Download or read book Systemic Drug Delivery Strategies written by Mansoor M. Amiji and published by Academic Press. This book was released on 2021-08-21 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Download or read book Tumor Associated Macrophages Reprogramming written by Jiao Peng and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Tumor associated macrophages reprogramming: the role of TGF-beta/TLR7 and adiponectin" by Jiao, Peng, 彭佼, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Tumor-associated macrophages (TAMs) play a key role in the escape of tumor cells from immune surveillance. "Re-programming" TAMs to switch from a M2 to a M1-type phenotype and thereby restore tumor specific immune responses that are protective continues stimulate considerable scientific interest in the field of tumor biology. The aims of this study focus on: 1) to identify the inhibition of TGF-β signaling in combination with TLR7 ligation could re-program the phenotype of TAMs and increase their tumoricidal activities; 2) to investigate that adiponectin (APN) deficiency can promote TAMs polarization towards a M1-like phenotype and reduce tumor progression in murine sarcoma model. TGF-β plays a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In a TAM/tumor cell co-culture system in which both cells were isolated from murine sarcoma model, I found inhibition of TGF-β signaling with TGF-β receptor I inhibitor in combination with TLR7 ligation could re-program TAMs to the M1-like type, evidenced by: 1) up-regulating the expression of M1-like type marker iNOS, CD80 and MHCII in TAMs; 2) down-regulating the expression of VEGF and CD31 to suppress angiogenesis; 3) increasing tumoricidal activity of TAMs and inducing tumor cells apoptosis and 4) elevating infiltration of inflammatory immune cells 〖CD4〗 DEGREES+,〖 CD8〗 DEGREES+ T cells and neutrophils in tumor mass. Mechanistically, it was also found that combination treatment could enhance NF-кB activation through up-regulating TRAF6 expression and increasing NF-кB nuclear translocation. APN, anti-inflammatory adipokine, has been shown to promote macrophage polarization to a M2 type in vitro. In the present study, APN and TAMs have high expression in infantile rhabdomyosarcoma, particularly in its malignant subtype. The study was then extended to investigate the effect of APN on TAMs polarization by murine MN/MCA1 sarcoma model. The results showed that exogenous APN had no direct effect on MN/MCA1 proliferation but tumor size was sharply reduced in 〖apn〗 DEGREES(-/-) mice compared to their wild type counterparts. Next, my study demonstrates that the accumulation of TAMs in 〖apn〗 DEGREES(-/-) mice was reduced correlated to down-regulation of serum MCP-1. Furthermore, TAMs showed a M1-like phenotype with a marked increase in the 〖MHCII 〗 DEGREEShighpopulation. Quantitative PCR analysis indicated that iNOS was increased, whereas the M2 markers IL-10 and YM1 were decreased. Increased TNF-α and reduced IL-10 were also observed in the serum and TAMs of 〖apn〗 DEGREES(-/-) mice. In addition, APN deficiency increased frequency of CD4+, CD8+ T cells and NK cells in the tumors and down-regulated MMP-9 and collagen to suppress tumor metastasis. Moreover, p-p38 was sharply decreased in TAMs of 〖apn〗 DEGREES(-/-) mice and adoption of p38 MAPK inhibitor could significantly reduce tumor size and increase MHCII expression in wild type mice, which suggested that APN regulated p38 MAPK signaling pathway may involve in TAMs polarization. In summary, the present study indicated the plasticity of TAMs which could be re-programmed depending on the alteration of microenvironment. Either inhibition of TGF-β in combination with TLR7 ligation or reducing APN in TAMs could polarize TAMs towards a M1-like type to restrict tumor progression. Subjects: Mac

Download or read book Tumor Associated Macrophages Reprogramming written by 彭佼 and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Download or read book Reprogramming of Tumor associated Macrophages by Targeting catenin FOSL2 ARID5A Signaling written by Poonam Ashwin Kumar Sarode and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer and Autoimmunity written by M.E. Gershwin and published by Elsevier. This book was released on 2000-03-27 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Download or read book Immune Cell Lineage Reprogramming in Cancer written by Jianmei Wu Leavenworth and published by Frontiers Media SA. This book was released on 2022-02-22 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Dr. Lewis Shi received financial support from Varian Medical System, Inc. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Download or read book Approaching Complex Diseases written by Mariano Bizzarri and published by Springer Nature. This book was released on 2020-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Download or read book Regulatory T Cells in Health and Disease written by and published by Academic Press. This book was released on 2015-11-26 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer. Contains contributions from leading authorities in the field of regulatory T cell biology Informs and updates on all the latest developments in the field Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer

Download or read book IRF4 Mediated Reprogramming of Myeloma Associated Macrophages to M1 Anti Tumoral Macrophages written by Trung Van Tran and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumor microenvironment (TME) has emerged as a key contributor to cancer progression in numerous solid tumors as well as blood cancers that evolve in the bone marrow (BM). Within the TME, tumor-associated macrophages (TAMs) play a significant role in cancer cell survival and progression and have been implicated in producing an immuno-suppressive TME by generating inflammatory mediators, growth factors, cytokines, chemokines, etc. In multiple myeloma (MM), a fatal plasma cell neoplasm, inflammatory and anti-viral pathways promote disease progression. Interferon regulatory factor 4 (IRF4) is a transcription factor that has previously been shown to promote MM progression through enhanced survival of malignant plasma cells. Under physiological conditions, IRF4 also regulates macrophage polarization, where its expression drives alternative activation of macrophages primarily to M2-like (anti-inflammatory) phenotypes. However, the extent to which IRF4 activation or direct inhibition governs the polarization status and pro-tumoral activity of macrophages in the MM microenvironment has not been fully elucidated. Here, we show that IRF4 activation in MM macrophage models correspond with a more M2-like phenotype and direct inhibition of IRF4 shifts the polarization status toward a more M1-like, anti-tumoral phenotype.

Download or read book Macrophages written by Hridayesh Prakash and published by BoD – Books on Demand. This book was released on 2021-02-24 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of chapters that discuss methodologies, resources, and technologies by dedicated authors. This book has addressed the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. All chapters have focused on the fate of differentiated macrophages and discussed molecular pathways that are important for the pathologic role of macrophages. I am confident that our readers will find this book useful in designing immune mediated strategies for managing various diseases that this book is based on.

Download or read book Reprogramming the Cellular Molecular and Metabolic Architecture of the Tumor Microenvironment for Effective Cancer Immunotherapy written by Soumen Chakraborty and published by Frontiers Media SA. This book was released on 2023-02-16 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Download or read book Phytochemistry An in silico and in vitro Update written by Shashank Kumar and published by Springer. This book was released on 2019-06-25 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemistry is the branch of science that deals with the study of plant-derived chemicals or compounds, which are also known as phytochemicals or plant-derived secondary metabolites. Plants are known to produce phytochemicals that are essential for their growth and reproduction, as they protect them from insects, pathogens, and herbivores. Some of the major groups of plant-derived secondary metabolites are phenolics, flavonoids, terpenoids, alkaloids, tannin etc. Plant-derived phytochemicals are pharmacologically active and have the potential to cure various human diseases and disorders. Natural plant products have been known for their medicinal properties for untold years, and form the basis of several medicinal systems such as Chinese, Unani, and Ayurvedic Medicine. This book offers an essential introduction to phytochemicals and their synthetic analogues. It discusses various in silico approaches used to identify pharmacologically active phytochemicals and their biological activities, as well as in vitro and in vivo models/assays that have been utilized for the pharmacological profiling of plant-derived products to combat cancer, diabetes, cardiovascular diseases and neurological disorders. The intended audience includes upper-level undergraduate and graduate students; researchers and scientists from the pharmaceutical/food chemistry/nutrition sciences/biochemistry, and clinical biochemistry fields; and medical students. Sharing the latest findings, the book will familiarize these readers with the concepts, chemistry, and tremendous potential of phytochemistry.

Download or read book Interaction of Immune and Cancer Cells written by Magdalena Klink and published by Springer Nature. This book was released on 2022-02-14 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.

Download or read book Tumour Associated Macrophages written by Toby Lawrence and published by Springer Science & Business Media. This book was released on 2011-10-06 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject of Tumour-Associated Macrophages is of interest in the cancer research community, and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development.

Download or read book Translocator Protein TSPO written by Giovanni Natile and published by MDPI. This book was released on 2018-03-05 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS