Download or read book Transmethylations and the Central Nervous System written by V. M. Andreoli and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: V M. ANDREOLl, A. AGNOLI, and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved, for instance, in the metabolism of porphyrins, nuc1eic acids, and fatty acids. Only recently, however, did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical mediators of neu ronal transmission and, more broadly, of behavior. The first suggestion that transmethylation processes might be involved in the origina tion of certain mental diseases came from Harley-Mason (1952), who noticed that many of the hallucinogenic substances known at that time contained methyl radicals, and par ticularly that mescaline represented the product of O-methylation of dopamine in posi tions 3, 4, and 5. This hypothesis was put forward when the O-methylation of catechol amines by catechol-O-methyltransferases had not yet been described. Harley-Mason further proposed that in the living organism the process of O-methyla tion might follow a "deviant" metabolie pathway, and that the accumulation of abnor mal methylated metabolites endowed with hallucinogenic properties might be responsi ble for the implementation of some mental diseases, notably schizophrenia. He also called attention to a substance, 3,4-dimethoxyphenylethylamine (3,4-DMPEA) as a possible psychotogenic moleeule, on the strength of its capacity for producing cata tonia in experimental animals
Download or read book Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System written by Vincenzo Zappia and published by Elsevier. This book was released on 2013-10-22 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System contains the proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System held in Naples, Italy, on May 2, 1978. The papers explore the biochemical and pharmacological roles of S-adenosylmethionine (SAM), with particular emphasis on its functions in the central nervous system (CNS). This book consists of 13 chapters and opens with an introduction to some novel biochemical aspects of SAM and related sulfur compounds, paying particular attention to transmethylation reactions; polyamine biosynthesis and unusual biological roles of adenosylmethionine; metabolic pathways related to adenosine-sulfur compounds; and transport of adenosylmethionine. The following chapters discuss a number of chemical and biochemical properties of SAM as well as its pharmacological aspects within the CNS. The relation between folate and adenosylmethionine metabolism in the brain is examined, along with the effect of SAM administration on noradrenaline and serotonin metabolism in rat brain; cerebral utilization of adenosylmethionine and adenosylhomocysteine; and antidepressant effects of adenosylmethionine. Methylation in schizophrenia is also considered. This monograph will be a valuable source of information for biochemists and pharmacologists.
Download or read book HIV AIDS and the Nervous System written by Peter Portegies and published by Newnes. This book was released on 2007-08-17 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive understanding of HIV/AIDS and neuro-AIDS, including a history of the disease, and an explanation of many of the conditions that can arise in afflicted patients, including opportunistic infections, central nervous system tumors, spinal cord disorders, myopathies and progressive encephalopathy, amongst others. Clinicians will gain a greater understanding of the complex mechanisms of the disease. Beginning with a basic introduction to HIV infections and Neuro-AIDS, practitioners will find useful data on advances in molecular biology, neuroepidemiology, neuroimaging, neuropathology, neuropharmacology, as well as information on the development of therapeutic strategies appropriate for the disorder, including groundbreaking retroviral therapies. In addition, the socioeconomic and political constraints that hinder treatment and disease management in developing parts of the world are presented. * A comprehensive understanding of HIV/AIDS and neuro-AIDS, and the progression of the scientific community's understanding of the disease * Detailed information on fields such as neuroepidemiology, neuropathology, neuropharmacology, and neuroimaging and their contributions to HIV/AIDS research * Subject specific chapters on conditions associated with HIV/AIDS, including opportunistic infections, central nervous system tumors, and myopathies, amongst others
Download or read book Adenosinergic System and Central Nervous System Disorders written by Francisney Pinto Nascimento and published by Frontiers Media SA. This book was released on 2022-08-17 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Infections of the Central Nervous System written by Fabrice Chretien and published by John Wiley & Sons. This book was released on 2020-01-08 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Der neue Band aus der Reihe International Society of Neuropathology wurde anlässlich der British Medical Association (BMA) Awards 2019 wärmstens empfohlen. Die Herausgeber sind Experten des Fachgebiets und beschreiben Infektionen des Nervensystems mit ihren klinischen, pathologischen und genetischen Eigenheiten. Auch seltene Erkrankungen werden in übersichtlichen Kapiteln erläutert, zusammen mit Definitionen, mikrobiologischen Eigenschaften, Epidemiologie, klinischen Ausprägungen, Labortests, Pathologie, Genetik und Behandlungsoptionen.
Download or read book Psychopharmacology Abstracts written by and published by . This book was released on 1976 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book International Journal of Clinical Pharmacology Therapy and Toxicology written by and published by . This book was released on 1983 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Canadian Journal of Neurological Sciences written by and published by . This book was released on 1979 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Schizophrenia written by Andrew Crider and published by Routledge. This book was released on 2020-09-10 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1979, this introductory text approaches schizophrenia as a complex biopsychological condition. Drawing from the fields of descriptive psychiatry, psychopathology, neurochemistry, genetics, life history research, and institutional practice, the author details our increasing understanding of the nature and etiology of schizophrenia at the time. He organizes and evaluates current concepts and findings from these areas, with a view towards integration. This volume was intended to serve as an introduction for advanced undergraduate and graduate students in psychology, as well as for students in psychiatry, psychiatric nursing, and clinical social work. The author assumes that a comprehensive understanding of schizophrenia requires a synthesis of findings from diverse fields and emphasizes the compatibility of, and points of contact between, clinical psychological, and biological approaches. Here is a text that introduces the reader to this challenging subject and to contributions from a variety of allied disciplines. Today it can be read in its historical context.
Download or read book Medical and Health Care Books and Serials in Print written by and published by . This book was released on 1985 with total page 1360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Medical Books and Serials in Print 1979 written by R. R. Bowker LLC and published by R. R. Bowker. This book was released on 1979-05 with total page 1536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nervous System written by Thomas C. Jones and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicological testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the nervous system, is the sixth volume of a set pre pared under the sponsorship of the International Life Sciences Insti tute (ILSI).
Download or read book Monographic Series written by Library of Congress and published by . This book was released on 1979 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Methylation and Drug Design written by Ronald T. Borchardt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans methylation inhibitors (Section E).
Download or read book Research Awards Index written by and published by . This book was released on 1982 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Psychiatry written by Giorgio Racagni and published by . This book was released on 1991 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological psychology represents a fusion of several scientific disciplines - pharmacology, neurobiology, biochemistry, genetics, physiology, anatomy, biophysics and psychology. All are focussed on acquiring an ultimate understanding of the relationships between brain and behaviour. Presented in two volumes are the papers of the 5th World Congress of Biological Psychiatry. Together they represent a significant contribution to complementary advances across a broad front of recently developed research areas. Psychiatric disorders include schizophrenia, affective disorders, the many forms of senile and presenile dementia including Alzheimer's disease, the anxiety disorders, childhood disorders and the variants of eating and sleeping dysfunctions. Each of these illnesses represents a complex interaction of biological, psychological and social variables. The growing number of neuroscientists adopting the biological approach to neuropsychiatric diseases has resulted in a fast expanding body of knowledge regarding brain function and pathology.Further, psychotherapeutic drugs used to treat psychiatric and neurologic disorders play a crucial role in elucidating the biological bases of these diseases. Studying the mechanism of action of these compounds should give us important clues about the normal and pathological functioning of the brain.
Download or read book Psychopathology and Psychopharmacology written by American Psychopathological Association and published by . This book was released on 1973 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
