Download or read book Understanding the Potential Mechanisms by which Peri vascular Adipose Tissue PVAT contributes to obesity related Cardiovascular Diseases CVDs written by Dr. Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2020-07-02 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the Potential Mechanisms by which Peri-vascular Adipose Tissue (PVAT) contributes to obesity-related Cardiovascular Diseases (CVDs)., Obesity is a fast-growing problem that is reaching epidemic magnitudes worldwide, affecting both children and adults. It is associated with increased risk of: ü premature death, ü morbidity, and ü mortality from several cardiovascular diseases (CVDs), including: ü stroke, ü coronary heart disease (CHD), ü myocardial infarction, and ü congestive heart failure. Although several studies have substantiated that obesity confers an independent and additive risk of all-cause and cardiovascular death, there is significant variability in these associations, with some lean individuals developing diseases and others remaining healthy despite severe obesity, the so-called metabolically healthy obese. Part of this variability has been attributed to the heterogeneity in both the distribution of body fat and the intrinsic properties of adipose tissue depots, including: ü developmental origin, ü adipogenic and proliferative capacity, ü glucose and lipid metabolism, ü hormonal control, ü thermogenic ability, and ü vascularization. In obesity, these depot-specific differences translate into specific fat distribution patterns, which are closely associated with differential cardiometabolic risks. The adventitial fat layer, also known as perivascular adipose tissue (PVAT), is of major importance. Similar to the visceral adipose tissue, PVAT has a pathophysiological role in CVDs. PVAT influences vascular homeostasis by releasing numerous vasoactive factors, cytokines, and adipokines, which can readily target the underlying smooth muscle cell layers, regulating the vascular tone, distribution of blood flow, as well as angiogenesis, inflammatory processes, and redox status. An effort has been made in this Booklet to summarize the current knowledge and discuss the role of PVAT within the scope of adipose tissue as a major contributing factor to obesity-associated cardiovascular risk along with several relevant illustrations. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Download or read book Perivascular Adipose Tissue PVAT in Health and Disease written by Stephanie W. Watts and published by Frontiers Media SA. This book was released on 2018-10-05 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contribution of Perivascular Adipose Tissue to Coronary Vascular Dysfunction written by Gregory Allen Payne and published by . This book was released on 2010 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epidemic of obesity and associated cardiovascular complications continues to grow at an alarming rate. Currently, obesity is thought to initiate a state of chronic inflammation, which if unresolved potentially causes cardiovascular dysfunction and disease. Although poorly understood, release of inflammatory mediators and other cytokines from adipose tissue (adipocytokines) has been proposed to be the molecular link between obesity and coronary artery disease. Furthermore, the anatomic location of adipose has been increasingly recognized as a potential contributor to vascular disease. Importantly, the development of coronary atherosclerosis, a key component of heart disease, is typically found in segments of coronary arteries surrounded by perivascular adipose tissue. Accordingly, the goal of this project was to determine how perivascular adipose tissue affects coronary artery function and elucidate the critical mechanisms involved. Initial studies assessing arterial function were conducted with and without perivascular adipose tissue. Preliminary results demonstrated that factors released by perivascular adipose tissue effectively impaired coronary endothelial function both in vitro and in vivo. This observation was determined to be caused by direct inhibition of nitric oxide synthase ос), А ЦРИТИЦАЛ ЕНЗЫМЕ ФОР ТХЕ ПРОДУЦТИОН НИТРИЦ ОЬИДЕ. аТТЕНУАТИОН ОФ ЕНДОТХЕЛИУМ-ДЕПЕНДЕНТ ЖАСОДИЛАТИОН ВАС ИНДЕПЕНДЕНТ ОФ ЦХАНГЕС ИН СУПЕРОЬИДЕ ПРОДУЦТИОН, СМООТХ МУСЦЛЕ РЕСПОНСЕ, ОР ПЕРОЬИДЕ-МЕДИАТЕД ЖАСОДИЛАТИОН. аДДИТИОНАЛ СТУДИЕС РЕЖЕАЛЕД ТХАТ ПЕРИЖАСЦУЛАР АДИПОСЕ-ИНДУЦЕД ИМПАИРМЕНТ ОФ нос ВАС ДУЕ ТО ИНЦРЕАСЕД ИНХИБИТОРЫ РЕГУЛАТИОН БЫ ТХЕ �ø ИСОФОРМ ОФ ПРОТЕИН КИНАСЕ ц (пкц-�ø). сПЕЦИФИЦАЛЛЫ, ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ФАЦТОРС ЦАУСЕД СИТЕ СПЕЦИФИЦ ПХОСПХОРЫЛАТИОН ОФ НИТРИЦ ОЬИДЕ СЫНТХАСЕ АТ тХР-495. аДДИТИОНАЛ ЕЬПЕРИМЕНТС ИНЖЕСТИГАТЕД ХОВ ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ФАЦТОРС ЦОНТРИБУТЕД ТО ЦОРОНАРЫ АРТЕРЫ ДИСЕАСЕ ИН АН АНИМАЛ МОДЕЛ ОФ ОБЕСИТЫ. рЕСУЛТС ФРОМ ТХЕСЕ СТУДИЕС ИНДИЦАТЕД ТХАТ ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ЛЕПТИН МАРКЕДЛЫ ЕЬАЦЕРБАТЕД УНДЕРЛЫИНГ ЕНДОТХЕЛИАЛ ДЫСФУНЦТИОН, АНД СИГНИФИЦАНТЛЫ ЦОНТРИБУТЕД ТО ЦОРОНАРЫ ЕНДОТХЕЛИАЛ ДЫСФУНЦТИОН ТХРОУГХ А пкц-�ø ДЕПЕНДЕНТ МЕЦХАНИСМ. фИНДИНГС ФРОМ ТХИС ПРОЙЕЦТ ЦОНФИРМ ЕПИЦАРДИАЛ ПЕРИЖАСЦУЛАР АДИПОСЕ ТИССУЕ АС А ЛОЦАЛ СОУРЦЕ ОФ ХАРМФУЛ АДИПОЦЫТОКИНЕС. иН АДДИТИОН, ПЕРИЖАСЦУЛАР АДИПОСЕ-ДЕРИЖЕД ЛЕПТИН ВАС ДЕМОНСТРАТЕД ТО БЕ А ЦРИТИЦАЛ МЕДИАТОР ОФ ЦОРОНАРЫ ЖАСЦУЛАР ДЫСФУНЦТИОН ИН ОБЕСИТЫ. тОГЕТХЕР, ТХЕ РЕСУЛТС СТРОНГЛЫ СУГГЕСТ ТХАТ ПЕРИЖАСЦУЛАР АДИПОСЕ ТИССУЕ ИС А КЕЫ ЦОНТРИБУТОР ТО ЦОРОНАРЫ АРТЕРЫ ДИСЕАСЕ ИН ОБЕСИТЫ.
Download or read book Epicardial Adipose Tissue written by Gianluca Iacobellis and published by Springer Nature. This book was released on 2020-03-25 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.
Download or read book Obesity and Cardiovascular Disease written by Gianluca Iacobellis and published by Oxford University Press. This book was released on 2009-10-08 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essential book comprehensively covers the diagnosis, treatment and management of cardiovascular disease in obese patients, translating up-to-date clinical research findings into clinical practice.
Download or read book Adipose Tissue in the Cardiovascular Homeostasis and Disease written by Thiago Bruder and published by Frontiers Media SA. This book was released on 2022-01-13 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Download or read book Microcirculation in Cardiovascular Diseases written by Enrico Agabiti-Rosei and published by Springer Nature. This book was released on 2020-10-03 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.
Download or read book Diabetes Augmentation on Vascular Disease written by Godfrey Getz and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vascular Adjustments in Cardiovascular Disorders written by Luciana Venturini Rossoni and published by Frontiers Media SA. This book was released on 2021-12-30 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Download or read book Exploring the Crosstalk Between Adipose Tissue and the Cardiovascular System written by Nadia Akawi and published by Frontiers Media SA. This book was released on 2022-09-27 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Pharmacology Endothelial Control written by and published by Academic Press. This book was released on 2010-12-16 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions. Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field
Download or read book The impact of adipose tissue dysfunction on cardiovascular and renal disease volume II written by Xiaodong Sun and published by Frontiers Media SA. This book was released on 2023-07-03 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Visceral and Ectopic Fat written by Hildo J. Lamb and published by Elsevier. This book was released on 2022-10-28 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers. Brings together up-to-date research on imaging, genetics, and risk factors for chronic diseases such as diabetes, heart disease, cancer, and fatty liver disease Takes a deep dive into the current state of knowledge regarding fat stores, ectopic fat, regulation of fat stores, clinical implications, interventions, and imagining techniques Provides up-to-date information specifically focused on visceral and ectopic fat. In addition, both pathophysiological and preventive and treatment aspects of the problem will be considered Covers a broad range of organs - different fat stores such as skeletal muscle, bone marrow, liver and kidney Discusses potential interventions to reduce abdominal fat
Download or read book Oxford Textbook of Medicine Cardiovascular Disorders written by David Warrell and published by Oxford University Press. This book was released on 2016-06-03 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Medicine: Cardiovascular Disorders is selected from the cardiology section of the renowned Oxford Textbook of Medicine. An authoritative resource on heart disease and beautifully illustrated in full colour, it is an essential guide to best practice in managing and preventing a wide variety of cardiovascular disorders. Chapters on arrhythmias, acute coronary syndromes and cardiac surgery have been completely revised and updated, together with new chapters on blood vessels and the endothelium, cardiac physiology, syncope and palpitations, and cardio-renal syndrome. Heart failure and heart disease in pregnancy are thoroughly treated, while imaging chapters evaluate the latest techniques and illustrate all clinical features with detailed images. In 46 finely crafted chapters with clear essentials, experts in cardiovascular disease review the essentials of diagnosis, guidelines and practice and provide a wealth of practical advice for use in clinical situations. In addition, background information on epidemiology, pathogenesis and pathophysiology encourages a fuller understanding of conditions, and more than 350 full colour images help with diagnosis. This essential reference tool supports all medical professionals seeking a general outline of treatment and prevention of cardiovascular disorders, and fills the gap between undergraduate teaching texts and specialist texts for cardiologists. Cardiologists and general physicians will find it immensely valuable when diagnosing and managing heart disease in their day-to-day practice. It is also of usefor trainees in cardiology and general medicine, especiallythose interested in applied cardiovascular pathophysiology.
Download or read book The Impact of Adipose Tissue Dysfunction on Cardiovascular and Renal Disease written by Xiaodong Sun and published by Frontiers Media SA. This book was released on 2022-02-11 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
