Download or read book Volume 3 The Predictive Value of Short Term Screening Tests in Carcinogenicity Evaluation written by GM Williams (Ed) and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Predictive Value of Short term Screening Tests in Carcinogenicity Evaluation written by Gary M. Williams and published by North Holland. This book was released on 1980-01-01 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Predictive Value of Short term Screening Tests in Carcinogenicity Evaluation written by and published by . This book was released on 1980 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Predictive Value of Short term Screening Tests in Carcinogenicity Evaluation written by and published by Elsevier-North-Holland Biomedical Press. This book was released on 1980 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Plants in cosmetics Volume 3 written by Council of Europe and published by Council of Europe. This book was released on 2006-09-12 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the third volume of a trilogy on Plants in cosmetics, this study concerns potentially harmful components which occur naturally in some plants the ingredients of which could likely be used in cosmetic products. Its aim is to raise awareness on the implication on consumer health by use of such ingredients and to trigger preventive measures. The 24 data sheets of components, selected by the authors because they are not regulated specifically in cosmetic legislation, give useful information particularly for the competent authorities and the manufacturers of raw materials and cosmetic products, mainly based on currently available pharmaco-toxicological data. Each monograph includes a bibliography and conclusions / recommendations.
Download or read book The Predicitive of Short term Screening Tests in Carcinogenicity Evaluation written by and published by . This book was released on 1980 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Review of Short term Screening Tests for Mutagens Toxigens and Carcinogens written by Heath J. Carney and published by . This book was released on 1979 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Short Term Test Systems for Detecting Carcinogens written by K.H. Norpoth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.
Download or read book Drug Discovery and Development written by Michael Williams and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures III written by Michael D. Waters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.
Download or read book Five Year Report written by United States-Japan Cooperative Medical Science Program and published by . This book was released on 1985 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peroxisomes written by G. Gordon Gibson and published by CRC Press. This book was released on 2013-04-08 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 1724 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Active Ingredients Used in Cosmetics written by Council of Europe. Committee of Experts on Cosmetic Products and published by Council of Europe. This book was released on 2008-01-01 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ingredients are used in cosmetics to give them specific properties. Certain ingredients, so called active ingredients, may produce pharmacological or toxic effects under certain conditions. Cosmetic products containing such ingredients may pose a health risk both because of their potential toxicity and because they may mask underlying serious diseases and consequently cause a dangerous delay in diagnosis and treatment.The objective of this study is to give safety information on certain active ingredients which give raise to toxicological concerns and for which restrictions of use in cosmetics should be considered.Monographs were prepared for 45 active ingredients for which no specific regulations exist including, inter alia, information about uses, properties, a risk evaluation of the use in cosmetic products considering as toxicological endpoints both systemic and local effects. Each monograph includes a bibliography, conclusions and recommendations.The study complements a series of three volumes containing monographs about the safety of certain natural ingredients used in cosmetics and will serve as a useful reference in the field, for health authorities, manufacturers and health professionals in particular.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1992 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Apocalyptics written by Edith Efron and published by Holiday House. This book was released on 1985 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ecotoxicology Modeling written by James Devillers and published by Springer Science & Business Media. This book was released on 2009-08-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecotoxicology Modeling is a comprehensive and well-documented text providing a collection of computational methods to the ecotoxicologists primarily interested in the study of the adverse effects of chemicals, their mechanisms of action and/or their environmental fate and behavior. Avoiding mathematical jargon, the book presents numerous case studies to enable the reader to understand the interest but also the limitations of linear and nonlinear models in ecotoxicology. Written by an international team of scientists, Ecotoxicology Modeling is of primary interest to those whose research or professional activity is directly concerned with the development and application of models in ecotoxicology. It is also intended to provide the graduate and post-graduate students with a clear and accessible text covering the main types of modeling approaches used in environmental sciences.
