Download or read book Two Decades of Adult T cell Leukemia and HTLV I Research written by Kazuo Sugamura and published by S. Karger AG (Switzerland). This book was released on 2003 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: In April 2001, the Japanese Cancer Association was privileged to host a symposium in Kyoto to commemorate the twentieth anniversary of the discovery of the viral pathogenesis of adult T-cell leukemia (ATL). In this monograph, the editors have selected not only papers presented at the symposium but also eminent papers of several individuals from around the world who have extensively researched human T-cell-leukemia virus type I (HTLV-I), the etiological virus of ATL, over the years. During the last two decades, HTLV-I was molecularly characterized as harboring a variety of oncogenic properties in its Tax protein. Epidemiological studies not only revealed the existence of HTLV-I-endemic areas in the world, but also disclosed the routes of transmission. Despite these great strides, the mechanisms of ATL development have not yet been fully clarified, and viable therapeutic measures are still to be established. This monograph contains recent exciting achievements in molecular virology, epidemiology, immunology and therapeutic trials as well as historical profiles of HTLV-I and HTLV-I-associated diseases.
Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Download or read book Adult T cell Leukaemia written by Kiyoshi Takatsuki and published by Oxford University Press, USA. This book was released on 1994 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances made so far in the worldwide study of AIDS and HIV owe much to our knowledge of T-cell leukaemia, which is the first human cancer known to be caused by a retrovirus. This book records the state-of-the-art findings on ATL and related diseases, and reviews the information which has been accumalated over the past two decades. Contributions from leading experts cover haematology, neurology, virology, epidemiology, pathophysiology, animal models, and treatment of ATL. The major contribution of ATL research to the understanding of AIDS, another retrovirus-caused disease, is clearly highlighted in this book. Contents include: ATL and HTLV-I-related diseases; regulation of HTLV-I-gene expression and its roles in ATL development; epidemiology of HTLV-I and HTLV-II infection; ethnoepidemiology of ATL in Japan, with special reference to mongoloid dispersal; ATL of Caribbean origin; molecular epidemiology of HTLV-I and HTLV-II; HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP); pathophysiology of ATL cells; cell growth characteristics; animal models of HTLV-1 infection; chemotherapy of ATL, and new approaches to the treatmant of ATL.
Download or read book HTLV 1 and Adult T cell Leukemia written by Kuan-Teh Jeang and published by . This book was released on 2005 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adult T cell Leukemia Lymphoma written by Toshiki Watanabe and published by Springer. This book was released on 2017-04-27 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.
Download or read book HTLV 1 and Adult T cell Leukemia 25 Years of Research on the First Human Retrovirus written by Kuan-Teh Jeang and published by . This book was released on 2005 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Adult T cell Leukemia and HTLV I Research written by Kiyoshi Takatsuki and published by CRC PressI Llc. This book was released on 1992 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an examination of the epidemiology, molecular biology, immunology, pathology and genetics of the HTLV-1 virus. The text reflects the advances in research conducted in Japan over the last 10 years and includes information on the molecular mechanisms of viral replication and leukemogenesis.
Download or read book Adult T Cell Leukemia Lymphoma New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adult T-Cell Leukemia-Lymphoma in a compact format. The editors have built Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adult T-Cell Leukemia-Lymphoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adult T-Cell Leukemia-Lymphoma: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Comparative studies between HTLV 1 and HTLV 2 function and pathobiology written by Umberto Bertazzoni and published by Frontiers Media SA. This book was released on 2015-06-11 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties.
Download or read book Adult T Cell Leukemia and Related Diseases written by Takashi Uchiyama and published by Springer. This book was released on 1995 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews research in adult T cell leukemia (ATL), one of the central disorders related to infections caused by the retrovirus human T lymphotrophic virus (HTLV-1), for researchers and clinicians. Describes clinical features of ATL and other related diseases and biological properties of cells, explains the IL-2/IL-2 receptor system in ATL and redox regulation and ATL-derived factor, and compares the relationship between AIDS and HIV to ATL and HTLV-1. Includes bandw diagrams and photos. Annotation copyright by Book News, Inc., Portland, OR
Download or read book Recent Advances in HTLV Research 2015 written by and published by Mdpi AG. This book was released on 2017-02-24 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) were both discovered over three decades ago and infect millions people worldwide. HTLV-1 is associated with the adult T-cell leukemia/lymphoma (ATLL) in about 2% of individuals infected, and another 2 to 3% of individuals develop a neurologic disorder called HTLV-associated myelopathy (HAM). HTLV-2 causes HAM in approximately 1 to 2% of infected individuals, but does not cause ATLL. HTLV-1 and HTLV-2 have served as excellent models for the study of the epidemiology and pathogenesis of virus-associated cancers as well as autoimmune conditions such as multiple sclerosis. Recently, two new members--HTLV-3 and HTLV-4--have been discovered in bushmeat hunters from central Africa, which emphasizes the urgent need for continual surveillance for new human retroviruses and their capacity to cause disease. Important public health issues remain open issues to be addressed in spite of the basic epidemiology of HTLV-1 and HTLV-2 being reasonably well defined. Clinical research is needed in developing potential HTLV-1 and HTLV-2 vaccines, as well as development of treatment options for ATLL and HAM. This 'Recent Advances Issue' contains both reviews and updates on research that encompasses these areas.
Download or read book Human T Cell Lymphotropic Virus Type I written by Per Höllsberg and published by John Wiley & Sons. This book was released on 1996-12-02 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: HTLV is made up of any of several retroviruses including the retrovirus known as AIDS. Devoted to the rapidly growing field of HTLV, this book explores the many different aspects of the virus.
Download or read book Molecular Pathology of HTLV 1 written by Umberto Bertazzoni and published by Frontiers Media SA. This book was released on 2019-03-25 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered, in 1980, by Gallo and co-workers. About 5-10% of HTLV-1-infected individuals are at risk of developing either a fatal malignancy, adult T-cell leukemia (ATL), or a chronic neuroinflammatory syndrome, HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Both diseases are incurable at present. Many issues concerning HTLV-1’s life cycle and pathobiology are still unsolved or controversial, and new approaches for prognostic stratification of patients and eradication of HTLV-1 infection are in high demand. In this Research Topic, the focus has been centered on discussing two main themes: the functional analysis and oncogenic potential of HTLV-1 regulatory proteins and the control of HTLV-1-associated diseases. The 22 articles in this eBook cover many different aspects of HTLV-1 infection and pathogenesis, providing new perspectives and groundwork for future studies.
Download or read book The Lymphomas written by George Peter Canellos and published by Saunders. This book was released on 2006 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and written by world authorities, this text encompasses all aspects of Hodgkin's disease, non-Hodgkin's lymphomas, and related disorders. Designed to be the "Bible" for both clinicians and scientists who deal with lymphoma, the book is packed with useful summary tables and abundant illustrations and translates cutting-edge discoveries into state-of-the-art management guidelines. The preeminent names in research and practice bring together today's entire spectrum of knowledge--from epidemiology, classification and prognosis through diagnosis and therapy, including the latest scientific advances, such as the impact of molecular biologic and genetic discoveries and new biologic markers. Covers molecular biology bone marrow transplantationlymphoma in AIDS and Hodgkins disease. Provides in-depth coverage of the underlying biology of the disease as well as etiology, pathology, diagnosis, and treatment. Discusses advances in the treatment of diseases including radiotherapy, radiolabeled monoclonal antibodies, treatment of cutaneous lymphoma, and metastatic disease. Contains precise clinical how-tos for managing bone marrow transplantation and diseases that resemble lymphomas. . Includes the recently codified new WHO classification of all lymphoid entities. . Offers new and updated information on the biology and recategorization (morphologic, clinical, genotypic/immunophenotypic) of distinct lymphoma entities.
Download or read book Emerging and Reemerging Viral Pathogens written by Moulay Mustapha Ennaji and published by Academic Press. This book was released on 2019-09-14 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and Reemerging Viral Pathogens: Applied Virology Approaches Related to Human, Animal and Environmental Pathogens, Volume Two presents new research information on viruses and their impact on the scientific community. It provides a reference book on certain viruses in humans, animals and vegetal, along with a comprehensive discussion on interspecies interactions. The book then looks at the drug, vaccine and bioinformatical strategies that can be used against these viruses, giving the reader a clear understanding of transmission. The book's end goal is to create awareness that the appearance of newly transmissible pathogens is a global risk that requires shared/adoptable policies for prevention and control. Covers most emerging viral disease in humans, animals and plants Provides the most advanced tools and techniques in molecular virology and the modeling of viruses Creates awareness that the appearance of new transmissible pathogens is a global risk Highlights the need to adopt shared policies for the prevention and control of infectious diseases
Download or read book Viral and Immunological Malignancies written by Paul Volberding and published by PMPH-USA. This book was released on 2006 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The precise relationship between viral infection and malignancy remains an epidemiologic association and the subject of active investigation. Nonmalignant hematologic disorders have a similarly complex relationship with cancer-associated viruses and may offer insight into the pathogenesis of oncogenesis. This book explores the relationships between viral infections, immune impairments and the hematologic and malignant diseases, particularly against the backdrop of the HIV epidemic. By extending the scope to all of viral oncology the editors provide an invaluable resource on tumors related to other viruses other than HIV, particularly carcinomas of the cervix and anus with HPV and tumors of the liver with the various hepatitis viruses.
Download or read book Cutaneous T Cell Lymphoma written by Herschel S. Zackheim and published by CRC Press. This book was released on 2004-10-28 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous T-cell lymphoma (CTCL) is a general term for many lymphomas of the skin including mycosis Fungoides and Sezary syndrome. This book presents the state of the art in CTCL epidemiology, clinical features, pathology, immunochemistry, diagnostic molecular techniques, staging and prognosis, and treatment. Edited by one of the leading experts in the disease, Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome provides comprehensive coverage of the disease and presents techniques for diagnosis and state-of-the-art treatment modalities, such as ultraviolet light, steroids, and topical chemotherapeutics.
