Download or read book Variation in Sodium Regulating Genes in Relation to Blood Pressure and Associated Phenotypes in Caucasians and Chinese written by Jiguang Wang and published by Leuven University Press. This book was released on 2004-09 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Variation and Environmental Factors in Biological and Arterial Ageing written by Tim Nawrot and published by Leuven University Press. This book was released on 2005 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ageing, the decline in survival and bodily functions, caused by damage to macromolecules and tissues is intrinsically linked to life. Although universal and unavoidable, ageing does not occur in a uniform way. In the general population, it is actually a continuously distributed phenotype, in which genetic as well as environmental factors play an interactive role and explain the large interindividual differences between biological and chronological age. Cardiovascular disorders, which find there origins in deterioration of the structure and function of the large arteries, explain a large part of morbidity and mortality in industrialized societies. In this doctoral dissertation, the focus was on telomere length and arterial stiffness as biomarkers of biological and arterial ageing, respectively. It was investigated to what extent genetic and environmental determinants of oxidative stress and inflammation impact on the ageing process. Contents include: Introduction, Arterial ageing in cardiovascular risk prediction, Genetic and environmental factors in biological and arterial ageing, Telomere length and possible link to X chromosome, Role of smoking, oxidative stress and the -174 G/C interleukin-6 polymorphism in biological and vascular ageing, Environmental factors in arterial ageing, Blood pressure and blood selenium: a cross-sectional and a longitudinal population study, Endothelial function and outdoor temperature, General Discussion, Summary, Short Curriculum Vitae.
Download or read book Generation and Characterization of a Mouse Model for a Sodium Channel Based Long QT Syndrome LQT3 written by Dieter Nuyens and published by Leuven University Press. This book was released on 2006 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanism and Role of Cyclooxygenase 2 Up Regulation by Photodynamic Therapy written by Nico Hendrickx and published by Leuven University Press. This book was released on 2006 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Role of Nitric Oxide Synthase in the Regulation of Pulmonary Vascular Tone written by Leifu Jiang and published by Leuven University Press. This book was released on 2006-09 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nitric Oxide and Cytochrome P450 Signaling in Experimental Pulmonary Hypertension written by Peter Pokreisz and published by Leuven University Press. This book was released on 2006 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of the Antibody Response to Pneumococcal Capsular Polysaccharides written by Axel Jeurissen and published by Leuven University Press. This book was released on 2005 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. S. pneumoniae is a major causative agent of serious infections. Besides, the emerging resistance of S. pneumoniae to multiple antibiotic drugs is a major concern in the treatment of infections caused by this micro-organism. Therefore it is important to study the molecular mechanisms that meditate the antibody response to caps-PS. The aim of the study is to better understand the regulation and the molecular mechanisms of the immune response to pneumococcal caps-PS. The present study was undertaken to determine the role of the CD40-CD40L interaction in the murine antibody response to pneumococcal caps-PS antigens.
Download or read book Genetic Modulators of Pulmonary Function in Cystic Fibrosis and Genetic Susceptibility Factors of Emphysema written by Jennifer S. Yarden and published by Leuven University Press. This book was released on 2005 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardioselective Nitric Oxide Synthase Gene Transfer to Target Myocardial Ischemia written by Zsolt Szelid and published by Leuven University Press. This book was released on 2005 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. Introduction: Cardiovascular and myocardial gene transfer, Gene delivery strategies to the cardiovascular system, Gene vector design, Adenovirus-mediated immunity and cardiovascular gene transfer, Myocardial gene transfer to target myocardial ischemia - reperfusion injury; Specific aims; Materials and methods: Construction of recombinant virus, Myocardial transfer and anti-adenoviral immunity, Gene transfer and myocardial ischemia-reperfusion injury, Statistical analysis; Results: Anti-adenoviral immunity and myocardial adenoviral gene transfer, Gene transfer and myocardial ischemia-reperfusion injury; Discussion: Pre-existing anti-adenoviral immunity and adenovirus-mediated myocardial gene transfer, Intramyocardial NOS3 gene transfer and adenovirus-mediated immune responses, Cardioselective NOS3 gene transfer and myocardial protection from reperfusion injury; General conclusions.
Download or read book Genetic Analysis of Herpesvirus Entry Receptors and Host Susceptibility to Herpes Simplex Virus Infection written by Frank Struyf and published by Leuven University Press. This book was released on 2004-09 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Axon Growth Injury and Regeneration in the Fly Brain written by Maarten Leyssen and published by Leuven University Press. This book was released on 2006 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physiological Study of Presenilins and Baces Two Proteases Involved in the Pathogenesis of Alzheimer s Disease written by Jos Tournoy and published by Leuven University Press. This book was released on 2006 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Anatomy of Visual Processing in the Cerebral Cortex of the Macaque written by Koen Nelissen and published by Leuven University Press. This book was released on 2006 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, we examined the monkey cortical regions involved in processing of color, visual motion information, and the recognition of actions done by others. The aim was to gain better insight in the functional organization of the monkey visual cortex using in-house developed functional imaging techniques. Two different functional imaging techniques were used in these studies, the double-label deoxyglucose technique (DG) and functional magnetic resonance imaging (fMRI) in the awake monkey (Chapter 2). Both techniques allow to obtain an overview of stimulus-related neural activity throughout the whole brain, integrated over a limited amount of time. The results of the color experiments (Chapter 3) clearly showed that color related information is processed within a group of areas belonging to the ventral stream, which is involved in the perception of objects. Color-related metabolic activity was observed in visual areas V1, V2, V3, V4 and inferotemporal cortex (area TEO and TE). These findings set to rest the longstanding controversial claims that color would be processed almost selectively in one extrastriate visual area (V4) (Zeki SM, Brain Res 1973 53: 422-427). These results also show the usefulness of whole brain functional mapping techniques, as a complimentary approach to single cell measurements. In Chapter 4, we investigated which regions in the superior temporal sulcus (STS) of the monkey are involved in the analysis of motion. While the caudal part of the STS has been studied extensively, including area MT/V5 and MST, little is known about motion sensitivity in more anterior-ventral STS regions. Using fMRI, we were able to localize and delineate six different motion sensitive regions in the STS. One of these regions, that we termed 1st (lower superior temporal), had not been described so far. We were able to further characterize the six motion sensitive regions, using a wide variety of motion-sensitivity tests. The results of the latter tests suggested that motion related information might be processed along a second pathway within the STS, in addition to the MT-MST path (which is involved in the perception of heading). This second pathway, which includes the more rostral motion sensitive STS regions (FST, 1st and STPm) is possibly involved in the visual processing of biological movements (movements of animate objects) and actions. Finally, we investigated how and where in the monkey brain visual information about actions done is processed (Chapter 5 and 6). We found (Chapter 5) that, in agreement with earlier single unit results, the observation of grasping movements activates several regions in the premotor cortex of the monkey. Remarkable is that these premotor regions predominantly have a motor function, coding different types of higher order motor acts (for instance grasping of an object). These results are in agreement with earlier suggestions that we are able to understand actions done by others, because observation of a particular motor act activates our own motor representation of the same act. Furthermore, these studies suggested that within the frontal cortex of the monkey, there is a distinction between context-dependent (a person grasping) and more abstract (a hand grasping) action representations. In Chapter 6 we studied two other regions which are involved in the processing of visual information of actions done by others, the superior temporal sulcus (STS) and the parietal cortex. In the parietal cortex, we found a similar distinction between context-dependent and more abstract action representations as observed in prefrontal cortex. These results suggest that the parietal cortex is not only involved in the visual control of action planning, but also in the visual processing of actions performed by others. Based upon anatomical connections between the STS, parietal and frontal regions and motion-, form- and action-related functional properties of the former regions, we tentatively suggest how information about actions done by others might be sent from the STS to the frontal cortex along three different pathways. The latter working hypothesis will be tested in the future by additional fMRI control experiments and by combining fMRI, inactivation and microstimulation experiments while monkeys perform grasping tasks and/or view actions performed by others.
Download or read book Biochemical and Immuno Histochemical Analysis of APP Processing and Amyloid Pathology in Single and Multiple Transgenic Mice as Models for Alzheimer s Disease written by Tom V. Dooren and published by Leuven University Press. This book was released on 2006-09 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Phosphatase 1 Binding Motifs written by Paulina Wakula and published by Leuven University Press. This book was released on 2006 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Repopulation of Bioprosthetic Heart Valves written by Jessa Yperman and published by Leuven University Press. This book was released on 2006 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Photoproduction of Vitamin D3 and Activation into 1a 25 Dihydroxyvitamin D3 in Human Epiderman Keratinocytes Dermal Fibroblasts and Other Cells written by Katleen Vantieghem and published by Leuven University Press. This book was released on 2006 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
