Download or read book Behavioral Genetics of the Fly Drosophila Melanogaster written by Josh Dubnau and published by Cambridge University Press. This book was released on 2014-06-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Download or read book First in Fly written by Stephanie Elizabeth Mohr and published by Harvard University Press. This book was released on 2018-03-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny? Drosophila’s importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases. Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these “first in fly” findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.

Download or read book Drosophila melanogaster written by Farzana Khan Perveen and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.

Download or read book Introduction to the New Statistics written by Geoff Cumming and published by Routledge. This book was released on 2016-10-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first introductory statistics text to use an estimation approach from the start to help readers understand effect sizes, confidence intervals (CIs), and meta-analysis (‘the new statistics’). It is also the first text to explain the new and exciting Open Science practices, which encourage replication and enhance the trustworthiness of research. In addition, the book explains NHST fully so students can understand published research. Numerous real research examples are used throughout. The book uses today’s most effective learning strategies and promotes critical thinking, comprehension, and retention, to deepen users’ understanding of statistics and modern research methods. The free ESCI (Exploratory Software for Confidence Intervals) software makes concepts visually vivid, and provides calculation and graphing facilities. The book can be used with or without ESCI. Other highlights include: - Coverage of both estimation and NHST approaches, and how to easily translate between the two. - Some exercises use ESCI to analyze data and create graphs including CIs, for best understanding of estimation methods. -Videos of the authors describing key concepts and demonstrating use of ESCI provide an engaging learning tool for traditional or flipped classrooms. -In-chapter exercises and quizzes with related commentary allow students to learn by doing, and to monitor their progress. -End-of-chapter exercises and commentary, many using real data, give practice for using the new statistics to analyze data, as well as for applying research judgment in realistic contexts. -Don’t fool yourself tips help students avoid common errors. -Red Flags highlight the meaning of "significance" and what p values actually mean. -Chapter outlines, defined key terms, sidebars of key points, and summarized take-home messages provide a study tool at exam time. -http://www.routledge.com/cw/cumming offers for students: ESCI downloads; data sets; key term flashcards; tips for using SPSS for analyzing data; and videos. For instructors it offers: tips for teaching the new statistics and Open Science; additional homework exercises; assessment items; answer keys for homework and assessment items; and downloadable text images; and PowerPoint lecture slides. Intended for introduction to statistics, data analysis, or quantitative methods courses in psychology, education, and other social and health sciences, researchers interested in understanding the new statistics will also appreciate this book. No familiarity with introductory statistics is assumed.

Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fly Pushing written by Ralph J. Greenspan and published by CSHL Press. This book was released on 2004 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: A second edition of the classic handbook has become a standard in the Drosophila field. This edition is expanded to include topics in which classical genetic strategies have been augmented with new molecular tools. Included are such new techniques as homologous recombination, RNAi, new mapping techniques, and new mosaic marking techniques.

Download or read book Neuromuscular Junctions in Drosophila written by and published by Academic Press. This book was released on 1999-04-29 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromuscular Junctions in Drosophila gathers the main contributions that research using the fruit fly Drosophila melanogaster has made in the area of synapse development, synapse physiology, and excitability of muscles and nerve cells. The chapters in this book represent a synthesis of major advances in our understanding of neuronal development and synaptic physiology, which have been obtained using the above approach.This book is directed to the general neuroscience audience: researchers, instructors, graduate students, and advanced undergraduates who are interested in the mechanisms of synapse development and physiology. However, the book will also be a valuable resource for those that use the fruit fly as a model system in their laboratories.Key Features* Synthesizes the genetic approaches used to study synaptic development and function at the neuromuscular junction, using flies as a model system* Covers major recent advances in muscle development, pathfinding, synapse maturation and plasticity, exo- and endocytosis, and ion channel function* Written in clear language that is easily understandable to readers not already familiar with fruit fly research* Includes numerous diagrams and extensive reference lists

Download or read book The Freeze 2 written by Dan Wickline and published by Image Comics. This book was released on 2019-01-09 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ray and his coworkers have begun to build their new society, but each newly unfrozen person has their own opinions about what happenedÑand how things should be done.

Download or read book Neurobiology of Chemical Communication written by Carla Mucignat-Caretta and published by CRC Press. This book was released on 2014-02-14 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.

Download or read book Principles of Biostatistics written by Marcello Pagano and published by CRC Press. This book was released on 2018-02-19 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition is a reprint of the second edition published in 2000 by Brooks/Cole and then Cengage Learning. Principles of Biostatistics is aimed at students in the biological and health sciences who wish to learn modern research methods. It is based on a required course offered at the Harvard School of Public Health. In addition to these graduate students, many health professionals from the Harvard medical area attend as well. The book is divided into three parts. The first five chapters deal with collections of numbers and ways in which to summarize, explore, and explain them. The next two chapters focus on probability and introduce the tools needed for the subsequent investigation of uncertainty. It is only in the eighth chapter and thereafter that the authors distinguish between populations and samples and begin to investigate the inherent variability introduced by sampling, thus progressing to inference. Postponing the slightly more difficult concepts until a solid foundation has been established makes it easier for the reader to comprehend them. All supplements, including a manual for students with solutions for odd-numbered exercises, a manual for instructors with solutions to all exercises, and selected data sets, are available at http://www.crcpress.com/9781138593145.

Download or read book Genes Development and Cancer written by Howard D. Lipshitz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: - For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume - Papers are organized into sections that reflect the focus of the research - Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers

Download or read book Brain Development in Drosophila melanogaster written by Gerhard Martin Technau and published by Springer Science & Business Media. This book was released on 2009-01-08 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1972 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biomedical Index to PHS supported Research written by and published by . This book was released on 1988 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetic Mosaics and Cell Differentiation written by W. J. Gehring and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relationship of cell lineage and differentiation is one of the most intriguing problems in developmental biology. In most higher organisms, the analysis of the cell lineage has to rely on indirect methods. Only in the most suitable systems, like the nematodes, can the pattern of cell division be determined by direct observation under the microscope. In cases where this is not possible, the fate of the cells has to be examined by using cell markers. Most suitable for this purpose are genetic markers, provided that they do not interfere with the developmental pathway to be studied. However, suitable genetic markers and techniques for generating genetic mosaics are available in a few organisms only. Therefore, this volume is largely concerned with Drosophila and the mouse, which have been studied most extensively. In 1929 STURTEVANT introduced the analysis of gynandromorphs into devel opmental genetics. However, this important contribution remained largely unnoticed until the late sixties, when the potential of this technique for deter mining embryonic fate maps and the number of primordial cells was exploited, and the methodology extended to the mapping of mutational foci. Mitotic recombination was demostrated by STER:-

Download or read book Learning and Memory A Comprehensive Reference written by and published by Academic Press. This book was released on 2017-07-07 with total page 2517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learning and Memory: A Comprehensive Reference, Second Edition, Four Volume Set is the authoritative resource for scientists and students interested in all facets of learning and memory. This updated edition includes chapters that reflect the state-of-the-art of research in this area. Coverage of sleep and memory has been significantly expanded, while neuromodulators in memory processing, neurogenesis and epigenetics are also covered in greater detail. New chapters have been included to reflect the massive increase in research into working memory and the educational relevance of memory research. No other reference work covers so wide a territory and in so much depth. Provides the most comprehensive and authoritative resource available on the study of learning and memory and its mechanisms Incorporates the expertise of over 150 outstanding investigators in the field, providing a ‘one-stop’ resource of reputable information from world-leading scholars with easy cross-referencing of related articles to promote understanding and further research Includes further reading for each chapter that helps readers continue their research Includes a glossary of key terms that is helpful for users who are unfamiliar with neuroscience terminology