Download or read book Two Weeks Until Enrollment written by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations and published by . This book was released on 2014 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Election Law of the State of New York with Notes and Instructions written by and published by . This book was released on 1918 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Clinical Trials Drug Resistance and Safety for Cancer Immunotherapy in Head and Neck Cancers and Brain Tumors written by Ling Zhang and published by Frontiers Media SA. This book was released on 2023-11-10 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and neck cancers (HNCs) and brain tumors continue to be fatal diseases in most countries of the world. In the past decade, cancer immunotherapy has emerged as a promising therapeutic strategy and achieved unprecedented bench-to-bedside clinical success in the field of oncology. Different from traditional surgery, chemotherapy, and radiotherapy, the current cancer immunotherapy aims to recover or enhance the immune system of a patient, to recognize and eliminate cancerous cells from the primary tumor and metastases. Numerous immunotherapy strategies, in particular immune checkpoint inhibitors, adoptive cellular therapies, and cancer vaccines, are under pre-clinical investigations or in ongoing clinical trials in a range of cancer types. Among them, novel drugs have continued to be approved by the FDA, which has revolutionized the current cancer treatment by prolonging the survival time of the patients, especially in advanced unresectable tumors. However, not all patients achieve complete responses to immunotherapy due to de novo or acquired resistance. Also, immunotherapy-related adverse events are common, although it has a better safety profile than the traditional treatments. It has limited the application and efficacy of cancer immunotherapy in tumors, including the HNCs and brain tumors, and highlights the need for new strategies.
Download or read book Lung Cancer written by Kishan J. Pandya and published by CRC Press. This book was released on 2016-04-19 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer-related deaths in the United States. Filling a gap in the literature, this resource translates recent laboratory findings into practical applications for the prevention and control of lung cancer. Featuring chapters by seasoned researchers in the field, this reference reviews current advances in imaging, d
Download or read book Audit and Accounting Guide written by AICPA and published by John Wiley & Sons. This book was released on 2019-04-23 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: ASC 606, Revenue from Contracts with Customers, replaces almost all previously existing revenue recognition guidance, including industry-specific guidance. That means unprecedented changes, affecting virtually all industries and all size organizations. For preparers, this guide provides the comprehensive, reliable accounting implementation guidance you need to unravel the complexities of this new standard. For practitioners, it provides in-depth coverage of audit considerations, including controls, fraud, risk assessment, and planning and execution of the audit. Recent audit challenges are spotlighted to allow for planning in avoiding these new areas of concern. This guide includes 16 industry-specific chapters for the following industries: Aerospace and Defense, Airlines, Asset Management, Broker-Dealers, Construction Contractors, Depository Institutions, Gaming, Health Care, Hospitality, Insurance, Not-for-Profits, Oil and Gas, Power and Utility, Software, Telecommunications, and Timeshare.
Download or read book Federal Register written by and published by . This book was released on 1979-11 with total page 1792 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Focus on Malignant Pleural Mesothelioma Immunology and Immunotherapy written by Christophe Blanquart and published by Frontiers Media SA. This book was released on 2023-08-15 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malignant pleural mesothelioma (MPM) is a rare thoracic cancer that derives from the mesothelial cells of the pleura and is causally associated with exposure to asbestos. Because of its aggressiveness and resistance to therapies, MPM prognosis is extremely poor and the 5-year survival rate is approximately 10%. Despite its poor effectiveness, chemotherapy with cisplatin and pemetrexed has long remained the standard-of-care for upfront treatment with no second line therapy available. Recently, the approval of ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) for the first-line treatment of unresectable MPM has marked a significant milestone, in particular for the non-epithelioid MPM subtype, which is more resistant to chemotherapy and associated with a poorer outcome. However, most MPM patients are still resistant to cancer therapies. Beyond histologic subtypes, recent studies have highlighted extensive genetic variation and gene expression deregulation both between and within MPM patients. This molecular heterogeneity highlights the need for a personalized treatment approach. Therefore, both multiple therapeutic options and predictive biomarkers that can guide clinical decision-making are urgently needed. Tumor cell immunogenicity and tumor microenvironment composition (TME) are the major determinants of the success of immunotherapy. Despite the low tumor mutational burden, recent studies indicate that chromoanagenesis and chromotripsis are molecular features of MPM. Since chromosomal instability can lead to the expression of neo-antigens, it could also influence the efficacy of immune checkpoint inhibitors (ICIs). The immunosuppressive TME is an additional important hurdle that limits the efficacy of immunotherapy. The combination of ICIs with strategies to boost anti-tumor immunity by restraining immunosuppressive myeloid cells or by reprograming “cold tumor” into “hot tumor” is an active area of research. This Research Topic aims to discuss recent advances in understanding and targeting MPM immune microenvironment for therapeutic purposes along with potential predictive biomarkers to select patients who most likely will respond to immunotherapies. We are interested in basic and clinical studies that explore the crosstalk between tumor and immune cells in order to highlight new molecular targets, approaches, and combination treatments to enhance anti-tumor immunity in MPM and assess potential predictive biomarkers of response to immunotherapy.
Download or read book Needle Exchange Legalization and the Failure of the Swiss Heroin Experiments written by United States. Congress. House. Committee on Government Reform and Oversight. Subcommittee on National Security, International Affairs, and Criminal Justice and published by . This book was released on 1998 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book General Laws of the State of New York written by New York (State) and published by . This book was released on 1918 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Student Financial Aid Handbook written by and published by . This book was released on with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Opening Fall Enrollment in Higher Education written by Joseph A. Vignone and published by . This book was released on 1974 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Activity Report of the Committee on Energy and Commerce of the U S House of Representatives Together with Dissenting Views written by United States. Congress. House. Committee on Energy and Commerce and published by . This book was released on 2013 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oregon Education Journal written by and published by . This book was released on 1926 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Legislative Calendar written by United States. Congress. Senate. Committee on Homeland Security and Governmental Affairs and published by . This book was released on with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Esophageal Cancer written by Nabil F. Saba and published by Springer Nature. This book was released on 2019-11-30 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this very successful book documents the latest progress in the prevention, diagnosis and treatment of esophageal cancer and includes additional sections covering novel targeted therapeutic approaches, immunotherapy and palliative and nutritional support for patients. Furthermore, the sections covering epidemiology, molecular biology, pathology, staging and radiologic and endoscopic assessments have been thoroughly updated and expanded. The principles of surgical resection, radiation therapy and systemic therapy are reviewed and attention is paid to the multidisciplinary approaches to the management of early stage cervical, thoracic, distal and junctional tumors. Updated information is also provided on the treatment of metastatic and recurrent disease as well as approaches that may impact future care, such as chemoprevention. Esophageal Cancer: Prevention, Diagnosis and Therapy will assist specialists from various disciplines, including surgery, radiation therapy, gastroenterology, medical oncology and palliative medicine, in delivering optimal, up-to-date care to the benefit of patients.
