Download or read book Translational Machine Learning for Epilepsy Therapy written by Steven Baldassano and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous medical data monitoring is playing an increasingly important role in patient care, both in and out the hospital. Diagnosing and treating patients with epilepsy is especially reliant on continuous EEG monitoring to identify and respond to seizures. However, as use of continuous EEG becomes more common, both for long-term inpatient monitoring and in ambulatory or implanted devices, the burden of study interpretation is rapidly outpacing available physician resources. In particular, the advent of implanted neuroresponsive devices for treating medically-refractory epilepsy is generating large, streaming datasets potentially lasting for several years and containing hundreds of seizures. The current need for manual review of long-term, continuous EEG data introduces tremendous health care costs and can result in significant delays in seizure diagnosis and treatment. Automated data processing is essential to improve data usage, accurately and rapidly detect seizures, and provide scalability in clinical practice. This thesis aims to develop platforms for automated data analysis and event detection using custom machine learning algorithms for application in the intensive care unit and in implanted neural devices. The work presented in this thesis progresses through the development of each component of an automated data analysis platform. The first section describes a system for real-time data analysis and caretaker notification in the ICU, with a focus on the process necessary to harness multi-modal data from clinical recording sources. The next section details the process of developing machine learning algorithms for seizure detection. In this section, I present novel seizure detection strategies as well as a competition designed to crowdsource algorithm development. This work produced several highly-accurate, open-source seizure detection methods, validated in extended human implanted device data, along with pipelines to facilitate algorithm application and benchmarking in new datasets. The last section covers the integration of data management and seizure detection for implementation in next-generation medical devices. I present a novel paradigm to leverage cloud computing resources for seizure detection in an implanted device. This system is then implemented in vivo using a canine epilepsy model, with real-time seizure detection on streaming data from Medtronic's RC+S neurostimulating device. These algorithms and flexible analysis platforms are a step toward automating analysis of EEG data for epilepsy therapy. It is my hope that such systems will improve medical data usage, reshape caretaker workflow, and increase the clinical power of continuous medical monitoring.

Download or read book Seizure Forecasting and Detection Computational Models Machine Learning and Translation into Devices written by Sharon Chiang and published by Frontiers Media SA. This book was released on 2022-03-31 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Application of Machine Learning to Epileptic Seizure Onset Detection and Treatment written by Ali Hossam Shoeb and published by . This book was released on 2009 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: (cont.) In this thesis we also discuss how our detector can be embedded within a low power, implantable medical device to enable the delivery of just-in-time therapy that has the potential to either eliminate or attenuate the clinical symptoms associated with seizures. Finally, we report on the in-hospital use of our detector to enable delay-sensitive therapeutic and diagnostic applications. We demonstrate the feasibility of using the algorithm to control the Vagus Nerve Stimulator (an implantable neuro stimulator for the treatment of intractable seizures), and to initiate ictal SPECT (a functional neuroimaging modality useful for localizing the cerebral site of origin of a seizure).

Download or read book Electroencephalogram Machine Learning to Assist Diagnosis and Treatment of Epilepsy written by Yuedong Song and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Machine Learning and Big Data for Personalized Epilepsy Treatment written by Samuel Håkansson and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Big Data in Psychiatry and Neurology written by Ahmed Moustafa and published by Academic Press. This book was released on 2021-06-11 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big Data in Psychiatry and Neurology provides an up-to-date overview of achievements in the field of big data in Psychiatry and Medicine, including applications of big data methods to aging disorders (e.g., Alzheimer’s disease and Parkinson’s disease), mood disorders (e.g., major depressive disorder), and drug addiction. This book will help researchers, students and clinicians implement new methods for collecting big datasets from various patient populations. Further, it will demonstrate how to use several algorithms and machine learning methods to analyze big datasets, thus providing individualized treatment for psychiatric and neurological patients. As big data analytics is gaining traction in psychiatric research, it is an essential component in providing predictive models for both clinical practice and public health systems. As compared with traditional statistical methods that provide primarily average group-level results, big data analytics allows predictions and stratification of clinical outcomes at an individual subject level. Discusses longitudinal big data and risk factors surrounding the development of psychiatric disorders Analyzes methods in using big data to treat psychiatric and neurological disorders Describes the role machine learning can play in the analysis of big data Demonstrates the various methods of gathering big data in medicine Reviews how to apply big data to genetics

Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Download or read book Conn s Translational Neuroscience written by P. Michael Conn and published by Academic Press. This book was released on 2016-09-28 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment

Download or read book Epileptic Seizure Disorders in Animal Models Advances in Translational Approaches written by Evgenia Sitnikova and published by Frontiers Media SA. This book was released on 2024-04-29 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Complex Systems Approach to Epilepsy written by Rod C. Scott and published by Cambridge University Press. This book was released on 2022-12-31 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a complex systems approach to understanding the clinical variability of epilepsy and designing new therapies for the disorder.

Download or read book Artificial Intelligence for Neurological Disorders written by Ajith Abraham and published by Academic Press. This book was released on 2022-09-23 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial Intelligence for Neurological Disorders provides a comprehensive resource of state-of-the-art approaches for AI, big data analytics and machine learning-based neurological research. The book discusses many machine learning techniques to detect neurological diseases at the cellular level, as well as other applications such as image segmentation, classification and image indexing, neural networks and image processing methods. Chapters include AI techniques for the early detection of neurological disease and deep learning applications using brain imaging methods like EEG, MEG, fMRI, fNIRS and PET for seizure prediction or neuromuscular rehabilitation. The goal of this book is to provide readers with broad coverage of these methods to encourage an even wider adoption of AI, Machine Learning and Big Data Analytics for problem-solving and stimulating neurological research and therapy advances. Discusses various AI and ML methods to apply for neurological research Explores Deep Learning techniques for brain MRI images Covers AI techniques for the early detection of neurological diseases and seizure prediction Examines cognitive therapies using AI and Deep Learning methods

Download or read book Translational Applications of Neuroimaging written by Stavros Skouras and published by Frontiers Media SA. This book was released on 2024-04-04 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite substantial progress in the development of neuroimaging methodologies, translational applications of neuroimaging remain scarce. This Research Topic invites article submissions that present promising neuroimaging applications and methods addressing critical needs for improving health outcomes. These may include Original Research, Clinical Trial, Systematic Review or Methods articles that investigate neuroimaging metrics as outcome measures or in combination with neural perturbation techniques (e.g., neurofeedback, neurostimulation), other translational applications (e.g., guiding neurosurgery). To foster debate, we also welcome critical Review, Opinion, and Perspective articles that survey the field and its progress towards clinical utility.

Download or read book Translational Neuroscience written by Mark H. Tuszynski and published by Springer. This book was released on 2016-03-08 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.

Download or read book Cell Biology and Translational Medicine Volume 13 written by Kursad Turksen and published by Springer Nature. This book was released on 2021-08-26 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the thirteenth volume of a continuing series.

Download or read book Translational Medicine in CNS Drug Development written by George G. Nomikos and published by Academic Press. This book was released on 2019-06-18 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Download or read book Epilepsy written by Jong Rho and published by CRC Press. This book was released on 2010-06-18 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo

Download or read book Temporal Lobe Epilepsy From Etiology to Treatment written by Fernando Cendes and published by Frontiers Media SA. This book was released on 2022-12-19 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: