Download or read book A Genetic Analysis of Ommatidial Planar Polarity Determination During the Development of the Drosophila Compound Eye written by Chung-Hui Yang (Neurobiology professor) and published by . This book was released on 2002 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drosophila Eye Development written by Kevin Moses and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Download or read book A Genetic Analysis of Retinal Development in Drosophila Melanogaster written by David Landreth Van Vactor and published by . This book was released on 1991 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Genetics of Axial Patterning Growth and Disease in the Drosophila Eye written by Amit Singh and published by Springer Science & Business Media. This book was released on 2013-09-14 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on how does a multi-cellular organism develop from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question, and led to other questions, such as the role of various genetics and cell biological pathways in regulating the crucial process of pattern formation and growth during organogenesis. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more. There have been no titles in the past ten years covering this topic, thus an update is urgently needed.
Download or read book The Roles of Drosophila Genes TF11A S and F125 During Compound Eye Development written by and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Drosophila compound eye represents an experimental system in which developmental decisions can be observed at a single-cell resolution. During larval development undifferentiated cells are sequentially recruited to form the individual subunits of the eye via cell-cell interactions which require Ras pathway activity.In this thesis I present the characterisation of two genes which play a part in eye development which were identified as part of the analysis of an enhancer detector P- element insertion. These are the small subunit of the basal transcription factor IIA (dTFIIA-S) and F125.dTFIIA-S was cloned and is transiently expressed in photoreceptor cells during their determination. Mutations generated in this locus are homozygous cellular lethal. However, a putative hypomorphic allele disrupts ommatidial assembly and eye development. In addition, these mutations act as dominant second-site suppressers of the rough eye phenotype caused by ectopic activation of the Ras pathway in eye development. The interactions between TFIIA and transcription factors activated by Ras in vivo can thus be genetically dissected and appear to support previous in vitro studies.FI25 was isolated and sequenced and encodes a novel protein. It is expressed during embryonic and eye development. A P-element allele of FI25 was obtained and represents a hypomorphic mutation in the locus which is characterised by a failure of rhabdomere development. Additional alleles of FI25 were generated by remobilisation of the mutagenic P-element insertion and are currently being investigated.
Download or read book Epidermal Growth Factor Receptor Signalling Regulates Ommatidial Rotation During Drosophila Eye Development written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell motility is essential for many aspects of normal animal development. However, little is known about how cell motility and associated changes in cell shape are regulated in the context of epithelial tissue patterning. This study investigates the cell motility of developing ommatidia, a process known as ommatidial rotation, during Drosophila eye development. The Drosophila eye consists of approximately 800 ommatidia that have to be precisely aligned with respect to one another for proper eye function. This precise alignment is achieved as ommatidia rotate 90° within the plain of the eye imaginal disc epithelium. Only a few mutations have been identified that disrupt this process and the signalling pathways regulating ommatidial rotation remain yet to be revealed. This study characterizes the argosroulette mutation, in which ommatidia rotate to various degrees. Argos is a secreted inhibitor of Spitz, the main activating ligand of the Epidermal growth factor receptor (Egfr). The experiments presented show that modulation of Egfr activity causes defects in ommatidial rotation and implicate the Raf/MAPK/Pointed cascade as well as the Ras binding protein Canoe as downstream effectors of Egfr/Ras in this process. Furthermore, evidence is provided indicating that the regulation of cell adhesion via cadherins is critical for this process. In particular, the atypical cadherin flamingo, a gene known to regulate epithelial planar polarity, appears to play a key role in ommatidial rotation, as its sub-cellular localisation is disturbed in argosroulette mutants. Genetic interactions further implicate non-muscle Myosin II as well as genes involved in actin polymerisation/depolymerisation in this process. This study also describes the design of an F1 screen intended to identify new genes involved in ommatidial rotation. Preliminary results obtained in a pilot screen identified the Drosophila PDGF/VEGF receptor orthologue (PVR) as a candidate. The requirement of Egfr and a poten.
Download or read book The Establishment of Planar Polarity in the Drosophila Compound Eye written by Manolis Fanto and published by . This book was released on 1999 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drosophila Eye Development written by Kevin Moses and published by . This book was released on 2002-03-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compound eye of "Drosophila" is used as a model for human disease and homology to eyes in other taxa. This book covers the major discoveries on the development of the compound eye of "Drosophila melanogaster" over the last 25 years. These include aspects of the biological mechanisms of pattern formation in the nervous system, the specification of neuronal cell types, unexpected phylogenetic conservation and many new insights into the function of several signal transduction pathways. All chapters in this book have been written by leading experts in this field who have made significant contributions to our understanding of fly eye development.
Download or read book A Morphological and Genetic Analysis of Directed Cell Movements During Drosophila Eye Development written by Ryan William Fiehler and published by . This book was released on 2007 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Planar Cell Polarity and Cell Fate Determination in Drosophila Eye written by Gishnu Das and published by . This book was released on 2005 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: A second phase of the work involves the establishment of PCP. A critical feature in this establishment is the asymmetric localization of PCP proteins, Fmi, Fz, Dsh, Prickle (Pk), Diego (Dgo) and Strabismus (Stbm). At an earlier stage in development these proteins are uniformly apically co-localized. Little is known about how the apical localization is maintained. (Abstract shortened by UMI.).
Download or read book Investigating the Co regulatory Role of Midline and Extramacrochaetae in Regulating Eye Development and Vision in Drosophila Melanogaster written by Lillian M. Forstall and published by . This book was released on 2014 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Honors thesis research focused on the roles of extramacrochaetae and midline in regulating eye development and the vision of Drosophila melanogaster. It is known from previous studies that extramacrochaetae (emc) and midline (mid) independently regulate the formation of ommatidial units in the Drosophila compound eye. However, the thesis focuses on the interaction of these two genes and their co-dependent roles in regulating eye development. This study also attempts to explain the recovered formation of ommatidial units and interommatidial bristles when the expression of both of these genes is reduced and whether flies doubly mutant for these genes have recovered phototactic ability. Specific genotypes of flies were subjected to larval and adult phototaxis assays to assay their phototactic ability. A Western analysis was performed on extramacrochaetae mutants, midline mutants, and wild-type flies to determine whether the Emc and Mid proteins interacted in a co-regulatory fashion within developing larval tissues. The larval phototaxis assays revealed a slight decrease in photoreception in the mid- RNAi larvae when compared to the wild-type larvae. However the data was not conclusive to definitively determine if the mid-RNAi mutants displayed a significant decrease in photoreceptive ability. The adult phototaxis assays were more definitive than the larval assays. The emc1 flies displayed a slight decrease in photoreceptive ability. Both the mid- RNAi and the flies doubly mutant for midGA174 and emc1 displayed a significant decrease in photoreceptive ability. The Western blot and immunofluorescence studies revealed an interaction between mid and emc, and the future nature of this interaction will be resolved in greater detail. --Page iv.
Download or read book Molecular Dynamics in the Developing Drosophila Eye written by Daisuke Yamamoto and published by Landes Bioscience. This book was released on 1996 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Genetic Analysis of the Drosophila Tissue Polarity Gene Strabismus Reveals Novel Roles for Fat Flamingo Prickle and Bedraggled in Ommatidial Polarity written by Amy Corrine Schrecengost Rawls and published by . This book was released on 2003 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Molecular Biology of Cadherins written by and published by Academic Press. This book was released on 2013-03-08 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field. Contributions from leading authorities Informs and updates on all the latest developments in the field
Download or read book Behavioral Genetics of the Fly Drosophila Melanogaster written by Josh Dubnau and published by Cambridge University Press. This book was released on 2014-06-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Download or read book Planar Cell Polarity During Development written by and published by Academic Press. This book was released on 2012-12-31 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Current Topics in Developmental Biology covers the area of Planar Cell Polarity with contributions from an international board of authors. The 12 chapters provide a comprehensive set of reviews covering such topics as PCP in Zebra fish, the role of Dishevelled in PCP regulation, and PCP in axon pathfinding. Covers the area of planar cell polarity International board of authors 12 chapters provide a comprehensive set of reviews covering such topics as planar cell polarity in Zebrafish, the role of disheveled in planar cell polarity regulation, and planar cell polarity in axon path finding
Download or read book Animal Anomalies written by Lewis I. Held, Jr and published by Cambridge University Press. This book was released on 2021-03-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights what we know about the pathways pursued by embryos and evolution, and stresses what we do not yet know.
