Download or read book A Science of Impurity written by Christopher Hamlin and published by Univ of California Press. This book was released on 1990-01-01 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Science of Impurity written by C Hamlin and published by CRC Press. This book was released on 1990-01-01 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Science of Impurity is the first detailed history of the mobilization of chemistry (and later bacteriology) to meet the public demand for good water. It also offers a perspective on understanding how modern physical sciences are tapped to ensure public good. A Science of Impurity explores the social framework in which chemists came to work on problems of water quality, the strategies they used to study the environment, their conclusions and their role in dealing with a fearful public. For historians of science, researchers and planners in the water industry.
Download or read book Measuring Elemental Impurities in Pharmaceuticals written by Robert Thomas and published by CRC Press. This book was released on 2018-01-29 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters , , and , together with Q3D, Step 4 guidelines for elemental impurities, drafted by the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use), a consortium of global pharmaceutical associations, including the European Pharmacopeia (Ph.Eur.), the Japanese Pharmacopeia (JP) and the USP. This book provides a complete guide to the analytical methodology, instrumental techniques and sample preparation procedures used for measuring elemental impurities in pharmaceutical and nutraceutical materials. It offers readers the tools to better understand plasma spectrochemistry to optimize detection capability for the full suite of elemental PDE (Permitted Daily Exposure) levels in the various drug delivery categories. Other relevant information covered in the book includes: The complete guide to measuring elemental impurities in pharmaceutical and nutraceutical materials. Covers heavy metals testing in the pharmaceutical industry from an historical perspective. Gives an overview of current USP Chapters and and ICH Q3D Step 4 Guidelines. Explains the purpose of validation protocols used in Chapter , including how J-values are calculated Describes fundamental principles and practical capabilities of ICP-MS and ICP-OES. Offers guidelines about the optimum strategy for risk assessment Provides tips on how best to prepare and present your data for regulatory inspection. An indispensable resource, the fundamental principles and practical benefits of ICP-OES and ICP-MS are covered in a reader-friendly format that a novice, who is carrying out elemental impurities testing in the pharmaceutical and nutraceutical communities, will find easy to understand.
Download or read book Chemistry written by Bernadette Bensaude-Vincent and published by World Scientific. This book was released on 2012 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces the central issues in the philosophy of chemistry. Mobilizing the theme of impurity, this book explores the tradition of chemistry's negative image. It argues for the positive philosophical value of chemistry, reflecting its characteristic practical engagement with the material world.
Download or read book Pharmaceutical Industry Practices on Genotoxic Impurities written by Heewon Lee and published by CRC Press. This book was released on 2014-08-29 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great deal of confusion and uncertainty over genotoxic impurity (GTI) identification, assessment, and control exists in the pharmaceutical industry today. Pharmaceutical Industry Practices on Genotoxic Impurities strives to facilitate scientific and systematic consensus on GTI management by presenting rationales, strategies, methods, interpretati
Download or read book THE IMPURITY OF SCIENCE written by and published by . This book was released on 1962 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science is impure in two ways. There is not a 'pure' science. By this I mean that physics impinges on astronomy, on the one hand, and chemistry on biology on the other. And not only does each support its neighbors but derives sustenance from them. The same can be said of chemistry. Biology is, perhaps, the example par excellence today of an 'impure' science. Beyond this, there is no 'pure' science itself divorced from human values. The importance of science to the humanities and the humanities to science in their complementary contribution to the variety of human life grows daily. The need for men familiar with both is imperative. We are faced today with a social decision resulting from our progress in molecular genetics at least equal to, and probably greater than, that required of us twenty years ago with the maturity of nuclear power.
Download or read book Impurity of Blood written by Joshua Goode and published by LSU Press. This book was released on 2009-12 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although Francisco Franco courted the Nazis as allies during the Spanish Civil War in the late 1930s, the Spanish dictator's racial ideals had little to do with the kind of pure lineage that obsessed the Nazis. Indeed, Franco's idea of race -- that of a National Catholic state as the happy meeting grounds of many different peoples willingly blended together -- differed from most European conceptions of race in this period and had its roots in earlier views of Spanish racial identity from the late nineteenth and early twentieth centuries. In Impurity of Blood, Joshua Goode traces the development of racial theories in Spain from 1870 to 1930 in the burgeoning human science of anthropology and in political and social debates, exploring the counterintuitive Spanish proposition that racial mixture rather than racial purity was the bulwark of national strength. Goode begins with a history of ethnic thought in Spain in the medieval and early modern era, and then details the formation of racial thought in Spain's nascent human sciences. He goes on to explore the political, social, and cultural manifestations of racial thought at the dawn of the Franco regime and, finally, discusses its ramifications in Francoist Spain and post--World War II Europe. In the process, he brings together normally segregated historiographies of race in Europe. Goode analyzes the findings of Spanish racial theorists working to forge a Spanish racial identity in the late nineteenth and early twentieth centuries, when race and racial sciences were most in vogue across Europe. Spaniards devised their own racial identities using scientifically substantiated racial ideas and confronted head-on the apparent limitations of Spain's history by considering them as the defining characteristics of la raza española. The task of the Spanish social sciences was to trace the history of racial fusion: to study both the separate elements of the Spanish composition and the factors that had nurtured them. Ultimately, by exploring the development of Spanish racial thought between 1870 and 1930, Goode demonstrates that national identity based on mixture -- the inclusion rather than the exclusion of different peoples -- did not preclude the establishment of finely wrought and politically charged racial hierarchies. Providing a new comprehensive view of racial thought in Spain and its connections to the larger twentieth-century formation of racial thought in the West, Impurity of Blood will enlighten and inform scholars of Spanish and European history, racial theory, historical anthropology, and the history of science.
Download or read book Handbook of Isolation and Characterization of Impurities in Pharmaceuticals written by Satinder Ahuja and published by Elsevier. This book was released on 2003-06-26 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product.This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements.It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization. - Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.
Download or read book Impurities in Semiconductors written by Victor I. Fistul and published by CRC Press. This book was released on 2004-01-27 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there is a good deal of research concerning semiconductor impurities available, most publications on the subject are very specialized and very theoretical. Until now, the field lacked a text that described the current experimental data, applications, and theory concerning impurities in semiconductor physics. Impurities in Semicondu
Download or read book Handbook of Isolation and Characterization of Impurities in Pharmaceuticals written by Satinder Ahuja and published by Academic Press. This book was released on 2003-07-18 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product. This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements. It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization. - Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.
Download or read book The Impurity of Science written by Melvin Calvin and published by . This book was released on 1962 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Exquisite Mixture written by Wolfram Schmidgen and published by University of Pennsylvania Press. This book was released on 2012-11-29 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: The culture of late seventeenth- and early eighteenth-century Britain is rarely credited with tolerance of diversity; this period saw a rising pride in national identity, the expansion of colonialism, and glorification of the Anglo-Saxon roots of the country. Yet at the same time, Wolfram Schmidgen observes, the concept of mixture became a critical element of Britons' belief in their own superiority. While the scientific, political, and religious establishment of the early 1600s could not imagine that anything truly formed, virtuous, or durable could be produced by mixing unlike kinds or merging absolute forms, intellectuals at the end of the century asserted that mixture could produce superior languages, new species, flawless ideas, and resilient civil societies. Exquisite Mixture examines the writing of Robert Boyle, John Locke, Daniel Defoe, and others who challenged the primacy of the one over the many, the whole over the parts, and form over matter. Schmidgen traces the emergence of the valuation of mixture to the political and scientific revolutions of the seventeenth century. The recurrent threat of absolutism in this period helped foster alliances within a broad range of writers and fields of inquiry, from geography, embryology, and chemistry to political science and philosophy. By retrieving early modern arguments for the civilizing effects of mixture, Schmidgen invites us to rethink the stories we tell about the development of modern society. Not merely the fruit of postmodernism, the theorization and valuation of hybridity have their roots in centuries past.
Download or read book Metal Impurities in Silicon Device Fabrication written by Klaus Graff and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: A discussion of the different mechanisms responsible for contamination together with a survey of their impact on device performance. The author examines the specific properties of main and rare impurities in silicon, as well as the detection methods and requirements in modern technology. Finally, impurity gettering is studied along with modern techniques to determine gettering efficiency. Throughout all of these subjects, the book presents only reliable and up-to-date data so as to provide a thorough review of recent scientific investigations.
Download or read book Impurity written by Ray Clark and published by Eternal Press. This book was released on 1916-05-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: When Detective Inspector Stewart Gardener investigates the discovery of a body in a run-down Victorian property in the suburb of Rawston near Leeds, he knows he's in for a tough time: ashen faced police constables testify to that.Nothing could have prepared him for what lay ahead.The corpse is beyond recognition.Distraught residents, drug dealers, pornographers, and paedophiles add to his list of complications, especially when they're all hiding something.With little time to recuperate, a second body, bearing the same hallmark is found in the grounds of a small church in the center of Leeds.Gardener's already overburdened work schedule is stretched beyond endurance. Over the last six months, children have been going missing: the dead body of the third child having recently been found on waste ground - naked, has instigated a murder hunt.He now knows he needs to find a deranged serial killer, but are the cases linked?With a complex murder case to unravel, the last thing he needs is another problem ... but life is about to deal Stewart Gardener a whole new deck of cards when the next child to go missing is his own...
Download or read book Practical Process Research and Development written by Neal G. Anderson and published by Academic Press. This book was released on 2012-05-23 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
Download or read book Identification and Determination of Impurities in Drugs written by S. Görög and published by Elsevier. This book was released on 2000-05-19 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Impurity profiling is the common name of a group of analytical activities, the aim of which is the detection, identification/structure elucidation and quantitative determination of organic and inorganic impurities, as well as residual solvents in bulk drugs and pharmaceutical formulations. Since this is the best way to characterise the quality and stability of bulk drugs and pharmaceutical formulations, this is the core activity in modern drug analysis.Due to the very rapid development of the analytical methodologies available for this purpose and the similarly rapid increase of the demands as regards the purity of drugs it is an important task to give a summary of the problems and the various possibilities offered by modern analytical chemistry for their solution. That is the aim of this book.The book is methodology-oriented. In the first chapter some important aspects of the background of impurity-related analytical studies (toxicological, pharmacopoeial aspects, the characterisation of the sources of impurities and the role of impurity profiling in various fields of drug research, production and therapeutic use) are summarised. Chapter two deals with related organic impurities, the strategies for impurity profiling, the use of chromatographic and related separation methods, spectroscopic, and hyphenated techniques. The subject of the third chapter is the identification and determination of residual solvents. The determination of inorganic impurities is discussed in chapter four. The special problems of degradation products as impurities are dealt with in chapter five. A separate chapter has been compiled to deal with one of the most up-to-date problems in contemporary pharmaceutical analysis, the estimation of enantiomeric purity of chiral drugs. Chapter seven is devoted to various approaches to solve the problem of polymorphic modifications as impurities. Since in the broader sense of the word the microbiological purity of drugs and drug products also belongs to this circle, the most important information from this field is summarised in chapter eight. After the mainly methodology-oriented chapters, the final one concentrates on four groups of drugs (peptides, biotechnological products, antibiotics and steroids) in order to demonstrate the use of the methods described earlier.
Download or read book Potable Water and Methods of Detecting Impurities written by Moses Nelson Baker and published by . This book was released on 1906 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
