Download or read book Tumor Suppressor Genes in the Pathogenesis of Prostate Cancer written by Suzana Sturlini Couto and published by . This book was released on 2008 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of DNA Methylation and Tumor Suppressor Genes in the Pathogenesis of Prostate Cancer and Leukemias written by TuDung Thi Nguyen and published by . This book was released on 1999 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prostate Cancer written by Leland W. K. Chung and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Understanding Prostate Cancer Pathogenesis written by Chieh-Yang Cheng and published by . This book was released on 2014 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most prevalent type of cancer in men. However, there is no cure for relapsed androgen withdrawal-refractory prostate cancer which is fatal due to metastasis. Many studies have demonstrated the existence of cancer cells with stem cell properties (aka cancer propagating cells (CPCs)) within the cancer cell population. CPCs may cause cancer recurrence due to resistence to conventional therapies. Understanding molecular and cellular mechanisms governing normal prostate stem cells and CPCs may improve our understanding and provide new opportunities for the design of therapeutics acting specifically on CPCs. Two of such mechanisms, p53/microRNA-34/Met network and neuroendocrine (NE) signaling are the topic of my dissertation. microRNA-34 (miR-34) family has been proposed to play a tumor suppressor role in various cancers, including the prostate cancer. However, direct genetic evidence for the tumor suppressor functions of miR-34 under physiologically relevant settings has been lacking. By using newly generated mice carrying conditional alleles of mir-34, we have shown that miR-34 cooperates with p53 in suppression of prostate carcinogenesis by joint control of MET-dependent prostate stem/progenitor cells. Thus, therapeutic targeting of MET is likely to affect CPCs, particularly in p53 and miR-34 deficient patients. NE signaling has been shown to be one of the features in advanced prostate cancer. However, the roles of NE cells in prostate carcinogenesis and development are insufficiently elucidated. By using bacterial artificial chromosome (BAC) we have generated a mouse model for conditional NE cell ablation, and shown that prostate epithelium-specific ablation of NE cells results in prostate hypotrophy, suggesting NE cells play an important role in prostate development. Moreover, we have studied effects of neuropeptide in membrane metallo-endopeptidase (Mme) null mice, and shown that Mme cooperates with Pten to suppress prostate carcinogenesis in the control of prostate stem/progenitor cells. Gastrin-releasing peptide (GRP), a substrate of MME, showed similar effects on mouse prostate stem/progenitor cells and human prostate CPCs. These effects were effectively abrogated by GRP receptor (GRPR) antagonist or knockdown of GRPR expression. Taken together, these findings show critical role of NE signaling in prostate development and carcinogenesis and GRPR is a potential therapeutics targeting prostate CPCs.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Prostate Cancer written by Leland W.K. Chung and published by Springer Science & Business Media. This book was released on 2000-12-15 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book embraces the wide field of prostate cancer genetics, biology, and therapy. It seems most appropriate to dedicate it to Donald S. Coffey, PhD, whose research vision is an inspiration to his colleagues and friends. Unraveling the secrets of prostate cancer is an intricate and sometimes frustrating process involving many researchers and many institutions. No one has seen through to the end of this road, and the list of researchers who have contributed to our understanding of the disease processes of prostate cancer is already a long one. But Donald Coffey stands out in his personal qualities as surely as in his roles as teacher and researcher. In the dedicatory article that begins this volume, Dr. Ward has spoken for all of us about Don Coffey's unique determination to build the road to defeat prostate cancer. This book is divided into three sections: Cancer Genetics, Cancer Biology, and Cancer Therapeutics. These sections, like the skill and knowledge of the contributors, overlap in many dimensions. The divisions between sections are somewhat arbitrary and have been made expressly for the convenience of the reader. The reader will find chapters in each section that illuminate aspects ofthe genetics, biology, and therapy of prostate cancer. Nothing better illustrates the breadth of the research being conducted today by these distinguished groups, who truly understand and appreciate the power of multi disciplinary and translational approaches to deciphering the intricacy of the object of this research.
Download or read book Prostate Cancer written by Donald J. Tindall and published by Springer Science & Business Media. This book was released on 2013-05-09 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate Cancer provides an up-to-date review of the biochemistry, molecular biology, and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer.
Download or read book Isolation of Novel Prostate Cancer Tumor Suppressor Genes in African American and Caucasian Men Thru Laser Microdissection and Representation Difference Analysis written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress has been made for all three specific aims. Specific Aim 1: Obtaining metastatic prostate cancer DNA of quality sufficient for Representational Difference Analysis (RDA), has been achieved using alternate means. Specific Aim 2: Employ RDA to identify DNA regions which have been homozygously deleted, has been achieved with identification of a novel region of homozygous deletion on chromosome 12p (Cancer Research, 58, 5652-5655, 1998). Specific Aim 3: To prioritize regions of homozygous deletion based on frequency of deletion of this region in metastatic tumors, and to identify candidate genes within these regions, has been achieved, with previously unidentified deletion of the identified chromosome 12p region in 50% of metastatic prostate cancers studied (Genes, Chromosomes, and Cancer 25:270-276, 1999) . Examination of genes within this region suggests that p27 or TEL to be likely candidates. These results validate this approach and additional studies are underway to identify additional genomic regions of interest in metastatic prostate cancer.
Download or read book Prostate Cancer written by Scott M. Dehm and published by Springer Nature. This book was released on 2020-01-03 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.
Download or read book PTEN a Tumor Suppressor Gene for Prostate Cancer written by and published by . This book was released on 1999 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inactivations of tumor suppressor genes are the most common genetic alterations in human cancers. The PTEN gene is a tumor suppressor gene recently cloned from human chromosome 10q23.3 that encodes a lipid phosphatase which influences a variety of cellular processes that impact on the neoplastic phenotype. The goal of this proposal is to characterize the role of the PTEN tumor suppressor gene in prostate cancer using the TRAMP mouse model, a well characterized transgenic mouse model of prostate cancer. Our research has shown that the region on mouse chromosome 19 homologous to human chromosome 10q23 is altered in a substantial fraction of TRAMP mouse prostate cancers as detected by analysis of loss of heterozygosity. We have not found a corresponding number of inactivating lesions of the retained PTEN allele, similar to the situation in clinically localized human prostate cancer as well as other human cancers such as breast cancer. We are now in a position to resolve this paradoxical observation by determining whether hemizygous loss of PTEN in itself promotes prostate tumorigenesis or whether there may be second tumor suppressor gene tightly linked to PTEN by analysis of tumor progression in PTEN heterozygote knockouts crossed with TRAMP mice
Download or read book Mechanisms of Inactivation of Multiple Tumor Suppressor Genes in Human Prostate Cancer written by Xiang Gao and published by . This book was released on 1997 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Isolation of Novel Prostate Cancer Tumor Suppressor Genes in African American and Caucasian Men Thru Laser Microdissection and Representational Difference Analysis written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: We used RDA to identify homozygously deleted DNA clones within metastatic prostate cancer xenograft DNA, and found that all of the homozygously deleted clones mapped to a single region of chromosome 12p. We confirmed that the metastatic lesions from this patient also contained this homozygous deletion, and then analyzed this region in a series of 41 metastatic tumors from 19 patients, where we found that 50% of patients' tumors show loss. This 12p deletion occurs with similar frequency in caucasians and african-americans based on our small sample. We mapped this genomic region, and found that two previously identified potential candidate genes ETV(tel) and CDKN1B(p27) are located there. Analysis of these genes has revealed no sequence changes consistent with an important tumor suppressor role. Extensive analysis of p27 for possible mutational or methylation changes was negative. Major observations from our work include the finding of a homozygous deletion on chromosome 12p in metastatic prostate cancer, considered to be a major indicator that an important gene is nearby on chromosome 12p. Further analysis of this region revealed unexpected high degree of allelic loss in this region. Specific genes in the region were analyzed, and p27 appears to be the likely target, inactivated by loss of one copy. Further analysis was curtailed due to lack of funding.
Download or read book Essential Concepts in Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2019-11-23 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
Download or read book Gynecologic and Urologic Pathology written by Maria Rosaria Raspollini and published by Cambridge University Press. This book was released on 2019-02-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the similarities and differences in the pathology of the genital and urinary tracts in males and females.
Download or read book Gene Discovery in Prostate Cancer Functional Identification and Isolation of PAC 1 a Novel Tumor Suppressor Gene Within Chromosome 10p written by Ann M. Killary and published by . This book was released on 2001 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose and scope of this project was to utilize a functional approach for the physical mapping and identification of a novel tumor suppressor gene for prostate cancer within chromosome l0p. The major findings include the development of a technology for serial microcell fusion to transfer defined lop fragments into a mouse A9 fibrosarcoma cell line. Once characterized by FISH and microsatellite analyses, the l0p fragments were subsequently transferred into PC-3H to generate a panel of microcell hybrid clones containing overlapping deletions of chromosome l0p. In vivo and micro satellite analyses of these PC hybrids identified a small chromosome lop fragment (an estimated 31 Mb in size inclusive of the centromere) that when transferred into the PC-3H background, resulted in significant tumor suppression and limited a region of functional tumor suppressor activity to chromosome 10p12.31-q11. This region coincides with a region of LOH demonstrated in prostate cancer. These studies demonstrate the utility of this approach as a powerful tool to limit regions of functional tumor suppressor activity. Furthermore, these data used in conjunction with data generated by the Human Genome Project lent a focused approach to identify candidate tumor suppressor genes involved in prostate cancer.
Download or read book Differentially Expressed Genes in Human Prostatic Carcinoma written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of the fact that prostate cancer has become a significant health burden, its molecular determinants are poorly understood. We have proposed to identify the genes that are differentially expressed in prostate cancer. One type of such gene is tumor suppressor gene. During the first year of this project, we applied the methods of tissue microdissection and deletion mapping to localize tumor suppressor genes on human chromosome 13. We also used PCR-SSCP and direct sequencing methods to analyze candidate genes for their involvement in prostate cancer. We identified three regions of chromosome 13 for harboring tumor suppressor gene, i.e., 13q14, 13q21, and 13q33. The ERCC5/XPG DNA repair gene at 13q33 was not involved in prostate cancer, neither was the RBl gene at 13q14. Therefore, each of the three tumor suppressor genes remains to be identified. More interestingly, alterations of 13q14 and 13q21 appeared to be specifically responsible for the aggressive behavior of prostate cancer. Currently, we are performing additional experiments to narrow down the deletion regions that harbor the tumor suppressor genes and started searching for the genes. Identification of these genes will provide targets for improving the diagnosis and therapy of prostate cancer.
