Download or read book Uptake of Ascorbic Acid by Adrenals and Brain and the Action of Steroid Hormones and ACTH written by Shail. K. Sharma and published by . This book was released on 1963 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "During the past three decades, following the isolation of ascorbic acid from bovine adrenal glands (1), there have been many investigations concerning the possible role of this vitamin in adrenal function. The elucidation of the mechanism and significance of ACTH (adrenocorticotrophic hormone) induced depletion of ascorbic acid is still a major problem in adrenocortical physiology. Ascorbic acid occurs in two forms, one being the oxidation product of the ether. Both forms are biologically active. They are water soluble, insoluble in organic solvents, and unstable when exposed to oxygen, light, alkalies and certain metals. The most prominent chemical property of ascorbic acid is its ready oxidation to dehydroascorbic acid, which is catalyzed by small concentrations of metal ions." --

Download or read book Adrenal Actions on Brain written by Detlev Ganten and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book ACTH Action in the Adrenal Cortex From Molecular Biology to Pathophysiology written by Nicole Gallo-Payet and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.

Download or read book Influence of Ascorbic Acid on Adrenal Calcium Uptake and Steroidogenesis in Young Guinea Pigs written by Marianna Karas Fordyce and published by . This book was released on 1976 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Adrenal Cortex written by Elaine Pandia Ralli and published by . This book was released on 1950 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Influence of Ascorbic Acid Nutriture on Basal Adrenocorticotrophin and Glucocorticoid Levels and the in Vivo Adrenal Response in ACTH Stimulation written by Margaret Mary Cobb and published by . This book was released on 1981 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Ascorbic Acid Transport and Steroidogenesis in the Rat Adrenal Gland in Vitro microfilm written by Michael Clayman and published by . This book was released on 1969 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application written by Klaus Ruckpaul and published by Taylor & Francis Group. This book was released on 1990 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of a series of books which aim to provide overviews of the current state of the art by specialists actively working in the field. The editors aim to focus on the borderline of our knowledge by presenting innovative results and controversial ideas.

Download or read book Van Nostrand s Scientific Encyclopedia written by Douglas M. Considine and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 3529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advancements in science and engineering have occurred at a surprisingly rapid pace since the release of the seventh edition of this encyclopedia. Large portions of the reference have required comprehensive rewriting and new illustrations. Scores of new topics have been included to create this thoroughly updated eighth edition. The appearance of this new edition in 1994 marks the continuation of a tradition commenced well over a half-century ago in 1938 Van Nostrand's Scientific Encyclopedia, First Edition, was published and welcomed by educators worldwide at a time when what we know today as modern science was just getting underway. The early encyclopedia was well received by students and educators alike during a critical time span when science became established as a major factor in shaping the progress and economy of individual nations and at the global level. A vital need existed for a permanent science reference that could be updated periodically and made conveniently available to audiences that numbered in the millions. The pioneering VNSE met these criteria and continues today as a reliable technical information source for making private and public decisions that present a backdrop of technical alternatives.

Download or read book Canadian Theses written by National Library of Canada and published by . This book was released on 1963 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1964 with total page 1098 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1985 with total page 1160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Vitamins and Hormones written by and published by Academic Press. This book was released on 1952-01-01 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamins and Hormones

Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

Download or read book Neurochemical Systems written by Abel Lajtha and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Understanding Pathophysiology E Book written by Sue E. Huether and published by Elsevier Health Sciences. This book was released on 2013-12-27 with total page 1187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn the essential concepts of pathophysiology and stay up to date on treatments, manifestations, and mechanisms of disease with Understanding Pathophysiology, 5th Edition. Filled with vibrant illustrations and complemented by online resources that bring pathophysiology concepts to life, this easy-to-read text delivers the latest, most accurate information on the disease process across the lifespan, giving you the fundamental knowledge you need to move forward in your nursing education. Consistent presentation helps you better distinguish pathophysiology, clinical manifestations, and evaluation and treatment for each disease. More than 1,000 high-quality illustrations vividly depict clinical manifestations and cellular mechanisms underlying diseases. Lifespan coverage details age-specific conditions affecting pediatric, adult, and aging patients in great depth. Algorithms throughout the text clarify disease progression. Risk Factor boxes alert you to important safety considerations associated with specific diseases. Health Alert boxes highlight new developments in biologic research, diagnostic studies, preventive care, treatments, and more. Quick Check boxes test your retention of important chapter concepts. Did You Understand? sections provide fast, efficient review of chapter content. Chapter outlines help you find specific information with ease. Chapter introductions explain why chapter content is important and how it fits into a broader health care context. Key terms are bolded throughout the text for fast, easy reference. Glossary of selected terms familiarizes you with the most difficult or important terminology. Companion Evolve website provides convenient online access to animations, review questions, key terms matching exercises, and more. NEW! Extensively updated content reflects the latest clinical findings and research across the full spectrum of pathophysiology. NEW! Hundreds of new and enhanced full-color illustrations clarify anatomy and physiologic concepts. NEW! 30 new animations on the companion Evolve website reinforce your understanding of complex processes.