Download or read book Vitamin D Receptor Gene Polymorphisms and the Risks of Breast Cancer written by Ejike R. Egwuekwe and published by iUniverse. This book was released on 2020-02-18 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Yes! What you are holding in your hands is the right book. It is an easy to read, user-friendly book that helps the reader understand breast cancer risks and how to minimize the risks and possibly prevent breast cancer from occuring in an individual person. The book provides diagrams, tables, and full-color images that are easy-to-follow. These are helpful in illustrating some points and concepts in various chapters of the book. Chapter summaries give overviews of important points . These are helpful in reinforcing understanding and retention of the matrial information gleaned from the book.
Download or read book Androgen and Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This project will assess the association between breast cancer risk and polymorphisms of the androgen receptor (AR) and vitamin D receptor (VDR) genes among subjects in a population-based case-control study in Sweden. From this study population, breast cancer cases and control women have been randomly selected for genomic DNA analysis. The collection of blood or tissue specimens has been funded from other sources; this award is for the measurement of the AR and VDR polymorphisms on 300 cases and 300 controls who never used HRT, and a similar number of cases and controls who used HRT for 4 years of more. Information on these polymorphisms will be incorporated into the established subject database, and odds ratios summarizing the associations with breast cancer risk will be computed. In the previous years of the project, the work was organized, a tracking database for subject recruitment and specimen accrual was built, and recruitment into the molecular epidemiology study completed. The laboratory investigators have completed DNA extraction and amplification from virtually all available specimens, and have as well completed most of the assays. All laboratory analyses will be completed in December 2001. Under a no-cost extension, data analysis and reporting will be completed in 2002.
Download or read book Vitamin D Its Receptor Gene Polymorphism and Breast Cancer written by Mehir un Nisa and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D is synthesized within skin followed by the peripheral maturation in liver and kidneys. Vitamin D is most essential secosteroid produced its systemic functions via complex with steroid/thyroid nuclear receptor called vitamin D receptor (VDR). The binding of the vitamin D3 to VDR causes conformational changes that permit VDR-RXR heterodimer formation and VDR/ SRC-1 (transcriptional co-activator proteins) interactions. Functional expression and nuclear activation of VDR is necessary to produce its effects upon binding with vitamin D response element (VDRE) on target gene where it causes transcriptional activation resulting in the prevention of breast cancer by inhibiting proliferation, impeding differentiation and stimulating pro-apoptosis. Season, latitude, pigmentation of skin, aging, sunscreen use, obesity, and smoking all affect the production of vitamin D. In case of vitamin D deficiency or VDR gene polymorphisms, vitamin D responses are altered and probably are involved in the risk of breast cancer. Since many epidemiological, observational and interventional studies have been done to illustrate the role of vitamin D and its receptor gene polymorphism in breast cancer development but controversial findings have been observed. Therefore, the role of vitamin D and its receptor gene polymorphisms in development of breast cancer are still a matter of discussion.
Download or read book Sunlight Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Download or read book A Critical Evaluation of Vitamin D written by Sivakumar Joghi Thatha Gowder and published by BoD – Books on Demand. This book was released on 2017-04-26 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D, a fat-soluble vitamin, also called as "sunshine vitamin" is derived mostly from sun exposure and food, and for normal activation, it has to undergo two hydroxylation reactions. Vitamin D affects more than 2000 genes in the body. Serum level of 25(OH) D is an ideal indicator of vitamin D status in our body. Vitamin D deficiency leads to various diseases. On a therapeutic point of view, vitamin D helps to treat many diseases. The book "A Critical Evaluation of Vitamin D - Clinical Overview" targets the principles, mechanisms, and clinical significance of vitamin D. This book covers four sections: "Vitamin D in Cardiovascular and Renal Diseases", "Vitamin D in Age and Neurological Diseases", "Vitamin D and Cancer" and "Therapeutic Measurements of Vitamin D". Each of these sections is interwoven with the theoretical aspects and experimental techniques of basic and clinical sciences. This book will be a significant source to students, scientists, physicians, healthcare professionals and also other members of this society who are interested in exploring the role of vitamin D in human life. [Vitamin D can be considered as vitamin of "defense" since it cures several diseases. - Sivakumar Gowder]
Download or read book Vitamin D Receptor Gene Polymorphisms Insulin like Growth Factors and Prostate Cancer Risk written by Anand P. Chokkalingam and published by . This book was released on 2001 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vitamin D and Breast Cancer Risk Association of Dietary Vitamin D Circulating 25 hydroxyvitamin D Concentration and Polymorphisms in Vitamin D Pathway Genes with Pre and Postmenopausal Breast Cancer Risk written by Sascha Abbas and published by . This book was released on 2008 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vitamin D and breast cancer risk written by Sascha Abbas and published by . This book was released on 2008 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Estrogen Receptor Gene Polymorphisms and Breast Cancer Risk written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose: to test the hypothesis that individual variation in the sensitivity to estrogens whether from endogenous or exogenous sources, affects woman's risk of breast cancer. Scope: to test if the variability in responses to estrogens in women may be determined by a functionally significant variation in the estrogen receptor alpha (ER) though which estrogens exert biologic effects. The ER polymorphism under study are: Xba-I, Pvu II and microsattelite polymorphism. In an exploratory analysis we will study the interaction between the Xba I, Pvu II and microsatellite ER polymorphism and estrogen-related risk factors for breast cancer such as reproductive history and menopausal hormone use. Major findings: not yet available (biological sample collection and laboratory analysis still ongoing. Up-to-date report of the progress in terms of results and significance: no results are yet available - we are still collecting biological samples, extracting DNA from the biological materials (leukocytes and pathological slides) and processing the laboratory analysis. These activities are following the time schedule as stated in the Proposal to the Army. We expect to have preliminary results by the spring of year 2001.
Download or read book Genetic Polymorphism and Disease written by Syed Sameer Aga and published by CRC Press. This book was released on 2022-12-06 with total page 1256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics
Download or read book Nutrient Gene Interactions in Cancer written by Sang-Woon Choi and published by CRC Press. This book was released on 2006-01-24 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complete mapping of the human genome, along with the development of sophisticated molecular technologies, has accelerated research on the relationship between nutrients and genes. This has led to compelling evidence garnered from epidemiological and experimental observations supporting the idea that the interaction between nutrients and genes i
Download or read book Nutrition and Cancer Prevention written by Thomas Prates Ong and published by Royal Society of Chemistry. This book was released on 2019-11-27 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a major global public health problem. Among different environmental and lifestyle factors contributing to cancer risk, diet is a key one. On the one hand, obesity and increased consumption of red and processed meat, ethanol, sugar and saturated fatty acids are associated with increased cancer risk. On the other hand, consumption of micronutrients such as vitamin D, selenium, zinc, folate and bioactive compounds from fruits and vegetables is associated with decreased risk. Written by an influential, international team of experts, this book presents and discusses current topics on nutrition and cancer prevention. It covers both nutritional influences on different cancers plus specific chapters on the commonly occurring cancers. Nutritional genomics-based studies show that some dietary components modulate carcinogenesis through complex cellular and molecular mechanisms. A better understanding of these different cellular and molecular mechanisms is needed to establish efficient dietary recommendations for cancer prevention. This book will provide such an understanding, serving as an important book for all those working in nutritional health, food science and cancer research.
Download or read book Vitamin D and Human Health written by Simon Spedding and published by MDPI. This book was released on 2019-02-21 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Vitamin D and Human Health" that was published in Nutrients
Download or read book Vitamin D written by Martin Hewison and published by Academic Press. This book was released on 2017-12-14 with total page 1268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Chapter authors include the most prominent and well-published names in the field Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis and vitamin D deficiency Presents a clinical focus on disorders, analogs, cancer, immunity, inflammation, disease and therapeutic applications
Download or read book Vitamin D and Cancer written by Donald L. Trump and published by Springer Science & Business Media. This book was released on 2010-12-09 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Substantial data indicate the broad importance of vitamin D-based signaling in normal human physiology and the broad effects of vitamin D deficiency. Vitamin D may play a role not only in the control of bone and mineral metabolism, but also appears to be involved in immune function, cardiovascular health, thrombosis and vasculogenesis and neuromuscular function. Considerable epidemiologic data demonstrate that low vitamin D serum levels occur very commonly in normal adult populations and that vitamin D deficiency is associated with an enhanced risk of cancer death from lung, prostate, head & neck, colorectal and other gastrointestinal cancers. In addition, preclinical data provide evidence that calcitriol and other active analogues of calcitriol have anti-proliferative, pro-differentiative, pro-apoptotic and anti-angiogenic activity in numerous in-vitro and in-vivo models. It is quite clear that, while it requires high exposure to calcitriol to induce these effects, such exposure can be readily achieved when high dose intermittent therapy is given.
Download or read book Nutrition and Cancer Prevention written by Atif B. Awad and published by CRC Press. This book was released on 2005-09-19 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies have estimated that approximately 35 percent of cancers are potentially avoidable by nutritional modification. These modifications include strategies such as caloric restriction and limitation of specific macro-nutrient groups. However, recent research indicates that what you eat may well be just as important as what you s
Download or read book Vitamin D Analogs in Cancer Prevention and Therapy written by J. Reichrath and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, highly readable overview of the topics discussed at the First International Symposium on "Vitamin D Analogs in Cancer Prevention and Therapy" held in Homburg/Saar, Germany in May 2002. Leading researchers discuss our present knowledge of the vitamin D system in cancer. Topics range from the newest findings in molecular biology, epidemiology, synthesis and metabolism of vitamin D to new concepts for the use of vitamin D analogs in cancer prophylaxis and treatment. The book provides essential up-to-date information for every researcher or clinician interested in the biology of vitamin D or cancer.
