Download or read book The Value of Knowing the Propensity Score for Estimating Average Treatment Effects written by Christoph Rothe and published by . This book was released on 2016 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a treatment effect model with unconfoundedness, treatment assignments are not only independent of potential outcomes given the covariates, but also given the propensity score alone. Despite this powerful dimension reduction property, adjusting for the propensity score is known to lead to an estimator of the average treatment effect with lower asymptotic efficiency than one based on adjusting for all covariates. Moreover, knowledge of the propensity score does not change the efficiency bound for estimating average treatment effects, and many empirical strategies are more efficient when an estimate of the propensity score is used instead of its true value. Here, we resolve this "propensity score paradox" by demonstrating the value of knowledge of the propensity score.We show that by exploiting such knowledge properly, it is possible to construct an efficient treatment effect estimator that is not affected by the "curse of dimensionality", which yields desirable second order asymptotic properties and finite sample performance. The method combines knowledge of the propensity score with a nonparametric adjustment for covariates, building on ideas from the literature on double robust estimation. It is straightforward to implement, and performs well in simulations. We also show that confidence intervals based on our estimator and a simple variance estimate have remarkably robust coverage properties with respect to the implementation details of the nonparametric adjustment step.
Download or read book What is the Value of Knowing the Propensity Score for Estimating Average Treatment Effects written by Markus Frölich and published by . This book was released on 2002 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Propensity Score Analysis written by Shenyang Guo and published by SAGE. This book was released on 2015 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides readers with a systematic review of the origins, history, and statistical foundations of Propensity Score Analysis (PSA) and illustrates how it can be used for solving evaluation and causal-inference problems.
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Download or read book Estimating Average Treatment Effects With Propensity Scores Estimated With Four Machine Learning Procedures written by Kip Brown and published by . This book was released on 2018 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: The increased availability of claims data allows one to build high dimensional datasets, rich in covariates, for accurately estimating treatment effects in medical and epidemiological cohort studies. This paper shows the full potential of machine learning for the estimation of average treatment effects with propensity score methods in a context rich and high dimensional datasets. Methods: Four different methods are used to estimate average treatment effects in the context of time to event outcomes. The four methods explored in this study are LASSO, Random Forest, Gradient Descent Boosting and Artificial Neural networks. Simulations based on an actual medical claims data set are used to assess the efficiency of these methods. The simulations are performed with over 100, 000 observations and 1,100 explanatory variables. Each method is tested on 500 datasets that are created from the original dataset, allowing us to report the mean and standard deviation of estimated average treatment effects. Results: The results are very promising for all four methods; however, LASSO, Random Forest and Gradient Boosting seem to be performing better than Random Forest. Conclusion: Machine Learning methods can be helpful for observational studies that use the propensity score when a very large number of covariates are available, the total number of observations is large, and the dependent event rare. This is an important result given the availability of big data related to Health Economics and Outcomes Research (HEOR) around the world.
Download or read book Propensity Score Analysis written by Wei Pan and published by Guilford Publications. This book was released on 2015-04-07 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to help researchers better design and analyze observational data from quasi-experimental studies and improve the validity of research on causal claims. It provides clear guidance on the use of different propensity score analysis (PSA) methods, from the fundamentals to complex, cutting-edge techniques. Experts in the field introduce underlying concepts and current issues and review relevant software programs for PSA. The book addresses the steps in propensity score estimation, including the use of generalized boosted models, how to identify which matching methods work best with specific types of data, and the evaluation of balance results on key background covariates after matching. Also covered are applications of PSA with complex data, working with missing data, controlling for unobserved confounding, and the extension of PSA to prognostic score analysis for causal inference. User-friendly features include statistical program codes and application examples. Data and software code for the examples are available at the companion website (www.guilford.com/pan-materials).
Download or read book Efficient Estimation of Average Treatment Effects Using the Estimated Propensity Score written by Keisuke Hirano and published by . This book was released on 2000 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are interested in estimating the average effect of a binary treatment on a scalar outcome. If assignment to the treatment is independent of the potential outcomes given pretreatment variables, biases associated with simple treatment-control average comparisons can be removed by adjusting for differences in the pre-treatment variables. Rosenbaum and Rubin (1983, 1984) show that adjusting solely for differences between treated and control units in a scalar function of the pre-treatment, the propensity score, also removes the entire bias associated with differences in pre-treatment variables. Thus it is possible to obtain unbiased estimates of the treatment effect without conditioning on a possibly high-dimensional vector of pre-treatment variables. Although adjusting for the propensity score removes all the bias, this can come at the expense of efficiency. We show that weighting with the inverse of a nonparametric estimate of the propensity score, rather than the true propensity score, leads to efficient estimates of the various average treatment effects. This result holds whether the pre-treatment variables have discrete or continuous distributions. We provide intuition for this result in a number of ways. First we show that with discrete covariates, exact adjustment for the estimated propensity score is identical to adjustment for the pre-treatment variables. Second, we show that weighting by the inverse of the estimated propensity score can be interpreted as an empirical likelihood estimator that efficiently incorporates the information about the propensity score. Finally, we make a connection to results to other results on efficient estimation through weighting in the context of variable probability sampling.
Download or read book Secondary Analysis of Electronic Health Records written by MIT Critical Data and published by Springer. This book was released on 2016-09-09 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a “data desert” when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.
Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Download or read book Matched Sampling for Causal Effects written by Donald B. Rubin and published by Cambridge University Press. This book was released on 2006-09-04 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matched sampling is often used to help assess the causal effect of some exposure or intervention, typically when randomized experiments are not available or cannot be conducted. This book presents a selection of Donald B. Rubin's research articles on matched sampling, from the early 1970s, when the author was one of the major researchers involved in establishing the field, to recent contributions to this now extremely active area. The articles include fundamental theoretical studies that have become classics, important extensions, and real applications that range from breast cancer treatments to tobacco litigation to studies of criminal tendencies. They are organized into seven parts, each with an introduction by the author that provides historical and personal context and discusses the relevance of the work today. A concluding essay offers advice to investigators designing observational studies. The book provides an accessible introduction to the study of matched sampling and will be an indispensable reference for students and researchers.
Download or read book Propensity Score Estimation with Random Forests written by Hei Ning Cham and published by . This book was released on 2013 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Random Forests is a statistical learning method which has been proposed for propensity score estimation models that involve complex interactions, nonlinear relationships, or both of the covariates. In this dissertation I conducted a simulation study to examine the effects of three Random Forests model specifications in propensity score analysis. The results suggested that, depending on the nature of data, optimal specification of (1) decision rules to select the covariate and its split value in a Classification Tree, (2) the number of covariates randomly sampled for selection, and (3) methods of estimating Random Forests propensity scores could potentially produce an unbiased average treatment effect estimate after propensity scores weighting by the odds adjustment. Compared to the logistic regression estimation model using the true propensity score model, Random Forests had an additional advantage in producing unbiased estimated standard error and correct statistical inference of the average treatment effect. The relationship between the balance on the covariates' means and the bias of average treatment effect estimate was examined both within and between conditions of the simulation. Within conditions, across repeated samples there was no noticeable correlation between the covariates' mean differences and the magnitude of bias of average treatment effect estimate for the covariates that were imbalanced before adjustment. Between conditions, small mean differences of covariates after propensity score adjustment were not sensitive enough to identify the optimal Random Forests model specification for propensity score analysis.
Download or read book The Role of Propensity Score in Estimating Dose response Functions written by Guido Imbens and published by . This book was released on 1999 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estimation of average treatment effects in observational, or non-experimental in pre-treatment variables. If the number of pre-treatment variables is large, and their distribution varies substantially with treatment status, standard adjustment methods such as covariance adjustment are often inadequate. Rosenbaum and Rubin (1983) propose an alternative method for adjusting for pre-treatment variables based on the propensity score conditional probability of receiving the treatment given pre-treatment variables. They demonstrate that adjusting solely for the propensity score removes all the bias associated with differences in pre-treatment variables between treatment and control groups. The Rosenbaum-Rubin proposals deal exclusively with the case where treatment takes on only two values. In this paper an extension of this methodology is proposed that allows for estimation of average causal effects with multi-valued treatments while maintaining the advantages of the propensity score approach.
Download or read book Practical Propensity Score Methods Using R written by Walter Leite and published by SAGE Publications. This book was released on 2016-10-28 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Propensity Score Methods Using R by Walter Leite is a practical book that uses a step-by-step analysis of realistic examples to help students understand the theory and code for implementing propensity score analysis with the R statistical language. With a comparison of both well-established and cutting-edge propensity score methods, the text highlights where solid guidelines exist to support best practices and where there is scarcity of research. Readers will find that this scaffolded approach to R and the book’s free online resources help them apply the text’s concepts to the analysis of their own data.
Download or read book The Performance of Propensity Score Methods to Estimate the Average Treatment Effect in Observational Studies with Selection Bias written by Sungur Gurel and published by . This book was released on 2012 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: We investigated the performance of four different propensity score (PS) methods to reduce selection bias in estimates of the average treatment effect (ATE) in observational studies: inverse probability of treatment weighting (IPTW), truncated inverse probability of treatment weighting (TIPTW), optimal full propensity score matching (OFPSM), and propensity score stratification (PSS). We compared these methods in combination with three methods of standard error estimation: weighted least squares regression (WLS), Taylor series linearization (TSL), and jackknife (JK). We conducted a Monte Carlo Simulation study manipulating the number of subjects and the ratio of treated to total sample size. The results indicated that IPTW and OFPSM methods removed almost all of the bias while TIPTW and PSS removed about 90% of the bias. Some of TSL and JK standard errors were acceptable, some marginally overestimated, and some moderately overestimated. For the lower ratio of treated on sample sizes, all of the WLS standard errors were strongly underestimated, as designs get balanced, the underestimation gets less serious. Especially for the OFPSM, all of the TSL and JK standard errors were overestimated and WLS standard errors under estimated under all simulated conditions.
Download or read book Targeted Learning written by Mark J. van der Laan and published by Springer Science & Business Media. This book was released on 2011-06-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.
Download or read book Analysis of Observational Health Care Data Using SAS written by Douglas E. Faries and published by SAS Press. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides researchers in performing and presenting high-quality analyses of all kinds of non-randomized studies, including analyses of observational studies, claims database analyses, assessment of registry data, survey data, pharmaco-economic data, and many more applications. The text is sufficiently detailed to provide not only general guidance, but to help the researcher through all of the standard issues that arise in such analyses. Just enough theory is included to allow the reader to understand the pros and cons of alternative approaches and when to use each method. The numerous contributors to this book illustrate, via real-world numerical examples and SAS code, appropriate implementations of alternative methods. The end result is that researchers will learn how to present high-quality and transparent analyses that will lead to fair and objective decisions from observational data. This book is part of the SAS Press program.
Download or read book Encyclopedia of Health Economics written by and published by Newnes. This book was released on 2014-02-21 with total page 1663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Health Economics offers students, researchers and policymakers objective and detailed empirical analysis and clear reviews of current theories and polices. It helps practitioners such as health care managers and planners by providing accessible overviews into the broad field of health economics, including the economics of designing health service finance and delivery and the economics of public and population health. This encyclopedia provides an organized overview of this diverse field, providing one trusted source for up-to-date research and analysis of this highly charged and fast-moving subject area. Features research-driven articles that are objective, better-crafted, and more detailed than is currently available in journals and handbooks Combines insights and scholarship across the breadth of health economics, where theory and empirical work increasingly come from non-economists Provides overviews of key policies, theories and programs in easy-to-understand language
