Download or read book What is Damage suppressor Protein A Tardigrade water bear Unique DNA associated Protein improves Radiotolerance in Human cultured cells written by Dr.Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2020-02-02 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic DNA (Genomic deoxyribonucleic acid is chromosomal DNA, in contrast to extra-chromosomal DNAs like plasmids, abbreviated as gDNA) stores all genetic information and is indispensable for maintenance of normal cellular activity and propagation. Radiation causes severe DNA lesions, including double-strand breaks, and leads to genome instability and even lethality. Regardless of the toxicity of radiation, some organisms exhibit extraordinary tolerance against radiation. · These organisms are supposed to possess special mechanisms to mitigate radiation-induced DNA damages. Extensive study using radio-tolerant bacteria suggested that effective protection of proteins and enhanced DNA repair system play important roles in tolerability against high-dose radiation. Recent studies using an extremotolerant animal, the tardigrade, provides new evidence that a tardigrade-unique DNA-associating protein, termed Dsup, suppresses the occurrence of DNA breaks by radiation in human-cultured cells. An attempt has been made in this Booklet to provide a brief summary of the current knowledge on extremely radiotolerant animals, and present novel insights from the tardigrade research, which expand our understanding on molecular mechanism of exceptional radio-tolerability. ……. Dr. H. K. Saboowala.M.B.(BoM) M.R.S.H.(London)
Download or read book Biotechnological Applications of Extremophilic Microorganisms written by Natuschka M. Lee and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-10-26 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a broad overview how extremophiles can be used in biotechnology, including for the production and degradation of compounds. It reviews various recent discoveries and applications related to a large variety of extremophiles, considering both prokaryotes as well as eukaryotes.
Download or read book The Impact of the Space Environment on Microbial Growth and Behavior written by Camilla Urbaniak and published by Frontiers Media SA. This book was released on 2024-04-02 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microorganisms play an important role in life on Earth and can adapt and survive in harsh and changing environments. Their aptitude to thrive under hostile conditions is reflected by their survival and activity in some of the most extreme environments on Earth and their presence and growth in low earth orbit and outer space. Spaceflight and the space environment have a unique set of stressors compared to Earth (microgravity, galactic cosmic radiation, solar UV radiation, space vacuum, thermal extremes) that microbes are exposed to, but how they adapt and respond is still poorly understood. Studies to date, though, have shown that these responses can range from being beneficial for human exploration to negatively impact long duration missions. Hence, investigating the reaction of microorganisms to space conditions, the alterations in their physiology and virulence, not only helps shed light on the molecular basis of tolerance, but has implications for both space exploration and astrobiological missions.
Download or read book Radiobiology Textbook written by Sarah Baatout and published by Springer Nature. This book was released on 2023-09-23 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.
Download or read book Water Bears The Biology of Tardigrades written by Ralph O. Schill and published by Springer. This book was released on 2019-02-14 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering extensive information on tardigrades, this volume begins with a chapter on the history of tardigrades, from the first description by Goeze in 1773, until 1929, when the most comprehensive monographic approach by E. Marcus was published. Tardigrades’ organ systems, including their integument, body cavity, digestive, muscular, nervous and reproductive systems, as well as their overall external morphology, are summarized in the second chapter. Subsequent chapters present the current state of knowledge on tardigrade phylogeny, biogeography, paleontology, cytology and cytogenetics. In addition, the book provides insights into the ecology of tardigrades in marine, freshwater and terrestrial habitats. The reproduction, development and life cycles are summarized and the extraordinary environmental adaptations of encystment and cyclomorphosis, desiccation tolerance, freezing tolerance and radiation tolerance are discussed in detail. Further chapters provide an overview of key approaches in molecular tardigrade studies and describe techniques for sampling and sample processing. The book closes with a list of tardigrade taxa up to a sub-generic level, including the type species of each genus, the numbers of lower taxa in each taxon, and the main environments in which the taxa were found. Given its depth of coverage, the volume offers an invaluable resource for scientists from various disciplines who plan to research tardigrades, and for all others who are interested in these fascinating animals.
Download or read book Human Enhancements for Space Missions written by Konrad Szocik and published by Springer Nature. This book was released on 2020-08-07 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of chapters, which address various contexts and challenges of the idea of human enhancement for the purposes of human space missions. The authors discuss pros and cons of mostly biological enhancement of human astronauts operating in hostile space environments, but also ethical and theological aspects are addressed. In contrast to the idea and program of human enhancement on Earth, human enhancement in space is considered a serious and necessary option. This book aims at scholars in the following fields: ethics and philosophy, space policy, public policy, as well as biologists and psychologists.
Download or read book Physiological and Biotechnological Aspects of Extremophiles written by Richa Salwan and published by Academic Press. This book was released on 2020-06-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological and Biotechnological Aspects of Extremophiles highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms of these fascinating organisms use to survive.The vast majority of extremophiles are microbes which include archaea, bacteria and some eukaryotes. These microbes live under chemical and physical extremes that are usually lethal to cellular molecules, yet they manage to survive and even thrive. Extremophiles have important practical uses. They are a valuable source of industrially important enzymes and recent research has revealed novel mechanisms and biomolecular structures with a broad range of potential applications in biotechnology, biomining, and bioremediation.Aimed at research scientists, students, microbiologists, and biotechnologists, this book is an essential reading for scientists working with extremophiles and a recommended reference text for anyone interested in the microbiology, bioprospecting, biomining, biofuels, and extremozymes of these organisms. - Shows the implications of the physiological adaptations of microbes from extreme habitats that are largely contributed by their biomolecules from basic to applied research - Provides in-depth knowledge of genomic plasticity and proteome of different extremophiles - Gives detailed and comprehensive insight about use of genetic engineering as well as genome editing for industrial applications
Download or read book The Invertebrate Tree of Life written by Gonzalo Giribet and published by Princeton University Press. This book was released on 2020-03-03 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most up-to-date book on invertebrates, providing a new framework for understanding their place in the tree of life In The Invertebrate Tree of Life, Gonzalo Giribet and Gregory Edgecombe, leading authorities on invertebrate biology and paleontology, utilize phylogenetics to trace the evolution of animals from their origins in the Proterozoic to today. Phylogenetic relationships between and within the major animal groups are based on the latest molecular analyses, which are increasingly genomic in scale and draw on the soundest methods of tree reconstruction. Giribet and Edgecombe evaluate the evolution of animal organ systems, exploring how current debates about phylogenetic relationships affect the ways in which aspects of invertebrate nervous systems, reproductive biology, and other key features are inferred to have developed. The authors review the systematics, natural history, anatomy, development, and fossil records of all major animal groups, employing seminal historical works and cutting-edge research in evolutionary developmental biology, genomics, and advanced imaging techniques. Overall, they provide a synthetic treatment of all animal phyla and discuss their relationships via an integrative approach to invertebrate systematics, anatomy, paleontology, and genomics. With numerous detailed illustrations and phylogenetic trees, The Invertebrate Tree of Life is a must-have reference for biologists and anyone interested in invertebrates, and will be an ideal text for courses in invertebrate biology. A must-have and up-to-date book on invertebrate biology Ideal as both a textbook and reference Suitable for courses in invertebrate biology Richly illustrated with black-and-white and color images and abundant tree diagrams Written by authorities on invertebrate evolution and phylogeny Factors in the latest understanding of animal genomics and original fossil material
Download or read book Evo Devo Non model Species in Cell and Developmental Biology written by Waclaw Tworzydlo and published by Springer Nature. This book was released on 2019-10-09 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book’s content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike.
Download or read book Anhydrobiosis written by John H. Crowe and published by Hutchinson Ross Publishing Company. This book was released on 1973 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Biology of the Endoplasmic Reticulum written by Luis B. Agellon and published by Springer Nature. This book was released on 2021-05-29 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the biology of the endoplasmic reticulum (ER) and the associated ER proteins, it discusses their structure, function and signaling mechanisms in the cell and their role in disease. This book also offers insights into the practical aspects of research and demonstrates the use of non-mammalian models to study the structure and function of the ER. Written by leading experts in the field, the book enables readers to gain a thorough understanding of current ER biology. It is intended for scientists and clinical researchers working on the endoplasmic reticulum in all its various roles and facets in health and disease.
Download or read book Ecology and Evolution of Cancer written by Beata Ujvari and published by Academic Press. This book was released on 2017-02-08 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. - Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine - Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors - Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems - Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
Download or read book Adaptive Oncogenesis written by James DeGregori and published by Harvard University Press. This book was released on 2018-03-09 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancerÕs occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the bodyÕs tissues. His theory ties cancerÕs progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genesÑbut not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cellsÕ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a speciesÕ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregoriÕs perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissuesÕ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.
Download or read book Protein Dimerization and Oligomerization in Biology written by Jacqueline M. Matthews and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
Download or read book Plant Functional Genomics written by Jose M. Alonso and published by Humana. This book was released on 2016-10-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume discusses the revolutionary development of faster and less expensive DNA sequencing technologies from the past 10 years and focuses on general technologies that can be utilized by a wide array of plant biologists to address specific questions in their favorite model systems. This book is organized into five parts. Part I examines the tools and methods required for identifying epigenetic and conformational changes at the whole-genome level. Part II presents approaches used to determine key aspects of a gene’s function, such as techniques used to identify and characterize gene regulatory networks. This is followed by a discussion of tools used to analyze the levels of mRNA, mRNA translation rates and metabolites. Part III features a compilation of forward and reverse genetic approaches that include recent implementation of high-throughput sequencing in classical methodologies such as QTL mapping. The final two parts explore strategies to facilitate and accelerate the generation and testing of functional DNA elements and basic computational tools used to facilitate the use of systems biology approached by a broad spectrum of plant researchers. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Practical and timely, Plant Functional Genomics: Methods and Protocols, Second Edition highlights the latest developments in DNA sequencing technologies that are likely to continue shaping the future of functional genomics.
Download or read book Mars Science Laboratory written by John Grotzinger and published by Springer. This book was released on 2012-12-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mars Science Laboratory is the latest and most advanced NASA roving vehicle to explore the surface of Mars. The Curiosity rover has landed in Gale crater and will explore this region assessing conditions on the surface that might be hospitable to life and paving the way for later even more sophisticated exploration of the surface. This book describes the mission, its exploration and scientific objectives, studies leading to the design of the mission and the instruments that accomplish the objectives of the mission. This book is aimed at all those engaged in Martian studies as well as those interested in the origin of life in other environments. It will be a valuable reference for anyone who uses data from the Mars Science Laboratory. Previously published in Space Science Reviews journal, Vol. 170/1-4, 2012.
Download or read book Dormancy and Resistance in Harsh Environments written by Esther Lubzens and published by Springer. This book was released on 2010-11-04 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many organisms have evolved the ability to enter into and revive from a dormant state. They can survive for long periods in this state (often even months to years), yet can become responsive again within minutes or hours. This is often, but not necessarily, associated with desiccation. Preserving one’s body and reviving it in future generations is a dream of mankind. To date, however, we have failed to learn how cells, tissues or entire organisms can be made dormant or be effectively revived at ambient temperatures. In this book studies on organisms, ranging from aquatic cyanobacteria that produce akinetes to hibernating mammals, are presented, and reveal common but also divergent physiological and molecular pathways for surviving in a dormant form or for tolerating harsh environments. Attempting to learn the functions associated with dormancy and how they are regulated is one of the great future challenges. Its relevance to the preservation of cells and tissues is one of the key concerns of this book.
