Download or read book Tumour Necrosis Factor Alpha and Atherogenic Index as Predictors of Insulin Resistance and Risks of Cardiovascular Disease among Obese Subjects in Calabar Nigeria written by Chidozie Agu and published by GRIN Verlag. This book was released on 2017-02-01 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master's Thesis from the year 2016 in the subject Medicine - Internal Medicine, grade: A, University of Calabar, course: Chemical Pathology/Immunology, language: English, abstract: Several studies in different population indicate that inflammation may be the link between obesity, insulin resistance and cardiovascular disease. However, this relationship has not been adequately explored in our population and among Africans with increasing high rate ofobesity and IR. In this study, the association between obesity markers (Body mass index, waist circumference, and waist-hip ratio), inflammatory marker (Tumour necrosis factor-alpha), insulin resistance markers (Homeostasis model assessment of insulin resistance, insulin) and markers of cardiovascular risks (Atherogenic index of plasma, lipid profile, blood pressure) were evaluated in a total of one hundred and sixty subjects (160). One hundred and ten (110) of which were obese subjects (BMI 30kg/m2 and above) and fifty (50) non-obesecontrols. Blood pressure and fasting samples were collected. Anthropometric parameters were measured; body mass index and waist-hip ratio were calculated for all the participants recruited in this study. Obese subjects were further grouped based on their BMI values as; class I (BMI 30-34.9kg/m2), class II (BMI 35-39.9kg/m2) and class III (BMI 40kg/m2 and above). TNF-α and insulin were determined using enzyme linked immunosorbent assay (ELISA). Total cholesterol and triglyceride were determined using the enzymatic colorimetric method; LDL, VLDL, HOMA-1R, AIP were respectively calculated. High density lipoprotein was determined using the precipitation/cholesterol enzymatic method. The mean values of TNF-α, insulin, FPG, HOMA-1R, TC, TG, LDL, VLDL, AIP, SBP and DBP were all significantly higher in obese subjects compared to non-obese controls group (P0.05). The mean value of HDL was significantly higher in the non-obese controls compared to the obese group (P

Download or read book Syndrome X written by Terry Kirsten Strom and published by Simon and Schuster. This book was released on 2002-02-28 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of Americans follow the "best" medical advice every day to prevent heart attacks -- eating the standard low-fat, high-carbohydrate diet so widely recommended by doctors -- but in fact they are placing themselves at greater risk for heart disease. In Syndrome X: Overcoming the Silent Killer That Can Give You a Heart Attack, Dr. Gerald Reaven, the world-renowned physician who identified and named this silent killer, explains why the standard heart-healthy diet can be dangerous and lays out a simple six-step program to reduce the risk of heart disease for everyone. The problem stems from a little-known cluster of metabolic abnormalities known as Syndrome X. The insulin resistance that lies at the heart of the syndrome can turn normal rules of good health upside down and dramatically increase the risk of heart disease. Fortunately, Syndrome X can be cured. This important book explains how to identify the disorder and provides a program of diet and exercise (plus medication when necessary) that can render Syndrome X harmless. Tested in carefully controlled research settings and in practice, this remarkable new approach has the ability to reduce the risk of heart attacks and heart disease for all of us. Dr. Reaven shows how eating a diet relatively high in "good" fats (40 percent of calories) can dramatically lower the risk of heart disease if you have Syndrome X. The approach seems paradoxical: Everyone "knows" that fat is bad, so how can more fat possibly lead to better health? The answer lies in the type of fat and the body chemistry of the people who consume it. If you have the abnormal metabolism called Syndrome X, eating a low-fat, high-carbohydrate diet to lower your LDL and blood fats won't protect you. In fact, doing so will increase the odds of heart disease. Millions of Americans have the potentially deadly, yet easily identifiable signs of Syndrome X -- but few cases are detected in time, because most physicians don't know what to look for. This trailblazing book will change that, making doctors and patients aware of the problem -- and its easy solution, an integrated program of diet and exercise that simultaneously reduces all the risk factors for heart disease, including Syndrome X. Dr. Reaven's discovery of Syndrome X has shown us that the standard approach to preventing heart disease is dangerous for many of us. Now, his safe, proven new approach explains how millions can drastically reduce their risk of heart disease. His program works not only for those who have Syndrome X, but also for anyone who simply wants to reduce the risk of heart disease.

Download or read book Diabetic Foot Ulcer written by Mohammad Zubair and published by Springer Nature. This book was released on 2020-10-05 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses essential aspects of diabetic foot ulcers, including evidence-based information on its pathogenesis and pathophysiology, as well as the molecular mechanisms and biomechanics of the diabetic foot. It also highlights the need for a multidisciplinary team to be involved in the management of diabetic patients with foot ulcers, and describes available and future tools for evaluating patients who are at risk. Exploring the main current therapies as well as the latest developments, future directions and potential new treatments, such as growth factors, stem cell therapy, alternative medicine and nanotechnology, the book is a valuable resource for clinicians and medical graduates but will also appeal to researchers working in the field.

Download or read book Voluntary Termination of Pregnancy written by E.S. Hafez and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Global Health Informatics written by Heimar Marin and published by Academic Press. This book was released on 2016-12-08 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global Health Informatics: How Information Technology Can Change Our Lives in a Globalized World discusses the critical role of information and communication technologies in health practice, health systems management and research in increasingly interconnected societies. In a global interconnected world the old standalone institutional information systems have proved to be inadequate for patient-centered care provided by multiple providers, for the early detection and response to emerging and re-emerging diseases, and to guide population-oriented public health interventions. The book reviews pertinent aspects and successful current experiences related to standards for health information systems; digital systems as a support for decision making, diagnosis and therapy; professional and client education and training; health systems operation; and intergovernmental collaboration. Discusses how standalone systems can compromise health care in globalized world Provides information on how information and communication technologies (ICT) can support diagnose, treatment, and prevention of emerging and re-emerging diseases Presents case studies about integrated information and how and why to share data can facilitate governance and strategies to improve life conditions

Download or read book Project written by Tom Hutchinson and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Incorporates ideas such as learner development, project work, a task-based methodology, role play, and cross-curricular themes, while providing a solid grammar framework and thorough practice of structures, functions and vocabulary"--Teacher's book, p. 6.

Download or read book Integrated Management of Acute Malnutrition written by Tanzania. Wizara ya Afya, Maendeleo ya Jamii, Jinsia, Wazee na Watoto and published by . This book was released on 2018 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book An Organisation with a Memory written by Departm Chief Medical Officer of Health and published by Stationery Office Books (TSO). This book was released on 2000 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of clinical governance gives National Health Service organisations a powerful incentive to focus on serious failures in health care. This report reviews what is known about the scale and nature of these failures, examining the extent to which the NHS has the capacity to learn from them when they do occur, and recommending measures which could help to minimise the likelihood of repeated failures in service in the future. Information was drawn from industry, aviation and academic research.

Download or read book School based Drug Abuse Prevention written by National Crime Prevention Centre (Canada) and published by . This book was released on 2009 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Clinical Diagnostic Technology written by Kory M. Ward and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2003 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Translational Toxicology written by Claude L. Hughes and published by Humana Press. This book was released on 2016-03-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Download or read book Best Practice Guide on the Control of Arsenic in Drinking Water written by Prosun Bhattacharya and published by IWA Publishing. This book was released on 2017-07-15 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arsenic in drinking water derived from groundwater is arguably the biggest environmental chemical human health risk known at the present time, with well over 100,000,000 people around the world being exposed. Monitoring the hazard, assessing exposure and health risks and implementing effective remediation are therefore key tasks for organisations and individuals with responsibilities related to the supply of safe, clean drinking water. Best Practice Guide on the Control of Arsenic in Drinking Water, covering aspects of hazard distribution, exposure, health impacts, biomonitoring and remediation, including social and economic issues, is therefore a very timely contribution to disseminating useful knowledge in this area. The volume contains 10 short reviews of key aspects of this issue, supplemented by a further 14 case studies, each of which focusses on a particular area or technological or other practice, and written by leading experts in the field. Detailed selective reference lists provide pointers to more detailed guidance on relevant practice. The volume includes coverage of (i) arsenic hazard in groundwater and exposure routes to humans, including case studies in USA, SE Asia and UK; (ii) health impacts arising from exposure to arsenic in drinking water and biomonitoring approaches; (iii) developments in the nature of regulation of arsenic in drinking water; (iv) sampling and monitoring of arsenic, including novel methodologies; (v) approaches to remediation, particularly in the context of water safety planning, and including case studies from the USA, Italy, Poland and Bangladesh; and (vi) socio-economic aspects of remediation, including non-market valuation methods and local community engagement.

Download or read book Sisters Super Creeps and Slushy Gushy Love Songs written by Karen McCombie and published by . This book was released on 2011 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ally knows her super-efficient big sis Linn finds their chaotic family a bit ... exasperating. But when Linn falls for Q, the tearaway lead singer in a local band, all her sensible ways go out of the window. Everyone else can see that Q's a creep, but does Ally have the courage to burst Linn's heart-shaped bubble?

Download or read book The Prevention and Control of Iodine Deficiency Disorders written by Basil S. Hetzel and published by Elsevier Publishing Company. This book was released on 1987 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Platelets and Megakaryocytes written by Jonathan M. Gibbins and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: 12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Download or read book Platelet Proteomics written by Ángel García-Alonso and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.