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EBookClubs

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Book Targeted Drug Strategies for Cancer and Inflammation

Download or read book Targeted Drug Strategies for Cancer and Inflammation written by Ann L. Jackman and published by Springer Science & Business Media. This book was released on 2011-05-05 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.

Book Biochemistry and Oral Biology

Download or read book Biochemistry and Oral Biology written by A. S. Cole and published by Butterworth-Heinemann. This book was released on 2014-06-28 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry and Oral Biology presents a unique exposition of biochemistry suitable for dental students. It discusses the structural basis of metabolism and the general principles of nutrition. It addresses the soft tissues, hard tissues, and the biology of the mouth. Some of the topics covered in the book are the free radical production; scope of biochemistry; characteristics of atoms; structure and properties of water; molecular building materials; ionization of proteins; affinity chromatography of proteins; structural organization of globular proteins; classification of enzymes; and biochemically important sugar derivatives. The naturally occurring fatty acids are fully covered. The nucleic acid components are discussed in detail. The text describes in depth the energy equivalents of different nutrients. The physiological effects of dietary fiber vitamin D deficiency are completely presented. A chapter is devoted to the alternative methods of fluoride administration and description of vitamins. The book can provide useful information to dental students, and researchers.

Book Bio  and Bioinspired Nanomaterials

Download or read book Bio and Bioinspired Nanomaterials written by Daniel Ruiz-Molina and published by John Wiley & Sons. This book was released on 2014-12-03 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of nanomaterials that are inspired by or targeted at biology, including some of the latest breakthrough research. Throughout, valuable contributions from top-level scientists illustrate how bionanomaterials could lead to novel devices or structures with unique properties. The first and second part cover the most relevant synthetic and bioinspired nanomaterials, including surfaces with extreme wettability properties, functional materials with improved adhesion or structural and functional systems based on the complex and hierarchical organization of natural composites. These lessons from nature are explored in the last section where bioinspired materials are proposed for biomedical applications, showing their potential for future applications in drug delivery, theragnosis, and regenerative medicine. A navigational guide aimed at advanced and specialist readers, while equally relevant for readers in research, academia or private companies focused on high added-value contributions. Young researchers will also find this an indispensable guide in choosing or continuing to work in this stimulating area, which involves a wide range of disciplines, including chemistry, physics, materials science and engineering, biology, and medicine.

Book Medical Laboratory Science Review

Download or read book Medical Laboratory Science Review written by Robert R Harr and published by F.A. Davis. This book was released on 2012-10-11 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use this comprehensive resource to gain the theoretical and practical knowledge you need to be prepared for classroom tests and certification and licensure examinations.

Book Inflammatory Bowel Disease

Download or read book Inflammatory Bowel Disease written by Ramona Rajapakse and published by Springer Nature. This book was released on 2021-09-23 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uses new thinking on precision medicine and the interplay of genetic factors, the microbiome, and external triggers to build on the core concepts of inflammatory bowel disease. It outlines the latest findings in targeting therapies to the individual patient with Crohn’s and colitis, management of chronic infections in the setting of immunomodulators and biologics, non-surgical therapy of dysplasia in colitis patients, and redefining and structuring the problematic pouch. In addition, this book features useful chapters dedicated to the economic aspects of IBD in an increasingly constrained healthcare system, as well as the patient experience and the role of subspecialist telemedicine care. Written by specialists and thought leaders in the field, Inflammatory Bowel Disease: Pathogenesis, Diagnosis and Management provides a concise but highly relevant account of the latest thinking and concepts in IBD.

Book Nutritional Biochemistry of the Vitamins

Download or read book Nutritional Biochemistry of the Vitamins written by David A. Bender and published by Cambridge University Press. This book was released on 2003-09-18 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and comprehensive review of our current knowledge of the vitamins, their metabolic functions and the scientific basis for setting recommended intakes for the prevention of deficiency and promotion of optimum health. This publication will be a valuable reference for students and specialists alike in the field of nutritional biochemistry.

Book Nutritional Management of Renal Disease

Download or read book Nutritional Management of Renal Disease written by Joel D. Kopple and published by Academic Press. This book was released on 2012-12-31 with total page 833 pages. Available in PDF, EPUB and Kindle. Book excerpt: This translational text offers in-depth reviews of the metabolic and nutritional disorders that are prevalent in patients with renal disease. Chapter topics address the growing epidemic of obesity and metabolic syndrome. Each chapter integrates basic and clinical approaches, from cell biology and genetics to diagnosis, patient management and treatment. Chapters in sections 4-7 include new illustrative case reports, and all chapters emphasize key concepts with chapter-ending summaries. New features also include the latest National Kidney Foundation Clinical Practice Guidelines on Nutrition in Chronic Renal Failure, the most recent scientific discoveries and the latest techniques for assessing nutritional status in renal disease, and literature reviews on patients who receive continuous veno-venous hemofiltration with or without dialysis. Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to discuss the underlying research and translation of best practices for the nutritional management and prevention of renal disease Saves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles Correct diagnosis (and therefore correct treatment) of renal, metabolic, and nutritional disorders depends on a strong understanding of the molecular basis for the disease – both nephrologists and nutritionists will benefit Nephrologists and nutritionists will gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient Case Reports will offer an added resource for fellows, nutritionists, and dieticians who need a refresher course

Book Medical Biochemistry

    Book Details:
  • Author : Antonio Blanco
  • Publisher : Academic Press
  • Release : 2022-03-23
  • ISBN : 0323916007
  • Pages : 910 pages

Download or read book Medical Biochemistry written by Antonio Blanco and published by Academic Press. This book was released on 2022-03-23 with total page 910 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance. Integrates basic biochemistry principles with molecular biology and molecular physiology Illustrates basic biochemical concepts through medical and physiological examples Utilizes a systems approach to understanding biological phenomena Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries

Book A Concise Review of Clinical Laboratory Science

Download or read book A Concise Review of Clinical Laboratory Science written by Joel Hubbard and published by Lippincott Williams & Wilkins. This book was released on 2011-12-21 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition offers a concise review of all areas of clinical lab science, including the standard areas, such as hematology, chemistry, hemostasis, immunohematology, clinical microbiology, parasitology, urinalysis and more, as well as lab management, lab government regulations, and quality assurance. A companion website offers 35 case studies, an image bank of color images, and a quiz bank with 500 questions in certification format.

Book Laboratory Assessment of Vitamin Status

Download or read book Laboratory Assessment of Vitamin Status written by Dominic J. Harrington and published by Academic Press. This book was released on 2018-11-28 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of ‘Best Practice’ approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status Informs laboratories looking for third party providers of specialist investigations Provides an essential overview of reference ranges for each vitamin

Book Biochemistry

    Book Details:
  • Author : Thomas Briggs
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 1468402943
  • Pages : 221 pages

Download or read book Biochemistry written by Thomas Briggs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended to be a review. We assume the reader has - ready had a course in biochemistry. The book covers only the high lights and omits much detailed knowledge that is usually found in textbooks, to which the reader should turn for further reference. We hope those who are studying for medical national board examinations will find it particularly useful. To this end we have included, with most chapters, some multiple-choice questions whose answers can be found in the text. Each chapter has been contributed by a colleague who is an expert in the field and/or an experienced teacher of the subject. The words are the authors' own, though we have done some editing in order to achieve a reasonably consistent format. Because of the multiple au thorship, there is inevitably some unevenness in the depth of treat ment of the various topics, but we accept responsibility for decisions on what to include and what to leave out. John w. campbell, Ph.D., a graduate of this institution, executed the drawings. We did some fig ures ourselves, typed most of the text, and printed all of it on our PC's. Future editions, should this one meet with success, will be revised periodically. We welcome comments and constructive suggestions.

Book Food  Facts and Principles

Download or read book Food Facts and Principles written by N. Shakuntala Manay and published by New Age International. This book was released on 2008 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Enrichment for Nonhuman Primates

Download or read book Enrichment for Nonhuman Primates written by and published by . This book was released on 2005 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Crash Course Metabolism and Nutrition

Download or read book Crash Course Metabolism and Nutrition written by Olivia Vanbergen and published by Elsevier Health Sciences. This book was released on 2018-11-29 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crash Course – your effective every-day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have the essential information you need in one place to excel on your course and achieve exam success. A winning formula now for over 20 years, each series volume has been fine-tuned and fully updated – with an improved full-colour layout tailored to make your life easier. Especially written by senior students or junior doctors – those who understand what is essential for exam success – with all information thoroughly checked and quality assured by expert Faculty Advisers, the result are books which exactly meet your needs and you know you can trust. Each chapter guides you succinctly through the full range of curriculum topics, integrating clinical considerations with the relevant basic science and avoiding unnecessary or confusing detail. A range of text boxes help you get to the hints, tips and key points you need fast! A fully revised self-assessment section matching the latest exam formats is included to check your understanding and aid exam preparation. The accompanying enhanced, downloadable eBook completes this invaluable learning package. Series volumes have been honed to meet the requirements of today’s medical students, although the range of other health students and professionals who need rapid access to the essentials of metabolism and nutrition will also love the unique approach of Crash Course. Whether you need to get out of a fix or aim for a distinction Crash Course is for you! Provides the exam syllabus in one place - saves valuable revision time Written by senior students and recent graduates - those closest to what is essential for exam success Quality assured by leading Faculty Advisors - ensures complete accuracy of information Features the ever popular 'Hints and Tips' boxes and other useful aide-mémoires - distilled wisdom from those in the know Updated self-assessment section matching the latest exam formats – confirm your understanding and improve exam technique fast

Book Handbook of Biology

    Book Details:
  • Author : Arihant Experts
  • Publisher : Arihant Publications India limited
  • Release : 2019-07-22
  • ISBN : 9313196514
  • Pages : 644 pages

Download or read book Handbook of Biology written by Arihant Experts and published by Arihant Publications India limited. This book was released on 2019-07-22 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of higher level has too many concept and remembering all them on tips all the time is not an easy task. Handbook of Biology is an important, useful and compact reference book suitable for everyday study, problem solving or exam revision for class XI – XII, Medical entrances and other medical Competitive. This book is a multi-purpose quick revision resource that contains almost all key notes, Diagrams, Flow Charts, Terms and Definitions that all students & professionals in biology will want to have this essential reference book within easy reach. Its unique format displays flow charts & diagrams clearly and places them in the context and crisply identifies describes all the variables involved, summary about every equation and formula that one might want while learning biology. A stimulating and crisp extract of fundamental biology is to be enjoyed by the beginners and experts equally. The book is best- selling from its first edition and one of the most useful books of its type. Table of contents The Living World, Biology Classification, Plant Kingdom, Animal Kingdom, Morphology of Flowering Plants, Anatomy of Flowering Plants, Structural Organisation in Animals, Cell: The Unit of Life, Biomolecules, Cell Cycle and Cell Division, Transport in Plants, Photosynthesis in Higher Plants, Respiration in Plants, Plant Growth and Development, Digestion and Absorption, Breathing and Exchange of Gases, Excretory Products and Their Elimination, Locomotion and Movement, Neural Control and Coordination, Chemical Coordination and Integration, Reproduction in Organisms, Sexual Reproduction in Flowering Plants, Human Reproduction, Reproductive Health, Principles of Inheritance and Variation, Molecular Basis of Inheritance, Evolution, Human Health and Diseases, Strategies for Enhancement in Food Production, Microbes in Human Welfare, Biotechnology: Principles and Processes, Biotechnology and Its Applications, Organisms and Population, Ecosystem, Biodiversity and Conversation, Environmental Issues, Appendix.

Book Cosmeceuticals and Active Cosmetics

Download or read book Cosmeceuticals and Active Cosmetics written by Raja K Sivamani and published by CRC Press. This book was released on 2015-09-18 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmeceuticals and Active Cosmetics discusses the science of nearly two dozen cosmeceuticals used today. This third edition provides ample evidence on specific cosmeceutical substances, their classes of use, skin conditions for which they are used, and points of interest arising from other considerations, such as toxicology and manufacturing. The book discusses both cosmetic and therapeutic uses of cosmeceuticals for various conditions including rosacea, dry skin, alopecia, eczema, seborrheic dermatitis, purpura, and vitiligo. Active ingredients in the following products are discussed: caffeine, curcumin, green tea, Rhodiola rosea, milk thistle, and more. Also covered are topical peptides and proteins, amino acids and derivatives, antioxidants, vitamins E and C, niacinamide, botanical extracts, and biomarine actives. Providing ample scientific references, this book is an excellent guide to understanding the science behind the use of cosmeceuticals to treat a variety of dermatological conditions.