Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Download or read book Hepatobiliary Transport From Bench to Bedside written by S. Matern and published by Springer Science & Business Media. This book was released on 2001-12-31 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a tremendous amount of scientific progress in our understanding of the molecular mechanisms of transport processes in the liver within the last few years. Cloning of various members of organic anion and cation transporters has provided the necessary tools to study their regulation under physiological and pathophysiological conditions and has advanced our knowledge about bile formation. Mutations of various hepatic organic anion transporters have been identified in humans as hereditary defects leading to the heterogenous syndrome of progressive familial intrahepatic cholestasis (PFIC). Various mouse models including knockout animals have given us the opportunity to gain insight into lipid transport by the liver and the genetics of cholesterol gallstone formation. The physiology of bile duct cells and the molecular mechanisms leading to various cholangiopathies have been a main scientific focus in hepatology in recent years. Drug targeting to the liver by hepatic organic anion transporters represents an attractive way of selective delivery of pharmaceutical agents in humans. Ursodeoxycholic acid is successfully used in the treatment of patients with chronic cholestatic liver disease and major advances have been made in understanding its mode of action in liver and bile duct cells. This book, the proceedings of the Falk Workshop held in Aachen, Germany, on 25-26 January 2001, contains chapters on all important aspects of biliary transport by well-known experts in this field. It is an essential resource for new developments in the field of biliary transport, both in basic science and clinical medicine.
Download or read book Hepatic Transport of Organic Substances written by Ernst Petzinger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.
Download or read book Liver Pathophysiology written by Pablo Muriel and published by Academic Press. This book was released on 2017-03-02 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.
Download or read book Hepatobiliary Transport in Health and Disease written by Dieter Häussinger and published by Walter de Gruyter. This book was released on 2012-05-29 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.
Download or read book Transport in the Liver written by D. Keppler and published by Springer. This book was released on 1994-09-30 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important functions of the liver are controlled by transport across different membrane domains. Advances in molecular cell biology have contributed to a better understanding of transport mechanisms in hepatocytes. The chapters in this book, the proceedings of the 74th Falk Symposium held in Heidelberg, Germany, 27--28 January 1994, discuss the current concepts in transport of low molecular weight substances across the sinusoidal membrane, intracellular events in conjugation and transport, as well as export across the canalicular hepatocyte membrane. Transport processes are discussed on the level of the carrier molecules, on the cellular level, as well as in the intact organ. In addition, the regulation of transport systems is addressed. An invaluable contribution to the exchange of information between basic scientists and clinical hepatologists in the rapidly expanding area of membrane transport.
Download or read book Hepatic Transport and Bile Secretion written by Nicola Tavoloni and published by . This book was released on 1993 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Download or read book Phosphate Transport and Turnover in the Liver written by Jacob Sacks and published by . This book was released on 1951 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Personal Experiences of Liver Transport and the Interactive Processes of Self Redefinition written by Janice Hays Chadha and published by . This book was released on 1995 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transport Functions of the Liver written by Ernst Petzinger and published by . This book was released on 1985 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Transporters in Drug Disposition Effects and Toxicity written by Xiaodong Liu and published by Springer Nature. This book was released on 2019-09-30 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Download or read book The Liver written by Irwin M. Arias and published by Lippincott Raven. This book was released on 2001 with total page 1112 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first major text to link the discoveries of basic biology to the understanding and clinical management of liver diseases, The Liver: Biology and Pathobiology has long been a classic in gastroenterology and hepatology. Now, this landmark work has been thoroughly revised and updated to reflect recent groundbreaking achievements in the laboratory and clinic. More than 100 world-renowned investigators provide a definitive account of current concepts on the structure and function of the liver and the mechanisms underlying liver diseases. This edition has been pared down to a smaller, more user-friendly size and focused more sharply on the most important advances. A Brandon-Hill recommended title.
Download or read book Assessment and Management of Hepatobiliary Disease written by Lajos Okolicsanyi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contributions to this volume cover all aspects of the assessment and management of hepatobiliary disease. The focal points of the book consist of three state-of-the-art summaries. The first of these deals with the highly topical problem of liver transplants from the point of view of patient selection. The second considers drug-induced liver injury in view of the fact that the liver is the main metabolic site for a number of drugs. The final summary deals with liver and aging: it asks whether the liver follows the aging process of the host organisms and whether the liver of aged liver transplant candidate donors could be suitable for grafting. Aside from these topics, the volume presents basic research on hepatic transport mechanisms, intrahepatic cholestasis and gall-stone disease, which serves as a background for the topics more specifically concerning the assessment of liver function. Much of the book is then devoted to the management of the commonest forms of liver diseases and their complications, such as chronic active hepatitis, liver cirrhosis, portal hypertension, hepatic encephalopathy, hepatorenal syndrome, and ascites.
Download or read book Insulin Activated Lipid Droplet Transport in the Liver written by Mukesh Kumar and published by . This book was released on 2023-03-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin Activated Lipid Droplet Transport in the Liver refers to the process by which insulin signaling regulates the transport of lipids, specifically triglycerides, in the liver. Insulin is a hormone that plays a critical role in the regulation of glucose and lipid metabolism in the body. When insulin levels are high, as occurs after a meal, it promotes the uptake and storage of glucose and lipids in tissues such as adipose tissue and the liver. In the liver, insulin signaling stimulates the formation of lipid droplets, which are storage organelles for triglycerides. The lipids are transported to the lipid droplets through a series of processes, including lipolysis, which breaks down stored triglycerides, and lipogenesis, which synthesizes new triglycerides. The transport of lipids to the lipid droplets is regulated by a complex network of proteins and enzymes, including perilipins, caveolins, adipophilins, and acyl-CoA synthetase. These proteins help to facilitate the movement of lipids into the lipid droplets and protect the droplets from degradation. Disruptions in insulin signaling and lipid transport can lead to metabolic disorders such as insulin resistance, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD). These disorders are characterized by the accumulation of lipids in the liver, which can cause oxidative stress, inflammation, and endoplasmic reticulum stress. Understanding the mechanisms of insulin activated lipid droplet transport in the liver is important for the development of therapies for metabolic disorders. Research in this area involves the investigation of gene expression, protein phosphorylation, mitochondrial function, autophagy, and other cellular processes that play a role in lipid metabolism and transport. Homeostasis i.e. a stable state of internal environment, is a fundamental attribute of animal physiology that involves maintenance of constant body temperature, blood pressure, nutrient, energy levels etc. Energy is required for sustenance of vital life processes, growth, development, reproduction and evolution. Animals must harness energy from food, but food sources are not always available on demand. Thus, they undergo phases of satiety and hunger. Balancing the internal energy needs in the phases of nutrient availability and scarcity is crucial for sustaining biological processes. Nature has devised adaptive mechanisms to cope with this fluctuation in nutrient availability by evolving molecules that are stored in unreactive forms when food is available in plenty, but are catabolized to provide energy at the time of scarcity. For instance, oils and fats provide neutral lipids that can be hydrolyzed to generate ATP when carbohydrates are not available and glucose level declines in the bloodstream.
Download or read book Transport of 3 0 methylene D glucose in Liver written by G. N. Europe-Finner and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
