Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

Download or read book Drug Metabolism in Diseases written by Wen Xie and published by Academic Press. This book was released on 2016-09-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Download or read book Measuring Immunity written by Michael T. Lotze and published by Elsevier. This book was released on 2011-05-04 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. Measuring Immunity is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology. * Defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity* Assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques * Includes basic science foundations as well as the approaches currently applied

Download or read book Biology of C Reactive Protein in Health and Disease written by Waliza Ansar and published by Springer. This book was released on 2016-03-23 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Download or read book Acute Phase Proteins in the Acute Phase Response written by Mark B. Pepys and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of C-reactive protein in the laboratory of O.T. Avery at Rockefeller University in 1929-30 was the first specific obser vation of the acute phase plasma protein response (Tillett and Francis 1930). This was one of three contributions of fundamental importance which emerged from that laboratory, the other two being the recognition that polysaccharides could act as antigens and that DNA transmits genetic information. In the course of charac terization of pneumococcal carbohydrate antigens, a somatic poly saccharide common to all Rand S forms of pneumococci was identified and designated Fraction "C" (Tillet et al. 1930). Testing of sera from patients with pneumococcal infection revealed the presence of material which precipitated with the C-polysaccharide but which differed from antibody in that calcium was required for the reaction. Furthermore, the amount of reactive material was greatest when patients were acutely ill and decreased in the convalescent phase, the precise opposite of specific anti-pneumo coccal antibodies. Subsequently, the C-reactive material was shown to be a protein and to be present in the sera of individuals who were acutely ill with other, non-pneumococcal infections and tissue damaging conditions, hence Avery coined the term "acute phase" and called the protein "acute phase protein" (Abernethy and Avery 1941; MacLeod and Avery 1941). At that time methods were too insensitive to detect C-reative protein (CRP) in sera of healthy subjects and it was considered to be a pathological product.

Download or read book New Insights to Neuroimmune Biology written by Istvan Berczi and published by Elsevier. This book was released on 2010-05-27 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Insights to Neuroimmune Biology investigates the mechanisms that and functions of the Neuroimmune Regulatory Supersystem. Covering molecular regulation of cytokines in brain astrocytes, immunoregulation by the sympathetic nervous system, circadian regulation of immune reactions, antigen recognition by the CNS, the modulation of the immune response by head injury, neurogenic inflammation, the role of tachykinins in asthma and allergic disease, defence and defeat reactions, cytokines, behavior and affective disorders, increased activity of type 1 helper T cell functions after reward stimulation. This book has relevance to the entire scientific community in Biology, Medicine and Veterinary medicine as it discusses molecular, cellular, organic and systemic aspects as well as the physological, pathophysiological and behavioral mechnisms which are involved in Neuroimmiune Biology.

Download or read book Acute Phase Proteins Molecular Biology Biochemistry and Clinical Applications written by Andrzej Mackiewicz and published by CRC Press. This book was released on 2020-07-24 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists.

Download or read book Acute Phase Proteins as Early Non Specific Biomarkers of Human and Veterinary Diseases written by Francisco Veas and published by BoD – Books on Demand. This book was released on 2011-10-10 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two volumes of Acute Phase Proteins book consist of chapters that give a large panel of fundamental and applied knowledge on one of the major elements of the inflammatory process during the acute phase response, i.e., the acute phase proteins expression and functions that regulate homeostasis. We have organized this book in two volumes - the first volume, mainly containing chapters on structure, biology and functions of APP, the second volume discussing different uses of APP as diagnostic tools in human and veterinary medicine.

Download or read book Clinical Significance of C reactive Protein written by Waliza Ansar and published by Springer Nature. This book was released on 2020-12-17 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology. Divided into 5 sections, the book examines important topics such as the role of CRP in neurodegenerative, cardiac and parasitic diseases, as well as in cancer and inflammatory bowel disease, and the expression of CRP in pediatric respiratory diseases. In addition it discusses the clinical role of CRP in diagnostics and therapeutics, sepsis, ICU and ITU patients, and also as a primary marker for inflammation. Given its scope, this book will appeal to scholars in various fields of medicine and biology.

Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Download or read book Structure and Function of Plasma Proteins written by A. Allison and published by Springer. This book was released on 2012-03-26 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Ontogeny of Human Plasma Proteins: Detection of the Onset and Site of Synthesis Using Genetic Markers and in Vitro Cultures.- 1.1. Introduction.- 1.2. Immunoglobulins.- 1.2.1. Classes and Subclasses and Genetic Markers.- 1.2.2. Synthesis of Ig Molecules at Cellular Level.- 1.2.3. Transfer of Immunoglobulins through the Placenta.- 1.2.4. Synthesis of Immunoglobulins during Fetal Life.- 1.3. Complement.- 1.3.1. The Components of Complement.- 1.3.2. Levels and Fetal Synthesis of the Components of C.- 1.4. Haptoglobin System.- 1.5. Transferrins.- 1.6.?-Lipoprotein Variants: The Ag and Lp System.

Download or read book Proceedings of the Second Symposium Lyon France June 27 30 1983 written by P. Arnaud and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-05-18 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Proceedings of the Second Symposium Lyon, France, June 27-30, 1983".

Download or read book Kuby Immunology written by Jenni Punt and published by Macmillan Higher Education. This book was released on 2018-10-16 with total page 2997 pages. Available in PDF, EPUB and Kindle. Book excerpt: Janis Kuby’s groundbreaking introduction to immunology was the first textbook for the course actually written to be a textbook. Like no other text, it combined an experimental emphasis with extensive pedagogical features to help students grasp basic concepts. Now in a thoroughly updated new edition, Kuby Immunology remains the only undergraduate introduction to immunology written by teachers of the course. In the Kuby tradition, authors Jenni Punt, Sharon Stranford, Patricia Jones, and Judy Owen present the most current topics in an experimental context, conveying the excitement of scientific discovery, and highlight important advances, but do so with the focus on the big picture of the study of immune response, enhanced by unsurpassed pedagogical support for the first-time learner. Punt, Stranford, Jones, and Owen bring an enormous range of teaching and research experiences to the text, as well as a dedication to continue the experiment-based, pedagogical-driven approach of Janis Kuby. For this edition, they have worked chapter by chapter to streamline the coverage, to address topics that students have the most trouble grasping, and to continually remind students where the topic at hand fits in the study of immunology as a whole.

Download or read book Acute Phase Proteins written by Sabina Janciauskiene and published by BoD – Books on Demand. This book was released on 2013-07-24 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The magnitude and rapidity of the changes in the concentrations of APPs, together with their short half-life, suggest an important role for these proteins in the establishment of host defense. APPs are regarded as having general functions in trapping of micro-organisms and their products, in activating complement, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free radicals, and in modulating the hosts immune response. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their function during health and disease remains incompletely defined.

Download or read book The Role of Protein and Amino Acids in Sustaining and Enhancing Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1999-09-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.

Download or read book Rickettsial Diseases written by Didier Raoult and published by CRC Press. This book was released on 2007-04-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho

Download or read book CDC Yellow Book 2018 Health Information for International Travel written by Centers for Disease Control and Prevention CDC and published by Oxford University Press. This book was released on 2017-04-17 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.