Download or read book Accelerated Partial Breast Irradiation written by David E. Wazer and published by Springer Science & Business Media. This book was released on 2009-08-11 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text is a concise handbook designed to assist the clinician in the implementation of APBI. This includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications.
Download or read book Accelerated Partial Breast Irradiation written by David E. Wazer and published by Springer. This book was released on 2009-09-02 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is a concise handbook designed to assist the clinician in the implementation of Accelerated Partial Breast Irradiation (APBI). It includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications. The book encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation.
Download or read book Accelerated Partial Breast Irradiation with Particle Could Significantly Spare Heart Contralateral Breast and Lung Compared to Photon Based Radiation Treatment written by Chae-Seon Hong and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-ion treatment for breast cancer was not effectively analyzed and compared with photon-based radiation treatment technique, yet. To quantitatively analyze the dosimetric effect of particle therapy on early-stage breast cancer, we compare three different kinds of radiation treatment planning by using RayStation treatment planning system including intensity modulated carbon-ion therapy (IMCT), intensity modulated proton therapy (IMPT), and conventional photon-based VMAT.For ten breast cancer patients referred for early stage T1N0M0 as APBI treatment, planning for IMCT, IMPT and VMAT was generated. All plan was generated based on the same CTV with different margins for PTV (2 mm for IMCT, IMPT, 3 mm for VMAT) to secure the reliability of treatment. IMCT, IMPT plan, consisting of three (non-)coplanar beam arrangement was applied with robust optimization for PTV (2 mm iso-tropical margin for patient setup uncertainty and 3.5% for range uncertainty) and VMAT with two arc beam arrangement was generated. 30 Gy in 5 fractions was applied for IMPT, VMAT whereas 30 gray equivalents (GyE; physical dose in Gy u00d7 RBE) in 5 fractions was applied for IMCT. CTV coverage and the organs at risk as well as conformity and homogeneity indexes for PTV was calculated from dose volume histograms.All treatment plan had fulfilled the prescription (D95% for CTV u2265u200999%). In planning comparison among the three different modalities, IMCT achieved better homogeneity compared to IMPT, VMAT and achieved better conformity compared to IMPT. Planning results from particle therapy has showed better OARs spare effect, especially for heart, contralateral breast and lung.
Download or read book Electronic Irradiation of Foods written by R. B. Miller and published by Springer Science & Business Media. This book was released on 2006-12-26 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food irradiation, the use of ionizing radiation to destroy harmful biological organism in food, is a safe, proven process that has many useful applications. It has been endorsed by numerous health organizations and has now been approved for many applications by governments around the world. Electronic Irradiation of Foods describes all the key aspects of electron accelerator technology in detail. It emphasizes the physical science and technology aspects of food irradiation using machine sources of ionizing radiation. The book provides significant technical depth for interested workers and present descriptive, introductory material that should help demystify technology for businessmen to make informed choices regarding important investments decisions. Introductory chapters summarize the effects of ionizing radiation on biological organisms and the organic compounds comprising foods, and give an overview of the food irradiation process. Subsequent chapters cover the details of the electron beam and x-ray energy deposition, electron accelerator technologies, beam scanning systems, material handling systems, shielding design, and process control considerations. Important appendices cover radiation dosimetry, induced radioactivity, and ozone generation.
Download or read book Short Course Breast Radiotherapy written by Douglas W Arthur and published by Springer. This book was released on 2015-12-31 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive handbook on the implementation of short course radiotherapy for the treatment of breast cancer is intended as an up-to-date resource for the clinician. The book opens with a series of chapters on underlying principles and diverse relevant topics, including pathologic anatomy of early-stage breast cancer, radiobiology of accelerated breast irradiation, quality assurance and radiation safety, surgical considerations in partial breast irradiation, and impact of oncoplastic surgery on adjuvant radiotherapy. Individual sections are then devoted to hypofractionated whole breast radiotherapy, accelerated partial breast irradiation, and intraoperative radiotherapy. Each section includes details of patient selection, physics, techniques, data, and toxicity. The reader is provided with clear guidance on the appropriate use of accelerated forms of adjuvant radiotherapy for treatment of early-stage breast cancer and on various emerging treatment approaches.
Download or read book Accelerated Partial Breast Irradiation written by Gregory M. Chronowski and published by . This book was released on 2007 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interstitial Brachytherapy written by Interstitial Collaborative Working Group and published by Lippincott Williams & Wilkins. This book was released on 1990 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Influence of Chronic Acceleration on the Effects of Whole body Irradiation in Rats written by Harold Wilton Casey and published by . This book was released on 1965 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The following conclusions are drawn from the results of the studies combining acute whole-body irradiation and acceleration. Rats survive and physiologically adapt to 3.0 G chronic acceleration. A reduced body mass and depletion of body fat deposits are the only detectable changes from normal rats. Acceleration following exposures to acute whole-body irradiation, with doses in the mid-lethal range, increases radiation mortality. The mortality increases progressively with accelerative forces of 2.0 and 3.0 G. Prior adaptation to acceleration does not influence the increased radiation mortality. The detrimental effects of acceleration are operative only during the first week following irradiation. Pathological lesions in rats dying or sacrificed following acceleration and irradiation are typical of those produced by irradiation and are not modified by acceleration. Deceleration to normal gravity followed by irradiation does not influence the effects produced by radiation. (Author).
Download or read book Acceleration of Aging by Ionizing Radiation written by George W. Casarett and published by . This book was released on 1957 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Laser Driven Particle Acceleration Towards Radiobiology and Medicine written by Antonio Giulietti and published by Springer. This book was released on 2016-05-04 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.
Download or read book Textbook of Radiation Oncology written by Steven A. Leibel and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, the 2nd Edition presents all of the latest advances in the field, including the most recent technologies and techniques. For each tumor site discussed, readers will find unparalleled coverage of multiple treatment plans, histology and biology of the tumor, its anatomic location and routes of spread, and utilization of specialized techniques. This convenient source also reviews all of the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Comprehensively reviews each topic, with a distinct clinical orientation throughout. Serves as a foundation for the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Guides readers through all stages of treatment application with step-by-step techniques for the assessment and implementation of radiotherapeutic options. Presents latest information on brachytherapy * 3-dimensional conformal treatment planning * sterotactic radiosurgery * and radiolabeled antibodies. Discusses the recent use of radiotherapy in the treatment of primary lymphoma, leukemia, multiple myeloma, and cancers of the prostate and central nervous system. Includes the latest AJCC staging system guidelines. Offers the latest advances in techniques, allowing you to deliver doses precisely to areas affected by malignancy and spare healthy tissue. Presents new chapters on the hottest topics including Three Dimensional Conformal Radiotherapy * Intensity Modulated Radiotherapy * Breathing Synchronized Radiotherapy * Plasma Cell Tumors: Multiple Myeloma and Solitary Plasmacytoma * Extracranial Stereotactic Radioablation * and [Imaging of the] Head and Neck * Thorax * Abdomen * and Pelvis.
Download or read book Limitations of Current Dosimetry for Intracavitary Accelerated Partial Breast Irradiation with High Dose Rate 192Ir and Electronic Brachytherapy Sources written by Julie A. Raffi and published by . This book was released on 2010 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Practical Radiation Oncology Physics E Book written by Sonja Dieterich and published by Elsevier Health Sciences. This book was released on 2015-06-24 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfect for radiation oncologists, medical physicists, and residents in both fields, Practical Radiation Oncology Physics provides a concise and practical summary of the current practice standards in therapeutic medical physics. A companion to the fourth edition of Clinical Radiation Oncology, by Drs. Leonard Gunderson and Joel Tepper, this indispensable guide helps you ensure a current, state-of-the art clinical practice. - Covers key topics such as relative and in-vivo dosimetry, imaging and clinical imaging, stereotactic body radiation therapy, and brachytherapy. - Describes technical aspects and patient-related aspects of current clinical practice. - Offers key practice guideline recommendations from professional societies throughout — including AAPM, ASTRO, ABS, ACR, IAEA, and others. - Includes therapeutic applications of x-rays, gamma rays, electron and charged particle beams, neutrons, and radiation from sealed radionuclide sources, plus the equipment associated with their production, use, measurement, and evaluation. - Features a "For the Physician" box in each chapter, which summarizes the key points with the most impact on the quality and safety of patient care. - Provides a user-friendly appendix with annotated compilations of all relevant recommendation documents. - Medicine eBook is accessible on a variety of devices.
Download or read book Surgical Management of Advanced Pelvic Cancer written by Desmond C. Winter and published by John Wiley & Sons. This book was released on 2021-11-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: An innovative guide to the practice of pelvic exenterative surgery for the management of advanced pelvic neoplasms Exenterative surgery plays an important role in the management of advanced pelvic cancer. However, while a large body of evidence regarding outcomes following pelvic exenteration now exists, practical strategies and management options remain unclear. Surgical Management of Advanced Pelvic Cancer addresses this problem by assembling world-leaders in the field to provide insights into the latest techniques and best practices. It includes detailed coverage of: Surgical anatomy Operative approaches and exenterative techniques Reconstruction options Current evidence on survival and quality of life outcomes Featuring essential information for those managing patients with advanced pelvic neoplasms, Surgical Management of Advanced Pelvic Cancer consolidates the latest data and practical advice in one indispensable guide.
Download or read book Food Irradiation Technologies written by Isabel C F R Ferreira and published by Royal Society of Chemistry. This book was released on 2017-12-19 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food preservation by irradiation is gaining recognition as a technology that is more environmentally benign than other current processes such as post-harvest chemical fumigation, it has less impact on thermally sensitive compounds than thermal decontamination technologies such as hot water or steam, and the technology is more accessible and cheaper. As the technical and economic feasibility, as well as the level of consumer acceptance, have increased its use has been growing fast. International organizations including the Food and Agriculture Organization of the United Nations (FAO), the International Atomic Energy Agency (IAEA) and the World Health Organization (WHO) have coordinated and worked with others to develop norms and review the safety and efficacy of irradiated foods. Commended in the Foreword by Carl Blackburn, Food Irradiation Specialist, Joint FAO / IAEA Division of Nuclear Techniques in Food and Agriculture, this book makes a strong case for the use of this overwhelmingly safe food processing technique. This comprehensive book is a useful reference for food technologists, analytical chemists and food processing professionals, covering all aspects of gamma, electron beam and X-ray food irradiation, its impact on food matrices and microorganisms, legislation and market aspects. It is the first book to cover control and structural analysis in food irradiation and, being written by leading experts in the field, addresses the current global best practices. It contains updated information about the commercial application of food irradiation technology, especially regarding the type of radiation based on food classes and covers dosimetry, radiation chemistry, food decontamination, food quarantine, food processing and food sterilization.
Download or read book An Investigation of Accelerated Partial Breast Irradiation APBI for the Treatment of Early Stage Breast Cancer written by Veeresh Michael and published by . This book was released on 2017 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose: Breast cancer is one of the most common cancers among American women and is the second leading cause of cancer death among women in the U.S. While its incidence in Mississippi is among the lowest in the country, the state mortality rate is among the highest. Traditionally, regardless of the severity of the diagnosis, radical mastectomy followed by a combination of radiation therapy (RT) and chemotherapy was a woman's only option to treat early-stage breast cancer. The advent of breast conservation surgery (BCS) offers a less intrusive alternative and has become a popular and preferred treatment option for clinically qualified women with early stage breast cancer. Studies show lumpectomy followed by RT as equivalent to mastectomy for early stage breast cancer. Radiation Therapy is important to reduce the risk for local recurrence. BCS followed by RT is called breast conservation therapy (BCT). BCT has given rise to an accelerated or hypo-fractionated RT to the lumpectomy bed where the greatest recurrence risk exists. This treatment method, also called partial breast irradiation (PBI), allows for the breast to experience less radiation toxicity and reduces radiation treatment time. Accelerated partial breast irradiation (APBI) typically involves a radiation regimen of one week as compared to conventional whole breast irradiation requiring up to six weeks of daily radiation. Few APBI treatment techniques have gained popularity due to technical challenges and painful surgical procedures. One form that has gained favorability among physicians and patients utilizes high dose rate (HDR) brachytherapy. APBI with HDR is a two-step process involving a lumpectomy followed by surgical insertion of a balloon or strut type catheter that is used for radiation delivery. Delivery of radiation is through temporary placement of radioactive Iridium-192 within the lumpectomy site via the catheter. This outpatient procedure is typically a five-day course. A few studies have examined the impact of facility access to APBI utility. Additional studies in various states have investigated the impact of patient demographics on APBI utilization. Others have explored the association of surgeon training, physician density, and referral patterns on APBI utilization. There is currently a lack of research in APBI utilization in the state of Mississippi with respect to APBI facility access, patient demographics, and density of surgeons and radiation oncologists. Methods: Research included the analysis of Mississippi Cancer Registry (MCR) data to identify early stage breast cancer patients who received mastectomy, BCS, or BCT to include adjuvant radiation. The MCR data sought included records of early-stage breast cancer in women from 2004 to 2013, which is appropriate since APBI brachytherapy gained popularity in the last 10 years. Analysis of MCR data will correlate patient demographics to surgical and radiation treatment modality (mastectomy, BCS, or BCT). Radiation therapy facilities and the subset that offer the APBI treatment option within the state were identified through the Mississippi State Department of Health (MSDH). The Mississippi State Medical Association (MSMA) was used to identify general surgeons and radiation oncologists per county. RT facilities and physician density data was used with MCR data to classify patterns of APBI utilization within Mississippi counties. Chi-square analysis was used to investigate if radiation treatment modality selected differs by patients' race, county of diagnosis, and insurance status. Binary logistic regression was used to investigate factors associated with radiation treatment modality. Results: An analysis was performed on APBI eligible early-stage female breast cancer patients. The selection included women who received BCS and met all of the eligibility criteria for APBI treatment. Statistical analysis was performed based on demographic factors such as race, county of diagnosis, and insurance status. Additionally, statistical analysis was performed on proximity to physician density and radiation facilities within the county of diagnosis. Among APBI eligible patients, Chi-square analysis indicated a statistically significant difference for radiation treatment modality selected based on race, urban vs. rural county of diagnosis, insurance status, availability of a radiation oncologist, and availability of external beam radiation treatment facilities within the diagnosis county. Binary logistic regression analysis was performed for an outcome of no radiation versus any radiation received, as well as analysis of no radiation versus APBI brachytherapy. For both binary logistic regression analyses, there was a significant difference among treatment for patients in urban versus rural counties, race, and availability of external beam radiation facilities. For the outcome of no radiation versus brachytherapy, the availability of a surgeon or APBI brachytherapy facility within the diagnosis county showed a significant difference in treatment modality chosen. Multinomial regression analysis considered all radiation treatment modalities on controlling for all other covariates. This analysis demonstrated a statistically significant difference for any radiation treatment modality when considering race, urban versus rural county of diagnosis, and availability of external beam radiation facilities within the county. For APBI brachytherapy, the availability of a surgeon and brachytherapy facilities within the county was shown to be statistically significant.Conclusion: This study examines the variation in radiation treatment among APBI eligible early stage breast cancer patients who received mastectomy versus BCS or BCT. The analysis showed that non-Hispanic white women are significantly more likely to receive external beam treatment or APBI brachytherapy treatment than non-Hispanic black women. Women in urban counties are significantly more likely to receive external beam or APBI brachytherapy than women in rural counties. When compared to uninsured women, those who have government insurance are more likely to receive external beam or APBI brachytherapy. Also, women with private pay insurance are more likely to receive APBI brachytherapy and significantly more likely to receive external beam treatment. While not statistically significant, not having a radiation oncologist available in the county of diagnosis decreased the likelihood of receiving either external beam RT or brachytherapy. Similarly not having a surgeon available within the diagnosis county decreased the likelihood of a patient receiving external beam treatment and significantly decreased the likelihood of brachytherapy. Not having a linear accelerator available within the county of diagnosis still increases the likelihood of receiving some type of radiation treatment, especially brachytherapy. Finally, having an HDR brachytherapy facility available within the county of diagnosis significantly increases the likelihood of receiving APBI brachytherapy treatment. Non-Hispanic white women with private or government insurance are more likely to receive external beam treatment or APBI brachytherapy treatment, indicating that race and insurance status have an impact on APBI utilization. Access to a radiation oncologist did not significantly have an impact on APBI utilization; however, not having a surgeon in the county significantly decreased the likelihood of APBI utilization. Patients were over five times more likely to receive APBI brachytherapy when there was no access to an external beam Linac facility within the county of diagnosis, indicating a significant impact on APBI utilization. Access to HDR brachytherapy facilities within the county of diagnosis did not significantly impact the utility of external beam radiation therapy, but did significantly decreased the likelihood of APBI utilization. Currently, there is a lack of APBI utilization data for the state of Mississippi, and this modality has not been analyzed with respect to race, location, insurance status, and access to radiation oncologists, surgeons, and treatment facilities in our state.
Download or read book Radiation Therapy Techniques and Treatment Planning for Breast Cancer written by Jennifer R. Bellon and published by Springer. This book was released on 2016-09-15 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the day-to-day treatment planning issues that radiation oncologists are likely to encounter during the treatment of breast cancer patients and provides numerous practical “tips” that will assist in navigation of the treatment planning process, from delineation of the tumor boundaries to discrimination of adjacent normal tissues and critical structures at risk of radiation injury. Differences in target delineation and treatment planning according to technique are emphasized, with coverage of conventional radiation therapy and advanced techniques including cardiac-sparing approaches, e.g., using active breathing control, intensity-modulated radiation therapy, proton beam therapy, and electron beam therapy post mastectomy. Individual chapters also focus on radiation setup and verification techniques and radiation treatment planning systems. The book, which is part of the Springer series Practical Guides in Radiation Oncology, is designed for hands-on use by radiation oncology residents/fellows in training and practicing radiation oncologists.
