Download or read book A Novel Method for Predicting Product Properties in Fluidized Bed Spray Granulation Band 19 written by Paul Kieckhefen and published by Cuvillier Verlag. This book was released on 2022-01-03 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluidized bed spray granulation is a process that facilities particle size enlargement by injecting solids in the form of a suspension, solution or melt. The produced particles are often of high value due to their highly specific, functionalized nature. This work provides a method for utilizing particle-scale simulations method like the coupled Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) to predict the properties of particles produced in scaled-up apparatuses based on laboratory-scale experiments by correlating the conditions that particle experience to the properties they develop. Furthermore, a method for calibrating DEM models of weakly wetted particle systems by utilizing a novel, probabilistic liquid bridge state model is proposed.
Download or read book Predicting Product Properties of Fluidized Bed Spray Granulation Using CFD DEM Simulations written by Paul Kieckhefen and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Predicting the Performance of Different Fluidized and Spouted Beds for Spray Granulation Using CFD DEM Simulations written by Paul Kieckhefen and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluidized bed spray granulation is the preferred way of generating functional, high value granular products. By injecting a solution or suspension onto a fluidized particle bed, the particles grow layer by layer. The process conditions, specifically the drying potential, influence the state of the spray droplets when they impinge on the particles, for example the droplet viscosity and the relative velocity. Both quantities affect the spreading behavior of droplets on the surface, together with the crystallization occurring within the droplets themselves in the case of solutions, resulting in either porous or dense layers. As these phenomena are well accessible in CFD-DEM simulations, their combination can be a powerful tool in the design of granulators that produce tailor-made particles. A concept to realize this goal is presented: The surface structure of granulation products is measured for a variety of different process conditions in small-scale experiments. These experiments are replicated in silico using CFD-DEM, tracking the state of the droplets at impact, as well as the time for the evaporation of liquid layer on the particle surfaces. A mapping between these particle-scale quantities from the simulations and the resulting surface properties in experiments is derived, avoiding the direct dependency process conditions that may be very inhomogeneous in larger apparatuses. The concept is applied to evaluate the influence of granulator geometry (fluidized bed, spouted bed), nozzle configuration (top-spray nozzle, bottom-spray nozzle) and stabilizing internals (Wurster tube, draft plates) on the surface structure of granulation products.
Download or read book Handbook of Pharmaceutical Granulation Technology written by Dilip M. Parikh and published by CRC Press. This book was released on 2021-05-11 with total page 905 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design and Processing of Particulate Products written by Jim Litster and published by Cambridge University Press. This book was released on 2016-10-20 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique text providing comprehensive coverage of fundamental particle science, processing and technology. Including quantitative tools, real-world case studies and end-of-chapter problems, it is ideal for students in engineering and applied sciences, as well as for practitioners in a range of industries manufacturing particulate products.
Download or read book The Science and Engineering of Granulation Processes written by Jim Litster and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book had its origins in a meeting between two (relatively) young particle technology researchers on Rehobeth Beach in Delaware in 1992 near the holiday house of Reg Davies (then Director of the Particle Science and Technology Research Center in Dupont). As we played in the sand, we shared an excitement for developments in particle technology, especially particle characterization, that would lead operations such as granulation to be placed on a sound scientific and engineering footing. The immediate outcome from this interaction was the development of new industry short courses in granulation and related topics which we taught together both in Australia and North America. This book follows closely the structure and approaches developed in these courses, particularly the emphasis on particle design in granulation, where the impact of both formulation properties and process variables on product attributes needs to be understood and quantified. The book has been a long time in the making. We have been actively preparing the book for at least five years. Although the chapters have relatively good bibliographies, this book is not a review of the field. Rather it is an attempt by the authors to present a comprehensive engineering approach to granulator design, scale up and operation. It is exciting for us to see the explosion of research interest around the world in this area in the last five to seven years. Some of the most recent work will have to find its way into the second edition.
Download or read book Fluid Bed Technology in Materials Processing written by C. K. Gupta and published by CRC Press. This book was released on 1998-12-28 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluid Bed Technology in Materials Processing comprehensively covers the various aspects of fluidization engineering and presents an elaborate examination of the applications in a multitude of materials processing techniques. This singular resource discusses: All the basic aspects of fluidization essential to understand and learn about various techniques The range of industrial applications Several examples in extraction and process metallurgy Fluidization in nuclear engineering and nuclear fuel cycle with numerous examples Innovative techniques and several advanced concepts of fluidization engineering, including use and applications in materials processing as well as environmental and bio-engineering Pros and cons of various fluidization equipment and specialty of their applications, including several examples Design aspects and modeling Topics related to distributors effects and flow regimes A separate chapter outlines the importance of fluidization engineering in high temperature processing, including an analysis of the fundamental concepts and applications of high temperature fluidized bed furnaces for several advanced materials processing techniques. Presenting information usually not available in a single source, Fluid Bed Technology in Materials Processing serves Fluidization engineers Practicing engineers in process metallurgy, mineral engineering, and chemical metallurgy Researchers in the field of chemical, metallurgical, nuclear, biological, environmental engineering Energy engineering professionals High temperature scientists and engineers Students and professionals who adopt modeling of fluidization in their venture for design and scale up
Download or read book Fluidized Bed Reactors Processes and Operating Conditions written by John G. Yates and published by Springer. This book was released on 2016-09-27 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluidized-bed reactor is the centerpiece of industrial fluidization processes. This book focuses on the design and operation of fluidized beds in many different industrial processes, emphasizing the rationale for choosing fluidized beds for each particular process. The book starts with a brief history of fluidization from its inception in the 1940’s. The authors present both the fluid dynamics of gas-solid fluidized beds and the extensive experimental studies of operating systems and they set them in the context of operating processes that use fluid-bed reactors. Chemical engineering students and postdocs as well as practicing engineers will find great interest in this book.
Download or read book Predictive Modeling of Pharmaceutical Unit Operations written by Preetanshu Pandey and published by Woodhead Publishing. This book was released on 2016-09-26 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. Explains the commonly used modeling and simulation tools Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing Practical examples of the application of modeling tools through case studies Discussion of modeling techniques used for a risk-based approach to regulatory filings Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points
Download or read book 26th European Symposium on Computer Aided Process Engineering written by and published by Elsevier. This book was released on 2016-10-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: 26th European Symposium on Computer Aided Process Engineering contains the papers presented at the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event held at Portoroz Slovenia, from June 12th to June 15th, 2016. Themes discussed at the conference include Process-product Synthesis, Design and Integration, Modelling, Numerical analysis, Simulation and Optimization, Process Operations and Control and Education in CAPE/PSE. Presents findings and discussions from the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event
Download or read book Current Awareness in Particle Technology written by and published by . This book was released on 1993 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spray Drying Techniques for Food Ingredient Encapsulation written by C. Anandharamakrishnan and published by John Wiley & Sons. This book was released on 2015-07-23 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spray drying is a well-established method for transforming liquid materials into dry powder form. Widely used in the food and pharmaceutical industries, this technology produces high quality powders with low moisture content, resulting in a wide range of shelf stable food and other biologically significant products. Encapsulation technology for bioactive compounds has gained momentum in the last few decades and a series of valuable food compounds, namely flavours, carotenoids and microbial cells have been successfully encapsulated using spray drying. Spray Drying Technique for Food Ingredient Encapsulation provides an insight into the engineering aspects of the spray drying process in relation to the encapsulation of food ingredients, choice of wall materials, and an overview of the various food ingredients encapsulated using spray drying. The book also throws light upon the recent advancements in the field of encapsulation by spray drying, i.e., nanospray dryers for production of nanocapsules and computational fluid dynamics (CFD) modeling. Addressing the basics of the technology and its applications, the book will be a reference for scientists, engineers and product developers in the industry.
Download or read book Process Modelling and Simulation written by César de Prada and published by MDPI. This book was released on 2019-09-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since process models are nowadays ubiquitous in many applications, the challenges and alternatives related to their development, validation, and efficient use have become more apparent. In addition, the massive amounts of both offline and online data available today open the door for new applications and solutions. However, transforming data into useful models and information in the context of the process industry or of bio-systems requires specific approaches and considerations such as new modelling methodologies incorporating the complex, stochastic, hybrid and distributed nature of many processes in particular. The same can be said about the tools and software environments used to describe, code, and solve such models for their further exploitation. Going well beyond mere simulation tools, these advanced tools offer a software suite built around the models, facilitating tasks such as experiment design, parameter estimation, model initialization, validation, analysis, size reduction, discretization, optimization, distributed computation, co-simulation, etc. This Special Issue collects novel developments in these topics in order to address the challenges brought by the use of models in their different facets, and to reflect state of the art developments in methods, tools and industrial applications.
Download or read book Aulton s Pharmaceutics written by Michael E. Aulton and published by Elsevier Health Sciences. This book was released on 2013 with total page 909 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.
Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
