Download or read book Xeno written by David K. C. Cooper and published by Oxford University Press, USA. This book was released on 2000 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: With profound implications for human health and longevity, "Xeno" is a fascinating exploration of the medical, ethical, legal, and social issues surrounding the future of organ transplantation. 17 halftones. Line illustrations.
Download or read book Xenotransplantation written by Institute of Medicine and published by National Academies Press. This book was released on 1996-07-12 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical trials. The volume focuses on the science base of xenotransplantation, public health risks of infectious disease transmission, and ethical and public policy issues, including the views of patients and their families.
Download or read book Xeno The Promise of Transplanting Animal Organs into Humans written by David K. C. Cooper M.D. and published by Oxford University Press. This book was released on 2000-03-23 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The plight of a patient waiting months, sometimes years, for an organ transplant is one of the most heart-wrenching predicaments confronting medicine today. But the current critical shortage of human donor organs has had one positive consequence: it has stimulated promising new research into the field of xenotransplantation--the transplantation of organs from one animal species to another. In Xeno: The Promise of Transplanting Animal Organs Into Humans, David Cooper and Robert Lanza explore what may become one of the greatest medical advances of the 21st century. As scientists genetically engineer animal organs to evade the problems of rejection, we can expect a tremendous increase in xenotransplantation. This book recounts the several historical attempts to transplant animal organs into humans, and draws attention to the immense potential and promise of this form of therapy. The problems which remain, and recent breakthroughs in overcoming rejection and in "humanizing" pig organs for transplantation, are fully discussed. The authors also provide a fascinating consideration of the social and ethical questions posed by such procedures. Which patients should be the first to be offered this new form of therapy? Will transplanted animal organs transfer infectious viruses to the human recipient, and will they then be passed on to the community at large? Can society afford the major increase in healthcare expenditure that will result from our ability to provide a limitless number of donor organs? With profound implications for human health and longevity in the next millennium, Xeno is essential reading for anyone interested in the future of medicine.
Download or read book Principles of Tissue Engineering written by Robert Lanza and published by Elsevier. This book was released on 2000-05-16 with total page 1039 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field.Key Features* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves* Essential to anyone working in the field* Educates and directs both the novice and advanced researcher* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell* Considered the definitive reference in the field* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others
Download or read book Clinical Xenotransplantation written by David K. C. Cooper and published by Springer Nature. This book was released on 2020-09-08 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
Download or read book The Xeno Chronicles written by G. Wayne Miller and published by PublicAffairs. This book was released on 2005-05-24 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. David H. Sachs of the Harvard Medical School and Massachusetts General Hospital is not a household name, but within medical science, he is a giant. An immunologist and surgeon, Sachs has made significant contributions in the field of organ transplantation. But Sachs's real passion— and the possibility for a revolution in medicine—lays in xenotransplantation: using animal parts to treat sick people. "Xeno" might save the lives of untold thousands. It could also lead to a multi-billion-dollar business. Millions of dollars have been invested in Sachs's work in the hopes of staking a lucrative claim in the future of medicine. As The Xeno Chronicles begins, Sachs's decades of work and hopes have all converged on a genetically engineered, cloned pig named Goldie, whose organs have been designed not to be rejected by their recipients. Experiments begin but just as Sachs begins to get unprecedented results, he loses his biggest financial support and the collaboration of an important outside lab. He is almost sixty-two. Time and money are starting to run out. G. Wayne Miller's absorbing, dramatic narrative account of a brilliant scientist's attempts to achieve a breakthrough offers an illuminating look into the minds, hearts, labs, and practical realities of those on the very forefront of medical science. Based on exclusive and unprecedented inside-the-lab access, The Xeno Chronicles clarifies both how science works and the ethical issues it raises through an absorbing human story and intimate portrait of Sachs, his colleagues, and patients.
Download or read book Xeno The Promise of Transplanting Animal Organs into Humans written by David K. C. Cooper M.D. and published by Oxford University Press. This book was released on 2000-03-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The plight of a patient waiting months, sometimes years, for an organ transplant is one of the most heart-wrenching predicaments confronting medicine today. But the current critical shortage of human donor organs has had one positive consequence: it has stimulated promising new research into the field of xenotransplantation--the transplantation of organs from one animal species to another. In Xeno: The Promise of Transplanting Animal Organs Into Humans, David Cooper and Robert Lanza explore what may become one of the greatest medical advances of the 21st century. As scientists genetically engineer animal organs to evade the problems of rejection, we can expect a tremendous increase in xenotransplantation. This book recounts the several historical attempts to transplant animal organs into humans, and draws attention to the immense potential and promise of this form of therapy. The problems which remain, and recent breakthroughs in overcoming rejection and in "humanizing" pig organs for transplantation, are fully discussed. The authors also provide a fascinating consideration of the social and ethical questions posed by such procedures. Which patients should be the first to be offered this new form of therapy? Will transplanted animal organs transfer infectious viruses to the human recipient, and will they then be passed on to the community at large? Can society afford the major increase in healthcare expenditure that will result from our ability to provide a limitless number of donor organs? With profound implications for human health and longevity in the next millennium, Xeno is essential reading for anyone interested in the future of medicine.
Download or read book Transplantation Ethics written by Robert M. Veatch and published by Georgetown University Press. This book was released on 2015-01-22 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the history of organ transplant has its roots in ancient Christian mythology, it is only in the past fifty years that body parts from a dead person have successfully been procured and transplanted into a living person. After fourteen years, the three main issues that Robert Veatch first outlined in his seminal study Transplantation Ethics still remain: deciding when human beings are dead; deciding when it is ethical to procure organs; and deciding how to allocate organs, once procured. However, much has changed. Enormous strides have been made in immunosuppression. Alternatives to the donation model are debated much more openly—living donors are used more widely and hand and face transplants have become more common, raising issues of personal identity. In this second edition of Transplantation Ethics, coauthored by Lainie F. Ross, transplant professionals and advocates will find a comprehensive update of this critical work on transplantation policies.
Download or read book Contemporary Liver Transplantation written by Cataldo Doria and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transplantation Surgery written by Nadey Hakim and published by Springer Science & Business Media. This book was released on 2001-03-10 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is like a fairy story! Or at least a beautiful epic, a truly significant page in the history of medicine, a staggering scene in which several actors come into play, both fundamentalists and clinical practitioners, eager to place all these new developments at the disposal of those suffering from ill health. Everyone is passionate about their work, be it providing new knowledge or perfecting new therapeutic methods. Man has always been fascinated by the possibility of replacing a damaged organ with a healthy one. Several attempts have been made over the centuries, and some miracles have been reported, such as those of Saint Damien and Saint Come as illustrated by Fra Angelico. The modern saga, however, started more modestly on the mouse. It is on the mouse that the first tissue group was discovered; yet the study of human tissue groups could only be carried out on a human. One human must be subjected to the thousands of tests that have enabled us to unravel the extraordinary complexity of the HLA system.
Download or read book The Transplant Imaginary written by Lesley A. Sharp and published by Univ of California Press. This book was released on 2014 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Transplant Imaginary, author Lesley Sharp explores the extraordinarily surgically successful realm of organ transplantation, which is plagued worldwide by the scarcity of donated human parts, a quandary that generates ongoing debates over the marketing of organs as patients die waiting for replacements. These widespread anxieties within and beyond medicine over organ scarcity inspire seemingly futuristic trajectories in other fields. Especially prominent, longstanding, and promising domains include xenotransplantation, or efforts to cull fleshy organs from animals for human use, and bioengineering, a field peopled with “tinkerers” intent on designing implantable mechanical devices, where the heart is of special interest. Scarcity, suffering, and sacrifice are pervasive and, seemingly, inescapable themes that frame the transplant imaginary. Xenotransplant experts and bioengineers at work in labs in five Anglophone countries share a marked determination to eliminate scarcity and human suffering, certain that their efforts might one day altogether eliminate any need for parts of human origin. A premise that drives Sharp’s compelling ethnographic project is that high-stakes experimentation inspires moral thinking, informing scientists’ determination to redirect the surgical trajectory of transplantation and, ultimately, alter the integrity of the human form.
Download or read book Xenotransplantation written by Shuji Miyagawa and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells.
Download or read book Immunology for Surgeons written by Andrew P. Zbar and published by Springer Science & Business Media. This book was released on 2002-02-20 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the complex workings of the immune system is essential for all surgeons. Immune responses play a crucial part in the way human body reacts to infection and trauma. Immunology for Surgeons contains a high-level discussion of this difficult clinical area. The text looks at tumor immunobiology and immunotherapy as well as the worldwide results of various clinical trials. The topics discussed focus on relevant immunological and molecular biological trends for future treatment of complex surgical disease. The main objective of the text is to render a difficult area accessible for the postgraduate surgical trainee and established surgeon who is interested in immunology.
Download or read book Decellularized Materials written by Xiaoming Li and published by Springer Nature. This book was released on 2021-04-28 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will consist of 8 chapters, in which important issues regarding decellularized materials (DMs) will be discussed. This book will provide special knowledge of materials for the persons with biomedical background, and special biomedical knowledge for the persons with the background of materials, which will hopefully become a valuable informative read for the researchers and students of biomedical engineering major.
Download or read book Strange Blood written by Boel Berner and published by transcript Verlag. This book was released on 2020-05-31 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the mid-1870s, the experimental therapy of lamb blood transfusion spread like an epidemic across Europe and the USA. Doctors tried it as a cure for tuberculosis, pellagra and anemia; proposed it as a means to reanimate seemingly dead soldiers on the battlefield. It was a contested therapy because it meant crossing boundaries and challenging taboos. Was the transfusion of lamb blood into desperately sick humans really defensible? The book takes the reader on a journey into hospital wards and lunatic asylums, physiological laboratories and 19th century wars. It presents a fascinating story of medical knowledge, ambitions and concerns - a story that provides lessons for current debates on the morality of medical experimentation and care.
Download or read book Species of Contagion written by Ray Carr and published by Springer Nature. This book was released on 2022-02-17 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Species of Contagion examines the political and social implications of xenotransplantation for bodies, nations, and species. Scientists are demonstrating a renewed interest in developing transplants for humans with tissues from pigs, with the aid of genetic engineering techniques, immunosuppressant drugs, and novel cellular technologies. Yet, some argue that these transspecies promiscuities threaten to enable new viruses to emerge in human populations. Drawing on the later works of Foucault, this book analyses contemporary power relations in animal-to-human transplantation research, ranging across governmental regulation, scientific understandings of infectious disease, and animal ethics. While many xenotransplantation practices resonate with a security approach that renders uncertainty an inherent condition of life and encourages adaptation across species boundaries, government regulation and industry also reinscribe sovereign boundaries of bodies, species, and nations. Species of Contagion illustrates the variation in the cultural and scientific imaginaries that governments and industry bring to bear on the problematic of xenotransplantation.
Download or read book Transgenic Animals written by Louis-Marie Houdebine and published by CRC Press. This book was released on 2022-04-19 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 20 years, transgenesis has become a popular technique and a crucial tool for molecular geneticists and biologists. Transgene expression is now better-controlled and even specifically inducible by exogenous factors. While these techniques have quite significantly transformed the experimental approaches taken by biologists, the applications are more limited than expected and concerns have arisen regarding biosafety as well as physiological, social, and philosophical issues. Transgenic Animals: Generation and Use contains articles on the techniques used to generate transgenic animals and a section on the preparation of vectors for the optimally controlled expression of transgenes. It also examines the use of transgenic animals in the study of gene function and human diseases, the preparation of recombinant proteins and organs for pharmaceutical and medical use, and the improvement of genetic characteristics of farm animals. Finally, it discusses more recent problems generated by transgenic animals including conservation of transgenic lines, specific database patenting, biosafety, and bioethics. Drawn from both academia and industry, the contributors to this monograph present in one concise volume all the relevant information on the different aspects of transgenesis. This book can be used as both a reference book and a textbook for specialized university courses and will be of interest to everyone involved in basic research in animal biology, molecular genetics, animal biotechnology, pharmaceutical science, and medicine.
