Download or read book Unintended Target written by Katie Reus and published by Katie Reus. This book was released on 2022-08-29 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: He’s not her type. Elementary school teacher Patience had her whole summer planned out, and it included margaritas and time at the beach. But when she agrees to a temporary nanny position as a favor to a friend, the last thing she expected was to butt heads with—or be attracted to—Brodie MacArthur, her employer’s sexy head of security. But that doesn’t stop her from wanting him. Brodie made a mistake with Patience and forever ruined her first impression of him. Just as their heated clashes reach a peak, Patience falls ill…and it’s something far more sinister than a simple summer bug. He screwed up once. He won’t do it again. And when he learns that the danger is closer than they imagined, he’ll have to fight to protect her—and win her heart. Length: NOVELLA MacArthur Family Series Falling for Irish, #1 Unintended Target, #2 Saving Sienna, #3

Download or read book Unintended Target written by Katie Reus and published by . This book was released on 2021-03-23 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: When Patience agrees to a temporary nanny position as a favor to a friend, she doesn't expect to run afoul of Brodie MacArthur, her employer's handsome head of security. Just as their heated clashes reach a peak, Patience falls ill?and it may be something far more sinister than a simple summer bug. She was so focused on her young charge, she failed to watch her own back. Can she trust Brodie to protect her while shielding her heart from the infuriating man she can't walk away from?MacArthur Series, #2

Download or read book Criminal Law written by David C. Brody and published by Jones & Bartlett Publishers. This book was released on 2014-06-04 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of Criminal Law introduces readers to the underlying principles, legal doctrine, and rules of criminal law. The innovative and highly student-friendly text uses real-world case examples to contextualize laws and give students a solid foundation in substantive criminal law while guiding them through what the law is, how it evolved, and the principles on which it is based. By studying case materials, students will develop the analytical skills essential to understanding how legal principles have developed over time and how they are best applied to ever-changing factual situations.

Download or read book Unintended Detour written by D L Wood and published by Independently Published. This book was released on 2021-09-29 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Can be read as a stand-alone novel.) A hundred-year-old secret might be the cause of and the key to solving a murder. Jack and Chloe Bartholomew just wanted a romantic second honeymoon in the beautiful Hudson River Valley at the legendary hotel his family recently acquired. After Chloe's job loss, Jack's writer's block, and a disheartening personal disappointment, they could use a break. However, instead of hot chocolate and horseback rides through the snow, things are all wrong at the Stonehall Estate Resort. First, they learn of months of unexplained mishaps. Then there's a murder-and it's not the first at this historically tragic mansion. It soon becomes clear someone wants the resort to fail and will stop at nothing to make that happen. The question is...why? Eager to help the family business, Chloe picks up where the hotel's last historical curator left off. But things quickly become dangerous when her research uncovers truths hidden for decades-clues related not only to mysteries sparked by a young girl's death in 1931, but also those haunting the estate today. Before long Chloe finds herself in a deadly race to expose the mansion's secrets before more innocents become victims of the malevolent force behind it all. Will Chloe bring the long-lost truth to light in time, or will she be the next to fall prey to the dark scheme that could claim everything, including her life? If you enjoy riveting intrigue, heart-warming romance and heroines and heroes you can't help but root for, you'll love USA TODAY bestselling author D.L. Wood's third installment in the award-winning Unintended Series of thrilling suspense novels laced with romance and faith.

Download or read book Criminal Law written by David Brody and published by Jones & Bartlett Learning. This book was released on 2010 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The highly anticipated Second Edition of Criminal Law introduces students to the underlying principles, legal doctrine, and rules regarding crimes, defenses, and punishment in substantive criminal law. Innovative in its case study approach, this thoroughly updated revision will help students develop analytical skills, while learning the content and context of substantive criminal law. Now with a more student-friendly format, this text guides students through theory and practice, using a blend of old and new materials to foster understanding of what the law is, how it evolved, the principles on which it is based, and how it applies to various circumstances.

Download or read book Early Drug Development written by Mitchell N. Cayen and published by John Wiley & Sons. This book was released on 2011-02-25 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an Investigational New Drug (IND) application. By explaining the nuts and bolts of preclinical development activities and their interplay in effectively identifying successful clinical candidates, the book helps pharmaceutical scientists determine what types of discovery and preclinical research studies are needed in order to support a submission to regulatory agencies.

Download or read book Introducing Pharmacology written by Roger McFadden and published by Taylor & Francis. This book was released on 2024-09-17 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of Introducing Pharmacology provides an accessible and engaging introduction to the subject of pharmacology for nursing and healthcare students – in fact any healthcare professional needing to refresh their knowledge of this important area. The fourth edition has been fully updated to include recently introduced drugs and a completely new chapter that takes the reader through the process of drug development and the clinical trials that are required before a drug is licensed for prescribing to patients. Acknowledging the COVID pandemic of 2020/21, a review of the vaccines and drugs used against coronavirus (SARS-CoV-2) is included in this edition. This popular text includes: Clear explanations of how drugs work in the human body The underlying physiology and pathophysiology necessary for an understanding of the action of drugs Coverage of the common drug groups that nurses and other healthcare professionals are likely to encounter in practice Case-studies relating pharmacological theory to clinical practice ‘Beyond the basics’. A feature providing an in-depth explanation of the mechanism of action of key drugs. Useful for students studying at a more advanced level New to this edition: A new chapter explaining how drugs are developed and undergo testing in clinical trials. This chapter also includes a section on the critical analysis of clinical trials and a brief explanation of the statistics used to present trial data An expanded chapter on pharmacokinetics, including the effect of renal and hepatic insufficiency on drug metabolism, and the new science of pharmacogenomics – the matching of drugs to patients, based on their individual genetics A new section on common skin complaints, psoriasis, eczema and the drugs used to treat them An expanded section on post-menopausal problems and the drugs used to alleviate symptoms Updated content that reflects the latest guidelines and recently licensed drugs This textbook is an essential companion for nursing, midwifery students and other healthcare professions, as well as those on post-registration courses, studying to become independent prescribers.

Download or read book Oligonucleotide Based Drugs and Therapeutics written by Nicolay Ferrari and published by John Wiley & Sons. This book was released on 2018-06-06 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates • Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide-Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post-graduates interested in therapeutics, antisense therapy, and oligonucleotides.

Download or read book Principles of Safety Pharmacology written by Michael K. Pugsley and published by Springer. This book was released on 2015-06-19 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

Download or read book Quadruplex Nucleic Acids As Targets For Medicinal Chemistry written by and published by Academic Press. This book was released on 2020-08-26 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Annual Reports in Medicinal Chemistry series

Download or read book Nonclinical Safety Assessment written by William J. Brock and published by John Wiley & Sons. This book was released on 2013-04-29 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonclinical Safety Assessment Nonclinical Safety Assessment A Guide to International Pharmaceutical Regulations Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a practical description of nonclinical drug development regulations and requirements in the major market regions. It includes: ICH – the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use National regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and Australia Repeated dose toxicity studies Carcinogenicity; Genotoxicity; Developmental and reproductive toxicology; Immunotoxicology Biotechnology-derived pharmaceuticals Vaccine development Phototoxicity and photocarcinogenicity Degradants, impurities, excipients and metabolites Primarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.

Download or read book The Modern Day Gunslinger written by Don Mann and published by Skyhorse Publishing, Inc.. This book was released on 2010-08-01 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: A result of twelve years of research, The Gunfighter's Bible was written to meet the needs of the gun owner, the experienced shooter, those who own a weapon strictly for home and self-defense, and for the military member who wants to become a better shooter in defense of our country. It's also for the law enforcement officer who risks his or her life going against the thugs of our society, and for anyone interested in learning the defensive and tactical training techniques from some of the best and most experienced shooters in the world. The shooting skills taught in this book carry broad application in civilian, law enforcement, and military contexts. Common criminals, terrorists, assailants—the enemy and threat—all will find themselves outgunned in the face of a properly armed and trained gunslinger. Members of the armed services, government and law enforcement agencies, as well as civilians, will find that the close-range shooting methods addressed in this book can provide a decisive advantage. An all-encompassing manual that addresses safety, equipment, tactics, and the best practices for all shooters, The Gunfighter's Bible is the most all-encompassing book on shooting ever published. It's a book that, in the words of senior special agent and U.S. government senior weapons and tactics instructor Dick Conger, "will save lives."

Download or read book Functional Protein Microarrays in Drug Discovery written by Paul F. Predki and published by CRC Press. This book was released on 2007-03-30 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic principles, methods, and applications. The book discusses the generation of functional protein content and describes both standard and state-of-the-art fabrication methods. It reviews current and next generation approaches to assay detection and presents a wide range of applications, from biomolecular interaction discovery and characterization to immune response profiling. The book also addresses several fundamental computational issues, bioinformatics and data analysis.

Download or read book Targeted Killings Law and Counter Terrorism Effectiveness written by Ophir Falk and published by Routledge. This book was released on 2020-06-01 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the permissibility and effectiveness of targeted killing in campaigns against terror. Targeted killing has become a primary counterterrorism measure used by several countries in their confrontation with lethal threats. The practice has been extensively used by the US in Afghanistan, Iraq, Pakistan, Yemen and Somalia, and by Israel in the West Bank and Gaza. Several studies have already explored the difficult balance between achieving security while maintaining the liberties and rights of a country’s civilians. This book goes a step further by seeking to examine whether maintaining those liberties by complying with legal standards and minimizing unintended deaths can be more effective for national security. Using targeted killing applied by Israel, in particular, as well as the United States during the first decade of the twenty-first century as case studies, this book explores that question and ultimately assesses whether compliance with legal standards can strengthen a state in its campaign against terrorism and thus provide stronger security. The book focuses on civilian-related criteria, hypothesizing that minimizing civilian casualties will maximize effectiveness in an asymmetric war setting. The conclusions are not limited to a specific tactic or theater, and if adopted might have far-reaching implications for how asymmetric warfare is strategized. This book will be of much interest to students of counter-terrorism, law, Middle Eastern studies, and security studies.

Download or read book Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2013 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 2012 with total page 1772 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetically Modified and Irradiated Food written by Veslemøy Andersen and published by Academic Press. This book was released on 2020-01-09 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetically Modified and Irradiated Food: Controversial Issues: Facts versus Perceptions explains the technologies used in these processes so they can be understood by those in general public health, scientific organizations, politicians and opinion makers/policymakers. The facts presented include a massive amount of scientific evidence that these technologies are safe and can be beneficial. Because the world is facing a future with an increasing number of people, new technologies are needed to ensure enough safe and healthy food, thus technologies that have the potential to dramatically increase the availability of safe and healthy food should be welcomed by everybody. - Includes references to science based research on GMOs - Explains the technologies in a clear way that can be understood by the general public - Includes a massive amount of scientific evidence that these technologies are safe and can be beneficial

Download or read book Targeted Sanctions written by Thomas J. Biersteker and published by Cambridge University Press. This book was released on 2016-03-17 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematically analyzes the impacts and the effectiveness of UN targeted sanctions over the past quarter century.