Download or read book When Genes Meet the Brain written by Liu Shu and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "While the investigation into complex human traits has extended for over a century, the mechanisms underlying many of them remain poorly understood. Imaging genetics is an interdisciplinary field that integrates genetic and neuroimaging techniques to explore the influence of genetic variations on brain structure and function, subsequently impacting complex traits. This thesis aims to identify the neural mechanisms underlying complex traits within the framework of imaging genetics. First, a systematic exploration of genetic relationships between the brain and various traits revealed distinct associations between brain structure/function and genetic predispositions to mental health and cognition. Second, we established links between gene expression and the neural correlates of major depressive disorder and risky behaviors, suggesting the intermediary processes bridging genes and their associated brain patterns. Addressing concerns about the replicability of neuroimaging analyses, the third objective of the thesis was to assess the replicability of brain-phenotype associations across various traits within different domains, emphasizing that large-scale neuroimaging data are required for replicable brain–phenotype associations. These findings have yielded valuable insights into the neural mechanisms underpinning complex traits, offering robust evidence for the pivotal roles of the brain in the pathways from genotype to phenotype."--

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Download or read book Where God and Science Meet written by Patrick McNamara Ph.D. and published by Bloomsbury Publishing USA. This book was released on 2006-09-30 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spiritual practices, or awakenings, have an impact on brain, mind and personality. These changes are being scientifically predicted and proven. For example, studies show Buddhist priests and Franciscan nuns at the peak of religious feelings show a functional change in the lobes of their brain. Similar processes have been found in people with epilepsy, which Hippocrates called the sacred disease. New research is showing that not only does a person's brain activity change in particular areas while that person is experiencing religious epiphany, but such events can be created for some people, even self-professed atheists, by stimulating various parts of the brain. In this far-reaching and novel set, experts from across the nation and around the world present evolutionary, neuroscientific, and psychological approaches to explaining and exploring religion, including the newest findings and evidence that have spurred the fledgling field of neurotheology. It is not the goal of neurotheology to prove or disprove the existence of God, but to understand the biology of spiritual experiences. Such experiences seem to exist outside time and space - caused by the brain for some reason losing its perception of a boundary between physical body and outside world - and could help explain other intangible events, such as altered states of consciousness, possessions, alien visitations, near-death experiences and out-of-body events. Understanding them - as well as how and why these abilities evolved in the brain - could also help us understand how religion contributes to survival of the human race. Eminent contributors to this set help us answer questions including: How does religion better our brain function? What is the difference between a religious person and a terrorist who kills in the name of religion? Is there one site or function in the brain necessary for religious experience?

Download or read book Pleased to Meet Me written by William J. Sullivan and published by National Geographic Society. This book was released on 2019 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why are you attracted to a certain type? Why do you vote the way you do? Why do you struggle to let certain things go? Philosophers and theologians have grappled with the mystery of human behavior for centuries--but now, science is revealing startling new insights into what makes us tick. This provocative narrative from Indiana University School of Medicine professor Bill Sullivan explores our behavior through. the lens of genetics, microbiology, psychology, neurology, and family history, revealing the hidden forces that drive our individual natures. A fascinating tour of the factors that shape our actions, moods, tastes, political beliefs, and more, [this book] unveils a surprising truth: that many of our most defining traits emerge from things we can't control, including our genes, our early environment, our evolutionary past, and the microbes that dwell inside us. In these pages, you'll learn the real reasons we struggle with infidelity, weight loss, drugs, and depression; discover the biological differences that may separate liberals and conservatives; discern the forces that shape human attraction; and comprehend your own impulse to extend a helping hand or throw a punch. These trail-blazing insights are sprinkled with pop culture references that elucidate the scientific imperatives behind them. Filled with revolutionary observations, this eye-opening book takes us on a riveting journey that reveals who we are--and how we can become our best selves."--Dust jacket.

Download or read book Fundamentals of Brain Network Analysis written by Alex Fornito and published by Academic Press. This book was released on 2016-03-04 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain

Download or read book The Birth of the Mind written by Gary Marcus and published by Harper Collins. This book was released on 2004-12 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Birth of the Mind, award-winning cognitive scientist Gary Marcus irrevocably alters the nature vs. nurture debate by linking the findings of the Human Genome Project to the development of the brain. Scientists have long struggled to understand how a tiny number of genes could contain the instructions for building the human brain, arguably the most complex device in the known universe. Synthesizing up-to-the-minute research with his own original findings on child development, Marcus is the first to resolve this apparent contradiction. Vibrantly written and completely accessible to the lay reader, The Birth of the Mind will forever change the way we think about our origins and ourselves.

Download or read book Brave New Brain written by Nancy C. Andreasen and published by . This book was released on 2004 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, leading neuroscientist Nancy Andreasen offers a state-of-the-art look at what we know about the human brain and the human genome--and shows how these two vast branches of knowledge are coming together in a boldly ambitious effort to conquer mental illness. Andreasen gives us an engaging and readable description of how it all works---from billions of neurons, to the tiny thalamus, to the moral monitor in our prefrontal cortex. She shows the progress made in mapping the human genome, whose 30,000 to 40,000 genes are almost all active in the brain. We read gripping stories of the people who develop mental illness, the friends and relatives who share their suffering, the physicians who treat them, and the scientists who study them so that better treatments can be found. Four major disorders are covered--schizophrenia, manic depression, anxiety disorders, and dementia--revealing what causes them and how they affect the mind and brain. Finally, the book shows how the powerful tools of genetics and neuroscience will be combined during the next decades to build healthier brains and minds. By revealing how combining genome mapping with brain mapping can unlock the mysteries of mental illness, Andreasen offers a remarkably fresh perspective on these devastating diseases.

Download or read book The Deeper Genome written by John Parrington and published by Oxford University Press. This book was released on 2017 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mapping the human genome proved to be just the beginning in understanding our genes, what makes us human, and how we can use the knowledge to cure inherited diseases. John Parrington describes an emerging picture of our genome, in 3D, with many non-gene players and environmental influences, that is far more complex and subtle than we ever imagined.

Download or read book Genes Brains and Human Potential written by Ken Richardson and published by Columbia University Press. This book was released on 2017-03-21 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: For countless generations people have been told that their potential as humans is limited and fundamentally unequal. The social order, they have been assured, is arranged by powers beyond their control. More recently the appeal has been to biology, specifically the genes, brain sciences, the concept of intelligence, and powerful new technologies. Reinforced through the authority of science and a growing belief in bio-determinism, the ordering of the many for the benefit of a few has become more entrenched. Yet scientists are now waking up to the influence of ideology on research and its interpretation. In Genes, Brains, and Human Potential, Ken Richardson illustrates how the ideology of human intelligence has infiltrated genetics, brain sciences, and psychology, flourishing in the vagueness of basic concepts, a shallow nature-versus-nurture debate, and the overhyped claims of reductionists. He shows how ideology, more than pure science, has come to dominate our institutions, especially education, encouraging fatalism about the development of human intelligence among individuals and societies. Genes, Brains, and Human Potential goes much further: building on work being done in molecular biology, epigenetics, dynamical systems, evolution theory, and complexity theory, it maps a fresh understanding of intelligence and the development of human potential. Concluding with an upbeat message for human possibilities, this synthesis of diverse perspectives will engender new conversations among students, researchers, and other interested readers.

Download or read book Mind Brain Gene Toward Psychotherapy Integration written by John Arden and published by W. W. Norton & Company. This book was released on 2019-01-15 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of the ways the immune system, epigenetics, affect regulation, and attachment intersect in mental health. The evolution of psychotherapy in the 21st Century demands integration. Instead of choosing from the blizzard of modalities and schools of the past, therapists must move toward finding common denominators among them. Similarly, today’s psychotherapy necessitates the integration of the mind and body, not the past practice of compartmentalization of mental health and physical health. This book contributes to the sea change in how we conceptualize mental health problems and their solutions. Mind-Brain-Gene describes the feedback loops between the multiple systems contributing to the emergence of the mind and the experience of the self. It explains how our mental operating networks “self”-organize, drawing from and modifying our memory systems to establish and maintain mental health. Synthesizing research in psychoneuroimmunology and epigenetics with interpersonal neurobiology and research on integrated psychotherapeutic approaches, John Arden explores how insecure attachment, deprivation, child abuse, and trauma contribute to anxiety disorders and depression to produce epigenetic affects. To help people suffering from anxiety and depression, it is necessary to make sense of the multidirectional feedback loops between the stress systems and the dysregulation of the immune system that lead to those conditions. Successful psychotherapy modifies the feedback loops among the self-maintenance systems. Through the orchestration of the mental operating networks, psychotherapy promotes the re-regulation of immune system functions, stress systems, nutrition, microbiome (gut bacteria), sleep, physical inactivity, affect regulation, and cognition. This book makes a strong case for healthcare and psychotherapy to be combined—together they can revolutionize the way we conceive of, and attain, optimal health in the 21st Century.

Download or read book Memory Makes the Brain written by Christian Hansel and published by World Scientific Publishing Company. This book was released on 2020-12-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of the young brain after birth and the emergence of cognitive capacities, mind, and individuality rest on the maturation of a dense net of synaptic connections between neurons. Memory Makes the Brain describes the dramatic, competitive elimination of surplus synapses that occur in the young, maturing brain -- in a process called synaptic pruning that was discovered by pediatric neurologist Peter Huttenlocher in the 1970's at the University of Chicago. Explaining similarities between developmental pruning and learning processes in the adult brain, neurobiologist Christian Hansel offers a unique perspective on brain adaptation and plasticity throughout lifetime, at times weaving in personal accounts and memories. The cellular plasticity machinery that enables learning is known to be affected in brain developmental disorders such as autism. Memory Makes the Brain explains how both maturation and adult synaptic plasticity are deregulated in autism, and how we begin to trace back autism-typical behavioral abnormalities to such synaptopathies.

Download or read book Am I My Genes written by Robert L. Klitzman M.D. and published by Oxford University Press. This book was released on 2012-03-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the fifty years since DNA was discovered, we have seen extraordinary advances. For example, genetic testing has rapidly improved the diagnosis and treatment of diseases such as Huntington's, cystic fibrosis, breast cancer, and Alzheimer's. But with this new knowledge comes difficult decisions for countless people, who wrestle with fear about whether to get tested, and if so, what to do with the results. Am I My Genes? shows how real individuals have confronted these issues in their daily lives. Robert L. Klitzman interviewed 64 people who faced Huntington's Disease, breast and ovarian cancer, or Alpha-1 antitrypsin deficiency. The book describes--often in the person's own words--how each has wrestled with the vast implications that genetics has for their lives and their families. Klitzman shows how these men and women struggle to make sense of their predicament and its causes. They confront a series of quandaries--whether to be tested; whether to disclose their genetic risks to parents, siblings, spouses, offspring, friends, doctors, insurers, employers, and schools; how to view and understand themselves and their genetics; what treatments, if any, to pursue; whether to have children, adopt, screen embryos, or abort; and whether to participate in genetic communities. In the face of these uncertainties, they have tried to understand these tests and probabilities, avoid fatalism, anxiety, despair, and discrimination, and find hope, meaning, and a sense of wholeness. Forced to wander through a wilderness of shifting sands, they chart paths that many others may eventually follow. Klitzman captures here the voices of pioneers, some of the first to encounter the personal dilemmas introduced by modern genetics. Am I My Genes? is an invaluable account of their experience, one that will become all the more common in the coming years. "An extraordinary exploration...probing the many roles and implications of genetics in our lives today.... Filled with astonishing insights, this riveting book is vital reading for us all." --Paula Zahn "Klitzman lucidly discusses the moral and psychological complexities that come in the wake of genetic testing.... An important book for anyone who has the genes for pathology, which is all of us, and I recommend it highly." --Kay Redfield Jamison, author of An Unquiet Mind "An illuminating voyage through the medical, familial and existential quandaries faced by those of us at genetic risk." --Thomas H. Murray, President and CEO, The Hastings Center

Download or read book Innate written by Kevin J. Mitchell and published by Princeton University Press. This book was released on 2020-03-31 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: "What makes you the way you are--and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains. Deftly guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world. We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired--differences that impact all aspects of our psychology--and this insight promises to transform the way we see the interplay of nature and nurture. Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits. Compelling and original, Innate will change the way you think about why and how we are who we are."--Provided by the publisher.

Download or read book Your Genes Your Choices written by Catherine Baker and published by . This book was released on 1996 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Program discusses the Human Genome Project, the science behind it, and the ethical, legal and social issues raised by the project.

Download or read book From Molecules to Minds written by Institute of Medicine and published by National Academies Press. This book was released on 2008-12-07 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?

Download or read book When Brains Meet Buildings written by Michael A. Arbib and published by Oxford University Press. This book was released on 2021 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Each brain enlivens a body in interaction with the social and physical environment. Peter Zumthor's Therme at Vals exemplifies the interplay of interior with surroundings, and ways the actions of users fuse with their multi-modal experience. The action-perception cycle includes both practical and contemplative actions. We analyze what Louis Sullivan meant by "form ever follows function" but will more often talk of aesthetics and utility. Not only are action, perception and emotion intertwined, but so are remembering and imagination. Architectural design leads to the physical construction of buildings - but much of what our brains achieve can be seen as a form of mental construction. A first look at neuroscience offers schema theory as a bridge from cognitive processes to neural circuitry. Some architects fear that neuroscience will strip the architect of any creativity. In counterpoint, two-way reduction explores how neuroscience can "dissect" phenomenology by showing how first-person experiences arise from melding diverse subconscious processes. This raises the possibility that neuroscience can extend the effectiveness of architectural design by showing how different aspects of a building may affect human experience in ways that are not apparent to self-reflection"--

Download or read book The Ancient Origins of Consciousness written by Todd E. Feinberg and published by MIT Press. This book was released on 2016-03-25 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: How consciousness appeared much earlier in evolutionary history than is commonly assumed, and why all vertebrates and perhaps even some invertebrates are conscious. How is consciousness created? When did it first appear on Earth, and how did it evolve? What constitutes consciousness, and which animals can be said to be sentient? In this book, Todd Feinberg and Jon Mallatt draw on recent scientific findings to answer these questions—and to tackle the most fundamental question about the nature of consciousness: how does the material brain create subjective experience? After assembling a list of the biological and neurobiological features that seem responsible for consciousness, and considering the fossil record of evolution, Feinberg and Mallatt argue that consciousness appeared much earlier in evolutionary history than is commonly assumed. About 520 to 560 million years ago, they explain, the great “Cambrian explosion” of animal diversity produced the first complex brains, which were accompanied by the first appearance of consciousness; simple reflexive behaviors evolved into a unified inner world of subjective experiences. From this they deduce that all vertebrates are and have always been conscious—not just humans and other mammals, but also every fish, reptile, amphibian, and bird. Considering invertebrates, they find that arthropods (including insects and probably crustaceans) and cephalopods (including the octopus) meet many of the criteria for consciousness. The obvious and conventional wisdom–shattering implication is that consciousness evolved simultaneously but independently in the first vertebrates and possibly arthropods more than half a billion years ago. Combining evolutionary, neurobiological, and philosophical approaches allows Feinberg and Mallatt to offer an original solution to the “hard problem” of consciousness.