Download or read book A Study of the Synthesis and Properties of Bicyclo 2 2 2 2 5 7 octatriene and Related Compounds written by Jack Hine and published by . This book was released on 1955 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Chemistry of Bicyclo 2 2 2 2 5 7 octatriene barrelene written by Gary L. Grunewald and published by . This book was released on 1966 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis of Bicyclo 2 2 1 2 5 heptadiene and Bicyclo 2 2 2 2 5 octadiene and Related Compounds written by John Angus Brown and published by . This book was released on 1954 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1970 with total page 1396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Dissertation Index written by and published by . This book was released on 1973 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies in the Synthesis of Heptalene and Bicyclo 2 2 2 Octatriene written by Melvin Joseph Goldstein and published by . This book was released on 1958 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Properties of Oligomers of Bicyclo 2 2 2 octane written by Michael Benedict Meinhardt and published by . This book was released on 1992 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Annual Report written by Georgia Institute of Technology. Engineering Experiment Station and published by . This book was released on 1952 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis and Properties of 1 4 dichlorobicyclo 2 2 1 Heptane and Related Compounds written by John George Zajacek and published by . This book was released on 1962 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Engineering College Research Review written by and published by . This book was released on 1953 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Dissertation Index 1861 1972 Chemistry written by Xerox University Microfilms and published by . This book was released on 1973 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Review of Current Research and Directory of Member Institutions written by and published by . This book was released on 1955 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis and Properties of 1 substituted Bicyclo 2 2 2 Octanes written by Adnan Abdul-Rida Sayigh and published by . This book was released on 1952 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Engineering Division Record written by American Association of Land-Grant Colleges and State Universities. Engineering Division and published by . This book was released on 1952 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Title Announcement Bulletin written by and published by . This book was released on 1956 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of BICYCLO 2 2 1 HEPTA 2 5 DIEN 7 ONE written by David Martin Birney and published by . This book was released on 1987 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of Optically Active Bicyclo 2 2 2 octa 2 5 dienes written by Breeyawn Nycole Lybbert and published by . This book was released on 2012 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optically active 2,5-disubstituted bicyclo[2.2.2]octa-2,5-dienes (bod) have found use within synthetic organic chemistry as chiral ligands for rhodium asymmetric catalysis reactions. These chiral ligands often provide greater enantioselectivity than their phosphorus-based chiral ligand cousins when employed in the formation of carbon-carbon bonds under rhodium catalysis. The drawback to using these types of 2,5-disubstituted bicyclo[2.2.2]octa-2,5-diene ligands is that they are very expensive to buy if they are commercially available or they must be synthesized if they are not commercially available. Present literature syntheses of these bod ligands rely on the physical separation of diastereomeric derivatives via recrystallization with low recovery or the separation of enantiomers via chiral HPLC, in which only small amounts of material may be separated. We have devised a synthesis of phenyl, benzyl, and methyl substituted bod ligands based on a bridged Robinson annulation reaction of 1,5-diketones and 1,5-ketoaldehydes, which gives the bicyclic core necessary for the bod ligand. Furthermore, our synthesis is designed to create optically active 1,5-diketones and 1,5-ketoaldehydes which transfer their chirality to the bicyclic core of the molecule. Our synthesis does not rely upon separation of racemic material at any step; instead we provide a method to synthesize any optically active bod ligand that is desired. We successfully synthesized the chiral 3-allylcyclohexanone (>95% ee), a key intermediate in our synthesis, using a chiral conjugate allylation of & alpha;, & beta;-unsaturated & beta;-ketoesters using Cu(OTf)2 and the chiral tBu-box ligand. We then successfully completed the racemic synthesis of 2,5-diphenylbicyclo[2.2.2]octa-2,5-diene (Ph-bod) over 11 steps in 4.4% yield. The chiral Ph-bod ligand is projected to take 14 steps and proceed in a 1.1% overall yield. We also synthesized the racemic 2,5-bis(phenylmethyl)bicyclo[2.2.2]octa-2,5-diene (Bn-bod) over 7 steps in 1.4% overall yield. The synthesis of 2,5-dimethylbicyclo[2.2.2]ocat-2,5-diene (Me-bod) was attempted but was unsuccessful at this time. Ultimately we proved the utility of the bridged Robinson annulation reaction for the synthesis of various bicyclo[2.2.2]octa-2,5-dienes.
