Download or read book A Summary of Progress Toward the Design and Synthesis of New Chiral Stationary Phases for High Performance Liquid Chromatography II Target Compounds Based on Natural Amino Acids written by David Billing Rusterholz and published by . This book was released on 1986 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Summary of Progress Toward the Synthesis of New Chiral Stationary Phases for High Performance Liquid Chromatography written by David B. Rusterholz and published by . This book was released on 1985 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of New Stationary Phases and Their Applications in High Performance Liquid Chromatography written by Haixiao Qiu and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: High performance liquid chromatography (HPLC) has proven to be the most widely applicable and versatile technique in separation science. Hydrophilic interaction liquid chromatography (HILIC) has attracted considerable interest and has become a viable option for the separation of polar compounds. Chirality is another major concern in the modern pharmaceutical industry for two reasons: 1). the majority of bio-organic molecules are chiral; 2). enantiomers of a racemic drug may often exhibit different biological activities, pharmacokinetics, and toxicities. The field of enantiomeric separations has reached a clear level of maturity after approximately 30 years of development. However, with the continued emphasis on stereochemistry in drug design and development, chiral separations are in ever increasing demand. The development of new, more effective methods is still challenging and demanding experimentally. This dissertation discusses new research in three areas: 1). Development and application of new HILIC stationary phases for the separation of polar organic compounds. Two types of new HILIC stationary phases have been successfully synthesized and evaluted. One is based on native cyclofructan 6 and another one is a zwitterionic stationary phase based on 3-P,P-diphenylphosphonium-propylsulfonate. Their performance and retention mechanisms in the HILIC mode will be discussed in this dissertation.2). Development and evaluation of new chiral stationary phases. R-naphthylethyl-carbamate cyclofructan 6 (RN-CF6) and dimethylphenyl-carbamate cyclofructan 7 (DMP-CF7) were successfully synthesized and provide enantioselectivity toward a broad range of chiral compounds. They were found to be the best aromatic-functionalized cyclofructan chiral stationary phases and provide enantiomeric separations complementary to the isopropyl-carbamate cyclofructan 6 based chiral stationary phase. This dissertation also describes method development of enantiomeric impurities quantification in chiral reagents. Three macrocyclic chiral stationary phases, including cyclodextrins, macrocyclic glycopeptides and cyclofructans, have been used to determine enantiomeric impurities in new chiral catalysts, auxiliaries and synthons used in asymmetric syntheses. It was found that many of the newer chiral reagents are highly enantiopure, probably due to continual improvements in asymmetric syntheses and purification in the manufacturing process. 3). Development and application of new stationary phases based on a resin substrate instead of silica gel. This dissertation describes methods for binding cyclofructan 6 to resin via "click" chemistry. It was found that these resin based stationary phases appear to have potential in HILIC separations (native cyclofructan 6 bonded to resin as stationary phases) and enantiomeric separations (isopropyl-carbamated cyclofructan 6 bonded to resin).
Download or read book Chiroptical Spectroscopy written by Prasad L. Polavarapu and published by CRC Press. This book was released on 2016-10-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details chiroptical spectroscopic methods: electronic circular dichroism (ECD), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational Raman optical activity (VROA). For each technique, the text presents experimental methods for measurements and theoretical methods for analyzing the experimental data. It also includes a set of experiments that can be adopted for undergraduate teaching laboratories. Each chapter is written in an easy-to-follow format for novice readers, with necessary theoretical formalism in appendices for advanced readers.
Download or read book Design Functionalization Synthesis and Evaluation of New Chiral Stationary Phases for U HPLC and Their Implementation in Drug Analysis enantio purification and Structural Elucidation written by Christian Geibel and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiral liquid chromatography is a field of utmost importance for a wide range of academic and industrial applications. Drug development, environmental analysis, laboratory-based diagnostics, or structure elucidation among others, strongly rely on chiral liquid chromatography nowadays. For this reason, this cumulative thesis describes the development and applications of chiral stationary phases for enantioselective (ultra-)high performance liquid chromatography ((U)HPLC). In the first part of the thesis, new chiral stationary phases (CSPs) based on anion-exchange and zwitterionic ion exchange chiral selectors were developed. The following goals were achieved during the work on this thesis: Various silica particles were evaluated for their kinetic performance optimization for enantioselective UHPLC and a deep insight into a variety of interactions between analyte and stationary phase was gained [Publication I]. The bonding chemistry and its generation by thermic or UV-driven radical starter was evaluated and systematically optimized by introducing a solvent-free photo-click immobilization strategy resulting in low-bleeding, “platform-type” stationary phases [Publication II]. Furthermore, the functionalization of bare silica, which can be seen as the starting point of the production of a CSP-based HPLC column, was varied and optimized for fast separations by the reduction of mass transfer resistance using silatranes and thus forming thin, homogeneous monolayer of thiol functionalization in a multiple-step [Publication III] and in a single-step approach [Publication IV]. The second part of the thesis focuses on the application of enantiomer separation. This includes the elaboration of the following aspects: Since chiral methods are becoming increasingly important in the fields of metabolomics and lipidomics, a guide for the chiral analysis of branched short-chain fatty acids based on polysaccharide columns was developed [Publication V]. Furthermore, the chirality of previously unknown natural compounds was elucidated [Publication VI]. A protocol for the enantiopurification of a radiotracer was established [Publication VII]. Knowledge about chiral HPLC was used for both analytical and preparative separation in the development of potential new drugs [Publications VIII and IX]. In summary, extensive research on the design, functionalization, synthesis, and evaluation of chiral stationary phases and their scope of applications has been performed.
Download or read book Chiral Separations written by Gerald Gübitz and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.
Download or read book Enantiomer Separation written by Fumio Toda and published by Springer Science & Business Media. This book was released on 2007-11-04 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
Download or read book Ionic Liquids in Separation Technology written by Antonia Perez De Los Rios and published by Elsevier. This book was released on 2014-08-08 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ionic Liquids in Separation Technology reports on the most important fundamental and technological advances in separation processes using ionic liquids. It brings together the latest developments in this fascinating field, supplements them with numerous practical tips, and thus provides those working in both research and industry with an indispensable source of information. The book covers fundamental topics of physical, thermal, and optical properties of ionic liquids, including green aspects. It then moves on to contexts and applications, including separation of proteins, reduction of environmental pollutants, separation of metal ions and organic compounds, use in electrochromic devices, and much more. For the specialist audience the book serves as a recompilation of the most important knowledge in this field, whereas for starting researchers in ionic liquid separation technology the book is a great introduction to the field. First book in the marketplace dedicated to ionic liquids in separation technology Contributions from scientists in academia and researchers in industry ensure the coverage of both scientific fundamentals and industrial applications Covers a broad collection of applications in separation technology which makes the book a single source of information Includes many practical tips for researchers in industry and scientists who apply ionic liquids in their work
Download or read book Applications of Ion Exchange Materials in Biomedical Industries written by Inamuddin and published by Springer. This book was released on 2019-01-30 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the applications of ion-exchange materials in the biomedical industries. It includes topics related to the application of ion exchange chromatography in determination, extraction and separation of various compounds such as amino acids, morphine, antibiotics, nucleotides, penicillin and many more. This title is a highly valuable source of knowledge on ion-exchange materials and their applications suitable for postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology. Additionally, this book will provide an in-depth knowledge of ion-exchange column and operations suitable for engineers and industrialists.
Download or read book Chiral Separations written by Bezhan Chankvetadze and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chiral Separation Techniques written by G. Subramanian and published by Wiley-VCH. This book was released on 2001 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor. The scope has been extended to further chiral separation techniques like electrophoresis, membrane separations, or biological assays. More emphasis is put on preparative separation techniques. From reviews of the previous edition: 'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field' European Journal of Drug Metabolism 'The dense mass of information contained in this book will make it a valuable resource ...' Chemical Engineering Research '... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field' The Analyst
Download or read book Isocyanide based Multicomponent Reactions written by Jonathan G. Rudick and published by Frontiers Media SA. This book was released on 2020-02-20 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Selection of the HPLC Method in Chemical Analysis written by Serban C. Moldoveanu and published by Elsevier. This book was released on 2016-11-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selection of the HPLC Method in Chemical Analysis serves as a practical guide to users of high-performance liquid chromatography and provides criteria for method selection, development, and validation. High-performance liquid chromatography (HPLC) is the most common analytical technique currently practiced in chemistry. However, the process of finding the appropriate information for a particular analytical project requires significant effort and pre-existent knowledge in the field. Further, sorting through the wealth of published data and literature takes both time and effort away from the critical aspects of HPLC method selection. For the first time, a systematic approach for sorting through the available information and reviewing critically the up-to-date progress in HPLC for selecting a specific analysis is available in a single book. Selection of the HPLC Method in Chemical Analysis is an inclusive go-to reference for HPLC method selection, development, and validation. Addresses the various aspects of practice and instrumentation needed to obtain reliable HPLC analysis results Leads researchers to the best choice of an HPLC method from the overabundance of information existent in the field Provides criteria for HPLC method selection, development, and validation Authored by world-renowned HPLC experts who have more than 60 years of combined experience in the field
Download or read book Chiral Recognition in Separation Methods written by Alain Berthod and published by Springer Science & Business Media. This book was released on 2010-06-16 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099.
Download or read book Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques written by Paul H. Gamache and published by John Wiley & Sons. This book was released on 2017-05-30 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors’ professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection Includes contributions from experts from various fields of applications who explore CAD’s advantages over traditional HPLC techniques, as well its limitations Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.
Download or read book Quantitative Structure written by Roman Kaliszan and published by Wiley-Interscience. This book was released on 1987-10-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of computers in numerical characterization of molecular structures has given chemists fundamentally new information on chemical structures, leading to major developments in physical, analytical, and medicinal chemistry. This book, written by a pioneer in the field, extends and updates research on quantitative structure retention relationships (QSRR) by consolidating and critically reviewing the extensive literature on the subject while providing basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Coverage includes detailed discussions of the general theories and mechanisms of chromatographic separations, prediction of retention coefficients, statistical techniques and formal requirements of QSRR studies, specific applications of chromatographic data, and much more. Also provides several carefully selected figures and tables plus extensive bibliographies.
Download or read book Handbook of Chiral Chemicals written by David Ager and published by CRC Press. This book was released on 2005-10-21 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook fir
