Download or read book Elements of Synthesis Planning written by R. W. Hoffmann and published by Springer Science & Business Media. This book was released on 2009-01-07 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.
Download or read book Umpoled Synthons written by Tapio A. Hase and published by Wiley-Interscience. This book was released on 1987-05-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide chemists who plan their synthetic routes manually with information on some of the new umpoled synthons. The introductory chapter examines, in general, the use of synthons in planning organic syntheses.
Download or read book Comprehensive Organic Functional Group Transformations Synthesis carbon with one heteroatom attached by a multiple bond written by Alan R. Katritzky and published by Elsevier. This book was released on 1995 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in the Use of Synthons in Organic Chemistry written by Alessandro Dondoni and published by Elsevier. This book was released on 2013-10-22 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the Use of Synthons in Organic Chemistry: A Research Annual, Volume 1 provides information pertinent to a useful reagent that can perform a certain chemical operation that is otherwise impossible or difficult to carry out. This book presents the developments on established synthons. Organized into four chapters, this volume begins with an overview of the significant role of the formyl group in synthetic methodologies, which has stimulated the search for other reagents. This text then describes trimethysilyldiazomethane as a stable and safe substitute for hazardous diazomethane. Other chapters consider the usefulness of trimethysilyldiazomethane in organic syntheses. This book discusses as well that malonic amides, silylenol ethers, malonic esters, and tetra-donor-substituted allenes serve as synthetic equivalents for the dianions of malonic esters, ketones, and malonic amides. The final chapter deals with the synthesis of biologically-active compounds, which has been one of the major challenges for organic chemists. This book is a valuable resource for practicing synthetic chemists.
Download or read book Polarity Control for Synthesis written by Tse-Lok Ho and published by John Wiley & Sons. This book was released on 1991-09-03 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identifies the polar reactions that are frequently employed in carbogenic synthesis. While touching on retrosynthetic analysis, it's emphasis is on the exploitation and manipulation of the electronic properites of synthons in response to synthetic necessity.
Download or read book March s Advanced Organic Chemistry written by Michael B. Smith and published by John Wiley & Sons. This book was released on 2007-01-29 with total page 2379 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
Download or read book Organic Chemistry in Action written by F. Serratosa and published by Elsevier. This book was released on 1996-05-09 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this book was welcomed with great enthusiasm by teachers and students. It therefore seemed opportune to publish a second, revised, updated and extended edition. Unfortunately, Professor Fèlix Serratosa died before he could complete this task. Some new material has been added, the more significant changes being:. The book has been restructured into two well-differentiated sections: Part A, dealing with conventional organic synthesis, and Part B, devoted exclusively to computer-assisted organic synthesis and based on the former Chapter 11 and Appendices 2, 3 and 4 of the first edition. As decided in advance, Part B was to be the sole responsibility of Dr. Josep Xicart, who prepared the first versions of the CHAOS (Computerisation and Heuristics Applied to Organic Synthesis) program under the direction of Professor Serratosa.
Download or read book Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience written by Zbigniew J. Witczak and published by John Wiley & Sons. This book was released on 2016-01-14 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book consists of a brief introduction, a foreward provided by professor Danishefsky of Columbia University, and about 14 - 16 chapters, each written by one or two eminent scholars/authors describing their recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. Three or four chapters will be reviews. The domino (cascade, tandem) reactions are always intramolecular. They are usually very fast, clean and offer highly complex structures in a one pot process. Intramolecular rearrangements offer very similar advantages and often lead to highly complex products as well. Although many recently isolated carbohydrates fulfill various sophisticated functions, their structures are often very complex. The editors cover the broadest scope of novel methodologies possible. All the synthetic and application aspects of domino/cascade reactions are explored in this book. A second theme that will be covered is intramolecular rearrangement, which is also fast, stereoselective, and often constitutes one or more steps of domino / cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. It appears that domino and intramolecular rearrangements are ideally suited to synthesize certain specific modified monosaccharides. What is particularly important is that both processes are intermolecular and almost always yield products with very well-defined stereochemistry. This high definition is absolutely crucial when synthesizing advanced, modified mono and oligosaccharides. The choice of contributors reflects an emphasis on both therapeutic and pharmacological aspects of carbohydrate chemistry.
Download or read book Activating Agents and Protecting Groups written by Anthony J. Pearson and published by John Wiley & Sons. This book was released on 1999-07-09 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aus dem bestehenden Material der "Encyclopedia of Reagents for Organic Synthesis" (EROS) werden Paquette und die Herausgeber 500 bevorzugte Reagenzien auswählen, die dann in 4 Bände entsprechend ihrer Klassifikation eingeteilt werden, z.B. Oxidations- und Reduktionsreagenzien. Die endgültigen Titel der Bände werden festgelegt, sobald die Auswahl der 500 Reagenzien vorgenommen wurde. Jeder Band wird sich in Umfang und Struktur an EROS orientieren, d.h. er verfügt über eine Einleitung, die ausgewählten Reagenzien erscheinen in alphabetischer Reihenfolge, und es gibt jeweils einen Index zu Reagenzien, Autoren und Themenkomplexen. Für jedes Reagenz werden die physikalischen und chemischen Daten detailliert angegeben, so daß der Leser den Gebrauch der jeweiligen Reagenz versteht und sicher mit ihr arbeiten kann. (01/99)
Download or read book Reactions and Syntheses written by Lutz F. Tietze and published by John Wiley & Sons. This book was released on 2015-02-23 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this classic text book has been completely revised, updated, and extended to include chapters on biomimetic amination reactions, Wacker oxidation, and useful domino reactions. The first-class author team with long-standing experience in practical courses on organic chemistry covers a multitude of preparative procedures of reaction types and compound classes indispensable in modern organic synthesis. Throughout, the experiments are accompanied by the theoretical and mechanistic fundamentals, while the clearly structured sub-chapters provide concise background information, retrosynthetic analysis, information on isolation and purification, analytical data as well as current literature citations. Finally, in each case the synthesis is labeled with one of three levels of difficulty. An indispensable manual for students and lecturers in chemistry, organic chemists, as well as lab technicians and chemists in the pharmaceutical and agrochemical industries.
Download or read book Additions to C X Bonds written by Barry M. Trost and published by Elsevier. This book was released on 1992-09-08 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 2 deals mainly with the addition reactions of delocalized carbanions (enolates) and their synthetic relatives (metalloenamines, enol ethers, allyl organometallics) with carbonyl compounds, imines and iminium ions. Major emphasis is placed on C-C bond-forming reactions such as the aldol and Mannich reactions. Acylation reactions are also included in this volume. Several topics that have not previously been reviewed are covered, including the use of enzymatic aldol reactions in synthesis and the Passerini-Ugi reactions.
Download or read book Aliphatic Compounds written by Malcolm Sainsbury and published by Elsevier. This book was released on 1992-01-01 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aliphatic Compounds
Download or read book Preparative Polar Organometallic Chemistry written by Lambert Brandsma and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preparative Polar Organometallic Chemistry is a collection of laboratory procedures for the synthesis and functionalization of organoalkali and Grignard compounds. The second volume with methods for generation and transformation of compounds bearing the metal at an sp3 carbon complements the first in which the metal was bound to an sp2 carbon atom in the reagent. Synthetically important intermediates such as metallated S,S-acetales, imines, nitriles, isonitriles and ketones are illustrated. All procedures have been worked out in full detail and tested in the author's own laboratory. Both books are intended to be practical bench-top laboratory manuals for working organic chemists, from the student to the advanced scientist.
Download or read book Synthetic and Mechanistic Organic Electron Transfer Reactions written by T. Fuchigami and published by The Electrochemical Society. This book was released on 2010-02 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers included in this issue of ECS Transactions were originally presented in the symposium ¿Synthetic and Mechanistic Organic Electron Transfer Reactions¿, held during the 216th meeting of The Electrochemical Society, in Vienna, Austria from October 4 to 9, 2009.
Download or read book Intermediate Organic Chemistry written by Ann M. Fabirkiewicz and published by John Wiley & Sons. This book was released on 2015-07-13 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents key aspects of organic synthesis – stereochemistry, functional group transformations, bond formation, synthesis planning, mechanisms, and spectroscopy – and a guide to literature searching in a reader-friendly manner. • Helps students understand the skills and basics they need to move from introductory to graduate organic chemistry classes • Balances synthetic and physical organic chemistry in a way accessible to students • Features extensive end-of-chapter problems • Updates include new examples and discussion of online resources now common for literature searches • Adds sections on protecting groups and green chemistry along with a rewritten chapter surveying organic spectroscopy
Download or read book Asymmetric Synthetic Methodology written by David John Ager and published by CRC Press. This book was released on 2020-08-18 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.
Download or read book Comprehensive Organic Functional Group Transformations II written by and published by Elsevier. This book was released on 2004-12-16 with total page 9196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Organic Functional Group Transformations II (COFGT-II) will provide the first point of entry to the literature for all scientists interested in chemical transformations. Presenting the vast subject of organic synthesis in terms of the introduction and interconversion of all known functional groups, COFGT-II provides a unique information source documenting all methods of efficiently performing a particular transformation. Organised by the functional group formed, COFGT-II consists of 144 specialist reviews, written by leading scientists who evaluate and summarise the methods available for each functional group transformation. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. By systematically treating each functional group in turn the work also identifies what is not known, thus pointing the way to new research areas Follows the systematic layout of the successful 1995 COFGT reference work, based on the arrangement and bonding of hetero-atoms around a central carbon atom The work will save researchers valuable time in their research as each chapter is written by experts who have critically read and reviewed the literature and presented the best methods of forming every known functional group
