics, to the patient him- or herself, to the treatment, and to the therapeutic relationship. Some of these factors are modifiable, and both pharmacological and non-pharmacological strategies have been developed for this purpose. This book addresses the different aspects of adherence to treatment in schizophrenia and related disorders in a systematic but easy-to-use manual format. Chapters focus on a full range of issues, including pharmacological and non-pharmacological strategies to enhance adherence and continuity of care, relevant psychological factors, the importance of the patient-doctor relationship, and the need for an alliance with other care-givers. Adherence to Antipsychotics in Schizophrenia will be an invaluable asset for all who are involved in the care of patients with schizophrenia. ​

Download or read book Antipsychotic Long acting Injections written by Peter Haddad and published by Oxford University Press. This book was released on 2016-05-10 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antipsychotic Long-acting Injections (LAIs) were introduced in the 1960s to improve treatment adherence in schizophrenia. Subsequently, first-generation antipsychotic LAIs became widely used in many countries. Since the initial publication of Antipsychotic Long-acting Injections in 2010, new trial data have been published on long-acting injection (LAI) preparations of the drugs Risperidone, Paliperidone, and Olanzapine. Furthermore, a new LAI preparation of the drug Aripiprazole has recently been approved for clinical use in the United States and is likely to be approved in Europe soon. The second edition of this successful book has been fully updated to include this new data, with reference to both observational studies and randomized controlled trials, as well as other new developments in the clinical use of antipsychotic LAIs. New chapters have been added covering the comparison between oral and injectable antipsychotics, Olanzapine LAI, Aripiprazole LAI, and the practicalities of organizing a specialized clinic for long-acting injectable antipsychotics. Existing chapters have also been thoroughly updated to take into account the most recently published research. Antipsychotic Long-acting Injections, Second edition brings together clinical and research findings on LAIs in a comprehensive volume, with chapters written by international experts.

Download or read book Pharmacological Treatment of Mental Disorders in Primary Health Care written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.

Download or read book The relationship between second generation antipsychotic medication adherence and negative symptoms in first episode schizophrenia written by Elisha R. Agee and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Current Antipsychotics written by Gerhard Gross and published by Springer. This book was released on 2014-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into the pathophysiology of psychotic disorders, especially the role of glutamatergic mechanisms in schizophrenia, are now under development, and further principles are on the horizon. This situation, in many respects similar to that when the initial second-generation antipsychotics became available, can be rewarding for all. Preclinical and clinical researchers now have the opportunity to confirm their hypotheses and the pharmaceutical industry may be able to develop really novel classes of therapeutics. When we were approached by the publishers of the Handbook of Experimental Pharmacology to prepare a new volume on antipsychotics, our intention was to capture both, the accumulated preclinical and clinical knowledge about current antipsychotics as well as prospects for new and potentially more specific antischizophrenia principles. These efforts should be based on the pathophysiology of the diseases and the affected neurotransmitter systems. Since preclinical research on antipsychotic compounds is only reliable when intimately linked through translational aspects to clinical results, we decided to include clinical science as well. It turned out that that this endeavor could not be covered by a single volume. We thank the editorial board and the publishers for supporting our decision to prepare two volumes: Current Antipsychotics and Novel Antischizophrenia Treatments. These topics cannot really be separated from one another and should be seen as a composite entity despite the somewhat arbitrary separation of contributions into two volumes. The continuing challenges of developing improved and safer antipsychotic medications remain of concern and are discussed in the first volume. The new opportunities for the field to develop and license adjunctive treatments for the negative symptoms and cognitive deficits that are treated inadequately by existing compounds have been incentivized recently and provide the focus for the second volume. We hope these collective contributions will facilitate the development of improved treatments for the full range of symptomatology seen in the group of schizophrenias and other major psychotic disorders. Gerhard Gross, Ludwigshafen, Germany Mark A. Geyer, La Jolla, CA This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. Non-schizophrenia indications will be covered to some extent, but not exhaustively.

Download or read book Treatment Refractory Schizophrenia written by Peter F. Buckley and published by Springer Science & Business Media. This book was released on 2014-03-18 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.

Download or read book The Wiley Handbook of Healthcare Treatment Engagement written by Andrew Hadler and published by John Wiley & Sons. This book was released on 2020-01-30 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Against a global backdrop of problematic adherence to medical treatment, this volume addresses and provides practical solutions to the simple question: “Why don’t patients take treatments that could save their lives?” The Wiley handbook of Healthcare Treatment Engagement offers a guide to the theory, research and clinical practice of promoting patient engagement in healthcare treatment at individual, organizational and systems levels. The concept of treatment engagement, as explained within the text, promotes a broader view than the related concept of treatment adherence. Treatment engagement encompasses more readily the lifestyle factors which may impact healthcare outcomes as much as medication-taking, as well as practical, economic and cultural factors which may determine access to treatment. Over a span of 32 chapters, an international panel of expert authors address this far-reaching and fascinating field, describing a broad range of evidence-based approaches which stand to improve clinical services and treatment outcomes, as well as the experience of users of healthcare service and practitioners alike. This comprehensive volume adopts an interdisciplinary approach to offer an understanding of the factors governing our healthcare systems and the motivations and behaviors of patients, clinicians and organizations. Presented in a user-friendly format for quick reference, the text first supports the reader’s understanding by exploring background topics such as the considerable impact of sub-optimal treatment adherence on healthcare outcomes, before describing practical clinical approaches to promote engagement in treatment, including chapters referring to specific patient populations. The text recognizes the support which may be required throughout the depth of each healthcare organization to promote patient engagement, and in the final section of the book, describes approaches to inform the development of healthcare services with which patients will be more likely to seek to engage. This important book: Provides a comprehensive summary of practical approaches developed across a wide range of clinical settings, integrating research findings and clinical literature from a variety of disciplines Introduces and compliments existing approaches to improve communication in healthcare settings and promote patient choice in planning treatment Presents a range of proven clinical solutions that will appeal to those seeking to improve outcomes on a budget Written for health professionals from all disciplines of clinical practice, as well as service planners and policy makers, The Wiley Handbook of Healthcare Treatment Engagement is a comprehensive guide for individual practitioners and organizations alike.

Download or read book Non Pharmacological Interventions for Schizophrenia How Much Can Be Achieved and How written by Christina Andreou and published by Frontiers Media SA. This book was released on 2017-01-10 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of antipsychotic agents in the 1950’s substantially improved the treatment of schizophrenia and other psychotic disorders. However, clinical and functional outcomes are still far less than optimal for patients, and have not improved in recent years despite the development of several new antipsychotics. Efficacy rates are further compromised by medication non-adherence, which has been reported to affect more than half of patients. In response to these issues, several non-pharmacological interventions have been developed for the treatment of schizophrenia, such as cognitive behavioral therapy, cognitive remediation, social cognition training and metacognitive approaches. Although these interventions have produced promising results, there is still much controversy regarding their usefulness and applicability in clinical practice. A major impeding factor for their dissemination is possibly a lack of sufficient evidence regarding their specific indications, mechanisms of action, adverse effects, but also practical issues concerning the interpretability of respective clinical studies, such as the choice of outcome variables and control of confounding factors. The present Research Topic includes original research articles and reviews addressing these issues.

Download or read book The American Psychiatric Association Practice Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients With Dementia written by American Psychiatric Association and published by American Psychiatric Pub. This book was released on 2016 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The guideline offers clear, concise, and actionable recommendation statements to help clinicians to incorporate recommendations into clinical practice, with the goal of improving quality of care. Each recommendation is given a rating that reflects the level of confidence that potential benefits of an intervention outweigh potential harms.

Download or read book The Clinical Use of Antipsychotic Plasma Levels written by Jonathan M. Meyer and published by Cambridge University Press. This book was released on 2021-09-02 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinicians recognize that monitoring psychotropic levels provides invaluable information to optimize therapy and track treatment adherence, but they lack formal training specifically focused on the use of plasma antipsychotic levels for these purposes. As new technologies emerge to rapidly provide these results, the opportunity to integrate this information into clinical care will grow. This practical handbook clarifies confusing concepts in the literature on use of antipsychotic levels, providing clear explanations for the logic underlying clinically relevant concepts such as the therapeutic threshold and the point of futility, and how these apply to individual antipsychotics. It offers accessible information on the expected correlation between dosages and trough levels, and also provides a clear explanation of how to use antipsychotic levels for monitoring oral antipsychotic adherence, and methods to help clinicians differentiate between poor adherence and variations in drug metabolism. An essential resource for psychiatrists, psychiatric nurse practitioners, and mental health professionals worldwide.

Download or read book Practice Guideline for the Treatment of Patients with Bipolar Disorder revision written by American Psychiatric Association and published by American Psychiatric Pub. This book was released on 2002 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides treatment recommendations for bipolar patients, a review of evidence about bipolar disorder, and states research needs

Download or read book Antipsychotic Trials in Schizophrenia written by T. Scott Stroup and published by Cambridge University Press. This book was released on 2010-04-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Antipsychotic medications are a key treatment for schizophrenia and sales of antipsychotic drugs approach $20 billion per year, with fierce marketing between the makers of the drugs. The U.S. National Institute of Mental Health sponsored the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project to provide independent information about the comparative effectiveness of medications. CATIE was the largest, longest and most comprehensive study of schizophrenia to date. Conducted under rigorous double-blind conditions, Antipsychotic Trials in Schizophrenia presents the definitive archival results of this landmark study. The core of the book consists of chapters focused on specific outcomes that set the CATIE findings in a wider context. Also included are chapters on the design, statistical analyses and implications for researchers, clinicians and policy makers. Psychiatrists, psychiatric researchers, mental health policy makers and those working in pharmaceutical companies will all find this to be essential reading.

Download or read book Epidemiological and Experimental Evidence to Improve Antipsychotic Medication Adherence Among Patients with Schizophrenia who are Homeless and Involved with the Criminal Justice System written by Stefanie Nadya Rezansoff and published by . This book was released on 2017 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Schizophrenia consistently ranks among the leading causes of disability worldwide, and is significantly overrepresented in socially disadvantaged populations. Despite demonstrated efficacy of antipsychotic medication in research studies, poor adherence limits its effectiveness in real-world practice. Remarkably, antipsychotic adherence has never been examined in homeless or justice-involved patient cohorts under naturalistic conditions, and current treatment guidelines provide little information on practices to improve outcomes in these important subgroups. The three original research studies that comprise this thesis address this substantial omission in existing literature. Methods: The studies include population-level analysis, retrospective cohort design and a randomized controlled trial. Offenders diagnosed with schizophrenia, prescribed antipsychotic medication and convicted under British Columbia jurisdiction were the basis for longitudinal epidemiological analysis. A homeless cohort of Vancouver patients with severe mental illness enabled retrospective analysis of antipsychotic use, and examination of changes in adherence following randomization to different supported-housing treatment conditions. All three analyses drew on a centralized administrative repository of comprehensive prescription details. Adherence was operationalized using the medication possession ratio (MPR). Results: Over an average follow-up of 10 years, findings from the offender sample (n=11,462) revealed a mean MPR of 0.41. Results further demonstrated that patients who met guideline-level adherence (MPR≥0.80) were significantly less likely to be convicted of both violent and non-violent offences. 15-year retrospective analyses of homeless patients also showed an average MPR of 0.41. Higher antipsychotic adherence was significantly associated with duration of homelessness, prescription of long-acting injectable medication and primary care engagement. Randomization to market housing with assertive community treatment resulted in near guideline-level adherence (0.78), while assignment to congregate supported-housing and treatment as usual led to relatively low levels of adherence (0.55 and 0.61, respectively). Conclusion: Results demonstrate that homeless and/or justice-involved patients with schizophrenia have very low levels of adherence to prescribed antipsychotic medication. Findings were corroborated using two separate samples, in the context of universal health care, where prescribed medication is provided at no cost to patients of limited means. Action is needed to implement measures including those detailed in this research that have demonstrated promise to improve adherence among highly vulnerable patient groups.

Download or read book Compliance With Treatment In Schizophrenia written by Alec Buchanan and published by Psychology Press. This book was released on 2013-06-20 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a myth that people with mental disorders comply poorly with treatment. In fact, psychiatric patients are no more likely than patients in other medical specialities to go against the advice of their doctor. That said, it is easy to find instances where psychotropic medication is refused by the supposed beneficiary. The value of neuroleptic treatment in schizophrenia is now widely accepted. Failure to take such treatment is associated with relapse and relapse may endanger the patient and other people. Despite this, people with schizophrenia frequently fail to take their treatment. This study shows that one third can be expected to be non-compliant within two years of leaving a general adult psychiatry ward. It also looks at the reasons for this: the influence of drug side-effects is examined, as well as the impact of each patient's attitude to treatment and whether or not they have stopped taking prescribed medication in the past.

Download or read book The UKU Side Effect Rating Scale written by O. Lingjaerde and published by . This book was released on 1987 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Treatment resistant Schizophrenia written by Leslie Citrome and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Treatment-resistant Schizophrenia is a concise review of treatment-resistant schizophrenia’s definition, measurement tools, adherence issues, substance abuse, optimal dosing, clinician–patient relationships, and current management approaches. The book was originally commissioned with the intention of creating a comprehensive text focusing on treatment-resistant schizophrenia and its management. The book explores many aspects of the background and practice- and research-based evidence for treating this complex subset of schizophrenia, including psychopharmacological, somatic, and nonpharmacological treatment approaches. While exploring the various therapies for treatment-resistant schizophrenia, Dr Citrome also emphasizes the importance of building strong and trusting relationships between patients and their clinicians so the clinician can best manage their patient’s adherence and overall treatment.

Download or read book Culturally Informed Therapy for Schizophrenia written by Amy Weisman de Mamani and published by Oxford University Press. This book was released on 2021 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is primarily designed for clinicians and researchers interested in learning how to conduct an empirically supported, Culturally Informed Therapy for Schizophrenia (CIT-S) that integrates core components of evidenced based family therapy. It is estimated that approximately one percent of adults in the United States will be diagnosed with schizophrenia or a related schizophrenia spectrum disorder (SSD). Without treatment, prognosis is generally poor. Fortunately, traditional family therapies have shown increasing promise in reducing relapse rates and improving mental health for this population. As more and more societies become multicultural, however, there is an increasing expectation that mental health providers will also be prepared to meet the needs of unique and culturally diverse clients in an efficient, skillful, and culturally relevant manner. CIT-S is a 15-week, family-focused, cognitive behavioral approach for managing schizophrenia spectrum disorders. The intervention draws upon clients' cultural beliefs, practices, and traditions to help them conceptualize and manage mental illness. It aims to improve the quality of clients' lives in a manner that is in line with their values and takes into account their cultural norms when discussing important issues and addressing challenges (such as mental illness) within the family. CIT-S contains five distinct modules: 1) Family Collectivism 2) Psychoeducation 3) Spirituality 4) Communication Training and 5) Problem Solving. For each module, a detailed rationale, background information, therapy instructions, suggested homework assignments, and a sample case vignette is provided in an accessible, easy-to-use, manner"--