Download or read book Using Studies of Treatment Response to Inform Treatment Choice in Heterogeneous Populations written by Charles F. Manski and published by . This book was released on 2000 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important practical objective of empirical studies of treatment response is to provide decision makers with information useful in choosing treatments. Often the decision maker is a planner who must choose treatments for the members of a heterogeneous population; for example, a physician may choose medical treatments for a population of patients. Studies of treatment response cannot provide all the information that planners would like to have as they choose treatments, but researchers can be of service by addressing several questions: How should studies be designed in order to be most informative? How should studies report their findings so as to be most useful in decision making? How should planners utilize the information that studies provide? This paper addresses aspects of these broad questions, focusing on pervasive problems of identification and statistical inference that arise when studying treatment response.

Download or read book Programme Evaluation and Treatment Choice written by Markus Frölich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Policy evaluation and programme choice are important tools for informed decision-making, for the administration of active labour market programmes, training programmes, tuition subsidies, rehabilitation programmes etc. Whereas the evaluation of programmes and policies is mainly concerned with an overall assessment of impact, benefits and costs, programme choice considers an optimal allocation of individuals to the programmes. This book surveys potential evaluation strategies for policies with multiple programmes and discusses evaluation and treatment choice in a coherent framework. Recommendations for choosing appropriate evaluation estimators are derived. Furthermore, a semiparametric estimator of optimal treatment choice is developed to assist in the optimal allocation of participants.

Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Download or read book Foundations of Statistical Inference written by Yoel Haitovsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of papers presented at a conference held in Shoresh Holiday Resort near Jerusalem, Israel, in December 2000 organized by the Israeli Ministry of Science, Culture and Sport. The theme of the conference was "Foundation of Statistical Inference: Applications in the Medical and Social Sciences and in Industry and the Interface of Computer Sciences". The following is a quotation from the Program and Abstract booklet of the conference. "Over the past several decades, the field of statistics has seen tremendous growth and development in theory and methodology. At the same time, the advent of computers has facilitated the use of modern statistics in all branches of science, making statistics even more interdisciplinary than in the past; statistics, thus, has become strongly rooted in all empirical research in the medical, social, and engineering sciences. The abundance of computer programs and the variety of methods available to users brought to light the critical issues of choosing models and, given a data set, the methods most suitable for its analysis. Mathematical statisticians have devoted a great deal of effort to studying the appropriateness of models for various types of data, and defining the conditions under which a particular method work. " In 1985 an international conference with a similar title* was held in Is rael. It provided a platform for a formal debate between the two main schools of thought in Statistics, the Bayesian, and the Frequentists.

Download or read book Social Choice with Partial Knowledge of Treatment Response written by Charles F. Manski and published by Princeton University Press. This book was released on 2020-09-01 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Economists have long sought to learn the effect of a "treatment" on some outcome of interest, just as doctors do with their patients. A central practical objective of research on treatment response is to provide decision makers with information useful in choosing treatments. Often the decision maker is a social planner who must choose treatments for a heterogeneous population--for example, a physician choosing medical treatments for diverse patients or a judge choosing sentences for convicted offenders. But research on treatment response rarely provides all the information that planners would like to have. How then should planners use the available evidence to choose treatments? This book addresses key aspects of this broad question, exploring and partially resolving pervasive problems of identification and statistical inference that arise when studying treatment response and making treatment choices. Charles Manski addresses the treatment-choice problem directly using Abraham Wald's statistical decision theory, taking into account the ambiguity that arises from identification problems under weak but justifiable assumptions. The book unifies and further develops the influential line of research the author began in the late 1990s. It will be a valuable resource to researchers and upper-level graduate students in economics as well as other social sciences, statistics, epidemiology and related areas of public health, and operations research.

Download or read book Microeconometric Evaluation of Labour Market Policies written by Marco Caliendo and published by Springer Science & Business Media. This book was released on 2006-01-23 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evaluation of labour market and other public policies has become increasingly important in recent years. In an era of tight government budgets, a thorough analysis of these measures is imperative. This book provides a comprehensive overview and assessment of the most relevant microeconometric evaluation methods. It focuses on the popular propensity score matching method and gives extensive guidance for its implementation. In the second part of the book, this method is used to evaluate the employment effects of job creation schemes on the participating individuals in Germany. Based on a large administrative dataset of over 11,000 participants, the study allows to draw policy-relevant conclusions for the first time.

Download or read book Journal of Statistical Planning and Inference written by North-Holland Publishing Company and published by . This book was released on 2002 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Evaluating the Employment Effects of Job Creation Schemes in Germany written by Stephan Lothar Thomsen and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyses the employment effects of job creation schemes for participating individuals in Germany. Programs provide subsidized jobs that are additional in nature and of value for society. International evidence on their effectiveness suggests that programs should be targeted to the needs of the unemployed and should be offered early in the period of unemployment. Both questions are studied for job creation schemes in Germany.

Download or read book Patient Care Under Uncertainty written by Charles F. Manski and published by Princeton University Press. This book was released on 2019-09-10 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past few years, the author, a renowned economist, has been applying the statistical tools of economics to decision making under uncertainty in the context of patient health status and response to treatment. He shows how statistical imprecision and identification problems affect empirical research in the patient-care sphere.

Download or read book Identification for Prediction and Decision written by Charles F. Manski and published by Harvard University Press. This book was released on 2009-06-30 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a full-scale exposition of Charles Manski's new methodology for analyzing empirical questions in the social sciences. He recommends that researchers first ask what can be learned from data alone, and then ask what can be learned when data are combined with credible weak assumptions. Inferences predicated on weak assumptions, he argues, can achieve wide consensus, while ones that require strong assumptions almost inevitably are subject to sharp disagreements. Building on the foundation laid in the author's Identification Problems in the Social Sciences (Harvard, 1995), the book's fifteen chapters are organized in three parts. Part I studies prediction with missing or otherwise incomplete data. Part II concerns the analysis of treatment response, which aims to predict outcomes when alternative treatment rules are applied to a population. Part III studies prediction of choice behavior. Each chapter juxtaposes developments of methodology with empirical or numerical illustrations. The book employs a simple notation and mathematical apparatus, using only basic elements of probability theory.

Download or read book Partial Identification of Probability Distributions written by Charles F. Manski and published by Springer Science & Business Media. This book was released on 2006-04-29 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents in a rigorous and thorough manner the main elements of Charles Manski's research on partial identification of probability distributions. The approach to inference that runs throughout the book is deliberately conservative and thoroughly nonparametric. There is an enormous scope for fruitful inference using data and assumptions that partially identify population parameters.

Download or read book Demand Estimation with Heterogeneous Consumers and Unobserved Product Characteristics written by Patrick Bajari and published by . This book was released on 2001 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: We study the identification and estimation of preferences in hedonic discrete choice models of demand for differentiated products. In the hedonic discrete choice model, products are represented as a finite dimensional bundle of characteristics, and consumers maximize utility subject to a budget constraint. Our hedonic model also incorporates product characteristics that are observed by consumers but not by the economist. We demonstrate that, unlike the case where all product characteristics are observed, it is not in general possible to uniquely recover consumer preferences from data on a consumer's choices. However, we provide several sets of assumptions under which preferences can be recovered uniquely, that we think may be satisfied in many applications. Our identification and estimation strategy is a two stage approach in the spirit of Rosen (1974). In the first stage, we show under some weak conditions that price data can be used to nonparametrically recover the unobserved product characteristics and the hedonic pricing function. In the second stage, we show under some weak conditions that if the product space is continuous and the functional form of utility is known, then there exists an inversion between a consumer's choices and her preference parameters. If the product space is discrete, we propose a Gibbs sampling algorithm to simulate the population distribution of consumers' taste coefficients.

Download or read book Planning Your Research and How to Write It written by Aziz Nather and published by World Scientific. This book was released on 2015-10-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical guide for residents and young researchers who are planning to embark on research. It details the significant planning one must first do including choosing a suitable experienced clinician as a supervisor, sourcing for a 'winning idea' with significant clinical impact, performing a proper review of literature, defining clearly the objectives to be set and adopting the appropriate methodology. Statistical evaluation must be done from the start of the research to define adequate sample size and also for evaluation of the results. It also advises how one should draw upon relevant and appropriate conclusions from the results obtained.The ethics of research is also discussed. An all-important factor in research is the procurement of research grants. Readers are guided how to write a proper research proposal to secure these much needed grants.Many research papers end up as presentations only in local or international conferences. An important additional objective of this book is to guide young researchers how to write their finished product -- as a publication in an important international, refereed journal or as a thesis. Chapters have been specially written with tips for scientific writing, selecting the right journal, writing for an original article for a journal, a review article, a case report as well as for a thesis. Tips are also written on what reviewers of a journal look for in an article as well as what examiners look for in a thesis.

Download or read book Identification Problems in the Social Sciences written by Charles F. Manski and published by Harvard University Press. This book was released on 1999-03-15 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a language and a set of tools for finding bounds on the predictions that social and behavioral scientists can logically make from nonexperimental and experimental data. The economist Charles Manski draws on examples from criminology, demography, epidemiology, social psychology, and sociology as well as economics to illustrate this language and to demonstrate the broad usefulness of the tools. There are many traditional ways to present identification problems in econometrics, sociology, and psychometrics. Some of these are primarily statistical in nature, using concepts such as flat likelihood functions and nondistinct parameter estimates. Manski's strategy is to divorce identification from purely statistical concepts and to present the logic of identification analysis in ways that are accessible to a wide audience in the social and behavioral sciences. In each case, problems are motivated by real examples with real policy importance, the mathematics is kept to a minimum, and the deductions on identifiability are derived giving fresh insights. Manski begins with the conceptual problem of extrapolating predictions from one population to some new population or to the future. He then analyzes in depth the fundamental selection problem that arises whenever a scientist tries to predict the effects of treatments on outcomes. He carefully specifies assumptions and develops his nonparametric methods of bounding predictions. Manski shows how these tools should be used to investigate common problems such as predicting the effect of family structure on children's outcomes and the effect of policing on crime rates. Successive chapters deal with topics ranging from the use of experiments to evaluate social programs, to the use of case-control sampling by epidemiologists studying the association of risk factors and disease, to the use of intentions data by demographers seeking to predict future fertility. The book closes by examining two central identification problems in the analysis of social interactions: the classical simultaneity problem of econometrics and the reflection problem faced in analyses of neighborhood and contextual effects.

Download or read book Rutter s Child and Adolescent Psychiatry written by Anita Thapar and published by John Wiley & Sons. This book was released on 2015-08-03 with total page 1109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rutter's Child and Adolescent Psychiatry is the leading textbook in its field. Both interdisciplinary and international, it provides a coherent appraisal of the current state of the field to help researchers, trainees and practicing clinicians in their daily work. Integrating science and clinical practice, it is a comprehensive reference for all aspects of child and adolescent psychiatry. New to this full color edition are expanded coverage on classification, including the newly revised Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and new chapters on systems neuroscience, relationship-based treatments, resilience, global psychiatry, and infant mental health. From an international team of expert editors and contributors, this sixth edition is essential reading for all professionals working and learning in the fields of child and adolescent mental health and developmental psychopathology as well as for clinicians working in primary care and pediatric settings. Michael Rutter has contributed a number of new chapters and a Foreword for this edition: "I greatly welcome this new edition as providing both a continuity with the past and a substantial new look." —Professor Sir Michael Rutter, extract from Foreword. Reviews of previous editions: "This book is by far the best textbook of Child & Adolescent Psychiatry written to date." —Dr Judith Rapoport, NIH "The editors and the authors are to be congratulated for providing us with such a high standard for a textbook on modern child psychiatry. I strongly recommend this book to every child psychiatrist who wants a reliable, up-to-date, comprehensive, informative and very useful textbook. To my mind this is the best book of its kind available today." —Journal of Child Psychology and Psychiatry

Download or read book Textbook of Pharmacoepidemiology written by Brian L. Strom and published by John Wiley & Sons. This book was released on 2013-07-08 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Pharmacoepidemiology, Second Edition, provides an introduction to pharmacoepidemiology and the data sources, methods and applications used in clinical research, the pharmaceutical industry and regulatory agencies. Drawing upon the fifth edition of the authoritative reference, Pharmacoepidemiology, this new edition covers the key learning requirements of the discipline. The textbook provides an introduction to pharmacoepidemiology, pharmacoepidemiological data sources, special issues in methodology, special applications and future developments in the field. Updated learning features such as case studies, key points and Suggested Further Reading are included throughout the text. Textbook of Pharmacoepidemiology is a practical educational resource for upper-level undergraduates, graduate students, post-doctoral fellows in schools of public health, pharmacy and medicine, and for everyone learning and working in pharmacoepidemiology.

Download or read book The Massachusetts General Hospital Guide to Depression written by Benjamin G. Shapero and published by Springer. This book was released on 2018-10-17 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders, with a lifetime prevalence rate of roughly 20%. MDD is a leading cause of disability and premature death worldwide, leads to greater impairment in work functioning than other chronic medical conditions, and has an estimated annual cost of $210 billion in the US. The proposed text is designed for mental health professionals and will present state-of-the-art treatment options that are used in the Depression Clinical and Research Program (DCRP) at the Massachusetts General Hospital. The text provides different treatment options so that providers can ‘think outside the box’ of conventional interventions. The introductory sections discuss general themes about diagnosing and treating depression. The major body of the book, however, consists of chapters organized under the topics of new medication, new psychotherapy, alternative treatments, and consideration of specific populations and how to modify interventions to best treat these patients. Each chapter begins with a case vignette to illustrate key characteristics of the disorder process or treatment and reviews the history, research support, and new advances of these topics. In addition, the chapters include a description of how to apply this topic in treatment and frequently asked questions and answers. This book will be a unique contribution to the field. Existing guides focus on individual treatments of Depression, or include brief descriptions of interventions as a whole. The DCRP has consistently been a forerunner of clinical treatments for depression and often treats challenging cases of this disorder. This book will provide a practical and useful resource with wide applicability.