Download or read book Transport Phenomena in Microfluidics and Microbicide Drug Delivery Systems written by Stéphane André Joseph Verguet and published by . This book was released on 2008 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transport Phenomena in Microfluidic Systems written by Pradipta Kumar Panigrahi and published by John Wiley & Sons. This book was released on 2016-02-15 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully comprehensive introduction to the rapidly emerging area of micro systems technology Transport Phenomena in Micro Systems explores the fundamentals of the new technologies related to Micro-Electro-Mechanical Systems (MEMS). It deals with the behavior, precise control and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale, such as nl, pl, fl, small size, low energy consumption, effects of the micro domain and heat transfer in the related devices. The author describes in detail and with extensive illustration micro fabrication, channel flow, transport laws, magnetophoresis, micro scale convection and micro sensors and activators, among others. This book spans multidisciplinary fields such as material science and mechanical engineering, engineering, physics, chemistry, microtechnology and biotechnology. Brings together in one collection recent and emerging developments in this fast-growing area of micro systems Covers multidisciplinary fields such as materials science, mechanical engineering, microtechnology and biotechnology, et al Comprehensive coverage of analytical models in microfluidics and MEMS technology Introduces micro fluidics applications include the development of inkjet printheads, micro-propulsion, and micro thermal technologies Presented in a very logical format Supplies readers with problems and solutions
Download or read book Transport Phenomena in Micro Process Engineering written by Norbert Kockmann and published by Springer Science & Business Media. This book was released on 2007-11-12 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the fundamentals of chemical engineering are presented with respect to applications in micro system technology, microfluidics, and transport processes within microstructures. Special features of the book include the state-of-the-art in micro process engineering, a detailed treatment of transport phenomena for engineers, and a design methodology from transport effects to economic considerations.
Download or read book Transport Phenomena and Pharmacokinetics of Anti HIV Microbicide Drug Delivery written by Savas Tasoglu and published by . This book was released on 2011 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbicides are agents that can be applied to vaginal mucosal surfaces with the goal of blocking the transmission of sexually transmitted pathogens including HIV. They can be formulated in various delivery vehicles, including gels, creams, lotions, tablets or films. A recent study in South Africa has confirmed, for the first time, that a vaginal gel formulation of the antiretroviral drug Tenofovir, when topically applied, significantly inhibits sexual HIV transmission to women. However the gel for this drug, and anti-HIV microbicide vehicles in general, have not been designed using an understanding of how their spreading and retention in the vagina govern successful drug delivery. Elastohydrodynamic lubrication theory can be applied to model spreading of microbicide gels and films. This should incorporate the full rheological behavior, including how rheological properties change due to contact with, and dilution by, ambient vaginal fluids. A Carreau-like non-Newtonian model is adopted as a rheological model. The effects of three important factors, i.e., dilution by vaginal fluid, a yield stress of the gel and swelling, are investigated. Dilution accelerates the coating flow by creating a slippery region near the vaginal wall akin to a dilution boundary layer. The concept of a yield stress fluid is attractive because such a material may tend to stay in place after coating vulnerable surfaces. We show that the lubrication approximation, which eases the efforts of design, may be applied to the elastic wall-squeezing problem for a prototype gel with yield stress. For the important presence of significant swelling of the gel by absorption of vaginal fluid, the model indicates more rapid coating. Then we study films that can be preferable over gels due to several reasons in many parts of the world. A model is developed for transient swelling and spreading of a film, and subsequent distribution of an active drug throughout the vaginal lumen. We investigate the effects of combination of many factors. The theory developed here improves our understanding of the biophysics of microbicide gel and film flows in vivo. Ultimately, this dissertation contributes to a methodology that provides objective evaluations of microbicide gel and film performance and in the design of new, improved vehicles.
Download or read book Microsystems for Pharmatechnology written by Andreas Dietzel and published by Springer. This book was released on 2016-01-22 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.
Download or read book Encyclopedia of Microfluidics and Nanofluidics written by Dongqing Li and published by Springer Science & Business Media. This book was released on 2008-08-06 with total page 2242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all aspects of transport phenomena on the nano- and micro-scale, this encyclopedia features over 750 entries in three alphabetically-arranged volumes including the most up-to-date research, insights, and applied techniques across all areas. Coverage includes electrical double-layers, optofluidics, DNC lab-on-a-chip, nanosensors, and more.
Download or read book Interfacial and Transport Phenomena of Bioinspired Vesicles written by Xiaolei Chu and published by . This book was released on 2016 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the design of drug delivery vehicles, self-assembled nanostructured materials such as liposomes, polymerosomes and hybrid biomaterials bears increasing attentions. The key challenges in the optimal modification of these soft materials is the prediction of resultant morphologies in favor of circulation time, as well as the optimization of surface properties to adjust the interactions between bio-inspired materials with nanoparticles and bio-macromolecules such as peptides, proteins and nucleic acids. One of the ways to overcome these challenges is through the development of flexible modeling tools to address physical phenomena under a mesoscopic scale, allowing us to deeply investigate interfacial problems of nanostructured materials in a dynamic approach. In this work, we utilize the Dissipative Particle Dynamics simulation technique to examine the interaction between peptide mimetic nanoparticles (nanopin) and multicomponent vesicles. We study the role of nanopin architecture and cholesterol concentration on the capture of the nanopins by the bilayer, their insertion and post-insertion self-organization. Furthermore, we investigate the transportation of hybrid vesicle with various concentrations of end-functionalized lipids. We draw correlation among the morphology, composition and mechanical properties of the vesicle and flow conditions. Our results can potentially help in the design of drug delivery system with respect to their transport in blood capillaries, and tissue engineering for the design of microfluidic devices with better in-vivo transportation efficiency. Our study can also provide guidelines for designing peptide-mimetic nanoparticles or macromolecules which can interface with living cells to serve as sensors for applications in medicine, sustainability and energy.
Download or read book Microfluidics in Pharmaceutical Sciences written by Dimitrios A. Lamprou and published by Springer Nature. This book was released on with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microfluidics for Pharmaceutical Applications written by Hélder A. Santos and published by William Andrew. This book was released on 2018-10-12 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications. - Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness - Includes a variety of case studies that explain principles - Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world
Download or read book Two phase Transport Phenomena in Microfluidic Devices written by Cheng-Chieh Hsieh and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microfluidics and Microscale Transport Processes written by Suman Chakraborty and published by CRC Press. This book was released on 2012-10-04 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advancements in micro- and nano-fabrication techniques, especially in the last couple of decades, have led research communities, over the world, to invest unprecedented levels of attention on the science and technology of micro- and nano-scale devices and the concerned applications. With an intense focus on micro- and nanotechnology from a fluidic perspective, Microfluidics and Microscale Transport Processes provides a broad review of advances in this field. A comprehensive compendium of key indicators to recent developments in some very active research topics in microscale transport processes, it supplies an optimal balance between discussions of concrete applications and development of fundamental understanding. The chapters discuss a wide range of issues in the sub-domains of capillary transport, fluidic resistance, electrokinetics, substrate modification, rotational microfluidics, and the applications of the phenomena of these sub-domains in diverse situations ranging from non-biological to biological ones like DNA hybridization and cellular biomicrofluidics. The book also addresses a generic problem of particle transport in nanoscale colloidal suspensions and includes a chapter on Lattice-Boltzmann methods for phase-changing problems which represents a generic particle based approach that may be useful to address many microfluidic problems of interdisciplinary relevance.
Download or read book Transport Phenomena in Medicine and Biology written by Marshall Min-Shing Lih and published by John Wiley & Sons. This book was released on 1975 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transport Phenomena in Microfluidic Devices microform written by Liqing Ren and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Both experimental and numerical studies about the transport phenomena in microfluidic devices are presented in this thesis. The transport phenomena of interest are pressure driven flow and electroosmotic driven flow with a Reynolds number on the order of unit, and the associated mass transport phenomena. The studied microfluidic devices include fused silicon capillaries, in-house made glass microchannels and a glass chip with a crossing-linked microchannel etched into its surface. The hydraulic diameter ranges from 20 mum to 200 mum. The on-chip sample injection processes are studied both experimentally and numerically. Fluorescent dyes are employed here as the sample and the sample injection (loading and dispensing) processes on a microfluidic chip are visualized using an in-house developed laser visualization system and techniques. The experimentally measured sample injection process is compared with the numerical simulation results. Reasonable agreements were found between the model predictions and experimental measurements. The model is further developed in order to improve the simulation accuracy and save significant computation time as compared with the previous model. A general model capable of simulating general on-chip injection processes is finally developed to make the numerical analysis tools complete. This general model considers the electrical conductivity difference present at microfluidic applications, which is not considered normally due to its complexity. The electroosomotic flow is commonly applied in microfluidic devices as a pump, therefore, the flow rate determination is of particular interest. An experimental setup and corresponding data acquisition system are developed to measure electroosmotic flow rate by employing solution displacement process and current monitoring technique. A theoretical model is developed to improve the accuracy of this technique. A numerical model is developed to simulate this displacing process and to obtain flow rate. Good agreements between numerical simulations and experimental measurements verified the developed model. The electrokinetic transport phenomena of pressure driven flow in microchannels are studied based on a simultaneous solution to the developed pressure driven flow model. It is found that the flow characteristics of microchannels differ significantly from that in macrosized devices showing high viscous effects. The numerical results are compared with the experimental measurements and good agreement verified the developed model.
Download or read book Water powered Microfluidic Devices for Disgnostic and Drug Delivery Systems written by Yu-Chuan Su and published by . This book was released on 2003 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transport Phenomena Associated with Complex Fluids in Microfluidic Devices written by Marianna Grammatika and published by . This book was released on 2007 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transport and Mixing in Laminar Flows written by Roman Grigoriev and published by Wiley-VCH. This book was released on 2011-12-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers from academia and industry with an up-to-date overview of important advances in the field, dealing with such fundamental fluid mechanics problems as nonlinear transport phenomena and optimal control of mixing at the micro- and nanoscale. The editors provide both in-depth knowledge of the topic as well as vast experience in guiding an expert team of authors. The review style articles offer a coherent view of the micromixing methods, resulting in a much-needed synopsis of the theoretical models needed to direct experimental research and establish engineering principles for future applications. Since these processes are governed by nonlinear phenomena, this book will appeal to readers from both communities: fluid mechanics and nonlinear dynamics.
Download or read book Microfluidic Systems written by Ernest F Hasselbrink and published by . This book was released on 2006-11-30 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidic systems are devices that take advantage of the physical and chemical properties of liquids and gases and the electrical properties of semiconductors and combine them on a single chip. The field of microfluidics is experiencing tremendous growth in the biomedical area as new advances in silicon and other materials have brought forth much better and smaller microchannels for fluid applications. Microfluidic Sytsems focuses on flow, transport, and basic chemical phenomena as motivated by the surge in interest in microfluidic systems and bioMEMS. It provides access to the field for readers who may have had limited exposure to transport phenomena in the past, but who want to become proficient in the myriad of transport and reaction issues related to designing a microfluidic system. Readers having a knowledge of fluid mechanics that focus mainly on high Re flows, but lacking training in low Re flows or electrokinetics will also benefit from this text. In addition, numerous exercises and cases studies as well as solutions are included.
