Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Download or read book Immunodeficient Animals written by Wolfgang Arnold and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research.
Download or read book Patient derived Tumor Models for Drug Development written by Hatim E. Sabaawy and published by Frontiers Media SA. This book was released on 2023-07-31 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organoids organs on chip nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment written by Fabrizio Mattei and published by Frontiers Media SA. This book was released on 2023-08-03 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recent 3D Tumor Models for Testing Immune Mediated Therapies written by Silvia Scaglione and published by Frontiers Media SA. This book was released on 2022-01-10 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomaterials for 3D Tumor Modeling written by Subhas C. Kundu and published by Elsevier. This book was released on 2020-08-22 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery
Download or read book Advances in Prostate Cancer Model Systems Molecular and Cellular Mechanisms Early Detection and Therapies written by Tanya I. Stoyanova and published by Frontiers Media SA. This book was released on 2022-08-08 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book FRONTIERS IN ONCOLOGY EDITOR S PICK 2021 written by Giuseppe Giaccone and published by Frontiers Media SA. This book was released on 2022-05-17 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are pleased to introduce the 2021 Frontiers in Oncology: Editor’s Pick collection, showcasing articles stimulating interest in the field, carefully selected by our Field Chief Editor, Prof. Giuseppe Giaccone, of Weill Cornell Medicine. With this ebook we aim to highlight and disseminate important findings across the domains of cancer research, capturing the multidisciplinary and inclusive approach our journal takes towards advancing the field of oncology and supporting the global effort towards improved quality of life and patient survival. 2021 was a year which saw our highest journal impact factor yet, international community growth, and a record-breaking number of articles to choose from. We wish to elevate the contributions made by authors, encourage readership and innovation through our open-access philosophies, and thank our Editorial Board for their continued hard work and collaboration.
Download or read book Individualized Patient Derived Tumor Organoids Model Brain Tumor Ecosystem written by Xiujian Ma and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Circulating Tumor Cells in Breast Cancer Metastatic Disease written by Roberto Piñeiro and published by Springer Nature. This book was released on 2020-04-17 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge about CTCs, framed in the context of breast cancer, by analysing basic and clinical research carried out so far. In a broader sense, we will address what are the main clinical needs of this disease based on its molecular heterogeneity (subtypes) and lay out the knowledge and understanding that CTCs are giving about it and how they are contributing and can still improve the better monitoring and management of breast cancer patients. We will discuss the evidences of the use of CTCs as a tool to monitor cancer progression and therapy response, based on the prognostic and predictive value they have, as well as a tool to unravel mechanisms of resistance to therapy and to identify new biomarkers allowing to predict therapy success. Moreover, we will analyse the main aspects of ongoing clinical trials and how they can contribute to determine the clinical utility of CTCs as a breast cancer biomarker. We will also touch upon general knowledge or basic notions of the biology of the metastatic process in epithelial cancers, in order to understand the origin and biology of CTCs. In this sense, we will pay special attention to EMT (epithelial to mesenchymal transition), dormancy and minimal residual disease, three key aspects that determine the outcome of the disease. We will also cover general aspects on the isolation and characterization techniques applies to the study of CTCs, and also the possibilities that the study of CTCs, as a biomarker with biological function, is opening in terms of understanding the biology of metastatic cells and the identification of therapeutic targets based on the functional and molecular characterization of CTCs. Lastly, we will try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.
Download or read book Biomaterial Based Approaches to Study the Tumour Microenvironment written by Jessica O Winter and published by Royal Society of Chemistry. This book was released on 2022-12-07 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening. Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.
Download or read book Organoids as Model Systems for Human Development Disease and Clinical Applications written by Eumorphia Remboutsika and published by Frontiers Media SA. This book was released on 2021-11-23 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanotechnology for Precision Cancer Therapy Advances in gene therapy immunotherapy and 3D bioprinting written by Christiane Pienna Soares and published by Frontiers Media SA. This book was released on 2021-12-07 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book From Single Stem Cells to Organoids Organ Repair and Public Health written by Lon J. Van Winkle and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Organoid Research written by Jay Gopalakrishnan and published by Springer Nature. This book was released on 2022-09-22 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores multiple methods and approaches used to generate human brain and neuroretinal organoids to address fundamental questions in human brain research. The chapters in this book cover topics such as self-organizing brain organoids with ventricles amenable to injection and electroporation; visualization of 3D organoids though the latest advancements in microscopy; generation of 3D retinal tissue with physiologically competent, light-sensitive photoreceptors; modeling brain tumors using genetically edited brain organoids; and brain organoids as a model to study Zika virus and SARS-CoV-2 infections. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Brain Organoid Research is a valuable resource for researchers at various levels of learning, ranging from undergraduate students, early researchers, and advanced laboratories. This book aims to be instrumental in moving this developing field forward.
Download or read book Biofabrication and 3D Tissue Modeling written by Dong-Woo Cho and published by Royal Society of Chemistry. This book was released on 2019-01-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.
Download or read book Organoid Technology for Disease Modelling and Personalized Treatment written by Badrul Hisham Yahaya and published by Springer Nature. This book was released on 2022-02-14 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biology and regenerative medicine, where chimaera research, biomaterials for tissue vascularisation, gene-editing technologies, and their use in clinical procedures especially issues related to ethical concern over the use of human organoids have gotten much attention. Organoid Technology for Disease Modelling and Personalised Treatment is an excellent resource for in-depth research on one of the most interesting and significant topics in stem cell and regenerative medicine. This book's chapter collection covers a fresh viewpoint on organoid technology that scholars will require reading.
