Download or read book Utilizing Neuromodulation of the Spinal Cord to Assess and Modulate Aberrant Spinal Physiology Below the Lesion Following Severe Upper Motor Neuron Injury written by Lisa Moore and published by . This book was released on 2018 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upper motor neuron injury damages the descending circuits connecting the brain to sensory and motor neurons responsible for sensing and interacting with the world. While spinal cord stimulation is showing extraordinary promise as a novel therapeutic to restore lost motor function following spinal cord injury, we have yet to fully characterize the mechanisms of its action or identify the limits of its therapeutic potential. Towards these ends I conducted a series of three studies which utilized spinal stimulation in novel subject populations to map the cervical spinal cord, identify and modulate aberrant spinal physiology, and enhance upper limb function. In the first study a group of SCI subjects with motor complete lesions, half of which had no measurable hand strength, received transcutaneous stimulation to the cervical spinal cord alone and in combination with the partial serotonergic agonist buspirone. Stimulation but not buspirone significantly improved hand function in subjects with measurable strength prior to the study and maintained hand strength for up to five months following treatment in more functional subjects. In the second study, two subjects who demonstrated improvement with transcutaneous stimulation but failed to maintain it 5 months after treatment, received epidural stimulators. The different properties and performance outcomes of the two forms of stimulation were compared in these severely impaired subjects. Finally in a cohort of rats, epidural stimulation was used to map the cervical spinal cord, track physiological changes in the spinal cord following a severe stroke injury to the motor cortex, and treat observed deficits in reaching success and muscle activity. While 20 Hz stimulation enhanced afferent derived spinal activity, only 1 Hz stimulation resulted in improved reaching success and muscle activity. Together these studies further our understanding, by identifying patient pools most receptive to spinal cord stimulation, characterizing the different properties and functional outcomes of transcutaneous versus epidural stimulation, and illustrating the potential to utilize spinal cord stimulation for other forms of upper motor neuron injury.
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Download or read book Peripheral Nerve Regeneration written by Giovanna Gambarotta and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Download or read book Spinal Cord Medicine written by Denise I. Campagnolo and published by Lippincott Williams & Wilkins. This book was released on 2011-12-07 with total page 1899 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and practical reference is the perfect resource for the medical specialist treating persons with spinal cord injuries. The book provides detail about all aspects of spinal cord injury and disease. The initial seven chapters present the history, anatomy, imaging, epidemiology, and general acute management of spinal cord injury. The next eleven chapters deal with medical aspects of spinal cord damage, such as pulmonary management and the neurogenic bladder. Chapters on rehabilitation are followed by nine chapters dealing with diseases that cause non-traumatic spinal cord injury. A comprehensive imaging chapter is included with 30 figures which provide the reader with an excellent resource to understand the complex issues of imaging the spine and spinal cord.
Download or read book Pain Modulation written by Howard L. Fields and published by Elsevier Publishing Company. This book was released on 1988-01-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.
Download or read book Treatment of Chronic Pain by Interventional Approaches written by Timothy R. Deer and published by Springer. This book was released on 2014-12-08 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: From reviews of Deer, eds., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches: "Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches is a major textbook... [I]t should be a part of all departmental libraries and in the reference collection of pain fellows and pain practitioners. In fact, this text could be to pain as Miller is to general anesthesia." Journal of Neurosurgical Anesthesiology Edited by master clinician-experts appointed by the American Academy of Pain Medicine, this is a soft cover version of the Interventional sections of the acclaimed Deer, eds., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches. It is intended as a primary reference for busy clinicians who seek up-to-date and authoritative information about interventional approaches to treating chronic pain. State-of-the-art coverage of full range of techniques: neural blockades, neurolysis blocks, and neurostimulation Review of clinically relevant anatomy and physiology "Key Points" preview contents of each chapter
Download or read book Case Studies in Pain Management written by Alan David Kaye and published by Cambridge University Press. This book was released on 2014-10-16 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.
Download or read book Neuromodulation written by and published by Academic Press. This book was released on 2009-05-05 with total page 1089 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices. All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come. Key Features The first comprehensive reference on the emerging field of Neuromodulation Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society Over 90 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise Over 1200 pages in splendid full color, richly illustrated Important areas of application include: control of chronic pain delivery of drugs to the nervous system via implanted devices control of epilepsy, Parkinson, etc. functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs) overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces
Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Download or read book Pelvic Organ Dysfunction in Neurological Disease written by Clare J. Fowler and published by Cambridge University Press. This book was released on 2010-11-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pelvic Organ Dysfunction in Neurological Disease describes the neurological control of human bladder, bowel and sexual function and then details the dysfunctions which may arise as a consequence of various neurological diseases. Easy to read, the book will be of value to any healthcare professional managing patients in whom pelvic organ functions have been compromised by neurological disease. The book provides a structured approach to present day understanding of the neurological control of pelvic organs and the investigation and management of each type of organ dysfunction. A unique feature of this book is that it addresses the impact of specific neurological disorders on all three functions. The authors have all been associated with the Department of Uro-Neurology at the National Hospital for Neurology and Neurosurgery, London since it was established 20 years ago. This book is a timely review of their accumulated knowledge and the latest literature.
Download or read book Brain Repair After Stroke written by Steven C. Cramer and published by Cambridge University Press. This book was released on 2010-10-28 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.
Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.
Download or read book Essentials of Interventional Techniques in Managing Chronic Pain written by Laxmaiah Manchikanti and published by Springer. This book was released on 2018-01-04 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive review covers the full and latest array of interventional techniques for managing chronic pain. Chapters are grouped by specific treatment modalities that include spinal interventional techniques, nonspinal and peripheral nerve blocks, sympathetic interventional techniques, soft tissue and joint injections, and implantables. Practical step-by-step and evidence-based guidance is given to each approach in order to improve the clinician's understanding. Innovative and timely, Essentials of Interventional Techniques in Managing Chronic Pain is a critical resource for anesthesiologists, neurologists, and rehabilitation and pain physicians.
Download or read book Pain Imaging written by Maria Assunta Cova and published by Springer. This book was released on 2019-03-06 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses all pain imaging aspects related to both the central nervous system and the body (thorax, abdomen and pelvis), thus updating the international literature on the topic. By adopting a clinical-radiological approach and offering a comprehensive differential diagnosis for a number of painful syndromes (many of which can mimic one other), the work aims to support and enhance the diagnostic management of these patients, suggesting the most appropriate diagnostic algorithm. The book is divided into separate sections for each anatomical macro-area, and the chapters cover the respective topics from both clinical and radiological perspectives. Further, the book includes extensive electronic supplementary material. As such, it offers an invaluable tool for radiologists, neuroradiologists and clinicians working in internal medicine, surgery and neurology, and could also be used in residency programs for these groups.
Download or read book The Pain Management Handbook written by M. Eric Gershwin and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those who do not feel pain seldom think that it is felt. SAMUEL JoHNSON, The Rambler, no. 48 (September 1, 1750) Who among us has not experienced the suffering of a patient with chronic disease, who in addition to the vicissitudes of fatigue, anxiety, and frustration, must also deal with the suffering of pain? Who among us has not considered, and then reconsidered, whether a patient's complaints are worthy of a narcotic and thence worried about the social and legal implications of chronic use? Who among us has not refused pain medications to our patients for fear that use was turning into abuse? Finally, who among us would not have liked a clinical guide to a myriad of syndromes, all of which have pain as their common denominator, in the hopes of developing some strategy to prioritize treatment. Our purpose in preparing The Pain Management Handbook is to provide the informa tion needed by clinicians to develop strategies that optimize pain management. It is the goal of the editors and authors that the present handbook, above all else, will be clinically useful. Its aim is to provide practical information regarding the diagnosis and treatment of disorders causing pain, along with tables and graphics to provide the busy practitioner with rapid access to relevant data.
Download or read book Essentials of Interventional Cancer Pain Management written by Amitabh Gulati and published by Springer. This book was released on 2018-12-28 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive review and expertise on various interventional cancer pain procedures. The first part of the text addresses the lack of consistency seen in the literature regarding interventional treatment options for specific cancer pain syndromes. Initially, it discusses primary cancer and treatment-related cancer pain syndromes that physicians may encounter when managing cancer patients. The implementation of paradigms that can be used in treating specific groups of cancer such as breast cancer, follows. The remainder of the text delves into a more common approach to addressing interventional cancer pain medicine. After discussing interventional options that are commonly employed by physicians, the text investigates how surgeons may address some of the more severe pain syndromes, and covers the most important interventional available for our patients, intrathecal drug delivery. Chapters also cover radiologic options in targeted neurolysis and ablative techniques, specifically for bone metastasis, rehabilitation to address patients’ quality of life and function, and integrative and psychological therapies. Essentials of Interventional Cancer Pain Management globally assesses and addresses patients’ needs throughout the cancer journey. Written by experts in the field, and packed with copious tables, figures, and flow charts, this book is a must-have for pain physicians, residents, and fellows.
