Download or read book A Case control Study on Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma HNSCC written by Valentina Maggini and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epidemiology Pathogenesis and Prevention of Head and Neck Cancer written by Andrew F. Olshan and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a current perspective on the epidemiology head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international patterns of incidence and mortality, established risk factors, suggested association with a virus, and potential genetic susceptibility determinants. These tumors offer a unique insight into mechanisms of cancer initiation and progression and gene-exposure interaction.
Download or read book Abnormal Glucose Metabolism and Metabolic Syndrome in the Etiology of Head and Neck Squamous Cell Carcinoma HNSCC written by Marni Stott-Miller and published by . This book was released on 2012 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abnormalities of glucose metabolism, such as impaired glucose tolerance and diabetes, have been associated with increased risk of multiple types of cancers. Similarly, metabolic syndrome, which is a cluster of health abnormalities including impaired fasting glucose, has been found to increase the risk of various cancers. Whether abnormal glucose metabolism is associated with risk of head and neck squamous cell carcinoma (HNSCC) has received little attention. To address this, we conducted three studies. First, we examined whether self-reported history of diabetes was associated with head and neck cancer in a pooled analysis of case-control studies. Second, we tested whether medical administrative records of type II diabetes or metabolic syndrome were associated with HNSCC using data from the SEER-Medicare database. Third, we compared gene expression profiles of oral squamous cell carcinoma (OSCC) and normal oral tissue from controls with respect to pathways and genes involved in glucose metabolism. In the pooled analysis, we observed a weak association between diabetes and head and neck cancer overall (OR=1.09; 95% CI: 0.95-1.24), but a modest association among never smokers (OR=1.59; 95% CI: 1.22-2.07) and no association among ever smokers. In the second study, we observed a marginal inverse association between type II diabetes and HNSCC (OR=0.92; 95% CI: 0.88-0.96) and a moderate inverse association for metabolic syndrome (OR=0.81; 95% CI: 0.78-0.85). We observed differential expression between normal tissue and OSCC, as well as dysplastic tissue, for pathways and genes involved in glucose metabolism. Contrasting results from the first two studies make conclusions about the role of diabetes and/or metabolic syndrome in HNSCC difficult. However, it is likely that results from the pooled study were closest to the truth, as we were better able to stratify by risk factors and adjust for important potential confounders. The third study provided some molecular evidence that glucose metabolism abnormalities play a role in HNSCC. Prospective studies incorporating biomarkers are needed to improve our understanding of the relationship between diabetes and HNSCC, possibly providing new prevention strategies. As rates of glucose metabolism abnormalities increase worldwide, even a small impact on HNSCC risk is of public health concern.
Download or read book Betel quid and Areca nut Chewing and Some Areca nut derived Nitrosamines written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC. This book was released on 2004 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: A working group of sixteen experts from seven countries re-evaluated the evidence of the carcinogenicity of betel-quid and areca-nut chewing and some areca-nut related nitrosamines. Betel-quid and areca-nut chewing are widely practised in many parts of Asia and in Asian-migrant communities elsewhere in the world. There are hundreds of millions of users worldwide. They evaluated betel quid with tobacco as carcinogenic to humans (Group 1) on the basis of sufficient evidence of an increased risk of cancer of the oral cavity, pharynx and oesophagus. The working group reviewed epidemiological studies of human cancer, mainly studies from India, Pakistan and Taiwan (China). Studies on betel quid with tobacco and areca nut with tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. The working group also evaluated betel quid without tobacco as carcinogenic to humans (Group 1), on the basis of sufficient evidence of an increased risk of oral cancer. Studies on betel quid without tobacco and areca nut without tobacco in experimental animals now also provide sufficient evidence of carcinogenicity. Areca nut, a common ingredient of betel quid and many different chewing preparations, including those available commercially, has been observed to cause oral submucous fibrosis
Download or read book Social Genetic and Behavioural Risk Factors of Head and Neck Cancers Elucidating Causal Pathways written by Akhil Soman Thekke Purakkal and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Introduction: Socioeconomic position (SEP), multiple variants in genes encoding Cytochrome P450 (CYP) and Glutathione S-transferase (GST) enzymes, and smoking and alcohol risk behaviours have been widely investigated in relation to the risk for squamous cell carcinomas of the head and neck (SCCHN). Although an accumulation of disadvantageous SEP over the life-course has been associated with increased risk for oral cancers, this association has not been explored through the lens of multiple life-course models within a single study. The evidence for the effect of multiple genetic variants in CYP1A1, CYP2E1, CYP2A6, CYP2D6, GSTP1 and GSTM1 genes on SCCHN is conflicting and their effect, independently or in interaction with smoking, has not been documented among the Canadian Caucasian population. Furthermore, smoking and alcohol use may interact as well as mediate the effect of genetic variants in CYP2A6 and ADH1B respectively on SCCHN. However, their effects, under combined mediation and interaction with the associated risk behaviours, have not been quantified yet. Addressing these gaps in knowledge has the potential to elucidate causal pathways underlying the relationship between these social, genetic and behavioural risk factors, and SCCHN.Methods: The data for this dissertation was drawn from the Indian and Canadian sites of an international multi-centre hospital-based case-control study: The Head and Neck Cancer (HeNCe) Life study. Information on childhood (0-16 years), early (17-30 years) and late adulthood (above 30 years) SEP, and smoking and alcohol risk behaviours along the life span were collected using interviews and a life-grid technique. The estimation of SEP-oral cancer association used data on 350 incident oral cancer cases and 371 controls frequency-matched by age and sex recruited from two main hospitals in Kozhikode, Kerala, India between 2008 and 2012 SEP and associated confounders were considered as time-varying variables. The estimation of the total effect of genetic variants and their interactive effects with multiple levels of smoking pack-years used data on 389 incident SCCHN cases and 429 age and sex frequency-matched controls recruited from hospitals in Montreal, Canada. Sub-samples of this data on smokers, and alcohol consumers was used to estimate the causal pathways between genetic variants in CYP2A6, ADH1B and SCCHN defined by mediation and interaction with frequencies of smoking and alcohol use. Analytical techniques described under the counterfactual causal framework such as inverse-probability weighted marginal structural models, and mediation and four-way decomposition techniques were used to derive the causal effect estimates.Results: Childhood and early adulthood SEP (advantageous vs. disadvantageous) were associated with oral cancer risk [(Odds Ratio (OR)=2.76, 95% Confidence interval (CI): 1.99, 3.81) and (OR=1.84, 95% CI: 1.21, 2.79), respectively]. In addition, participants who were in a disadvantageous (vs. advantageous) SEP during the three periods of life had an increased oral cancer risk [OR=4.86, 95% CI: 2.61, 9.06]. The childhood to early adulthood social mobility model and overall life-course trajectories indicated a strong influence of exposure to disadvantageous SEP in childhood on oral cancer risk. Of all genetic variants analysed in the Canadian sample, carriers of GSTP1 105Val (vs non-carriers) were at 29% (OR=0.71, 95% CI: 0.53, 0.95) decreased risk of SCCHN. Stratum-specific analyses showed that carriers of this variant were at 41% (OR=0.59, 95% CI: 0.36, 0.95) and 51% (OR= 0.49, 95% CI: 0.24, 0.98) decreased risk for SCCHN relative to non-carriers, among the strata of heavy smokers and non-smokers respectively. There was no evidence for statistical interaction on an additive or multiplicative scale for any of the variants analysed. Among smokers, the total effect estimate of the CYP2A6 variant on SCCHN [Relative risk (RR)=1.28, 95% CI: 0.46, 3.59] was composed of a direc" --
Download or read book HPV Infection in Head and Neck Cancer written by Wojciech Golusiński and published by Springer. This book was released on 2016-10-03 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.
Download or read book Re Irradiation New Frontiers written by Carsten Nieder and published by Springer. This book was released on 2016-10-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Download or read book AJCC Cancer Staging Manual written by Frederick L, Greene and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.
Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Download or read book Textbook of Oral Cancer written by Saman Warnakulasuriya and published by Springer Nature. This book was released on 2020-02-22 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors – all experts in the field of oral oncology – provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.
Download or read book Head and Neck Cancer New Insights for the Healthcare Professional 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and Neck Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Head and Neck Cancer. The editors have built Head and Neck Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Head and Neck Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Head and Neck Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1999 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Head and Neck Cancer New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and Neck Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Head and Neck Cancer. The editors have built Head and Neck Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Head and Neck Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Head and Neck Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Pathology and Genetics of Head and Neck Tumours written by World Health Organization and published by IARC. This book was released on 2005 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise reference book provides an international standard for pathologists and oncologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all WHO-recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors. This volume covers tumours of the nasal cavity and paranasal sinuses, of the nasopharynx, of the hypophyranyx, larynx and trachea, of the oral cavity and oropharynx, of salivary glands, as well as odontogenetic tumours, tumours of the ear, the paraganglionic system, and inherited tumour syndromes. Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases.
Download or read book Contemporary Oral Medicine written by Camile S. Farah and published by Springer. This book was released on 2019-03-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by world authorities in the field, is a comprehensive, up-to-date guide to the specialty of Oral Medicine, which is concerned with the diagnosis, prevention, and predominantly non-surgical management of medically related disorders and conditions affecting the oral and maxillofacial region. The pathophysiology, clinical presentation, diagnostic evaluation, and treatment of all relevant diseases and disorders are described with the aid of a wealth of clinical cases and illustrations that enable the reader to appreciate the diversity and potential complexity of Oral Medicine. In addition to the wide-ranging coverage of oral conditions, separate sections are devoted to bone and cutaneous pathology and to orofacial pain and its management, in addition to dental sleep medicine. The clinician who treats Oral Medicine patients will find this book to be an excellent aid to optimal management grounded in a sound knowledge of basic science and the dental and medical aspects of each disorder. In addition, it will serve as an outstanding textbook for undergraduate and postgraduate students.
Download or read book Selected Health Conditions and Likelihood of Improvement with Treatment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-12 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.
Download or read book Head and Neck Cancer New Insights for the Healthcare Professional 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
