Download or read book Introduction to Cellular Biophysics Volume 2 written by Armin Kargol and published by Morgan & Claypool Publishers. This book was released on 2019-12-13 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: All living matter is comprised of cells, small compartments isolated from the environment by a cell membrane and filled with concentrated solutions of various organic and inorganic compounds. Some organisms are single-cell, where all life functions are performed by that cell. Others have groups of cells, or organs, specializing in one particular function. The survival of the entire organism depends on all of its cells and organs fulfilling their roles. While the cells are studied by different sciences, they are seen differently by biologists, chemists, or physicists. Biologists concentrate their attention on cell structure and function. What the cells consists of? Where are its organelles? What function each organelle fulfils? From a chemists’ point of view, a cell is a complex chemical reaction chamber where various molecules are synthesized or degraded. The main question is how these, sometimes very complicated chains of reactions are controlled. Finally, from a physics standpoint, some of the fundamental questions are about the physical movement of all these molecules between organelles within the cell, their exchange with the extracellular medium, as well as electrical phenomena resulting from such transport. The aim of this book is to look into the basic physical phenomena occurring in cells. These physical transport processes facilitate chemical reactions in the cell and various electrical effects, and that in turn leads to biological functions necessary for the cell to satisfy its role in the mother organism. Ultimately, the goals of every cell are to stay alive and to fulfill its function as a part of a larger organ or organism. The first volume of this book is an inventory of physical transport processes occurring in cells while this second volume provides a closer look at how complex biological and physiological cell phenomena result from these very basic physical processes.

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Channels Carriers and Pumps written by Wilfred D. Stein and published by Elsevier. This book was released on 2014-12-09 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered. - Provides an introduction to the properties of transport proteins: channels, carriers, and pumps - Presents up-to-date information on the structure of transport proteins and on their function and regulation - Includes introductions to transport kinetics and to the cloning of genes that code transport proteins - Furnishes a link between the experimental basis of the subject and theoretical model building

Download or read book Biological Barriers to Protein Delivery written by Kenneth L. Audus and published by Springer Science & Business Media. This book was released on 1993 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: A current and critical review of information regarding peptide and protein transport and metabolism as it relates to delivery of endogenous (physiological ligands) and recombinant proteins to mammalian organs, tissues, and cells. Each chapter emphasizes mechanisms of transport including quantitative evidence and structure/function (cause/effect) relationships. The volume is intended to be a comprehensive, state-of-the-art treatise for use by academic and industrial scientists who either are just beginning or are entrenched in the field of protein drug delivery. Annotation copyright by Book News, Inc., Portland, OR

Download or read book Viruses and Human Disease written by Ellen G. Strauss and published by Elsevier. This book was released on 2007-09-21 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss' virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. - Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information - Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia - Further reading sections at the end of each chapter make it easy find key references - World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text

Download or read book Microcirculation written by Ronald F. Tuma and published by Academic Press. This book was released on 2011-04-28 with total page 999 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. - Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship - Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume

Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Download or read book The Retinal Pigment Epithelium written by Michael F. Marmor and published by Oxford University Press, USA. This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The retinal pigment epithelium is a critical tissue within the eye. It lies directly behind the retina, where it provides metabolic support to the photoreceptors and controls their local environment. As a result, the RPE is vital to retinal function, but also a site of aging and disease that cause dysfunction and visual loss. This book brings together comprehensive reviews of basic and clinical science concerning the RPE. It is organized to juxtapose chapters on RPE disease with chapters on the underlying pathophysiology. These include up-to-date accounts of growth factors, laser effects, proliferative vitreoretinopathy, Bruch's membrane pathology, as well as new diagnostic tools such as ocular coherence tomography, in vivo imaging of lipofuscin and non-photic electrical responses. Other chapters cover pharmacology and toxicology, mechanisms of retinal adhesion and detachment, RPE pigments and transport, congenital and dystrophic diseases, animal models of RPE disease, and different aspects of age-related macular degeneration. The history and evolutionary aspects of the RPE are also presented. The contributing authors are experienced clinicians and eminent basic scientists who work on this critical part of the eye. The book will be a valuable resource for anyone interested in the eye, and a necessity for specialists in the fields of retinal physiology and retinal disease.

Download or read book NaCl Transport in Epithelia written by R. Greger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the pioneering studies by Ussing and co-workers, studies of epithelial Nael transport have come a long way. The first phase of the phenomenological description of the cell as a black box has been follow ed by studies of cellular mechanisms, the interplay of the different trans port components, and the mechanisms of regulation. A broad spectrum of methods has been applied to many epithelia in a variety of species. For the individual epithelia transport schemes have been proposed, and, at this point I think it is appropriate to take a pause and search for elements common to several epithelia. This aspect triggered the publica tion of this book, and in fact the various chapters emphasize that the funetional eomponents, expressed in the various epithelia, are not in finite in number, but they occur in epithelia which are separated in evolu tion by several hundred million years. The authors come both from the field of veterinary and human physiology as weIl as from biology. In my opinion, the close contacts and eollaborations between physiologists and biologists have been essential for the progress in this field. I wish to thank all authors for their con tributions, and I hope that the reader will appreciate this collection of up to date reviews on epithelia in nonvertebrates and vertebrates.

Download or read book Physiology of Membrane Disorders written by Thomas Andreoli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Download or read book Membrane Transport written by D. C. Tosteson and published by Oxford University Press, USA. This book was released on 1989 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Transport, a major volume in the American Physiological Society's People and Ideas series, presents a vivid picture of the history of membrane physiology. The significant conceptual and experimental advances are given comprehensive treatment, while key investigators are described in detail. The book will be of interest to those who work in the field of membrane transport including membrane biologists, cell physiologists and biologists, and historians of science.

Download or read book Transporting Epithelia written by Michael Berridge and published by Elsevier. This book was released on 2012-12-02 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transporting Epithelia summarizes the progress that has been made in understanding a wide range of epithelial transport systems. This book discusses the epithelia involved in osmotic and ionic regulation from protonephridia to the mammalian kidney. It also explains the digestive and absorptive epithelia, as well as the epithelia that produce special secretions, such as milk, endolymph, aqueous humor, cerebrospinal fluid, sweat, and tears. Furthermore, this book describes the role of the epithelium in the physiology of the animal and the structure of the epithelium. Then, the structure of the epithelium is correlated with its physiological properties. This book will be valuable both for teaching and as a reference for research workers interested in comparative aspects of transport phenomena.

Download or read book Advances in Comparative and Environmental Physiology written by and published by Springer. This book was released on 2013-11-20 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Comparative and Environmental Physiology provides comprehensive, integrated reviews giving sound, critical, and provocative summaries of our present knowledge in environmental and comparative physiology, from the molecular to the organismic level. The field has now gained the international status it deserves and the organization of a series devoted to it is very timely in view of its actual rapid development. Biologists, physiologists, and biochemists, independently of their basic scientific orientation, will find this new series of major interest.

Download or read book Molecular Mechanisms of Water Transport Across Biological Membranes written by Wilfred D. Stein and published by Gulf Professional Publishing. This book was released on 2002-04-02 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology--both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. This volume looks at water movements from a wide range of levels. It examines how water interacts with the major components of the cell, including proteins and lipids. It discusses how water moves across cell membranes by diffusion, how it is chanelled across these membranes or, in certain cases, pumped across, and how water movements are controlled. This book demonstrates how water and ion movements are closely linked in order to provide a better understanding of their behavior. *Essential Physical chemistry of water at biological interfaces *Up-to-date reviews of water behavior in cells *Water in integrated systems *Current information on water channels across membranes

Download or read book The Pathophysiology of Biliary Epithelia written by Gianfranco Alpini and published by CRC Press. This book was released on 2020-02-03 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of the biliary epithelia pathophysiology. Biliary epithelial cells (also referred to as cholangiocytes) line the intra- and extrahepatic bile ducts. Cholangiocytes have immerged in the last several years as one of the more important epithelial cells in the gastrointestinal system due to their large contribution to bile formation and tendency to be involved in human diseases. The book’s 35 chapters represent a nearly complete review of the function and disease of bile ducts. The gestational development of bile ducts is shown to be a complex interaction between hepatocyte and biliary precursors. The structure of bile ducts can be defined by ultrastructural studies and by 3D reconstruction studies which show that the bile duct system resembles a tree. The array of membrane transporters and channels involved in ductal absorption and secretion of water and electrolytes is reviewed. Like other gastrointestinal epithelial cells, the physiologic responses of cholangiocytes are regulated by hormones, nerve input, cytokines, factors in bile and intracellular signals (e.g., cyclic AMP and intracellular calcium). The potential role of the cholangiocyte in production of collagen in cholestatic liver disease is discussed. A number of important models used in the study of cholangiocyte physiology and reactions to injury are reviewed. Finally the relationships between the cholangiocyte responses and human liver diseases are discussed. While many basic scientists and hepatologists who devote their careers to the study of the liver will find this book useful, the intended audience of this book is the more heterogeneous group of individuals who study clinical and/ or basic science digestive physiology and due to their interest in epithelial function will find the cutting edge information in this book both enlightening and useful to their progression of their work.

Download or read book Calcium Entry Channels in Non Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.