Download or read book Understanding Prostate Cancer Pathogenesis written by Chieh-Yang Cheng and published by . This book was released on 2014 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most prevalent type of cancer in men. However, there is no cure for relapsed androgen withdrawal-refractory prostate cancer which is fatal due to metastasis. Many studies have demonstrated the existence of cancer cells with stem cell properties (aka cancer propagating cells (CPCs)) within the cancer cell population. CPCs may cause cancer recurrence due to resistence to conventional therapies. Understanding molecular and cellular mechanisms governing normal prostate stem cells and CPCs may improve our understanding and provide new opportunities for the design of therapeutics acting specifically on CPCs. Two of such mechanisms, p53/microRNA-34/Met network and neuroendocrine (NE) signaling are the topic of my dissertation. microRNA-34 (miR-34) family has been proposed to play a tumor suppressor role in various cancers, including the prostate cancer. However, direct genetic evidence for the tumor suppressor functions of miR-34 under physiologically relevant settings has been lacking. By using newly generated mice carrying conditional alleles of mir-34, we have shown that miR-34 cooperates with p53 in suppression of prostate carcinogenesis by joint control of MET-dependent prostate stem/progenitor cells. Thus, therapeutic targeting of MET is likely to affect CPCs, particularly in p53 and miR-34 deficient patients. NE signaling has been shown to be one of the features in advanced prostate cancer. However, the roles of NE cells in prostate carcinogenesis and development are insufficiently elucidated. By using bacterial artificial chromosome (BAC) we have generated a mouse model for conditional NE cell ablation, and shown that prostate epithelium-specific ablation of NE cells results in prostate hypotrophy, suggesting NE cells play an important role in prostate development. Moreover, we have studied effects of neuropeptide in membrane metallo-endopeptidase (Mme) null mice, and shown that Mme cooperates with Pten to suppress prostate carcinogenesis in the control of prostate stem/progenitor cells. Gastrin-releasing peptide (GRP), a substrate of MME, showed similar effects on mouse prostate stem/progenitor cells and human prostate CPCs. These effects were effectively abrogated by GRP receptor (GRPR) antagonist or knockdown of GRPR expression. Taken together, these findings show critical role of NE signaling in prostate development and carcinogenesis and GRPR is a potential therapeutics targeting prostate CPCs.
Download or read book Prostate Cancer written by Gordana Kocic and published by Springer Nature. This book was released on with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Precision Molecular Pathology of Prostate Cancer written by Brian D. Robinson and published by Springer. This book was released on 2018-02-13 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.
Download or read book Prostate Cancer written by Leland W. K. Chung and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.
Download or read book Fast Facts Prostate Cancer written by Roger S. Kirby and published by Karger Medical and Scientific Publishers. This book was released on 2017-03-08 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is unusual among solid tumors in that the majority of affected men die with, rather than of, the disease. This presents many challenges to healthcare professionals and patients in terms of deciding if, when and how to intervene in order to control tumor growth and spread, thereby extending survival but without compromising quality of life. This is the ninth edition of 'Fast Facts: Prostate Cancer' since 1996, testament to the rapid changes in the field and the steadily improving outlook for patients. This new edition provides many key updates: • the Gleason grade grouping, which has valuable prognostic value • nomograms to evaluate risk • our rapidly expanding understanding of the genetics and underlying pathogenesis of prostate cancer and the development of genomic tests to help identify those at greatest risk of developing clinically significant disease • the continuing debate about the role of PSA in the screening, detection and monitoring of prostate cancer • advances in imaging techniques, particularly multiparametric MRI, which is improving the accuracy of biopsy and reducing the numbers of negative biopsies • the roles of drugs, surgery and radiotherapy in the treatment of prostate cancer at different stages, and our ever-improving understanding of when and how best to intervene, aided by improving understanding of the risk factors for disease progression. Primarily intended for primary care providers, specialist nurses, junior doctors and allied healthcare professionals, this highly readable resource provides a comprehensive overview of prostate cancer, enabling fully informed discussions with patients about this complex disease. Contents: • Epidemiology and pathophysiology • Diet, lifestyle and chemoprevention • Screening and early detection • Diagnosis, staging and prognostic indicators • Management of clinically localized disease • Managing recurrence after initial therapy • Management of metastatic prostate cancer • Management of castrate-resistant prostate cancer • Survivorship and treatment complications
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book PROSTATE CANCER 20 20 A Practical Guide to Understanding Management Options for Patients and Their Families written by Andrew Siegel MD and published by Rogue Wave Press. This book was released on 2019-01-01 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: PROSTATE CANCER 20/20 is a streamlined guide to understanding prostate cancer and its management options to enable the newly-diagnosed patient to make an informed choice. Advances in prostate cancer are reviewed: screening and diagnostic testing refinements; preventive measures; advanced imaging techniques; genetic/genomic testing; active surveillance; technical progress in surgical, radiation and focal therapies; new medications for advanced prostate cancer. In-depth information is provided on sexual and urinary complications of treatments and how they are managed. This book is intended for: · Newly diagnosed patients · Patients who have failed primary treatments · Patients with urinary and sexual side effects · Family members
Download or read book Textbook of Prostate Cancer Pathology Diagnosis and Treatment written by Louis J Denis and published by CRC Press. This book was released on 1999-03-01 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Prostate Cancer covers major developments in diagnosis, surgery and medical treatment.
Download or read book Prostate Cancer written by Scott M. Dehm and published by Springer Nature. This book was released on 2020-01-03 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.
Download or read book The Oncobiology of the Prostate written by D.P. Wood and published by Elsevier. This book was released on 2000-12-20 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer (PCa) is the most common newly diagnosed cancer among men in the United States today. With the advent of the prostate-specific antigen (PSA) test, the number of newly diagnosed cases has increased tremendously. The rates of PCa have increased so dramatically over the last decade that the age-adjusted incidence rate of PCa is no greater than that for any other cancer among men in the United States. Although PCa rates have risen steadily since 1973, there has been a dramatic acceleration in the late 1980s which has been associated with the introduction and use of PSA for screening and early detection. There is now some evidence that the rates may be levelling off and even decreasing in some areas. After lung cancer, PCa is the leading cause of death due to cancer in men in the United States. Although PCa can occur in younger men, it is essentially a cancer of elderly men. The highest rates of PCa in the world occur among African-American men in the United States. African-Americans have higher rates than Caucasians at all age levels in the United States, and adjusting for social-economic status does not appear to account for this difference to any appreciable extent. There is no clear reason why PCa rates are so much greater among African-Americans compared with Caucasians in the United States. The reported rates in Africans are substantially lower than those of an African-American, suggesting that environmental factors have an influence on PCa. In spite of this substantial impact on our society. PCa remains a relatively understudied disease, with an essentially unknown etiology. The reviews contained in this book are by no means exhaustive. We have, however, attempted to provide information regarding the pathology of prostate cancer, the status of diagnostic and prognostic markers, as well as a discussion of our understanding of the molecular basis for the disease. The biology of prostate cancer is covered with a discussion on the role of apoptosis in prostate cancer and the suggestion of it being the target for new therapeutic development, as well as the role played by integrins and angiogenesis. The status of current therapies, both hormonal and chemotherapy, are also discussed. This volume should provide a useful background for individuals wishing to commence an in-depth understanding of prostate cancer.
Download or read book Essential Concepts in Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2019-11-23 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
Download or read book Prostate Cancer written by Jack H. Mydlo and published by Elsevier. This book was released on 2003-07-11 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important translational book bridging the gap between science and clinical medicine, Prostate Cancer reviews the biological processes that can be implicated in the disease, reviews current treatments, highlighting the pitfalls where relevant and examines the scientific developments that might result in novel treatments in the future.Key Features* Provides a translational resource for scientists and clinicians working on prostate cancer* Reviews current surgical interventions and highlights their related pitfalls* Presents the latest laparoscopic techniques with figures and illustrations of step-by-step procedures* Offers insight into the potential for novel approaches to treatment in the future* Includes personal perspectives from patients
Download or read book Fast Facts Prostate Cancer written by R.S. Kirby and published by Karger Medical and Scientific Publishers. This book was released on 2020-07-07 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the tenth edition of this Fast Facts handbook since the first was published in 1996 – the many iterations are testament to the rapid changes in the field and steadily improving outlook for patients. This new edition introduces the Gleason grade grouping (Chapter 1), which has important prognostic value, and nomograms that are used to evaluate risk (Chapter 3). Our understanding of the genetics and underlying pathogenesis of prostate cancer is growing apace, leading to the identification of germline mutations and the development of genomic tests to help identify and direct therapy for those at greatest risk of developing clinically significant disease. They also provide reassurance for those patients who have opted for active surveillance (Chapters 3 and 5). Imaging techniques are also improving rapidly, particularly multiparametric MRI (Chapter 4). As this book is concise, fully up to date and evidence based, we believe it is an ideal resource for those general urologists, primary care providers, specialist nurses, trainees and allied healthcare professionals who want to get quickly up to speed in this fast-moving and ever-expanding field. Contents: • Epidemiology and pathophysiology • Diet, lifestyle and chemoprevention • Screening and early detection • Diagnosis, staging and prognostic indicators • Management of clinically localized disease • Managing recurrence after initial therapy • Managing metastatic hormone-sensitive prostate cancer • Management of castrate-resistant prostate cancer • Survivorship and management of treatment-related side effects and complications
Download or read book Insights Into Prostate Cancer Pathogenesis written by Behnam Sayanjali and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adenocarcinoma of the Prostate written by Andrew W. Bruce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.
Download or read book Pathogenesis and Treatment of Canine Prostate Cancer written by Said Elshafae and published by . This book was released on 2017 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer (PCa) is the most common malignant neoplasm among men in Western countries and the second leading cause of cancer mortalities after lung cancer. It is expected that by 2016, 180,890 men will be diagnosed with prostate cancer and 26,120 will die due to the disease. One of the most frequent complications of prostate cancer in patients is bone metastasis. Osteoblastic bone metastasis is the predominant finding at sites of skeletal metastases. Understanding the pathogenesis of prostate cancer progression and bone metastasis and targeting these processes are very important to control this aggressive disease. The main objectives of this work were to identify the role of signaling pathways that have shown to be upregulated in prostate cancer, evaluate a histone deacetylase inhibitor in treatment of prostate cancer metastasis and develop an osteoblastic PCa model for further understanding the molecular mechanisms of bone metastases. Intensive studies have been performed for better understanding the role of various signaling pathways in PCa progression and metastasis. Importantly, gastrin-releasing peptide receptor (GRPr) signaling was shown to be upregulated in human prostatic intraepithelial neoplasia (PIN), invasive prostatic carcinoma and related skeletal metastases. Our objective in this study was to determine the importance of this signaling in the pathogenesis of PCa progression. By activation of GRPr signaling using bombesin (BBN), there was an increase in proliferation and migration of canine prostate cancer cells. GRPR signaling also modulated the expression level of genes that are implicated in epithelial-mesenchymal transition (EMT), growth, invasion and metastasis of PCa. Histone deacetylase inhibitors (HDACi) are a class of therapeutics that can prevent tumor growth and induce differentiation and apoptosis in a wide group of cancers. AR-42, a HDACi, was shown to be efficient against multiple myeloma, lung cancer and hepatocellular carcinoma. In this study, we evaluated AR-42 as an anti-metastatic drug against canine prostate cancer. AR-42 decreased the mRNA expression level of anoikis resistance and osteomimicry genes in vitro. AR-42 declined the incidence of xenograft bone metastases and tumor growth and increased apoptosis and stemness of metastatic tumors. Osteoblastic bone metastasis is very common finding in PCa patients. During PCa progression, cancer cells acquire osteomimicry properties that facilitate their metastasis and support their proliferation and survival in the bone microenvironment. The pathogenesis of osteoblastic bone metastasis and osteomimicry is still not well understood. For this reason, we developed and characterized a novel canine prostatic cancer cell line (LuMa) that had osteomimicry properties and induced osteoblastic bone metastasis in vivo. The predominant sites of LuMa cells metastasis were bone, brain and adrenal glands.
